Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

G.I. Detox INT Ingredients & Drug Interactions

by Biocidin Botanicals

G.I. Detox INT label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking G.I. Detox INT against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

G.I. Detox INT is a dietary supplement by Biocidin Botanicals with 6 active ingredients. Its ingredients are commonly taken for hair, skin, and nail health, bone health and osteoporosis, joint and connective tissue support.Based on those ingredients, 2,082 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Charcoal, Activated, Aloe Vera Gel, Apple Pectin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against G.I. Detox INT by Biocidin Botanicals

Ask about any prescription or over-the-counter medication and we check it for interactions with G.I. Detox INT by Biocidin Botanicals — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of G.I. Detox INT by Biocidin Botanicals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • “Proprietary Herbal Blend” is a proprietary blend — the label gives one combined amount (500 mg) without saying how much of each component you get.

G.I. Detox INT contains 6 active ingredients.

The main ones are activated charcoal, a highly absorbent compound used to trap substances in your digestive tract; aloe vera gel, a plant extract with laxative and anti-inflammatory properties; apple pectin, a soluble fiber from fruit; silica, a mineral form of silicon; velay green clay, a mineral-based absorbent; and humic powder, a compound derived from organic matter. There are also inactive ingredients — hydroxypropyl methylcellulose, water, and rice extract — that act as fillers and binders to hold the capsule together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Gentle full-spectrum binder for digestive support.
  • We looked for evidence on: Constipation, Diarrhea, Dyspepsia, Flatulence, Irritable bowel syndrome (IBS), Toxin binding — and 2 related terms.
  • The strongest evidence on file: Aloe is rated "Possibly Effective" for Constipation (Natural Medicines).
  • Also on file: Clay is rated "Possibly Effective" for Rotaviral diarrhea.
  • Also on file: Activated Charcoal is rated "Insufficient Reliable Evidence To Rate" for Chemotherapy-induced diarrhea, Constipation, Dyspepsia, Flatulence.

The evidence for this product's ingredients is mixed. Activated charcoal is possibly effective for poisoning; aloe vera gel is possibly effective for acne, weight loss, diabetes, psoriasis, burns, and constipation; apple pectin is possibly effective for high cholesterol; silica is possibly effective for osteoporosis; and velay green clay is possibly effective for rotaviral diarrhea.

For most other claimed uses — like prediabetes, wound healing, IBS, and chemotherapy-related diarrhea — the evidence we hold is insufficient to rate. Humic powder has no effectiveness data on file.

The evidence, ingredient by ingredient Silicon Pectin Activated Charcoal Aloe Humic Acid Clay

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Activated charcoal is generally low-risk for short-term use but can cause constipation, black stools, bloating, and gas. Rarely, it may cause gastrointestinal obstruction.

Apple pectin from food and typical supplement amounts is generally well tolerated, though some people experience diarrhea, gas, loose stools, or mild cramps. Aloe vera gel applied topically is generally well tolerated, but oral aloe latex can cause abdominal pain, cramps, and diarrhea; long-term use may cause more serious effects including muscle weakness and irregular heartbeat from potassium loss.

Silica from food and most supplements is generally well tolerated, though high-dose or long-term safety hasn't been well studied. Velay green clay is generally low-risk topically but can be contaminated with heavy metals when taken orally; constipation, vomiting, and diarrhea are common, and habitual use has been linked to heart problems and severe iron deficiency anemia.

Humic powder has limited safety data.

Side effects, ingredient by ingredient Silicon Pectin Activated Charcoal Aloe Humic Acid Clay

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 4 of the 6 matched ingredients can interact with medications — Activated Charcoal, Pectin, Aloe, Clay.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; heart-rhythm medications.
  • For scale: 2,083 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking G.I. Detox INT, double-check any oral medications you take — activated charcoal can reduce their absorption.

If you take digoxin or other heart medications, blood thinners (including warfarin), diabetes drugs, water pills/diuretics, strong laxatives, tetracycline antibiotics, lovastatin, cimetidine, or quinine, talk to your pharmacist first. No interactions are documented for silica or humic powder, which we hold data for.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

G.I. Detox INT isn't a product you can take casually with other medications — its main ingredients (especially activated charcoal) bind to many drugs and reduce how well they work.

If you take any prescription medication, blood thinner, heart drug, diabetes medication, or acid reflux medication, check with your pharmacist before you start. This product is best used under professional guidance.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 20, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about G.I. Detox INT, straight from the product label.

