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Dietary supplement

Folic Acid 400 mcg Ingredients & Drug Interactions

by Sundown Naturals

Folic Acid 400 mcg label
See full label image
Tablet Or Pill Category: Vitamin
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Folic Acid 400 mcg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Folic Acid 400 mcg is a dietary supplement by Sundown Naturals with 1 active ingredient. Its ingredients are commonly taken for preventing neural tube birth defects, treating or preventing folate deficiency, supporting pregnancy health.Based on those ingredients, 40 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Folic Acid. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Folic Acid 400 mcg by Sundown Naturals

Ask about any prescription or over-the-counter medication and we check it for interactions with Folic Acid 400 mcg by Sundown Naturals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Folic Acid 400 mcg by Sundown Naturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This supplement contains one active ingredient: folic acid, a B vitamin that your body needs to make new cells and DNA. The tablet also includes inactive ingredients—cellulose and dicalcium phosphate—which are fillers and binders that hold the tablet together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Supports heart and cardiovascular health.
  • We looked for evidence on: Cardiovascular disease (CVD), Angioplasty, Stroke, Nitrate tolerance, Fenofibrate (Tricor)-induced hyperhomocysteinemia, Homocysteine reduction — and 1 related terms.
  • The strongest evidence on file: Folic Acid is rated "Possibly Effective" for Stroke (Natural Medicines).
  • Also on file: Folic Acid is rated "Insufficient Reliable Evidence To Rate" for Fenofibrate (Tricor)-induced hyperhomocysteinemia, Nitrate tolerance, Angioplasty.

Folic acid 400 mcg is effective for treating or preventing folate deficiency. The evidence also shows it's likely effective for reducing the toxicity of methotrexate (a cancer and autoimmune drug) and for preventing neural tube birth defects when taken during pregnancy or before conception.

For depression, cognitive impairment, and phenytoin-related gum overgrowth, the evidence is more limited—it's possibly effective, meaning some research supports it but more data would help confirm the benefit.

The evidence, ingredient by ingredient Folic Acid

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Folic acid at the 400 mcg dose in this product is generally well-tolerated in most adults. Folic acid is recommended during pregnancy at standard prenatal doses to help prevent birth defects, and it's considered safe at normal doses while breastfeeding.

At higher doses (5 mg daily or more), some people report stomach cramps, diarrhea, or rash; at 15 mg daily, confusion, sleep problems, and nausea can occur. Very high long-term doses carry rare but serious risks including seizures and liver injury.

One important caution: if you have undiagnosed anemia, folic acid supplements can mask the symptoms of pernicious anemia (a vitamin B12 deficiency condition), potentially delaying treatment and causing nerve damage—so don't self-treat suspected anemia without medical evaluation.

Side effects, ingredient by ingredient Folic Acid

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Folic Acid.
  • The most serious interaction on file is rated Moderate.
  • For scale: 40 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take seizure medications (phenobarbital, phenytoin, or primidone), cancer treatments (methotrexate, capecitabine, or 5-fluorouracil), or pyrimethamine for infection. All of these have Moderate-severity interactions with folic acid that affect how well they work or how safe they are.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This folic acid supplement works well for preventing or correcting folate deficiency and is likely helpful for preventing birth defects in pregnancy. If you take seizure medications, cancer drugs, or pyrimethamine, you need to talk with your doctor or pharmacist before taking it—folic acid can interfere with how these work.

For everyone else at standard doses, it's generally well-tolerated, but confirm your medications first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 26, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Folic Acid 400 mcg, straight from the product label.

Brand Sundown Naturals
Barcode (UPC) 030768035570
Net contents 250 Tablet(s)
Market status On market
Date entered into DSLD Feb 26, 2014
DSLD ID 30350
Product type Vitamin
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Approved Health, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Folic Acid 400 mcg by Sundown Naturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
UPC/BARCODE
030768035570
IngredientAmount% DV
Folic Acid400 mcg100%

Other ingredients: Vegetable Cellulose, Dicalcium Phosphate, Contains <2% of

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

No Artificial Color, Flavor or Sweetener, No Preservatives, No Sugar, No Starch, No Milk, No Lactose, No Soy, No Gluten, No Wheat, No Yeast, No Fish. Sodium Free.

VEGETARIAN FORMULA

General Statements

Supports Heart & Cardiovascular Health*

As a reminder, discuss the supplements and medications you take with your health care providers.

Smart Facts Folic acid is an essential B Vitamin that supports heart health.* In addition, women who consume healthful diets with adequate folic acid may reduce their risk of having a child with birth defects of the brain or spinal cord.

FDA Statement of Identity

VITAMIN SUPPLEMENT

Precautions

Folic acid intake should not exceed 250% of the Daily Value (1,000 mcg).

