Interactions on record — worth a quick check against your medications. Based on 2 of 4 ingredients. Check your meds →
Dietary supplement

CLA Pro-Cut Ingredients & Drug Interactions

by Applied Nutrition

Softgel Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

CLA Pro-Cut is a dietary supplement by Applied Nutrition with 4 active ingredients. Its ingredients are commonly taken for skin and hair care, source of dietary fats (mcts), hydration with coconut water.Based on those ingredients, 208 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Safflower Oil, Coconut Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of CLA Pro-Cut by Applied Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 4 active ingredients.
  • “CLA Pro-Cut Blend” is a proprietary blend — the label gives one combined amount (3,000 mg) without saying how much of each component you get.

This product contains 4 active ingredients. Conjugated linoleic acid (CLA) is a fatty acid; coconut oil and safflower oil are plant oils; and MCT oil is a medium-chain triglyceride oil.

The product also includes inactive ingredients like gelatin for the capsule shell, glycerin, water, and several colorants (annatto, titanium dioxide, caramel, turmeric, canthaxanthin, and carmine).

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: weight management and lean muscle mass.
  • We looked for evidence on: Obesity, Metabolic syndrome, body composition, fat loss.
  • The closest evidence on file: Safflower is rated "Insufficient Reliable Evidence To Rate" for Obesity (Natural Medicines).
  • Also on file: Safflower is rated "Insufficient Reliable Evidence To Rate" for Metabolic syndrome.
  • Also on file: Coconut is rated "Insufficient Reliable Evidence To Rate" for Obesity.

The evidence on these ingredients for their intended purposes is not well established. Coconut oil and safflower oil both show insufficient reliable evidence for uses like diabetes management, cholesterol support, or weight loss.

We hold no effectiveness data for conjugated linoleic acid or MCT oil in the facts provided. If you're considering this product for a specific health goal, talk with your doctor or pharmacist about what the research actually supports.

The evidence, ingredient by ingredient Coconut Safflower

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Coconut oil and safflower oil are generally well tolerated when used in typical food amounts. However, concentrated supplement doses have less safety data.

Coconut can trigger allergic reactions ranging from hives to anaphylaxis in people with coconut sensitivity — about half of reported reactions involved severe anaphylaxis. Safflower oil has been linked in case reports to liver failure when overused, though the exact dose that caused harm isn't clear.

Safflower should be avoided in medicinal amounts during pregnancy because it may stimulate the uterus. We hold no pregnancy or breastfeeding safety data for conjugated linoleic acid or MCT oil.

Side effects, ingredient by ingredient Coconut Safflower

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Safflower, Coconut.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 208 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking CLA Pro-Cut, double-check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (warfarin, aspirin, clopidogrel, etc.) — safflower oil may increase bleeding risk at high doses. Also flag antidiabetes medications, since both coconut oil and safflower oil may affect how they work and your blood sugar control.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

CLA Pro-Cut is generally well tolerated, but if you take blood thinners (like warfarin), antidiabetes drugs, or antiplatelet medications, you'll want to discuss this product with your doctor or pharmacist before starting — the safflower oil content carries Moderate interaction risk with these drug types. Check your exact medications with our search tool on this page before using it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 22, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about CLA Pro-Cut, straight from the product label.

Brand Applied Nutrition
Barcode (UPC) 710363580766
Net contents 42 Fast-Acting Liquid Softgel(s)
Market status On market
Date entered into DSLD Oct 22, 2016
DSLD ID 64130
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for CLA Pro-Cut by Applied Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Liquid Soft-Gel(s)
Maximum serving Sizes:
3 Liquid Soft-Gel(s)
Servings per container
14
UPC/BARCODE
710363580766
IngredientAmount% DV
Conjugated Linoleic Acid0 NP--
Coconut Oil0 NP--
Safflower Oil0 NP--
MCT (Medium Chain Triglyceride) oil0 NP--
CLA Pro-Cut Blend3000 mg--

Other ingredients: Gelatin, purified Water, Glycerin, Annatto, Titanium Dioxide, St. John's Bread, Caramel, Turmeric, Canthaxanthin, Carmine

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

At the center of this formula is CLA (Conjugated Linoleic Acid), known for its weight management properties. When used in conjunction with a healthy diet and exercise plan, CLA can help you maintain or increase lean muscle mass and at the same time reduce body fat.