Brand Biocidin Botanicals
Barcode (UPC) 899870002258
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Jun 20, 2024
DSLD ID 314058
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for G.I. Detox INT by Biocidin Botanicals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
899870002258
IngredientAmount% DV
Silica80 mg--
Apple Pectin80 mg--
Charcoal, Activated147 mg--
Proprietary Herbal Blend500 mg--
Aloe Vera Gel100 mg--
Humic, Powder56 mg--
Velay Green Clay37 mg--

Other ingredients: Hydroxypropyl Methylcellulose, Water, Rice extract

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use 1 capsule on an empty stomach with a full glass of water or as directed by a healthcare professional. Take 1 hour apart from the other medications and supplements.

Precautions

Warning: Not recommended for use during pregnancy. Consult your physician before using any supplement, especially if you are nursing, have a medical condition, or are taking medication.

Discontinue use should adverse reactions occur. Do not consume more than the recommended serving.

Keep out of reach of children.

Storage

Store in a cool, dry place.

Formula

Velay green clay, charcoal & herbal formula

General Statements

Bind

Formulation

Gentle full-spectrum binder

This product is made without dairy, gluten, soy, corn, animal products, artificial coloring or flavoring.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

G.I. Detox INT by Biocidin Botanicals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

G.I. Detox INT label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in G.I. Detox INT by Biocidin Botanicals

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Herbal Blend

500 mg per serving

Other (inactive) ingredients: Hydroxypropyl Methylcellulose, Water, Rice extract. These complete the product’s ingredient list but are not active constituents.

Interaction report

G.I. Detox INT by Biocidin Botanicals Drug Interactions

Want to check YOUR meds against G.I. Detox INT?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,082Drugs
2,022 Major 57 Moderate 3 Minor

Ingredients driving the most interactions

Charcoal, Activated 2,027
Aloe Vera Gel 461
Apple Pectin 23
Velay Green Clay 3

Individual Drug Interactions

The ingredients in G.I. Detox INT interact with 2,082 drugs. Click any drug to see the details.

4 of the 6 ingredients in G.I. Detox INT interact with drugs. Each result below shows which ingredient is responsible. Charcoal, Activated Aloe Vera Gel Apple Pectin Velay Green Clay

Each ingredient & the kinds of drugs it affects

For each ingredient in G.I. Detox INT with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Charcoal, Activated3 drug types · 2,027 drugs

Oral Drugs

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.
Activated charcoal adsorbs various drugs and may reduce their absorption and/or half-life. Examples of affected drugs include acetaminophen, aminophylline, amiodarone, atenolol, carbamazepine, dapsone, digoxin, disopyramide, fluoxetine, indomethacin, moxifloxacin, nadolol, phenytoin, phenobarbital, piroxicam, quinine, sotalol, theophylline, tricyclic antidepressants, valproate, and verapamil. Avoid co-administration, except after drug overdose.

Likelihood Probable Evidence B
Alcohol (Ethanol)

The binding action of activated charcoal may be reduced by alcohol.
Alcohol may lower the adsorptive capacity of activated charcoal.

Likelihood Probable Evidence D
Contraceptive Drugs

Activated charcoal may reduce the clinical effects of oral contraceptives.
Activated charcoal, taken in a dose of 5 grams four times daily for 3 days, may bind to, and reduce the absorption of, oral contraceptives, thereby limiting their effectiveness and increasing the risk of contraceptive failure. However, some clinical research shows that the risk for this interaction is minimal when activated charcoal is taken either 3 hours after or at least 12 hours before oral contraceptives.

Likelihood Possible Evidence B
Charcoal, Activated full monograph & interactions

Aloe Vera Gel7 drug types · 461 drugs

Digoxin (Lanoxin)

Theoretically, aloe latex might increase the risk of adverse effects when taken with cardiac glycosides.
Overuse of aloe latex can increase the risk of adverse effects from cardiac glycoside drugs, such as digoxin, due to potassium depletion. Overuse of aloe, along with cardiac glycoside drugs, can increase the risk of toxicity.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that aloe gel can inhibit platelet aggregation. This inhibition was greater than that seen with celecoxib, but less than that seen with aspirin.

Likelihood Possible Evidence D
Antidiabetes Drugs

Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Preliminary clinical research suggests aloe gel might lower blood glucose levels and have additive effects when used with antidiabetes drugs. Monitor blood glucose levels closely.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Overuse of aloe latex might compound diuretic-induced potassium loss, increasing the risk of hypokalemia.

