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Dietary supplement

Rue Vanilla Flavor Ingredients & Drug Interactions

by TerraVita

Rue Vanilla Flavor label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Rue Vanilla Flavor against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Rue Vanilla Flavor is a dietary supplement by TerraVita with 1 active ingredient. Its ingredients are commonly taken for menstrual cramps, digestive upset, muscle spasms and pain.Based on those ingredients, 335 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Rue Glycerite Liquid Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Rue Vanilla Flavor by TerraVita

Ask about any prescription or over-the-counter medication and we check it for interactions with Rue Vanilla Flavor by TerraVita — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Rue Vanilla Flavor by TerraVita

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: rue glycerite liquid extract. Rue is a plant extract traditionally used for various purposes, though the evidence supporting most of these uses is insufficient.

The product also contains glycerin and vanilla flavor as inactive ingredients.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Rue product and its label doesn't state a use — see Rue's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold on rue is incomplete for the conditions it's been used for — abortion, cancer prevention, contraception, and digestive upset all carry a rating of insufficient reliable evidence. That means we don't have enough solid research to say whether it works for any of these uses.

The evidence, ingredient by ingredient Rue

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Rue in food amounts is generally well tolerated. When taken as a medicinal dose in dried form, it's generally well tolerated, though a full safety review hasn't been done.

Fresh rue is considered unsafe. The dried herb may cause cramps, drowsiness, depression, dizziness, stomach irritation, or sleep problems.

High doses can trigger respiratory distress. Topically, it can cause contact dermatitis or phototoxic skin damage.

Rue is rated likely unsafe in pregnancy because it has traditionally been used to bring on miscarriage and may harm a developing baby. It should be avoided during pregnancy and breastfeeding — safety data isn't established, and potentially toxic compounds may pass to an infant.

Side effects, ingredient by ingredient Rue

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Rue.
  • The most serious interaction on file is rated Moderate.
  • For scale: 335 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take photosensitizing drugs — medications that increase your skin's sensitivity to sunlight — check with your pharmacist before using this product. The combination carries a Moderate risk of phototoxic skin reactions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Rue extract isn't well-studied for the conditions people have traditionally used it for. If you take any photosensitizing medication (especially ones used with light therapy), talk to your pharmacist before using this product.

Pregnant and breastfeeding people should avoid it. For anyone else, check your medications first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Rue Vanilla Flavor, straight from the product label.

Brand TerraVita
Barcode (UPC) 064435229498
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Nov 22, 2022
DSLD ID 280917
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Rue Vanilla Flavor by TerraVita, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
25 Drop(s)
Maximum serving Sizes:
40 Drop(s)
Servings per container
227
UPC/BARCODE
064435229498
IngredientAmount% DV
Rue Glycerite Liquid Extract0.13 mL--

Other ingredients: Glycerin, Vanilla Flavor

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Copyright 2018 TerraVita - Distributed by ZooScape LLC, All Rights Reserved.

Formula

Glycerite liquid extract (1:5)

Formulation

Alcohol free

Suggested/Recommended/Usage/Directions

Suggested Use: Take 25-40 drops of extract in a small amount of warm water 3-4 times daily. Shake well before using.

Precautions

Keep away from children.

Do not use if safety seal around cap is broken or missing.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Rue Vanilla Flavor by TerraVita label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Rue Vanilla Flavor label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Rue Vanilla Flavor by TerraVita

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size25 Drop(s) Dosage formLiquid Servings per container227 Amounts shown are per serving.

Rue Glycerite Liquid Extract

Interacts with
335 drugs
0.13 mL per serving

Rue is a strong-smelling herb from southern Europe with a long history in folk medicine, but there is very little reliable human research to support i...

Rue Glycerite Liquid Extract monograph & interactions

Other (inactive) ingredients: Glycerin, Vanilla Flavor. These complete the product’s ingredient list but are not active constituents.