Fat Reduction Formula

Maintain Lean Muscle Mass & Reduce Body Fat

6107-BOX-07/14 AN077891 V3

Liquid Soft-Gel Technology Ensures You Get The Nutrients Fast! This advanced formula is derived in fast-acting Liquid Soft-Gels. This optimal delivery system ensures that vital nutrients are released quickly, so they can get to work fast. In addition to CLA (Conjugated Linoleic Acid), this powerful formula also supplies a spectrum of healthy fats, including quick-energy MCTs (Medium Chain Triglycerides). These good fatty acids can give you a quick boost of energy on the cellular level.

As a leader in innovation, we continuously strive to bring forward new ideas and groundbreaking formulas that enhance health and well-being. To view our entire line of products, please visit us online at: www.Applied Nutrition.com

To join our wellness club and receive tips on how to improve your health, please visit us at: www.AppliedNutrition.com/wellness1

A Powerful Formula That Can Help You Achieve Your Weight Loss Goals!

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

Fast-Acting Liquid Soft-Gels Deliver: CLA Coconut Oil, MCT's & Safflower Oil

Contains: Soy, Tree Nuts (Coconut, Palm Kernel)

Plus: MCT's coconut oil & safflower oil

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Applied Nutrition is committed to developing science-based products that exceed the highest standards for quality and purity.

CLA Pro-Cut is a powerful "fat reduction formula" that is specially designed to help you achieve your weight loss goals.

Suggested/Recommended/Usage/Directions

Directions: (Adult) As an addition to a reduced calorie diet & exercise plan, take three (3) liquid soft-gels in the morning, and three (3) in the afternoon with meals and a full glass of water.

Precautions

Contains: Soy, Tree Nuts (Coconut, Palm Kernel)

Usage Warnings: Do not use if safety seal is broken.

Check with your doctor before using this product if you are using medication or have any medical conditions, including heart disease, diabetes, metabolic syndrome, insulin resistance and immune or inflammatory conditions. Do not use if you may become pregnant, are pregnant or nursing.

Do not exceed recommended daily intake.

Not intended for use by persons under 18. Keep out of reach of children.

Storage

Store in a cool, dry place.

General

6139-LAB 07/01 AN037891 V2

See for yourself

CLA Pro-Cut by Applied Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in CLA Pro-Cut by Applied Nutrition

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Liquid Soft-Gel(s) Dosage formSoftgel Capsule Servings per container14 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

CLA Pro-Cut Blend

3000 mg per serving

Other (inactive) ingredients: Gelatin, Purified Water, Glycerin, Annatto, Titanium Dioxide, St. John's Bread, Caramel, Turmeric, Canthaxanthin, Carmine. These complete the product’s ingredient list but are not active constituents.

Interaction report

CLA Pro-Cut by Applied Nutrition Drug Interactions

Want to check YOUR meds against CLA Pro-Cut?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
208Drugs
208 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in CLA Pro-Cut with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Safflower Oil3 drug types · 208 drugs

Anticoagulant/Antiplatelet Drugs

High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Small clinical studies show that taking safflower oil, approximately 55 grams daily for 2-3 weeks, decreases platelet aggregation. However, taking lower doses of safflower oil, such as 5 grams daily for 4 weeks, does not seem to affect platelet function. In one case report, a 74-year-old male stabilized on warfarin developed urinary tract bleeding and an elevated INR after taking a safflower extract 20 grams daily for 14 days.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, safflower oil might alter the effects of antidiabetes drugs.
Some clinical research shows that taking safflower oil 10 grams daily for 3 weeks can increase fasting blood glucose in patients with type 2 diabetes. However, clinical research in patients with metabolic syndrome with or without impaired glucose tolerance shows that taking safflower oil 8 grams daily for 12 weeks reduces fasting glucose levels by around 8 mg/dL. Some clinical research also shows that taking safflower oil 8 grams daily for 16 weeks does not affect fasting glucose levels in patients with type 2 diabetes.

