Major interaction on record — check this product against your medications before combining. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

G.U.M Canker-X Ingredients & Drug Interactions

by Sunstar

G.U.M Canker-X label
See full label image
Liquid Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking G.U.M Canker-X against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

G.U.M Canker-X is a dietary supplement by Sunstar with 3 active ingredients. Its ingredients are commonly taken for minor burns and skin irritation, wound healing, constipation.Based on those ingredients, 589 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Aloe vera, Sodium Hyaluronate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against G.U.M Canker-X by Sunstar

Ask about any prescription or over-the-counter medication and we check it for interactions with G.U.M Canker-X by Sunstar — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of G.U.M Canker-X by Sunstar

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.

G.U.M Canker-X contains three active ingredients: aloe vera, polyvinylpyrrolidone, and sodium hyaluronate. Aloe vera is a plant extract used for its soothing and healing properties.

Sodium hyaluronate is a moisturizing ingredient that helps retain water. The product also contains inactive ingredients — water, xanthan gum, flavoring, preservatives, and other excipients that give the liquid its form and stability.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Pain relief for canker and mouth sores.
  • We looked for evidence on: Canker sores, Traumatic oral ulcers, Oral mucositis, Wound healing, Aphthous ulcers, Oral ulceration — and 1 related terms.
  • The strongest evidence on file: Aloe is rated "Possibly Effective" for Traumatic oral ulcers (Natural Medicines).
  • Also on file: Aloe is rated "Insufficient Reliable Evidence To Rate" for Oral mucositis, Wound healing, Canker sores.
  • Also on file: Sodium is rated "Insufficient Reliable Evidence To Rate" for Canker sores.

Aloe vera in this product is rated possibly effective for several uses: acne, burns, constipation, diabetes, obesity, and psoriasis. Sodium hyaluronate is rated likely effective for cystic fibrosis and possibly effective for kidney protection when used with the drug amphotericin B.

The evidence for other uses of sodium hyaluronate is insufficient to rate. Keep in mind this is a topical liquid designed for canker sores, and the ingredient research may not directly match that specific use.

The evidence, ingredient by ingredient Aloe Sodium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Aloe vera's safety depends on how it's used. The topical gel form — which is what's in this liquid — is generally well tolerated.

However, if you're pregnant, avoid oral aloe because it may stimulate the uterus and act as a strong laxative. If you're breastfeeding, there isn't enough safety data, so it's best to avoid it as well.

Sodium is essential in small amounts, but excess intake is linked to high blood pressure and heart strain — important if you take blood pressure medications or have heart or kidney disease. This product is a topical liquid, so sodium absorption should be minimal, but if you use other sodium-containing products or take lithium, check with your doctor or pharmacist first.

Side effects, ingredient by ingredient Aloe Sodium

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Aloe, Sodium.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; heart-rhythm medications; lithium.
  • For scale: 589 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before using G.U.M Canker-X, double-check with your doctor or pharmacist if you take digoxin or other heart medications (Major risk), blood thinners or antiplatelet drugs, diabetes medications, blood pressure medications, diuretics, stimulant laxatives, lithium, corticosteroids, or didanosine. These are the drug types with documented interactions with the active ingredients in this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product may be worth trying if you have a canker sore and aren't taking digoxin, blood thinners, diabetes drugs, or blood pressure medications. If you take any prescription medication — especially for the heart, blood thinning, blood sugar, or blood pressure — talk with your doctor or pharmacist before you start.

If you're pregnant or breastfeeding, check with your healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about G.U.M Canker-X, straight from the product label.

Brand Sunstar
Barcode (UPC) 070942306607
Net contents 0.28 Fluid Ounce(s); 8 mL
Market status On market
Date entered into DSLD Oct 24, 2023
DSLD ID 302103
Product type Other Combinations
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for G.U.M Canker-X by Sunstar, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Drop(s)
Maximum serving Sizes:
2 Drop(s)
UPC/BARCODE
070942306607
IngredientAmount% DV
Aloe vera0 NP--
Polyvinylpyrrolidone0 NP--
Sodium Hyaluronate0 NP--

Other ingredients: Water, Maltodextrin, Propylene Glycol, PEG-40 Hydrogenated Castor Oil, Xanthan Gum, Potassium Sorbate, Sodium Benzoate, Flavour, Disodium Edetate, Benzalkonium Chloride, Saccharin Sodium, Sodium Hyaluronate, Glycyrrhetinic Acid, Aloe Vera

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Aloe vera

Contains soothing aloe vera

Key Ingredients: Polyvinylpyrrolidone-Purpose: Micro-Thin, Invisible protective coating promotes healing and quickly relieves pain; Sodium Hyaluronate-Hydrates sore; Aloe Vera-Soothes the sore

General Statements

Unique applicator nozzle 1772

100% money back guarantee

For more information, visit us at: gumbrand.com or canker-x.com Or call us at: 1-888-777-3101 We guarantee you will be more satisfied with Canker-X than any other canker sore product. If you are not completely satisfied with this product, Sunstar will refund your money. See Canker-X.com for details.

