Interactions on record — worth a quick check against your medications. Based on 5 of 6 ingredients. Check your meds →
Dietary supplement

Full Diet Ingredients & Drug Interactions

by Applied Nutrition

Full Diet label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Full Diet against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Full Diet is a dietary supplement by Applied Nutrition with 6 active ingredients. Its ingredients are commonly taken for constipation, diarrhea, high cholesterol.Based on those ingredients, 2,135 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Dietary Fiber, LuraLean(R), Lychee extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Full Diet by Applied Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Full Diet by Applied Nutrition — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Full Diet by Applied Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 2 of its 6 active ingredients.
  • “Lipo-Metabolic Blend” is a proprietary blend — the label gives one combined amount (300 mg) without saying how much of each component you get.

Full Diet contains five active ingredients. Raspberry ketones and glucomannan (the fiber in LuraLean®) make up the core; African mango extract and lychee extract are added for metabolic support.

The product also includes a proprietary Lipo-Metabolic Blend — we don't have the details on what's inside that blend, so it's listed as a group. White kidney bean extract rounds out the formula.

The remaining ingredients are inactive — fillers and binders like microcrystalline cellulose, calcium carbonate, and magnesium stearate that give the tablet its form.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: promote fullness and reduce calorie intake.
  • We looked for evidence on: Obesity, Constipation, Hypercholesterolemia, Hyperlipidemia, Diabetes, Metabolic syndrome — and 3 related terms.
  • The strongest evidence on file: Black Psyllium is rated "Effective" for Constipation (Natural Medicines).
  • Also on file: Glucomannan is rated "Possibly Effective" for Constipation, Diabetes, Hyperlipidemia.
  • Also on file: Black Psyllium is rated "Insufficient Reliable Evidence To Rate" for Diabetes, Obesity.

The evidence on these ingredients is sparse. Glucomannan shows possibly effective ratings for constipation, diabetes support, and high cholesterol — those are the strongest claims in the product.

Raspberry ketones, African mango extract, and lychee extract are all rated as having insufficient reliable evidence for their intended uses (weight loss, metabolic support, and related goals). The data we hold doesn't establish that these ingredients work as a weight-loss or metabolism aid.

The evidence, ingredient by ingredient Black Psyllium Glucomannan Raspberry Ketone Irvingia Gabonensis Lychee

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Raspberry ketones have stirred case reports of heart palpitations, rapid heartbeat, and elevated blood pressure — the ingredient resembles a stimulant — though human studies are limited. Glucomannan is generally well tolerated when taken with plenty of water, but it can cause bloating, gas, diarrhea, nausea, and rarely, choking or blockage if swallowed dry.

African mango extract is generally tolerated short-term, though one case of hepatitis has been reported; headache and insomnia occurred in studies. Lychee extract can trigger allergic reactions including swelling of the tongue and lips, and has been linked in children to a serious condition called hypoglycemic encephalopathy, though the link is debated.

For pregnancy, the safety data advises against raspberry ketones and African mango — there isn't enough information on glucomannan or lychee extracts in pregnancy, so talk with your doctor. For breastfeeding, avoid raspberry ketones and African mango; glucomannan and lychee lack enough safety data as well.

Side effects, ingredient by ingredient Black Psyllium Glucomannan Raspberry Ketone Irvingia Gabonensis Lychee

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Black Psyllium, Glucomannan, Irvingia Gabonensis, Raspberry Ketone, Lychee.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; heart-rhythm medications; lithium.
  • For scale: 2,136 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Full Diet, double-check with your own doctor or pharmacist if you take a stimulant drug (risk of heart palpitations and dangerous heart rhythms), warfarin or another blood thinner (may need dose adjustment), diabetes medication (risk of blood sugar dropping too low), any oral medication (glucomannan may reduce absorption), or an immunosuppressant (lychee may weaken it). These are Moderate-severity interactions except the immunosuppressant one, which is Minor.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Full Diet is built on ingredients with very limited evidence for weight loss or metabolism — only glucomannan has a possibly effective rating, and that's for constipation and cholesterol, not weight. More importantly, if you take a blood thinner, a stimulant, diabetes medication, or an immunosuppressant, this product carries real interaction risks that could change how your drugs work or cause serious side effects.

Talk with your doctor or pharmacist before starting it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Full Diet, straight from the product label.

