Interactions on record — worth a quick check against your medications. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

Fish Oil +Resveratrol Ingredients & Drug Interactions

by GNC Triple Strength

Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Fish Oil +Resveratrol is a dietary supplement by GNC Triple Strength with 3 active ingredients. Its ingredients are commonly taken for heart and blood vessel health, antioxidant support, anti-aging.Based on those ingredients, 822 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Resveratrol. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Fish Oil +Resveratrol by GNC Triple Strength

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 3 active ingredients: two omega-3 fatty acids from fish oil (eicosapentaenoic acid and docosahexaenoic acid) and resveratrol, a plant compound. The inactive ingredients are fish body oil, gelatin, glycerin, an enteric coating (which helps the capsule dissolve in your intestines rather than your stomach), titanium dioxide, soy lecithin, and riboflavin.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Resveratrol's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: heart, brain, joint, eye and skin health.
  • We looked for evidence on: Cardiovascular disease (CVD), Age-related cognitive decline, Cognitive function, Cognitive impairment, Alzheimer disease, Osteoarthritis — and 4 related terms.
  • The closest evidence on file: Resveratrol is rated "Possibly Ineffective" for Cardiovascular disease (CVD) (Natural Medicines).
  • Also on file: Resveratrol is rated "Possibly Ineffective" for Hypercholesterolemia.
  • Also on file: Resveratrol is rated "Insufficient Reliable Evidence To Rate" for Age-related cognitive decline, Aging skin, Alzheimer disease, Cognitive function, and more.

Resveratrol shows possibly effective evidence for obesity and allergic rhinitis (hay fever). For cardiovascular disease and high cholesterol, the evidence currently leans toward possibly ineffective.

The fish oil ingredients themselves have no effectiveness ratings in our data, so we can't speak to what they may or may not do in this formulation.

The evidence, ingredient by ingredient Resveratrol

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Resveratrol is generally well tolerated at typical supplement doses. At higher doses, some people report diarrhea, loose stools, and general digestive upset.

A small number of trial participants and case reports have noted headache, fatigue, memory loss, or skin rashes, though in most cases these went away once the supplement was stopped. The safety data advises against this concentrated supplement during pregnancy and breastfeeding — there isn't enough information to know whether it's safe for you or your baby at those times.

Side effects, ingredient by ingredient Resveratrol

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Resveratrol.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 823 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check this product if you take blood thinners or antiplatelet medications like warfarin, aspirin, or clopidogrel — resveratrol may add to the bleeding risk. Also check if you take drugs metabolized by liver enzymes CYP2C19, CYP1A2, CYP2E1, or CYP3A4, since resveratrol may raise their levels.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you take blood thinners, antiplatelet drugs, or medications your liver processes through CYP enzymes, you'll want to check this product with your pharmacist or doctor first. Otherwise, for general use, resveratrol is generally well tolerated, though some people get digestive upset at higher doses.

Talk to your pharmacist about your own medications before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 26, 2011.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Fish Oil +Resveratrol, straight from the product label.

Brand GNC Triple Strength
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Oct 26, 2011
DSLD ID 1071
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Fish Oil +Resveratrol by GNC Triple Strength, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
IngredientAmount% DV
Calories15 {Calories}--
Calories from Fat15 {Calories}--
Total Fat1.5 g2%
Eicosapentaenoic Acid647 mg--
Docosahexaenoic Acid253 mg--
Resveratrol125 mg--

Other ingredients: Fish Body Oil, Gelatin, Glycerin, Enteric Coating, Titanium Dioxide, Soy Lecithin, Riboflavin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

DIETARY SUPPLEMENT

Formula

• 900 mg of total omega-3 fatty acids and 125 mg of trans-resveratrol • Breakthrough antioxidant protection to fight cell-aging* • Provides heart, brain, joint, eye and skin heaIth*

Formulation

No Sugar, No Starch, No Artificial Colors, No Artificial Flavors, No Preservatives, No Wheat, No Gluten, No Corn, No Dairy, Yeast Free.