KEEP OUT OF REACH OF CHILDREN.

TAMPER RESISTANT: DO NOT USE IF SEAL UNDER CAP IS BROKEN OR MISSING.

WARNING: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Storage

STORE AT ROOM TEMPERATURE AND AVOID EXCESSIVE HEAT.

Seals/Symbols

{Wheat} FREE OF Gluten & Wheat

GUARANTEED LABORATORY TESTED QUALITY

{Bottle} PLEASE RECYCLE

General

Prod. No. 44843 08F B1400 CAC

Suggested/Recommended/Usage/Directions

DIRECTIONS: FOR ADULTS, TAKE ONE (1) TABLET DAILY, PREFERABLY WITH A MEAL.

Formula

Essential B Vitamin

Brand IP Statement(s)

(C)2013

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Folic Acid 400 mcg by Sundown Naturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Folic Acid 400 mcg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Folic Acid 400 mcg by Sundown Naturals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Folic Acid

Interacts with
40 drugs
400 mcg per serving

Folic acid is the man-made form of vitamin B9 and is one of the most well-studied supplements, especially for preventing serious birth defects when ta...

Folic Acid monograph & interactions

Other (inactive) ingredients: Vegetable Cellulose, Dicalcium Phosphate, Contains <2% of. These complete the product’s ingredient list but are not active constituents.

Interaction report

Folic Acid 400 mcg by Sundown Naturals Drug Interactions

Want to check YOUR meds against Folic Acid 400 mcg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
40Drugs
40 Moderate

Ingredients driving the most interactions

Folic Acid 40

Individual Drug Interactions

The ingredients in Folic Acid 400 mcg interact with 40 drugs. Click any drug to see the details.

1 of the 1 ingredient in Folic Acid 400 mcg interact with drugs. Each result below shows which ingredient is responsible. Folic Acid

Each ingredient & the kinds of drugs it affects

For each ingredient in Folic Acid 400 mcg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Folic Acid7 drug types · 40 drugs

5-Fluorouracil

Theoretically, high doses of folic acid might increase the toxicity of 5-fluorouracil.
Increases in gastrointestinal side effects of 5-fluorouracil, such as stomatitis and diarrhea, have been described in two clinical studies when leucovorin, a form of folic acid, was administered with 5-fluorouracil.

Likelihood Possible Evidence D
Capecitabine (Xeloda)

Use of high-dose folic acid might contribute to capecitabine toxicity.
Clinical research suggests that higher serum folate levels are associated with an increased risk for moderate or severe toxicity during capecitabine-based treatment for colorectal cancer. Additionally, in one case report, taking folic acid 15 mg daily might have contributed to increased toxicity, including severe diarrhea, vomiting, edema, hand-foot syndrome, and eventually death, in a patient prescribed capecitabine.

Likelihood Possible Evidence D
Methotrexate (Trexall, Others)

Folic acid might reduce the efficacy of methotrexate as a cancer treatment when given concurrently.
Methotrexate exerts its cytotoxic effects by preventing conversion of folic acid to the active form needed by cells. There is some evidence that folic acid supplements reduce the efficacy of methotrexate in the treatment of acute lymphoblastic leukemia, and theoretically they could reduce its efficacy in the treatment of other cancers. Advise cancer patients to consult their oncologist before using folic acid supplements. In patients treated with long-term, low-dose methotrexate for rheumatoid arthritis (RA) or psoriasis, folic acid supplements can reduce the incidence of side effects, without reducing efficacy.

Likelihood Probable Evidence B
Phenobarbital (Luminal)

Folic acid might have antagonistic effects on phenobarbital and increase the risk for seizures.
Folic acid can have direct convulsant activity in some people, reversing the effects of phenobarbital and worsening seizure control. Monitor closely for increased seizure activity.

Likelihood Probable Evidence B
Phenytoin (Dilantin)

Folic acid might reduce serum levels of phenytoin in some patients.
Folic acid may be a cofactor in phenytoin metabolism. Folic acid, in doses of 1 mg daily or more, can reduce serum levels of phenytoin in some patients. Increases in seizure frequency have been reported. If folic acid supplements are added to established phenytoin therapy, monitor serum phenytoin levels closely. If phenytoin and folic acid are started at the same time and continued together, adverse changes in phenytoin pharmacokinetics are avoided. Note that phenytoin also reduces serum folate levels.

Likelihood Probable Evidence B
Primidone (Mysoline)

Folic acid might have antagonistic effects on primidone and increase the risk for seizures.
Folic acid can have direct convulsant activity in some people, reversing the effects of primidone and worsening seizure control. Monitor closely for increased seizure activity. Note that primidone also reduces serum folate levels.