Likelihood Possible Evidence B
Warfarin

Theoretically, safflower oil might increase the risk of bleeding when taken with warfarin.
In one case report, a 74-year-old male stabilized on warfarin developed urinary tract bleeding and an elevated INR after taking a safflower extract 20 grams daily for 14 days.

Likelihood Possible Evidence D

Coconut Oil1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking coconut with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that coconut milk might increase insulin levels and/or decrease blood glucose levels.

Likelihood Unlikely Evidence D
The maker

Brand information

Manufacturer and brand details for CLA Pro-Cut, from the product label.

Applied Nutrition

See all Applied Nutrition products
Name
Applied Nutrition
Street Address
P.O. Box 66457
City
Los Angeles
State
CA
ZipCode
90066
Web Address
www.AppliedNutrition.com
Pharmacist Counseling Corner

CLA Pro-Cut by Applied Nutrition: Common Questions

Does CLA Pro-Cut by Applied Nutrition interact with any medications?
Yes. Based on its ingredients, CLA Pro-Cut has a known interaction with 208 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
CLA Pro-Cut contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is CLA Pro-Cut safe if I'm allergic to tree nuts?
Coconut is grouped with tree nuts for allergen labeling in the US, and coconut can cause allergic reactions in people with coconut sensitivity — ranging from hives to severe anaphylaxis. If you have any tree nut allergy or coconut sensitivity, skip this product and talk to your doctor or pharmacist first.
Can I take this while breastfeeding?
Coconut oil is likely safe while breastfeeding, but we hold no safety data for conjugated linoleic acid or MCT oil. For safflower oil specifically, there isn't enough reliable information on medicinal amounts while breastfeeding, so it's best avoided beyond normal food use. Talk with your doctor or pharmacist about whether this product is right for you.
Does this product actually help with weight loss?
The evidence for weight loss isn't established in our data. Coconut and safflower oils both show insufficient reliable evidence for obesity support. Conjugated linoleic acid and MCT oil have no effectiveness ratings in the facts we hold.
What's the difference between this and taking coconut or safflower oil by itself?
This product combines four ingredients (conjugated linoleic acid, coconut oil, safflower oil, and MCT oil) in a single softgel capsule. It's meant to give you all four at once rather than managing separate oils or supplements.
Is there anything in the capsule itself I should know about?
The capsule is made from gelatin, and the product includes colorants like annatto, turmeric, titanium dioxide, and carmine. If you have sensitivities to any of these, check the full ingredient list.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if CLA Pro-Cut is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

CLA Pro-Cut label
Sources

Sources & How We Checked

CLA Pro-Cut's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 24 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Coconut 10 references
  1. Teuber SS, Peterson WR. Systemic allergic reaction to coconut (Cocos nucifera) in 2 subjects with hypersensitivity to tree nut and demonstration of cross-reactivity to legumin-like seed storage proteins: new coconut and walnut food allergens. J Allergy Cl PubMed
  2. Rosado A, Fernandez-Rivas M, Gonzalez-Mancebo E, et al. Anaphylaxis to coconut. Allergy 2002;57(2):182-3. PubMed
  3. Karmakar PR, Das A, Chatterjee BP. Placebo-controlled immunotherapy with Cocos nucifera pollen extract. Int Arch Allergy Immunol 1994;103(2):194-201. PubMed
  4. Anagnostou K. Coconut Allergy Revisited. Children (Basel). 2017;4(10). pii: E85. PubMed
  5. Cifuentes L, Mistrello G, Amato S, et al. Identification of cross-reactivity between buckwheat and coconut. Ann Allergy Asthma Immunol. 2015;115(6):530-2. PubMed
  6. Michavila Gomez A, Amat Bou M, Gonzalez Cortés MV, Segura Navas L, Moreno Palanques MA, Bartolomé B. Coconut anaphylaxis: Case report and review. Allergol Immunopathol (Madr). 2015;43(2):219-20. PubMed
  7. 21CFR170.3. U.S. Food and Drug Administration Department of Health and Human Services. Updated April 1, 2017. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=170.3
  8. Alatawi KA, Alshubaily FA. Coconut products alleviate hyperglycaemic, hyperlipidimic and nephropathy indices in streptozotocin-induced diabetic wistar rats. Saudi J Biol Sci. 2021;28(8):4224-4231. PubMed
  9. Kruse L, Lor J, Yousif R, Pongracic JA, Fishbein AB. Coconut allergy: Characteristics of reactions and diagnostic predictors in a pediatric tertiary care center. Ann Allergy Asthma Immunol 2021;126(5):562-568.
  10. Pathmanandavel K, Kaur N, Joshi P, Ford LS. Anaphylaxis and allergy to coconut: An Australian pediatric case series. J Allergy Clin Immunol Pract 2020;8(10):3657-3659. PubMed