Likelihood Possible Evidence D
Stimulant Laxatives

Theoretically, aloe latex might increase the risk for fluid and electrolyte loss when taken with stimulant laxatives.
Due to cathartic laxative effects of aloe latex, concomitant use with other stimulant laxatives might compound fluid and electrolyte loss.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, aloe latex might increase the risk of bleeding when taken with warfarin.
Aloe latex has stimulant laxative effects. In some people aloe latex can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding. Advise patients who take warfarin not to take excessive amounts of aloe vera.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, aloe might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that aloe extract induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Aloe Vera Gel full monograph & interactions

Apple Pectin3 drug types · 23 drugs

Digoxin (Lanoxin)

Theoretically, pectin might reduce the absorption of digoxin, potentially decreasing its effectiveness.
A small clinical study shows that taking digoxin with a kaolin-pectin suspension reduces the absorption of digoxin by about 62%. It is unclear if these effects are due to pectin, kaolin, or the combination.

Likelihood Possible Evidence B
Lovastatin (Mevacor)

Theoretically, pectin might reduce the absorption of lovastatin, potentially decreasing its effectiveness.
Case reports suggest that concomitant use of pectin and lovastatin might reduce the cholesterol-lowering effect of lovastatin, possibly due to reduced intestinal absorption of lovastatin.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, pectin might reduce the absorption of tetracycline antibiotics, potentially decreasing their effectiveness.
A small clinical study shows that taking tetracycline with bismuth subsalicylate in a kaolin-pectin suspension reduces the absorption of tetracycline by about 34%. It is unclear if these effects are due to pectin, kaolin, bismuth subsalicylate, or the combination.

Likelihood Possible Evidence B
Apple Pectin full monograph & interactions

Velay Green Clay2 drug types · 3 drugs

Cimetidine (Tagamet)

Preliminary clinical research suggests that clay might inhibit the absorption of cimetidine when taken simultaneously. Consumption of clay along with cimetidine might reduce the effectiveness of cimetidine therapy.

Likelihood Possible Evidence B
Quinine

In vitro evidence suggests that consuming clay reduces the bioavailability of quinine by about 30%. Theoretically, consumption of clay along with quinine might reduce the effectiveness of quinine therapy.

Likelihood Probable Evidence D
Velay Green Clay full monograph & interactions
The maker

Brand information

Manufacturer and brand details for G.I. Detox INT, from the product label.

Biocidin Botanicals

See all Biocidin Botanicals products
Name
Biocidin Botanicals
Street Address
P.O. Box 2499
City
Aptos
State
CA
ZipCode
95001
Phone Number
1(800)775-4140
Web Address
Biocidin.com
Pharmacist Counseling Corner

G.I. Detox INT by Biocidin Botanicals: Common Questions

Does G.I. Detox INT by Biocidin Botanicals interact with any medications?
Yes. Based on its ingredients, G.I. Detox INT has a known interaction with 2,082 medications, including 2022 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
G.I. Detox INT contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm pregnant?
The product contains several ingredients with safety concerns in pregnancy. Silica and apple pectin are likely safe in food amounts, but concentrated supplement safety hasn't been well studied. Activated charcoal is possibly safe but not well studied for routine use in pregnancy. Aloe is possibly unsafe — the latex can stimulate the uterus and cause strong laxative effects. Humic powder and velay green clay lack enough safety data. Talk with your doctor before taking this product while pregnant.
Is this safe to use while breastfeeding?
Apple pectin in dietary amounts is likely fine, but supplement safety while breastfeeding hasn't been well studied. Activated charcoal, silica, aloe, humic powder, and velay green clay all have limited or no reliable safety data for nursing. Check with your pharmacist or doctor before use.
What does activated charcoal actually do in this product?
Activated charcoal is a highly porous form of carbon that binds to substances in your digestive tract. It's used to trap toxins, gases, and other compounds so your body can eliminate them. The downside is it also binds to medications, which is why timing matters if you take other drugs.
Will this cause constipation?
Yes, constipation is a common side effect of activated charcoal, and the clay and silica can also contribute to it. You may also experience black stools, bloating, or gas. On the flip side, aloe has laxative properties, so your bowel habits could shift unpredictably depending on which ingredient dominates.
What's the difference between aloe vera gel and aloe latex?
This product contains aloe vera gel, which is the clear inner part of the leaf and is generally well tolerated topically. Aloe latex is the yellow substance found just under the leaf skin and has strong laxative effects and more serious side effects. Both are in this supplement, so the laxative and drug-interaction concerns apply.
Why should I be worried about heavy metals in the clay?
Velay green clay is a natural mineral that can absorb heavy metals like lead, arsenic, and iron from soil and water during growth. Long-term ingestion of contaminated clay has been linked to heavy-metal poisoning, anemia, and heart problems. Product purity varies, so look for third-party testing if you use this regularly.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

G.I. Detox INT label
Go deeper

The Full Monographs Behind G.I. Detox INT’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Silicon

Silicon is a trace mineral found in the body and in foods like oats, barley, and certain fruits and vegetables, and it is popular in supplements for hair, skin, nail, and bone health. Some s...

