Garlic Oil Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Garlic Oil against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Garlic Oil is a dietary supplement by Nature's Sunshine with 2 active ingredients. Its ingredients are commonly taken for source of dietary fat and calories, heart and cholesterol support, skin moisturizing and barrier care.Based on those ingredients, 989 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Garlic bulb Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Garlic Oil by Nature's Sunshine
Ask about any prescription or over-the-counter medication and we check it for interactions with Garlic Oil by Nature's Sunshine — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Garlic Oil by Nature's Sunshine
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
This product has 2 active ingredients: garlic bulb oil and soybean oil. Garlic is the main player here — it's the bulb oil that carries the active compounds studied for effects on blood pressure, cholesterol, blood sugar, and bleeding.
Soybean oil is included as a carrier and base oil; it's a common food ingredient widely consumed in cooking. The softgel capsule itself is an inactive ingredient (the container that holds the oil).
Does it work?
Not established
Garlic has been studied for several conditions. The evidence rates it possibly effective for high cholesterol, high blood pressure, diabetes, atherosclerosis (clogged arteries), and nonalcoholic fatty liver disease.
For periodontitis (gum disease), the data also shows possibly effective. Soybean oil is rated likely effective as a mosquito repellent and possibly effective for high cholesterol, though evidence for cancer-related fatigue is insufficient.
How safe is it?
Well-documented data
Garlic is generally well tolerated when taken by mouth. The most common side effects are mild: stomach upset, flatulence, body odor, and bad breath.
Some people report skin reactions like rashes, flushing, or acne. Raw garlic can cause allergic reactions in sensitive individuals — people allergic to raw garlic may tolerate cooked garlic better.
Soybean oil is safe as food in normal amounts; people with allergies to the legume family (peanuts, soybeans) may have a reaction. For pregnancy, garlic is rated likely safe in food amounts, though one source notes it's possibly unsafe — food amounts are probably fine, but concentrated supplement doses haven't been well studied.
Talk with your doctor or pharmacist about whether this product is right for you during pregnancy or while breastfeeding. Soybean oil is rated likely safe in both pregnancy and lactation at food levels; supplement doses are not well studied.
Meds to double-check
Moderate interaction found
Before taking this product, double-check with your doctor or pharmacist if you're on blood thinners (anticoagulants) or antiplatelet drugs — garlic increases bleeding risk. Also confirm it's okay if you take blood pressure medications, diabetes medications, HIV protease inhibitors, or drugs metabolized by your liver's cytochrome P450 enzymes, since garlic may change how these work.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
If you take blood thinners, blood pressure medications, diabetes drugs, or HIV protease inhibitors, you need to check with your doctor or pharmacist before starting garlic oil — it can change how these drugs work. Garlic is well tolerated in most people, but it does carry real interaction risks with common medications.
If none of those apply to you, talk it over with your own healthcare provider to make sure it's the right fit.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Garlic Oil, straight from the product label.
| Brand | Nature's Sunshine |
|---|---|
| Barcode (UPC) | 099904016941 |
| Net contents | 60 Softgel(s) |
| Market status | On market |
| Date entered into DSLD | Oct 24, 2022 |
| DSLD ID | 278104 |
| Product type | Botanical With Nutrients |
| Supplement form | Softgel Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Garlic Oil by Nature's Sunshine, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Soybean Oil | 0 NP | -- |
| Proprietary Blend | 225 mg | -- |
| Garlic bulb Oil | 0 NP | -- |
Other ingredients: Softgel
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
General Statements
Bottle made from 100% post consumer recycled material. We are committed to you and our planet. Scan to learn more.
We source the world's purest ingredients, no matter where they are grown, to ensure the active nutrients are delivered just as nature intended.
New look! Same great product
Precautions
Do not use if inner seal is missing or damaged.