Brand Applied Nutrition
Net contents 60 Tablet(s)
Market status On market
Date entered into DSLD Nov 25, 2013
DSLD ID 27228
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Full Diet by Applied Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Tablet(s)
Maximum serving Sizes:
3 Tablet(s)
Servings per container
20
IngredientAmount% DV
Dietary Fiber1 Gram(s)4%
Raspberry Ketones0 Not Present--
LuraLean(R)1500 mg--
Lipo-Metabolic Blend300 mg--
African Mango (Irvingia gabonensis) extract0 Not Present--
Lychee extract0 Not Present--
White Kidney Bean extract0 Not Present--

Other ingredients: Microcrystalline Cellulose, Calcium Carbonate, dicalcium phosphate anhydrous, Silicon Dioxide, Stearic Acid, Croscarmellose Sodium, Hydroxypropyl Cellulose, Magnesium Stearate, Sodium Carboxymethylcellulose, Dextrose, Soy Lecithin, Sodium Citrate, Dextrin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

¥ All weight management programs should also contain a reduced calorie diet and exercise.

To join our Wellness Club and receive tips on how to improve you health, please visit us at: www.AppliedNutrition.com/wellness1

FEEL FULL : EAT LESS

Helps Support Weight Loss

The Smart Way to Diet!

It not only helps to curb your appetite,* but also supports numerous factors that are important to overall health. It can help you : • Eat smaller meals, while feeling satisfied* • Maintain healthy blood sugar levels already within a normal range* • Reduce the absorption of dietary fats* • Maintain healthy cholesterol levels already within a normal range*

As a leader in innovation, we continuously strive to bring forward new ideas and groundbreaking formulas that enhance health and well-being.

A Breakthrough Weight Loss Support Formula that Works on a Simple Truth!

This breakthrough product can help you achieve your weight loss goals!* It has been scientifically formulated to “turn-on” satiety before meals.*

When taken 45 minutes before a meal, this ingredient swells and expands up to 200 times its original size to induce a feeling of fullness while traveling through the digestive tract.*

For best results, use in combination with a reduced calorie diet and exercise.*

CURB APPETITE : EAT LESS

Suggested/Recommended/Usage/Directions

DIRECTIONS: (Adult) Take three (3) tablets twice daily 45 minutes before two of your largest meals, with a full glass of water. Taking this product without adequate water may cause choking.

Precautions

Contains: Soy

Usage Warnings: Do not use if safety seal is broken.

Check with your doctor before using this product if you are using medication or have any medical conditions.

Taking this product without adequate water may cause product to swell and block your throat or esophagus, which may cause choking. Do not take if you are having difficulty swallowing. If you experience chest pain, vomiting, or difficulty in swallowing or breathing after taking this product, seek immediate medical attention.

Do not use if you may become pregnant, are pregnant or nursing.

Do not exceed recommended daily intake.

Not intended for use by persons under 18. KEEP OUT OF REACH OF CHILDREN.

WARNING: (State of California Prop 65) This product contains a chemical known to the State of California to cause birth defects and other reproductive harm.

Brand IP Statement(s)

By promoting a pleasant feeling of fullness, Full Diet(R) can help you eat less food and consume fewer calories – without feeling hungry.*

‡ Research suggests that LuraLean(R) helps support weight loss.*

Super-Condensed LuraLean(R) expands in the stomach to promote a feeling of fullness while traveling through the digestive tract.

Full Diet(R) is a multi-benefit product that can easily be incorporated into your daily diet.*

LuraLean(R) is a registered trademark of AHD International, LLC

Super-condensed LuraLean(R) is at the center of this amazing formula. LuraLean(R) is a glucomannan fiber derived from the Japanese Konjac plant.

Full Diet(R) is more than just a “diet” product… it is a whole-body approach to better health.* ¥

Applied Nutrition(R) is committed to developing science-based products that exceed the highest standards for quality and purity.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

Contains: Soy

PLUS: RASPBERRY KETONES

Plus Raspberry Ketones, African Mango, Lychee Berry and White Kidney Bean Extract

Storage

Store in a cool, dry place.

FDA Statement of Identity

DIETARY SUPPLEMENT

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Full Diet by Applied Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Full Diet label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Full Diet by Applied Nutrition

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Tablet(s) Dosage formTablet Or Pill Servings per container20 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Dietary Fiber

Interacts with
2,025 drugs
1 Gram(s) per serving

Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. I...