See these in context on the Coconut monograph →

Safflower 14 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  4. Borkman M, Chisholm DJ, Furler SM, et al. Effects of fish oil supplementation on glucose and lipid metabolism in NIDDM. Diabetes 1989;38:1314-9.. PubMed
  5. Amato, P. and Quercia, R. A. A historical perspective and review of the safety of lipid emulsion in pregnancy. Nutr Clin Pract. 1991;6(5):189-192. PubMed
  6. Demke, D. M., Peters, G. R., Linet, O. I., Metzler, C. M., and Klott, K. A. Effects of a fish oil concentrate in patients with hypercholesterolemia. Atherosclerosis 1988;70(1-2):73-80. PubMed
  7. Kaji, K., Yoshida, S., Nagata, N., Yamashita, T., Mizukoshi, E., Honda, M., Kojima, Y., and Kaneko, S. An open-label study of administration of EH0202, a health-food additive, to patients with chronic hepatitis C. J Gastroenterol. 2004;39(9):873-878. PubMed
  8. Kwon, J. S., Snook, J. T., Wardlaw, G. M., and Hwang, D. H. Effects of diets high in saturated fatty acids, canola oil, or safflower oil on platelet function, thromboxane B2 formation, and fatty acid composition of platelet phospholipids. Am.J.Clin.Nutr. PubMed
  9. Lloyd-Still, J. D., Simon, S. H., Wessel, H. U., and Gibson, L. E. Negative effects of oral fatty acid supplementation on sweat chloride in cystic fibrosis. Pediatrics 1979;64(1):50-52. DOI
  10. Challen, A. D., Branch, W. J., and Cummings, J. H. The effect of aspirin and linoleic acid on platelet aggregation, platelet fatty acid composition and haemostasis in man. Hum Nutr Clin Nutr 1983;37(3):197-208.
  11. Asp ML, Collene AL, Norris LE, Cole RM, Stout MB, Tang SY, Hsu JC, Belury MA. Time-dependent effects of safflower oil to improve glycemia, inflammation and blood lipids in obese, post-menopausal women with type 2 diabetes: a randomized, double-masked, cro
  12. Liu Y, Liu S, Shi Y, et al. Effects of safflower injection on the pharmacodynamics and pharmacokinetics of warfarin in rats. Xenobiotica. 2017 Oct 25:1-6. [Epub ahead of print] PubMed
  13. de Ataide EC, Reges Perales S, de Oliveira Peres MA, et al. Acute liver failure induced by Carthamus tinctorius oil: Case reports and literature review. Transplant Proc. 2018;50(2):476-477. PubMed
  14. Ruyvaran M, Zamani A, Mohamadian A, et al. Safflower (Carthamus tinctorius L.) oil could improve abdominal obesity, blood pressure, and insulin resistance in patients with metabolic syndrome: a randomized, double-blind, placebo-controlled clinical trial. PubMed

See these in context on the Safflower monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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