Precautions

KEEP OUT OF REACH OF CHILDREN.

WARNING: Consult your physician prior to using this product if you are pregnant, nursing, taking medication, or have a medical condition. Discontinue use two weeks prior to surgery.

Storage

Store in a cool, dry place.

General Statements

ACTUAL SIZE

Conforms to USP <2091> for weight.

Enteric Coated

GNC GUARANTEE Use any GNC supplement for as little as 10 days. If you are not 100% completely satisfied, return the unused portion of the product with proof of purchase to your GNC store for a complete refund of your purchase price. No questions asked!

GNC QUALITY COMMITMENT GNC, the leader in the development and manufacture of dietary supplements, is committed to producing the highest quality products available. This commitment begins with quality designed supplement formulations. Every raw material that goes into a GNC supplement is guaranteed as to quality and potency. Each product is dated and then shipped immediately to our stores, so you can be sure you are purchasing the freshest supplements available. At GNC, we extend our quality commitment to you by offering our money-back guarantee.

GNC Triple Strength Fish Oil plus Resveratrol combines a total of 900 mg of heart-healthy omega-3 fatty acids, EPA and DHA, with 125 mg of trans-resveratrol the potent cell protector and polyphenol found in the skin of red grapes and in some plants and berries. This formula has been enteric coated to control or reduce fishy burps by allowing the softgel capsule to break down and absorb in the small intestine. GNC Triple Strength Fish Oil plus Resveratrol offers many health benefits: The omega-3 fatty acids found in fish oil: • Are necessary for heart health and help support healthy joints* • Support normal, healthy cholesterol levels and are necessary in the maintenance of normal blood pressure* • Support skin heaIth* Resveratrol: • Helps protect against free radicals that can destroy healthy cells, damage tissue and promote the celI-aging process* GNC Triple Strength Fish Oil plus Resveratrol has been purified and manufactured for freshness and found to be free of detectable levels of mercury, cadmium, lead and PCBs. We use only the best quality ingredients derived from wild, deep ocean fish.

Please recycle this box.

Potency verified by GNC procedureS #5123 & #5297.

General

CODE 883411 AMG

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take one softgel capsule daily with food.

See for yourself

Fish Oil +Resveratrol by GNC Triple Strength label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Fish Oil +Resveratrol by GNC Triple Strength

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Eicosapentaenoic Acid

647 mg per serving

Docosahexaenoic Acid

253 mg per serving

Resveratrol

Interacts with
822 drugs
125 mg per serving Form: Polygonum cuspidatum root extract

Resveratrol is a plant compound found in red grapes, berries, and peanuts that is popular for heart health, anti-aging, and antioxidant support. While...

Resveratrol monograph & interactions

Other (inactive) ingredients: Fish Body Oil, Gelatin, Glycerin, Enteric Coating, Titanium Dioxide, Soy Lecithin, Riboflavin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Fish Oil +Resveratrol by GNC Triple Strength Drug Interactions

Want to check YOUR meds against Fish Oil +Resveratrol?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
822Drugs
822 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Fish Oil +Resveratrol with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Resveratrol5 drug types · 822 drugs

Anticoagulant/Antiplatelet Drugs

Resveratrol may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Resveratrol seems to have antiplatelet effects.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, resveratrol might increase levels of drugs metabolized by CYP1A2.
In vitro research shows that resveratrol can inhibit CYP1A2 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, resveratrol might increase levels of drugs metabolized by CYP2C19.
In vitro research shows that resveratrol can inhibit CYP2C19 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Resveratrol might increase levels of drugs metabolized by CYP2E1.
In vitro research suggests that resveratrol inhibits CYP2E1 isoenzyme. Also, a pharmacokinetic study shows that taking resveratrol 500 mg daily for 10 days prior to taking a single dose of chlorzoxazone 250 mg increases the maximum concentration of chlorzoxazone by about 54%, the area under the curve of chlorzoxazone by about 72%, and the half-life of chlorzoxazone by about 35%. Chlorzoxazone is used as a probe drug for CYP2E1.