Dietary Fiber monograph & interactions

LuraLean(R)

Interacts with
2,022 drugs
1500 mg per serving

Glucomannan is a soluble fiber from the konjac root that swells into a gel in your stomach, which may help with mild weight loss, constipation, and mo...

LuraLean(R) monograph & interactions

Lipo-Metabolic Blend

300 mg per serving

Other (inactive) ingredients: Microcrystalline Cellulose, Calcium Carbonate, Dicalcium phosphate anhydrous, Silicon Dioxide, Stearic Acid, Croscarmellose Sodium, Hydroxypropyl Cellulose, Magnesium Stearate, Sodium Carboxymethylcellulose, Dextrose, Soy Lecithin, Sodium Citrate, Dextrin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Full Diet by Applied Nutrition Drug Interactions

Want to check YOUR meds against Full Diet?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,135Drugs
2,060 Moderate 75 Minor

Ingredients driving the most interactions

Dietary Fiber 2,025
LuraLean(R) 2,022
Lychee extract 207
Raspberry Ketones 174
African Mango (Irvingia gabonensis) extract 94

Individual Drug Interactions

The ingredients in Full Diet interact with 2,135 drugs. Click any drug to see the details.

5 of the 6 ingredients in Full Diet interact with drugs. Each result below shows which ingredient is responsible. Dietary Fiber LuraLean(R) Lychee extract Raspberry Ketones African Mango (Irvingia gabonensis) extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Full Diet with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Dietary Fiber7 drug types · 2,025 drugs

Carbamazepine (Tegretol)

Theoretically, black psyllium might reduce the effects of carbamazepine and increase the risk for convulsions.
Theoretically, black psyllium might reduce carbamazepine absorption. A preliminary study using blond psyllium reported decreased carbamazepine bioavailability due to binding of the drug to psyllium, as well as reduction of available fluid in the gut for dissolution of the drug. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Lithium

Theoretically, taking black psyllium at the same time as lithium might reduce lithium absorption.
The fiber in black psyllium might reduce lithium absorption and plasma levels. Some case reports describe a reduction in plasma lithium levels with concomitant administration of blond psyllium. This was reversed when psyllium was stopped. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Metformin (Glucophage)

Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Animal research shows that concurrent consumption of blond psyllium with metformin slows and increases the absorption of metformin. This interaction may also occur with black psyllium. To avoid changes in absorption, take psyllium 30-60 minutes after metformin.

Likelihood Possible Evidence D
Olanzapine (Zyprexa)

Theoretically, taking black psyllium at the same time as olanzapine might reduce olanzapine absorption.
The fiber in black psyllium might decrease the absorption of olanzapine. A single case report describes a reduction in the effectiveness of olanzapine when it was concomitantly administered with an unspecified type of psyllium 3 grams orally twice daily. This effect was reversed when psyllium was stopped.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, taking black psyllium at the same time as digoxin might reduce digoxin absorption and decrease digoxin levels.
Psyllium might bind digoxin in the gut. However, some clinical evidence suggests that psyllium does not impact digoxin absorption.

Likelihood Unlikely Evidence B
Ethinyl Estradiol

Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Concurrent use of blond psyllium with ethinyl estradiol results in a slight increase in the extent of ethinyl estradiol absorption and a slower rate of absorption. This is unlikely to be clinically significant.

Likelihood Unlikely Evidence D
Oral Drugs

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Psyllium seems to have variable effects on drug absorption. To avoid changes in absorption, take psyllium 30-60 minutes after oral medications. Animal research shows that blond psyllium delays and increases the absorption of metformin and ethinyl estradiol. Case reports and animal research suggest that blond psyllium might reduce absorption of lithium, digoxin, olanzapine, and carbamazepine. Finally, some pharmacokinetic studies show that psyllium does not affect the absorption of levothyroxine or warfarin. Although many of these studies evaluated blond psyllium, the fiber content in black psyllium may have similar effects.

Likelihood Possible Evidence B
Dietary Fiber full monograph & interactions

LuraLean(R)1 drug type · 2,022 drugs

Oral Drugs

Theoretically, glucomannan may decrease absorption of drugs taken orally.
Due to its viscosity and bulking effects, there is concern that glucomannan can decrease the absorption of oral drugs. A small clinical study in healthy volunteers shows that taking glyburide 2.5 mg plus glucomannan 3.9 grams with breakfast reduces plasma levels of glyburide when compared with breakfast and glyburide alone. In addition, animal research demonstrates this effect on amoxicillin, but shows increased absorption of metronidazole. This mouse model also demonstrates that metronidazole elimination is prolonged, but amoxicillin elimination is enhanced by 38%; glucomannan may also affect the distribution of some drugs. To avoid changes in absorption, take glucomannan 30-60 minutes after taking oral drugs.