Formulation
Immune system support
Guaranteed pure
FDA Statement of Identity
Dietary Supplement
Brand IP Statement(s)
Natures Sunshine Herbal experts since 1972
Suggested/Recommended/Usage/Directions
Recommended Use: Take 1 softgel with a meal three times daily.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Garlic Oil by Nature's Sunshine label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Garlic Oil by Nature's Sunshine
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Blend
Other (inactive) ingredients: Softgel. These complete the product’s ingredient list but are not active constituents.
Garlic Oil by Nature's Sunshine Drug Interactions
HelloPharmacist Interaction Report
Garlic Oil by Nature's Sunshine contains garlic, which interacts with a number of medications.
The most serious concern is its effect on blood thinners (anticoagulants) and antiplatelet drugs — garlic has antiplatelet activity and may increase your bleeding risk if you're taking these medications, including warfarin. Altogether, these interactions span 990 individual medications.
Read the full breakdown — every affected drug type, severity by severity
Garlic also interacts with blood pressure medications (antihypertensive drugs), diabetes medications, and several drug-metabolizing enzymes in your liver and gut. It may lower blood pressure further or increase low blood sugar (hypoglycemia) risk, and it can raise or lower levels of drugs broken down by cytochrome P450 enzymes — including protease inhibitors used for HIV and tacrolimus used after transplant.
It may also affect warfarin specifically by raising your INR (a measure of how thin your blood is).
Soybean oil, the other ingredient, carries no documented interactions with medications. However, if you take any prescription or over-the-counter drugs, run them through the search tool on this page before you start garlic oil.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Garlic Oil?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Garlic Oil interact with 989 drugs. Click any drug to see the details.
1 of the 2 ingredients in Garlic Oil interact with drugs. Each result below shows which ingredient is responsible. Garlic bulb Oil
Ado-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Garlic Oil — through 1 ingredient. Tap an ingredient for the detail:
Garlic Bulb OilCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Garlic Bulb Oil + Ado-trastuzumab Emtansine interactionAbciximabReoPro
How Abciximab interacts with Garlic Oil — through 1 ingredient. Tap an ingredient for the detail:
Garlic Bulb OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Garlic may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Garlic Bulb Oil + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Garlic Oil — through 1 ingredient. Tap an ingredient for the detail:
Garlic Bulb OilCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Garlic Bulb Oil + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Garlic Oil — through 1 ingredient. Tap an ingredient for the detail:
Garlic Bulb OilCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Garlic Bulb Oil + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Garlic Oil — through 1 ingredient. Tap an ingredient for the detail:
Garlic Bulb OilCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Garlic Bulb Oil + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Garlic Oil — through 1 ingredient. Tap an ingredient for the detail:
Garlic Bulb OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Garlic may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Garlic Bulb Oil + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Garlic Oil — through 1 ingredient. Tap an ingredient for the detail:
Garlic Bulb OilCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Garlic Bulb Oil + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Garlic Oil — through 1 ingredient. Tap an ingredient for the detail:
Garlic Bulb OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking garlic with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Garlic Bulb Oil + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Garlic Oil — through 1 ingredient. Tap an ingredient for the detail:
Garlic Bulb OilAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking garlic with antihypertensive drugs might increase the risk of hypotension.