Likelihood Probable Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
In vitro research shows that resveratrol can inhibit the CYP3A4 enzyme. However, clinical research shows that taking resveratrol 3000 mg daily for 8 weeks does not necessitate dose adjustments to medications metabolized by CYP3A4.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Fish Oil +Resveratrol, from the product label.

GNC Triple Strength

See all GNC Triple Strength products
Phone Number
1-888-462-2548
Pharmacist Counseling Corner

Fish Oil +Resveratrol by GNC Triple Strength: Common Questions

Does Fish Oil +Resveratrol by GNC Triple Strength interact with any medications?
Yes. Based on its ingredients, Fish Oil +Resveratrol has a known interaction with 822 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Fish Oil +Resveratrol contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help me lose weight?
Resveratrol shows possibly effective evidence for obesity, so it may help — but that's not the same as proven. Talk to your pharmacist about realistic expectations and whether it fits your overall plan.
Can I take this if I'm pregnant or breastfeeding?
The safety data advises against this concentrated supplement during pregnancy and while breastfeeding. There isn't enough information to know whether it's safe at those times. Please talk with your doctor or pharmacist for personalized advice.
What side effects should I expect?
Most people tolerate it well. At higher doses, the most common issues are diarrhea, loose stools, and digestive discomfort. A small number of people have reported headache, fatigue, or skin rashes — these cleared up once they stopped taking it.
What's in the capsule besides the active ingredients?
The capsule itself is gelatin with an enteric coating — that's the special layer that lets it dissolve lower in your gut instead of your stomach. The other inactive ingredients are fish body oil, glycerin, titanium dioxide, soy lecithin, and riboflavin.
Will this help my cholesterol or heart health?
For high cholesterol and cardiovascular disease, the evidence for resveratrol currently leans toward possibly ineffective. We don't have effectiveness data on the fish oil ingredients themselves in this formulation.
Does this contain soy?
Yes — soy lecithin is listed as an inactive ingredient. If you have a soy allergy, talk to your pharmacist before taking it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Fish Oil +Resveratrol is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Fish Oil +Resveratrol label
Go deeper

The Full Monographs Behind Fish Oil +Resveratrol’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