Likelihood Probable Evidence B
LuraLean(R) full monograph & interactions

Lychee extract2 drug types · 207 drugs

Antidiabetes Drugs

Theoretically, lychee seed might increase the risk of hypoglycemia when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lychee seed reduces fasting and 2-hour postprandial blood glucose and improves impaired glucose tolerance in rats with type 2 diabetes. Additionally, retrospective research in children has found an association between lychee consumption and increased odds of acute hypoglycemic encephalopathy.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, lychee might reduce the effectiveness of immunosuppressant drugs.
In vitro, flavonoids extracted from lychee show immunostimulant effects. So far, this effect has not been reported in humans.

Likelihood Possible Evidence D
Lychee extract full monograph & interactions

Raspberry Ketones2 drug types · 174 drugs

Stimulant Drugs

Theoretically, raspberry ketone might increase the risk of adverse cardiovascular effects with stimulant drugs.
Structurally, raspberry ketone resembles synephrine, a known stimulant agent. Heart palpitations, elevated blood pressure, coronary vasospasm, pulseless electrical activity arrest, and resistant polymorphic ventricular tachycardia have been reported in patients taking raspberry ketone.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, raspberry ketone might increase warfarin dose requirements.
In one case report, a patient taking warfarin 55 mg per week had a decrease in INR over a period of one month while taking raspberry ketone 250 mg daily. A warfarin dose increase to 70 mg per week was necessary to maintain a therapeutic INR while taking raspberry ketone. The mechanism for this potential interaction is not known.

Likelihood Possible Evidence D
Raspberry Ketones full monograph & interactions

African Mango (Irvingia gabonensis) extract2 drug types · 94 drugs

Antidiabetes Drugs

Theoretically, taking Irvingia gabonensis with antidiabetes drugs might increase the risk of hypoglycemia in some patients.
Human research shows that Irvingia gabonensis decreases blood sugar in diabetic patients being treated with antidiabetes agents. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence B
Testosterone

Theoretically, taking Irvingia gabonensis with testosterone products drugs might cause additive effects in some patients.
Animal research suggests that Irvingia gabonensis increases testosterone levels. The mechanism of action is unclear. Until more is known, advise patients taking testosterone to avoid using or use Irvingia gabonensis cautiously.

Likelihood Possible Evidence D
African Mango (Irvingia gabonensis) extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Full Diet, from the product label.

Applied Nutrition

See all Applied Nutrition products
Web Address
www.AppliedNutrition.com
Pharmacist Counseling Corner

Full Diet by Applied Nutrition: Common Questions

Does Full Diet by Applied Nutrition interact with any medications?
Yes. Based on its ingredients, Full Diet has a known interaction with 2,135 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Full Diet contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Full Diet if I'm on blood pressure or heart medication?
Raspberry ketones in this product resemble a stimulant and have caused heart palpitations and elevated blood pressure in case reports. If you take any heart or blood pressure medication, or a stimulant drug, check with your doctor or pharmacist first — the risks are real.
I take diabetes medication. Is this safe for me?
Both African mango and lychee in this product may lower blood sugar further, increasing your risk of low blood sugar (hypoglycemia). Also, glucomannan may reduce how well your body absorbs oral medication. Talk with your doctor or pharmacist before starting — you may need monitoring or dose adjustments.
Does this product actually help with weight loss?
The evidence doesn't support it. Raspberry ketones, African mango, and lychee all lack reliable evidence for weight loss. Only glucomannan — the fiber — has a possibly effective rating, and that's for constipation and cholesterol, not weight.
Are there side effects I should know about?
Raspberry ketones have caused heart palpitations and rapid heartbeat in case reports. Glucomannan commonly causes bloating, gas, or diarrhea, and rarely can cause choking or blockage if not taken with enough water. African mango and lychee can cause headache, insomnia, nausea, and allergic reactions including swelling.
Can I take Full Diet while pregnant?
No — the safety data advises against raspberry ketones and African mango during pregnancy. Glucomannan and lychee don't have enough information. Talk with your doctor for personalized advice.
Is this safe while breastfeeding?
No — the safety data advises against raspberry ketones and African mango while breastfeeding. Glucomannan and lychee lack enough safety data as well. Ask your doctor or pharmacist for guidance on your situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Full Diet is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Full Diet label
Go deeper

The Full Monographs Behind Full Diet’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Black Psyllium

Interacts with 2,025 drugs

Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. It is best known and most studied for rel...