Read the full Silicon monograph → Herb & supplement monograph

Pectin

Interacts with 23 drugs

Pectin is a natural soluble fiber found in fruits like apples and citrus, and it is widely used in foods and as a fiber supplement. It may modestly help with cholesterol, blood sugar, and di...

Read the full Pectin monograph → Herb & supplement monograph

Activated Charcoal

Interacts with 2,027 drugs

Activated charcoal is a highly porous form of carbon that can bind certain substances in the gut, and it is used in hospitals to treat some poisonings and overdoses. For everyday uses like g...

Read the full Activated Charcoal monograph → Herb & supplement monograph

Aloe

Interacts with 461 drugs

Aloe vera gel is widely used on the skin for minor burns and irritation, and some research suggests it may help. Aloe latex (the yellow part) is a strong laxative that can cause cramping and...

Read the full Aloe monograph → Herb & supplement monograph

Humic Acid

Humic acid is a natural substance formed when plant and animal matter break down in soil, peat, and coal-like deposits, and it is sold as a supplement marketed for immune, gut, and 'detox' s...

Read the full Humic Acid monograph → Herb & supplement monograph

Clay

Interacts with 3 drugs

Clay is a fine, mineral-rich earth (such as bentonite or kaolin) used on the skin and sometimes taken by mouth for digestive and 'detox' purposes. Topical use for masks and minor skin issues...

Read the full Clay monograph →
Sources

Sources & How We Checked

G.I. Detox INT's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 119 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Silicon 19 references
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  2. Jugdaohsingh R, Anderson SH, Tucker KL, et al. Dietary silicon intake and absorption. Am J Clin Nutr 2002;75:887-93. PubMed
  3. Ichiyanagi O, Sasagawa I, Adachi Y, et al. Silica urolithiasis without magnesium trisilicate intake. Urol Int 1998;61:39-42. PubMed
  4. Levison DA, Crocker PR, Banim S, Wallace DM. Silica stones in the urinary bladder. Lancet 1982;1:704-5. PubMed
  5. Lee MH, Lee YH, Hsu TH, et al. Silica stone--development due to long time oral trisilicate intake. Scand J Urol Nephrol 1993;27:267-9. PubMed
  6. Cruz Guerra, N. A., Gomez Garcia, M. A., Lovaco, Castellano F., Saez Garrido, J. C., Garcia, Cuerpo E., and Escudero, Barrilero A. [Silica urolithiasis: report of a new case]. Actas Urol.Esp 2000;24(2):202-204.
  7. Merget, R., Bauer, T., Kupper, H. U., Philippou, S., Bauer, H. D., Breitstadt, R., and Bruening, T. Health hazards due to the inhalation of amorphous silica. Arch Toxicol. 2002;75(11-12):625-634. PubMed
  8. Khuder, S. A., Peshimam, A. Z., and Agraharam, S. Environmental risk factors for rheumatoid arthritis. Rev Environ Health 2002;17(4):307-315. PubMed
  9. McLaughlin, J. K., Chow, W. H., and Levy, L. S. Amorphous silica: a review of health effects from inhalation exposure with particular reference to cancer. J Toxicol.Environ Health 4-25-1997;50(6):553-566. DOI
  10. Pelucchi, C., Pira, E., Piolatto, G., Coggiola, M., Carta, P., and La, Vecchia C. Occupational silica exposure and lung cancer risk: a review of epidemiological studies 1996-2005. Ann.Oncol. 2006;17(7):1039-1050. PubMed
  11. Gillissen, A., Gessner, C., Hammerschmidt, S., Hoheisel, G., and Wirtz, H. [Health significance of inhaled particles]. Dtsch.Med Wochenschr. 3-24-2006;131(12):639-644.
  12. Hu, J. F., Qu, H., and Wang, J. Z. [Meta analysis for relationship between exposure of free silicon dioxide and lung tumor]. Zhonghua Lao.Dong.Wei Sheng Zhi.Ye.Bing.Za Zhi. 2006;24(7):415-417.
  13. Jugdaohsingh, R. Silicon and bone health. J Nutr Health Aging 2007;11(2):99-110.
  14. Lacasse, Y., Martin, S., Gagne, D., and Lakhal, L. Dose-response meta-analysis of silica and lung cancer. Cancer Causes Control 2009;20(6):925-933. PubMed
  15. McCormic, Z. D., Khuder, S. S., Aryal, B. K., Ames, A. L., and Khuder, S. A. Occupational silica exposure as a risk factor for scleroderma: a meta-analysis. Int Arch Occup.Environ Health 2010;83(7):763-769. PubMed
  16. Haddad, F. S. and Kouyoumdjian, A. Silica stones in humans. Urol.Int 1986;41(1):70-76. PubMed
  17. Tervaert, J. W., Stegeman, C. A., and Kallenberg, C. G. Silicon exposure and vasculitis. Curr Opin.Rheumatol 1998;10(1):12-17. PubMed
  18. Steenland, K. and Stayner, L. Silica, asbestos, man-made mineral fibers, and cancer. Cancer Causes Control 1997;8(3):491-503. PubMed
  19. Boqué N, Valls RM, Pedret A, Puiggrós F, Arola L, Solà R. Relative absorption of silicon from different formulations of dietary supplements: a pilot randomized, double-blind, crossover post-prandial study. Sci Rep 2021;11(1):16479. PubMed