Formulation

Pain relief gel For canker and mouth sores Coats, hydrates and soothes canker and mouth sores Fast pain relief without the burning and numbing!

Uses: best for pain relief due to canker sores, mouth sores, cheek bites and abrasions from braces and dentures Promotes healing by forming a protective barrier against irritants Helps promote healing without stinging or burning Quickly relieves pain

Canker-X is a unique, patented and clinically tested formula that contains no alcohol or benzocaine for long lasting relief

Manufactured in Italy

Brand IP Statement(s)

Canker-X is a unique, patented and clinically tested formula that contains no alcohol or benzocaine for long lasting relief

Suggested/Recommended/Usage/Directions

Directions: apply gel directly to canker sore or mouth sore as often as needed Apply 1 or 2 drops of gel to cover the whole sore Apply a thin of gel with a cotton swab or clean finger Do not touch the sore with the tongue for at least two minutes after application to allow the protective barrier to form Avoid eating or drinking for one hour

Precautions

Warnings: do not use a package if package is damaged

Keep out of reach of children

Storage

Store at room temperature, out of direct sunlight Do not freeze 41 degrees Fahrenheit 5 degrees Celsius 77 degrees Fahrenheit 25 degrees Celsius

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

G.U.M Canker-X by Sunstar label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

G.U.M Canker-X label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in G.U.M Canker-X by Sunstar

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Drop(s) Dosage formLiquid Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Aloe vera

Interacts with
461 drugs
0 NP per serving

Aloe vera gel is widely used on the skin for minor burns and irritation, and some research suggests it may help. Aloe latex (the yellow part) is a str...

Aloe vera monograph & interactions

Polyvinylpyrrolidone

0 NP per serving

Sodium Hyaluronate

Interacts with
205 drugs
0 NP per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium Hyaluronate monograph & interactions

Other (inactive) ingredients: Water, Maltodextrin, Propylene Glycol, PEG-40 Hydrogenated Castor Oil, Xanthan Gum, Potassium Sorbate, Sodium Benzoate, Flavour, Disodium Edetate, Benzalkonium Chloride, Saccharin Sodium, Sodium Hyaluronate, Glycyrrhetinic Acid, Aloe Vera. These complete the product’s ingredient list but are not active constituents.

Interaction report

G.U.M Canker-X by Sunstar Drug Interactions

Want to check YOUR meds against G.U.M Canker-X?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
589Drugs
1 Major 436 Moderate 152 Minor

Ingredients driving the most interactions

Aloe vera 461
Sodium Hyaluronate 205

Individual Drug Interactions

The ingredients in G.U.M Canker-X interact with 589 drugs. Click any drug to see the details.

2 of the 3 ingredients in G.U.M Canker-X interact with drugs. Each result below shows which ingredient is responsible. Aloe vera Sodium Hyaluronate

Each ingredient & the kinds of drugs it affects

For each ingredient in G.U.M Canker-X with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Aloe vera7 drug types · 461 drugs

Digoxin (Lanoxin)

Theoretically, aloe latex might increase the risk of adverse effects when taken with cardiac glycosides.
Overuse of aloe latex can increase the risk of adverse effects from cardiac glycoside drugs, such as digoxin, due to potassium depletion. Overuse of aloe, along with cardiac glycoside drugs, can increase the risk of toxicity.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that aloe gel can inhibit platelet aggregation. This inhibition was greater than that seen with celecoxib, but less than that seen with aspirin.

Likelihood Possible Evidence D
Antidiabetes Drugs

Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Preliminary clinical research suggests aloe gel might lower blood glucose levels and have additive effects when used with antidiabetes drugs. Monitor blood glucose levels closely.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Overuse of aloe latex might compound diuretic-induced potassium loss, increasing the risk of hypokalemia.

Likelihood Possible Evidence D
Stimulant Laxatives

Theoretically, aloe latex might increase the risk for fluid and electrolyte loss when taken with stimulant laxatives.
Due to cathartic laxative effects of aloe latex, concomitant use with other stimulant laxatives might compound fluid and electrolyte loss.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, aloe latex might increase the risk of bleeding when taken with warfarin.
Aloe latex has stimulant laxative effects. In some people aloe latex can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding. Advise patients who take warfarin not to take excessive amounts of aloe vera.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, aloe might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that aloe extract induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Aloe vera full monograph & interactions

Sodium Hyaluronate7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium Hyaluronate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for G.U.M Canker-X, from the product label.