Read the full Black Psyllium monograph → Herb & supplement monograph

Glucomannan

Interacts with 2,022 drugs

Glucomannan is a soluble fiber from the konjac root that swells into a gel in your stomach, which may help with mild weight loss, constipation, and modestly lowering cholesterol. It is gener...

Read the full Glucomannan monograph → Herb & supplement monograph

Raspberry Ketone

Interacts with 174 drugs

Raspberry ketone is a natural aroma compound found in red raspberries that is heavily marketed for weight loss, but there is no good human evidence that it helps people lose weight. Most cla...

Read the full Raspberry Ketone monograph → Herb & supplement monograph

Irvingia Gabonensis

Interacts with 94 drugs

Irvingia gabonensis (African mango) is a seed extract marketed mainly for weight loss and metabolic health. A few small studies suggest possible benefits, but the research is limited and low...

Read the full Irvingia Gabonensis monograph → Herb & supplement monograph

Lychee

Interacts with 207 drugs

Lychee is a sweet tropical fruit that is nutritious and a source of vitamin C and antioxidant plant compounds. While the fruit is a healthy food for most people, supplement-strength extracts...

Read the full Lychee monograph →
Sources

Sources & How We Checked

Full Diet's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 56 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Black Psyllium 18 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
  4. Etman M. Effect of a bulk forming laxative on the bioavailablility of carbamazepine in man. Drug Dev Ind Pharm 1995;21:1901-6.
  5. Perlman BB. Interaction between lithium salts and ispaghula husk. Lancet 1990;335:416.
  6. Vaswani SK, Hamilton RG, Valentine MD, Adkinson NF. Psyllium laxative-induced anaphylaxis, asthma, and rhinitis. Allergy 1996;51:266-8. PubMed
  7. Lantner RR, Espiritu BR, Zumerchik P, Tobin MC. Anaphylaxis following ingestion of a psyllium-containing cereal. JAMA 1990;264:2534-6. DOI
  8. Kaplan MJ. Anaphylactic reaction to "Heartwise." N Engl J Med 1990;323:1072-3. DOI
  9. Nordstrom M, Melander A, Robertsson E, Steen B. Influence of wheat bran and of a bulk-forming ispaghula cathartic on the bioavailability of digoxin in geriatric in-patients. Drug Nutr Interact 1987;5:67-9..
  10. Robinson DS, Benjamin DM, McCormack JJ. Interaction of warfarin and nonsystemic gastrointestinal drugs. Clin Pharmacol Ther 1971;12:491-5. PubMed
  11. Garcia JJ, Fernandez N, Diez MJ, et al. Influence of two dietary fibers in the oral bioavailability and other pharmacokinetic parameters of ethinyloestradiol. Contraception 2000;62:253-7. PubMed
  12. Fernandez N, Lopez C, Díez R, et al. Drug interactions with the dietary fiber Plantago ovata husk. Expert Opin Drug Metab Toxicol 2012;8(11):1377-86.
  13. Semen plantaginis in: WHO Monographs on Selected Medicinal Plants, volume 1. World Health Organization, Geneva, 1999. Available at http://apps.who.int/medicinedocs/en/d/Js2200e/. Accessed November 26, 1026.
  14. Code of Federal Regulations, Title 21 (21CFR 101.17). Food labeling warning, notice, and safe handling statements. Available at www.ecfr.gov/cgi-bin/text-idx?SID=20f647d3b74161501f46564b915b4048&mc=true&node=se21.2.101_117&rgn=div8. Accessed December 3, 2
  15. Code of Federal Regulations, Title 21 (21CFR 201.319). Specific labeling requirements - water-soluble gums, hydrophilic gums, and hydrophilic mucilloids. Available at www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=201.319. Accessed Dece
  16. Diez R, Garcia JJ, Diez MJ, Sierra M, Sahagun AM, Fernandez N. Influence of Plantago ovata husk (dietary fiber) on the bioavailability and other pharmacokinetic parameters of metformin in diabetic rabbits. BMC Complement Altern Med. 2017 Jun 7;17(1):298. PubMed
  17. Chiu AC, Sherman SI. Effects of pharmacological fiber supplements on levothyroxine absorption. Thyroid. 1998;8(8):667-71. PubMed
  18. Merrick C, Madden CA, Capurso NA. A Case of Blunted Orally Disintegrating Olanzapine Effect Due to Coadministered Psyllium. J Clin Psychiatry 2021;82(2):20cr13633. PubMed