See these in context on the Silicon monograph →

Pectin 11 references
  1. Jaakkola MS, et al. Asthma caused by occupational exposure to pectin. J Allergy Clin Immunol 1997;100:575-6. PubMed
  2. Westphal W, et al. [Exogenous allergic asthma following pectin exposure-a new occupational allergen]. Pneumologie 1990;44(Suppl 1):337-8.
  3. Baldwin JL, et al. Pectin-induced occupational asthma. Chest 1993;104:1936-7. PubMed
  4. Cohen AJ, Forse MS, Tarlo SM. Occupational asthma caused by pectin inhalation during the manufacture of jam. Chest 1993;103:309-11.
  5. Kraut A, et al. Christmas candy maker's asthma. IgG4-mediated pectin allergy. Chest 1992;102:1605-7. PubMed
  6. Richter WO, Jacob BG, Schwandt P. Interaction between fibre and lovastatin. Lancet 1991;338:706.
  7. Albert KS, Ayres JW, DiSanto AR, et al. Influence of kaolin-pectin suspension on digoxin bioavailability. J Pharm Sci 1978;67:1582-6. PubMed
  8. Albert KS, Welch RD, DeSante KA, et al. Decreased tetracycline bioavailability caused by a bismuth subsalicylate antidiarrheal mixture. J Pharm Sci 1979;68:586-8. PubMed
  9. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  10. Federal Register April 17,2003. Anti-Diarrheal Products for over-the-counter human use; final monograph. Available at: http://www.fda.gov/OHRMS/DOCKETS/98fr/03-9380.pdf (Accessed 27 December 2004).
  11. Washio K, Nakamura M, Sato N, et al. Anaphylaxis in a pectin- and cashew nut-allergic child caused by a citrus bath. Allergol Int 2022;71(1):155-157. PubMed

See these in context on the Pectin monograph →

Activated Charcoal 14 references
  1. Kaaja RJ, Kontula KK, Raiha A, Laatikainen T. Treatment of cholestasis of pregnancy with peroral activated charcoal. A preliminary study. Scand J Gastroenterol 1994;29:178-81.
  2. Anon. Position statement and practice guidelines on the use of multi-dose activated charcoal in the treatment of acute poisoning. American Academy of Clinical Toxicology; European Association of Poisons Centres and Clinical Toxicologists. J Toxicol Clin T
  3. Park GD, Spector R, Kitt TM. Superactivated charcoal versus cholestyramine for cholesterol lowering: a randomized cross-over trial. J Clin Pharmacol 1988;28:416-9. PubMed
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Aloe 41 references
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See these in context on the Aloe monograph →

Humic Acid 3 references
  1. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source
  2. Using Dietary Supplements Wisely — NIH NCCIH Source
  3. Dietary Supplements — MedlinePlus Source

See these in context on the Humic Acid monograph →

Clay 31 references
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  27. Mitchell NJ, Kumi J, Aleser M, et al. Short-term safety and efficacy of calcium montmorillonite clay (UPSN) in children. Am J Trop Med Hyg. 2014;91(4):777-85. PubMed
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  30. Lai BY, Liang N, Cao HJ, et al. Pediatric Tui Na for acute diarrhea in children under 5 years old: A systematic review and meta-analysis of randomized clinical trials. Complement Ther Med. 2018;41:10-22. PubMed
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See these in context on the Clay monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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