Interaction report

Rue Vanilla Flavor by TerraVita Drug Interactions

Want to check YOUR meds against Rue Vanilla Flavor?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
335Drugs
335 Moderate

Ingredients driving the most interactions

Rue Glycerite Liquid Extract 335

Individual Drug Interactions

The ingredients in Rue Vanilla Flavor interact with 335 drugs. Click any drug to see the details.

1 of the 1 ingredient in Rue Vanilla Flavor interact with drugs. Each result below shows which ingredient is responsible. Rue Glycerite Liquid Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Rue Vanilla Flavor with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Rue Glycerite Liquid Extract1 drug type · 335 drugs

Photosensitizing Drugs

Theoretically, rue might increase the risk for phototoxicity when used with photosensitizing drugs.
Rue contains photosensitizing furanocoumarins and psoralens and has been associated with multiple reports of phototoxic reactions. There is also one case report of an increased phototoxic response to psoralen and ultraviolet A (PUVA) therapy associated with ingestion of rue.

Likelihood Possible Evidence D
Rue Glycerite Liquid Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Rue Vanilla Flavor, from the product label.

TerraVita

See all TerraVita products
Name
ZooScape LLC
Phone Number
844-449-0444
Web Address
www.ZooScape.com
Pharmacist Counseling Corner

Rue Vanilla Flavor by TerraVita: Common Questions

Does Rue Vanilla Flavor by TerraVita interact with any medications?
Yes. Based on its ingredients, Rue Vanilla Flavor has a known interaction with 335 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Rue Vanilla Flavor contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I use this if I'm pregnant or breastfeeding?
No. Rue is rated likely unsafe in pregnancy because it's been traditionally used to cause miscarriage and may harm the baby. It should also be avoided while breastfeeding — we don't have enough safety data, and potentially toxic compounds could pass to your infant. Talk to your doctor or pharmacist about alternatives.
What side effects might I get from rue?
When taken as a medicinal dose of the dried herb, some people experience cramps, drowsiness, depression, dizziness, stomach irritation, or sleep problems. High doses can cause breathing trouble. Topically, it can cause skin contact reactions or severe sun-sensitivity reactions. Fresh rue is considered unsafe.
Is rue safe to take every day?
A thorough safety evaluation hasn't been done, so we don't have enough data to recommend daily use. Rue can be toxic at higher doses, and the oil especially carries risk. Use it cautiously, if at all, and talk to your pharmacist about whether it's right for you.
What is rue traditionally used for?
Rue has been used for abortion, contraception, cancer, and digestive upset. Unfortunately, the evidence supporting these uses is insufficient to say whether it actually works for any of them.
Does this interact with sunscreen or light therapy?
Rue can increase your risk of phototoxic reactions — severe sun damage to your skin — especially if you're using photosensitizing medications or undergoing light-based treatment like PUVA therapy. Check with your pharmacist about your specific medications before using this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Rue Vanilla Flavor is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Rue Vanilla Flavor label
Go deeper

The Full Monographs Behind Rue Vanilla Flavor’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Rue

Interacts with 335 drugs

Rue is a strong-smelling herb from southern Europe with a long history in folk medicine, but there is very little reliable human research to support its health uses. It can be toxic in large...

Read the full Rue monograph →
Sources

Sources & How We Checked

Rue Vanilla Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Rue 8 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  3. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  4. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  5. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  6. Puig L. Pharmacodynamic interaction with phototoxic plants during PUVA therapy. Br J Dermatol 1997;136:973-4. PubMed
  7. Radotra I, Gardiner S, Barnes D. A phytophototoxic injury at a burns unit: the ungraceful after-effects of the "common rue" plant. J Burn Care Res. 2018;39(6):1064-6. PubMed
  8. Avallone G, Mastorino L, Agostini A, et al. Ruta graveolens phytophotodermatitis. Dermatol Online J 2021;27(7). PubMed

See these in context on the Rue monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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