See these in context on the Black Psyllium monograph →

Raspberry Ketone 4 references
  1. Adverse Event Report. Raspberry Ketone. Natural MedWatch, April 27, 2012.
  2. Adverse Event Report. Raspberry Ketone. Natural MedWatch, September 18, 2011.
  3. Ansari SA, Patel F, Ashouri D, Dhaliwal JSS, Desai A. Resistant Polymorphic Ventricular Tachycardia in a Patient Taking Raspberry Ketones Weight Loss Supplement. Cureus 2022;14(12):e33089. PubMed
  4. Khattar A, Beeton I. Coronary vasospasm and raspberry ketones weight-loss supplement: Is there a connection? Anatol J Cardiol. 2020;24(3):205-208.

See these in context on the Raspberry Ketone monograph →

Glucomannan 15 references
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  4. Yoshida, M., Vanstone, C. A., Parsons, W. D., Zawistowski, J., and Jones, P. J. Effect of plant sterols and glucomannan on lipids in individuals with and without type II diabetes. Eur.J Clin Nutr. 2006;60(4):529-537. PubMed
  5. Wood, R. J., Fernandez, M. L., Sharman, M. J., Silvestre, R., Greene, C. M., Zern, T. L., Shrestha, S., Judelson, D. A., Gomez, A. L., Kraemer, W. J., and Volek, J. S. Effects of a carbohydrate-restricted diet with and without supplemental soluble fiber
  6. Vanderbeek, P. B., Fasano, C., O'Malley, G., and Hornstein, J. Esophageal obstruction from a hygroscopic pharmacobezoar containing glucomannan. Clin Toxicol.(Phila) 2007;45(1):80-82. PubMed
  7. Bernstein, J. A., Crandall, M. S., and Floyd, R. Respiratory sensitization of a food manufacturing worker to konjac glucomannan. J Asthma 2007;44(8):675-680. PubMed
  8. Shichijo, K., Kobayashi, Y., Fueki, R., Shimoyama, K., and Masaya, M. [2 cases of konjac bronchial asthma found outside the "konnyaku" producing district]. Arerugi 1969;18(2):97-100.
  9. Carabin IG, Lyon MR, Wood S, et al. Supplementation of the diet with the functional fiber PolyGlycoplex is well tolerated by healthy subjects in a clinical trial. Nutr J 2009;8:9. PubMed
  10. Lyon MR, Reichert RG. The effect of a novel viscous polysaccharide along with lifestyle changes on short-term weight loss and associated risk factors in overweight and obese adults: an observational retrospective clinical program analysis. Altern Med Rev
  11. Lyon M, Wood S, Pelletier X, et al. Effects of a 3-month supplementation with a novel soluble highly viscous polysaccharide on anthropometry and blood lipids in nondieting overweight or obese adults. J Hum Nutr Diet 2011;24(4):351-9. PubMed
  12. Han Y, Zhang L, Liu XQ, Zhao ZJ, Lv LX. Effect of glucomannan on functional constipation in children: a systematic review and meta-analysis of randomised controlled trials. Asia Pac J Clin Nutr 2017;26(3):471-7.
  13. Health Canada Safety Alert. Health Canada Advises Canadians that natural health products containing glucomannan may cause serious choking if used with insufficient fluid. January 29, 2010. Alert # RA-110003825. https://healthycanadians.gc.ca/recall-alert-
  14. Mortensen A, Aguilar F, Crebelli, et al. EFSA Panel on Food Additives and Nutrient Sources added to Food. Re-evaluation of konjac gum (E 425 i) and konjac glucomannan (E425 ii) as food additives. EFSA Journal 2017;15(6):4864.
  15. Zhang Y, Aldamarany WAS, Song G, et al. Influence of konjac glucomannan and its derivatives on the oral pharmacokinetics of antimicrobial agent in antibiotics cocktails: Keep vigilant on dietary fiber supplement. Int J Biol Macromol 2023;251:126306. PubMed