Sunstar

See all Sunstar products
Name
Sunstar Americas, Inc.
City
Schaumburg
State
IL
ZipCode
60195
Phone Number
1-888-777-3101
Web Address
gumbrand.com
Pharmacist Counseling Corner

G.U.M Canker-X by Sunstar: Common Questions

Does G.U.M Canker-X by Sunstar interact with any medications?
Yes. Based on its ingredients, G.U.M Canker-X has a known interaction with 589 medications, including 1 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
G.U.M Canker-X contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I use this if I'm pregnant?
Aloe vera, one of the active ingredients, is rated possibly unsafe in pregnancy because it may stimulate the uterus and cause strong laxative effects. There isn't enough safety data on sodium hyaluronate in pregnancy. Talk with your doctor before using this product while pregnant.
Is this safe to use while breastfeeding?
Aloe vera is rated possibly unsafe while breastfeeding because of limited safety data and its laxative effects. Check with your doctor or pharmacist before starting it if you're nursing.
What side effects might I experience from the aloe in this product?
Since this is a topical liquid, the main risk is minor — burning, redness, or itching at the site, or contact dermatitis in sensitive skin. Orally taken aloe can cause abdominal pain and diarrhea, but this is a topical product, so oral effects are unlikely unless you swallow it.
Does this product actually work for canker sores?
The data we hold shows aloe vera is possibly effective for burns and wound healing. While canker sores aren't listed in our effectiveness ratings for this ingredient, aloe's soothing and healing properties are commonly used for mouth sores. Results vary by person.
What is sodium hyaluronate doing in a canker sore product?
Sodium hyaluronate is a moisturizing ingredient that helps the skin and tissues hold water, which can help soothe irritation and support healing in the mouth. It's not the main active ingredient here, but it supports the product's soothing action.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if G.U.M Canker-X is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

G.U.M Canker-X label
Go deeper

The Full Monographs Behind G.U.M Canker-X’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Aloe

Interacts with 461 drugs

Aloe vera gel is widely used on the skin for minor burns and irritation, and some research suggests it may help. Aloe latex (the yellow part) is a strong laxative that can cause cramping and...

Read the full Aloe monograph → Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph →
Sources