Likelihood Probable Evidence B
Pyrimethamine (Daraprim)

Folic acid might antagonize the effects of pyrimethamine.
Folic acid can antagonize the antiparasitic effects of pyrimethamine against toxoplasmosis and Pneumocystis carinii pneumonia. Folic acid doesn't antagonize the effects of pyrimethamine in the treatment of malaria, because malarial parasites cannot use exogenous folic acid. Use folinic acid as an alternative to folic acid when indicated.

Likelihood Probable Evidence D
Folic Acid full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Folic Acid 400 mcg, from the product label.

Sundown Naturals

See all Sundown Naturals products
Web Address
www.sundownnaturals.com
Pharmacist Counseling Corner

Folic Acid 400 mcg by Sundown Naturals: Common Questions

Does Folic Acid 400 mcg by Sundown Naturals interact with any medications?
Yes. Based on its ingredients, Folic Acid 400 mcg has a known interaction with 40 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Folic Acid 400 mcg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is 400 mcg folic acid safe to take while pregnant?
Yes—folic acid is recommended during pregnancy at standard prenatal doses to help prevent birth defects. This product's 400 mcg dose falls within the standard prenatal range and is considered safe.
Can I take this if I take seizure medication?
No, not without talking to your doctor first. Folic acid can interfere with phenobarbital, phenytoin, and primidone, potentially reversing their effects and increasing your seizure risk. Your doctor needs to monitor you if you combine them.
What side effects might I get from folic acid?
At the 400 mcg dose in this product, side effects are rare. Higher doses (5 mg or more daily) can cause stomach cramps, diarrhea, or rash. At 15 mg daily, some people report confusion, sleep disturbances, and nausea.
Can folic acid help with depression or brain fog?
The evidence is limited but possibly supportive. Folic acid is possibly effective for depression and cognitive impairment, meaning some research backs it but more data would help confirm the benefit. Talk with your doctor about whether it's right for you.
Will this supplement interact with birth control or other common medications?
The documented interactions are with seizure drugs, cancer medications, and pyrimethamine. No interactions are documented in our data for birth control or most other common medications, though you should always check your full medication list with your pharmacist or doctor.
Is this safe if I'm breastfeeding?
Yes, folic acid is considered safe at normal recommended doses while breastfeeding.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Folic Acid 400 mcg label
Go deeper

The Full Monographs Behind Folic Acid 400 mcg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Folic Acid

Interacts with 40 drugs

Folic acid is the man-made form of vitamin B9 and is one of the most well-studied supplements, especially for preventing serious birth defects when taken before and during early pregnancy. I...

Read the full Folic Acid monograph →
Sources

Sources & How We Checked

Folic Acid 400 mcg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 56 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Folic Acid 56 references
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  10. Morgan SL, Baggott JE, Lee JY, Alarcón GS. Folic acid supplementation prevents deficient blood folate levels and hyperhomocysteinemia during longterm, low dose methotrexate therapy for rheumatoid arthritis: implications for cardiovascular disease preventi
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  39. van Wijngaarden JP, Swart KM, Enneman AW, et al. Effect of daily vitamin B-12 and folic acid supplementation on fracture incidence in elderly individuals with an elevated plasma homocysteine concentration: B-PROOF, a randomized controlled trial. Am J Clin
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  47. Van Der Woude DA, De Vries J, Van Wijk EM, Verzijl JM, Pijnenborg JM. A randomized controlled trial examining the addition of folic acid to iron supplementation in the treatment of postpartum anemia. Int J Gynaecol Obstet. 2014;126(2):101-5. PubMed
  48. Vila-Nova C, Wehby GL, Queirós FC, Chakraborty H, Félix TM, Goco N, Moore J, Gewehr EV, Lins L, Affonso CM, Murray JC. Periconceptional use of folic acid and risk of miscarriage - findings of the Oral Cleft Prevention Program in Brazil. J Perinat Med. 201 PubMed
  49. Vollset SE, Clarke R, Lewington S, Ebbing M, Halsey J, Lonn E, Armitage J, Manson JE, Hankey GJ, Spence JD, Galan P, Bønaa KH, Jamison R, Gaziano JM, Guarino P, Baron JA, Logan RF, Giovannucci EL, den Heijer M, Ueland PM, Bennett D, Collins R, Peto R; B-V
  50. Wehby GL, Félix TM, Goco N, Richieri-Costa A, Chakraborty H, Souza J, Pereira R, Padovani C, Moretti-Ferreira D, Murray JC. High dosage folic acid supplementation, oral cleft recurrence and fetal growth. Int J Environ Res Public Health. 2013 4;10(2):590-6 PubMed
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See these in context on the Folic Acid monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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