See these in context on the Glucomannan monograph →

Irvingia Gabonensis 7 references
  1. Oben JE, Ngondi JL, Momo CN, et al. The use of Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids Health Dis 2008;7:12.
  2. Ngondi JL, Etoundi BC, Nyangono CB, et al. IGOB131, a novel seed extract of the West African plant Irvingia gabonensis, significantly reduces body weight and improves metabolic parameters in overweight humans in a randomized double-blind placebo controll
  3. Adamson, I., Okafor, C., and Abu-Bakare, A. A supplement of Dikanut (Irvingia gabonesis) improves treatment of type II diabetics. West Afr.J.Med. 1990;9(2):108-115.
  4. Adamson, I., Okafor, C., and Abu-Bakare, A. Erythrocyte membrane ATPases in diabetes: effect of dikanut (Irvingia gabonensis). Enzyme 1986;36(3):212-215. PubMed
  5. Wolfe OA, Ijeoma UF. Effects of aqueous extracts of Irvingia gabonensis seeds on the hormonal parameters of male guinea pigs. Asian Pacific Journal of Tropical Medicine. 2010;3(3):200-204. DOI
  6. Kilinçalp S, Basar O, Coban S, Yüksel I. Irvingia gabonensis (African mango): innocent magic formula? Acta Gastroenterol Belg 2014;77(1):75-6.
  7. Nonsa-Ard R, Aneknan P, Tong-Un T, Honsawek S, Leelayuwat N. Effects of Irvingia gabonensis Extract on Metabolism, Antioxidants, Adipocytokines, Telomere Length, and Aerobic Capacity in Overweight/Obese Individuals. Nutrients 2022;14(21):4646. PubMed

See these in context on the Irvingia Gabonensis monograph →

Lychee 12 references
  1. Niggemann B, Reibel S, Hipler C, Wahn U. Anaphylactic reaction to lychee in a 12-year-old girl: cross-reactivity to latex? Pediatr Allergy Immunol 2002;13(1):64-7. PubMed
  2. Giannattasio M, Serafini M, Guarrera P, et al. Contact urticaria from litchi fruit (Litchi chinensis Sonn.). Contact Dermatitis 1995;33(1):67.
  3. Raap U, Schaefer T, Kapp A, Wedi B. Exotic food allergy: anaphylactic reaction to lychee. J Investig Allergol Clin Immunol 2007;17(3):199-201.
  4. Guo JW. Effects of Litchi seed on enhancing insulin sensitivity in type 2 diabetic-insulin resistant rats. Chinese J New Drugs 2003;12:526-9.
  5. Zhao M, Yang B, Wang J, et al. Immunomodulatory and anticancer activities of flavonoids extracted from litchi (Litchi chinensis Sonn) pericarp. Int Immunopharmacol 2007;7(2):162-6. PubMed
  6. John TJ, Das M. Outbreaks of Hypoglycemic Encephalopathy in Muzaffarpur, India: Are These Caused by Toxins in Litchi Fruit?: The Point. Indian Pediatr. 2016;53(5):399.
  7. John TJ. Exploration of Association between Litchi Consumption and Seasonal Acute Encephalopathy Syndrome: Pediatric Infectious Disease Specialist's Viewpoint. Indian Pediatr. 2017;54(4):323-325. DOI
  8. Mathew JL. Exploration of Association between Litchi Consumption and Seasonal Acute Encephalopathy Syndrome: Evidence-based Medicine Viewpoint. Indian Pediatr. 2017;54(4):319-323. PubMed
  9. Shrivastava A, Kumar A, Thomas JD, et al. Association of acute toxic encephalopathy with litchi consumption in an outbreak in Muzaffarpur, India, 2014: a case-control study. Lancet Glob Health. 2017;5(4):e458-e466.
  10. Spencer PS, Palmer VS, Mazumder R. Probable toxic cause for suspected lychee-linked viral encephalitis. Emerg Infect Dis. 2015;21(5):904-5. DOI
  11. Valsecchi R, Leghissa P. Contact allergy due to lychee. Acta Derm Venereol. 2013;93(1):90-1. PubMed
  12. Vashishtha VM. Outbreaks of Hypoglycemic Encephalopathy in Muzaffarpur, India: Are These Caused by Toxins in Litchi Fruit?: The Counterpoint. Indian Pediatr. 2016 May 8;53(5):399-402.

See these in context on the Lychee monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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