Sources & How We Checked

G.U.M Canker-X's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 79 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Aloe 41 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Wichtl MW. Herbal Drugs and Phytopharmaceuticals. Ed. N.M. Bisset. Stuttgart: Medpharm GmbH Scientific Publishers, 1994.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Nusko G, Schneider B, Schneider I, et al. Anthranoid laxative use is not a risk factor for colorectal neoplasia: results of a prospective case control study. Gut 2000;46:651-5. PubMed
  5. Luyckx VA, Ballantine R, Claeys M, et al. Herbal remedy-associated acute renal failure secondary to Cape aloes. Am J Kidney Dis 2002;39:E13. PubMed
  6. Rajasekaran S, Sivagnanam K, Ravi K, Subramanian S. Hypoglycemic effect of Aloe vera gel on streptozotocin-induced diabetes in experimental rats. J Med Food 2004;7:61-6.
  7. Williams MS, Burk M, Loprinzi CL, et al. Phase III double-blind evaluation of an aloe vera gel as a prophylactic agent for radiation-induced skin toxicity. Int J Radiat Oncol Biol Phys 1996;36:345-9. PubMed
  8. Vogler BK, Ernst E. Aloe vera: a systematic review of its clinical effectiveness. Br J Gen Pract 1999;49:823-8.
  9. Bottenberg MM, Wall GC, Harvey RL, Habib S. Oral aloe vera-induced hepatitis. Ann Pharmacother 2007;41:1740-3. PubMed
  10. Rabe C, Musch A, Schirmacher P, et al. Acute hepatitis induced by an Aloe vera preparation: a case report. World J Gastroenterol 2005;11:303-4. PubMed
  11. Kanat O, Ozet A, Ataergin S. Aloe vera-induced acute toxic hepatitis in a healthy young man. Eur J Int Med 2006;17:589. PubMed
  12. Mueller SO, Stopper H. Characterization of the genotoxicity of anthraquinones in mammalian cells. Biochim Biophys Acta 1999;1428:406-14. PubMed
  13. Schorkhuber M, Richter M, Dutter A, et al. Effect of anthraquinone laxatives on the proliferation and urokinase secretion of normal, premalignant and malignant colonic epithelial cells. Eur J Cancer 1998;34:1091-8. PubMed
  14. Yang HN, Kim DJ, Kim YM, et al. Aloe-induced toxic hepatitis. J Korean Med Sci 2010;25:492-5. PubMed
  15. Choonhakarn C, Busaracome P, Sripanidkulchai B, et al. A prospective, randomized clinical trial comparing topical aloe vera with 0.1% triamcinolone acetonide in mild to moderate plaque psoriasis. J.Eur.Acad.Dermatol.Venereol. 2010;24:168-72. PubMed
  16. Ishii Y, Tanizawa H, Takino Y. Studies of aloe. IV. Mechanism of cathartic effect. (3). Biol Pharm Bull. 1994;17:495-7. PubMed
  17. Ishii Y, Tanizawa H, Takino Y. Studies of aloe. V. Mechanism of cathartic effect. (4). Biol Pharm Bull. 1994;17:651-3. PubMed
  18. Nelemans FA. Clinical and toxicological aspects of anthraquinone laxatives. Pharmacology. 1976;14 Suppl 1:73-7. PubMed
  19. Paulsen E, Korsholm L, Brandrup F. A double-blind, placebo-controlled study of a commercial Aloe vera gel in the treatment of slight to moderate psoriasis vulgaris. J Eur Acad Dermatol Venereol. 2005;19:326-31.
  20. Huseini HF, Kianbakht S, Hajiaghaee R, et al. Anti-hyperglycemic and anti-hypercholesterolemic effects of Aloe vera leaf gel in hyperlipidemic type 2 diabetic patients: a randomized double-blind placebo-controlled clinical trial. Planta Med. 2012;78:311-6
  21. Ferreira, M., Teixeira, M., Silva, E., and Selores, M. Allergic contact dermatitis to Aloe vera. Contact Dermatitis 2007;57(4):278-279.
  22. Choonhakarn, C., Busaracome, P., Sripanidkulchai, B., and Sarakarn, P. The efficacy of aloe vera gel in the treatment of oral lichen planus: a randomized controlled trial. Br J Dermatol 2008;158(3):573-577. PubMed
  23. Baretta, Z., Ghiotto, C., Marino, D., and Jirillo, A. Aloe-induced hypokalemia in a patient with breast cancer during chemotherapy. Ann.Oncol. 2009;20(8):1445-1446. PubMed
  24. Hunter, D. and Frumkin, A. Adverse reactions to vitamin E and aloe vera preparations after dermabrasion and chemical peel. Cutis 1991;47(3):193-196.
  25. Alvarez-Perea, A., Garcia, A. P., Hernandez, A. L., de, Barrio M., and Baeza, M. L. Urticaria due to aloe vera: a new sensitizer? Ann.Allergy Asthma Immunol. 2010;105(5):404-405. PubMed
  26. Hogan, D. J. Widespread dermatitis after topical treatment of chronic leg ulcers and stasis dermatitis. CMAJ. 2-15-1988;138(4):336-338.
  27. Savchak VI. Acute bullous allergic dermatitis due to local application of aloe leaves. Vestnik Dermatologii i Venerologii 1977;12:44-45.
  28. Nakamura, T. and Kotajima, S. Contact dermatitis from aloe arborescens. Contact Dermatitis 1984;11(1):51. PubMed
  29. Shoji, A. Contact dermatitis to Aloe arborescens. Contact Dermatitis 1982;8(3):164-167. PubMed
  30. Morrow, D. M., Rapaport, M. J., and Strick, R. A. Hypersensitivity to aloe. Arch Dermatol. 1980;116(9):1064-1065. DOI
  31. Cosmetic Ingredient Review Expert Panel. Final report on the safety assessment of AloeAndongensis Extract, Aloe Andongensis Leaf Juice,aloe Arborescens Leaf Extract, Aloe Arborescens Leaf Juice, Aloe Arborescens Leaf Protoplasts, Aloe Barbadensis Flower E
  32. Bhalang K, Thunyakitpisal P, Rungsirisatean N. Acemannan, a polysaccharide extracted from Aloe vera, is effective in the treatment of oral aphthous ulceration. J Altern Complement Med 2013;19(5):429-34.
  33. Hajheydari Z, Saeedi M, Morteza-Semnani K, Soltani A. Effect of Aloe vera topical gel combined with tretinoin in treatment of mild and moderate acne vulgaris: a randomized, double-blind, prospective trial. J Dermatolog Treat 2014;25(2):123-9.
  34. Jiménez-Encarnación E, Ríos G, Muñoz-Mirabal A, Vilá LM. Euforia-induced acute hepatitis in a patient with scleroderma. BMJ Case Rep 2012;2012. PubMed
  35. Lee J, Lee MS, Nam KW. Acute toxic hepatitis caused by an aloe vera preparation in a young patient: a case report with a literature review. Korean J Gastroenterol 2014;64(1):54-8. PubMed
  36. Guo X, Mei N. Aloe Vera - A Review of Toxicity and Adverse Clinical Effects. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 2016;34(2):77-96.
  37. Hoogenboom TCH, Patel N, Cook NA, Williams R, Taylor-Robinson SD, Lim AKP. The effect of Aloe vera juice on liver enzymes and hepatic structure in a healthy population. Integr Med (Encinitas) 2020;19(3):30-4.
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See these in context on the Sodium monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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