Fish Oil +Resveratrol's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 24 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Resveratrol 24 references
  1. Soleas GJ, Diamandis EP, Goldberg DM. Resveratrol: a molecule whose time has come? And gone? Clin Biochem 1997;30:91-113.
  2. Pace-Asciak CR, Rounova O, Hahn SE, et al. Wines and grape juices as modulators of platelet aggregation in healthy human subjects. Clin Chim Acta 1996;246:163-82. PubMed
  3. Bertelli AA, Giovannini L, Bernini W, et al. Antiplatelet activity of cis-resveratrol. Drugs Exp Clin Res 1996;22:61-3.
  4. Pace-Asciak CR, Hahn S, Diamandis EP, et al. The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease. Clin Chim Acta 1995;235:207-19.
  5. Bertelli A, Bertelli AA, Gozzini A, Giovannini L. Plasma and tissue resveratrol concentrations and pharmacological activity. Drugs Exp Clin Res 1998;24:133-8.
  6. Bertelli AA, Giovannini L, Giannessi D, et al. Antiplatelet activity of synthetic and natural resveratrol in red wine. Int J Tissue React 1995;17:1-3.
  7. Piver B, Berthou F, Dreano Y, Lucas D. Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components. Toxicol Lett 2001;125:83-91. PubMed
  8. Chang, T. K., Chen, J., and Lee, W. B. Differential inhibition and inactivation of human CYP1 enzymes by trans-resveratrol: evidence for mechanism-based inactivation of CYP1A2. J.Pharmacol.Exp.Ther. 2001;299(3):874-882.
  9. Dobrydneva, Y., Williams, R. L., and Blackmore, P. F. trans-Resveratrol inhibits calcium influx in thrombin-stimulated human platelets. Br.J.Pharmacol. 1999;128(1):149-157.
  10. Kirk, R. I., Deitch, J. A., Wu, J. M., and Lerea, K. M. Resveratrol decreases early signaling events in washed platelets but has little effect on platalet in whole food. Blood Cells Mol.Dis. 2000;26(2):144-150.
  11. Zbikowska, H. M. and Olas, B. Antioxidants with carcinostatic activity (resveratrol, vitamin E and selenium) in modulation of blood platelet adhesion. J Physiol Pharmacol. 2000;51(3):513-520.
  12. Olas, B., Wachowicz, B., Saluk-Juszczak, J., and Zielinski, T. Effect of resveratrol, a natural polyphenolic compound, on platelet activation induced by endotoxin or thrombin. Thromb.Res 8-15-2002;107(3-4):141-145. PubMed
  13. Yu, C., Shin, Y. G., Kosmeder, J. W., Pezzuto, J. M., and van Breemen, R. B. Liquid chromatography/tandem mass spectrometric determination of inhibition of human cytochrome P450 isozymes by resveratrol and resveratrol-3-sulfate. Rapid Commun.Mass Spectro PubMed
  14. Ma, Z. H. and Ma, Q. Y. Resveratrol: a medical drug for acute pancreatitis. World J Gastroenterol. 6-7-2005;11(21):3171-3174. PubMed
  15. la, Porte C., Voduc, N., Zhang, G., Seguin, I., Tardiff, D., Singhal, N., and Cameron, D. W. Steady-State pharmacokinetics and tolerability of trans-resveratrol 2000 mg twice daily with food, quercetin and alcohol (ethanol) in healthy human subjects. Cli PubMed
  16. Brown, V. A., Patel, K. R., Viskaduraki, M., Crowell, J. A., Perloff, M., Booth, T. D., Vasilinin, G., Sen, A., Schinas, A. M., Piccirilli, G., Brown, K., Steward, W. P., Gescher, A. J., and Brenner, D. E. Repeat dose study of the cancer chemopreventive
  17. Pendurthi, U. R., Williams, J. T., and Rao, L. V. Resveratrol, a polyphenolic compound found in wine, inhibits tissue factor expression in vascular cells : A possible mechanism for the cardiovascular benefits associated with moderate consumption of wine. PubMed
  18. Chachay VS, Macdonald GA, Martin JH, Whitehead JP, O'Moore-Sullivan TM, Lee P, Franklin M, Klein K, Taylor PJ, Ferguson M, Coombes JS, Thomas GP, Cowin GJ, Kirkpatrick CM, Prins JB, Hickman IJ. Resveratrol does not benefit patients with nonalcoholic fatty
  19. Bedada SK, Neerati P. Resveratrol Pretreatment Affects CYP2E1 Activity of Chlorzoxazone in Healthy Human Volunteers. Phytother Res. 2016;30(3):463-8. PubMed
  20. Lin CT, Sun XY, Lin AX. Supplementation with high-dose trans-resveratrol improves ultrafiltration in peritoneal dialysis patients: a prospective, randomized, double-blind study. Ren Fail. 2016;38(2):214-21. PubMed
  21. Li Q, Yang G, Xu H, Tang S, Lee WY. Effects of resveratrol supplementation on bone quality: a systematic review and meta-analysis of randomized controlled trials. BMC Complement Med Ther 2021;21(1):214. PubMed
  22. McCreary MR, Schnell PM, Rhoda DA. Randomized double-blind placebo-controlled proof-of-concept trial of resveratrol for outpatient treatment of mild coronavirus disease (COVID-19). Sci Rep 2022;12(1):10978. PubMed
  23. Abdelhaleem IA, Brakat AM, Adayel HM, Asla MM, Rizk MA, Aboalfetoh AY. The effects of resveratrol on glycemic control and cardiometabolic parameters in patients with T2DM: A systematic review and meta-analysis. Med Clin (Barc) 2022;158(12):576-585. PubMed
  24. Badaoui A. Allergic contact dermatitis to resveratrol and Scutellaria baicalensis root extract in a cosmetic product. Contact Dermatitis 2022.

See these in context on the Resveratrol monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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