Read the full Garlic Bulb Oil + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Garlic Oil — through 1 ingredient. Tap an ingredient for the detail:
Garlic Bulb OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Garlic may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Garlic Bulb Oil + Acenocoumarol interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Garlic Oil — through 1 ingredient. Tap an ingredient for the detail:
Garlic Bulb OilCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Garlic Bulb Oil + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Garlic Oil — through 1 ingredient. Tap an ingredient for the detail:
Garlic Bulb OilCytochrome P450 2e1 (cyp2e1) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Garlic Bulb Oil + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Garlic Oil — through 1 ingredient. Tap an ingredient for the detail:
Garlic Bulb OilAnticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Garlic may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Garlic Bulb Oil + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Garlic Oil — through 1 ingredient. Tap an ingredient for the detail:
Garlic Bulb OilCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Garlic Bulb Oil + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Garlic Oil — through 1 ingredient. Tap an ingredient for the detail:
Garlic Bulb OilCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Garlic Bulb Oil + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Garlic Oil — through 1 ingredient. Tap an ingredient for the detail:
Garlic Bulb OilCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Garlic Bulb Oil + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Garlic Oil — through 1 ingredient. Tap an ingredient for the detail:
Garlic Bulb OilCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Garlic Bulb Oil + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Garlic Oil — through 1 ingredient. Tap an ingredient for the detail:
Garlic Bulb OilCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Garlic Bulb Oil + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Garlic Oil — through 1 ingredient. Tap an ingredient for the detail:
Garlic Bulb OilCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Garlic Bulb Oil + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Garlic Oil — through 1 ingredient. Tap an ingredient for the detail:
Garlic Bulb OilCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Garlic Bulb Oil + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Garlic Oil — through 1 ingredient. Tap an ingredient for the detail:
Garlic Bulb OilCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Garlic Bulb Oil + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Garlic Oil — through 1 ingredient. Tap an ingredient for the detail:
Garlic Bulb OilCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Garlic Bulb Oil + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Garlic Oil — through 1 ingredient. Tap an ingredient for the detail:
Garlic Bulb OilCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Garlic Bulb Oil + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Garlic Oil — through 1 ingredient. Tap an ingredient for the detail:
Garlic Bulb OilCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Garlic Bulb Oil + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Garlic Oil — through 1 ingredient. Tap an ingredient for the detail:
Garlic Bulb OilCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Garlic Bulb Oil + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Garlic Oil — through 1 ingredient. Tap an ingredient for the detail:
Garlic Bulb OilCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Garlic Bulb Oil + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Garlic Oil — through 1 ingredient. Tap an ingredient for the detail:
Garlic Bulb OilCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Garlic Bulb Oil + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Garlic Oil — through 1 ingredient. Tap an ingredient for the detail:
Garlic Bulb OilCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Garlic Bulb Oil + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Garlic Oil — through 1 ingredient. Tap an ingredient for the detail:
Garlic Bulb OilCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Garlic Bulb Oil + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Garlic Oil — through 1 ingredient. Tap an ingredient for the detail:
Garlic Bulb OilCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Garlic Bulb Oil + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Garlic Oil with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Garlic bulb Oil
Anticoagulant/Antiplatelet Drugs
Garlic may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Raw garlic and a variety of garlic extracts have antiplatelet activity and can increase prothrombin time.
Antidiabetes Drugs
Theoretically, taking garlic with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research suggests that garlic and garlic extract lower blood glucose levels in healthy and diabetic individuals.
Antihypertensive Drugs
Theoretically, taking garlic with antihypertensive drugs might increase the risk of hypotension.
In human research, both garlic and garlic extracts have blood pressure-lowering effects.
Atazanavir (Reyataz)
Theoretically, garlic might decrease levels and effects of atazanavir.
In a case report, a patient consuming six stir-fried garlic cloves three times weekly developed suboptimal atazanavir levels and increases in HIV viral load. While the exact cause of this interaction is unclear, there is speculation that garlic might decrease the intestinal absorption of atazanavir or increase its metabolism by inducing cytochrome P450 3A4 (CYP3A4). Until more is known, advise patients not to consume large amounts of garlic while taking atazanavir.
Cytochrome P450 2E1 (Cyp2E1) Substrates
Garlic might increase levels of drugs metabolized by CYP2E1.
Clinical research suggests garlic oil can inhibit the activity of CYP2E1 by 39%. Use garlic oil cautiously in patients taking drugs metabolized by these enzymes.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4. This may increase or decrease levels of drugs metabolized by CYP3A4.
Some human research suggests that garlic may induce INTESTINAL CYP3A4, reducing levels of drugs metabolized by this enzyme. This is primarily based on a study showing that taking a specific allicin-containing garlic product (GarliPure Maximum Allicin Formula, Natrol Inc.) twice daily for 3 days reduces saquinavir levels by approximately 50%. It is speculated that the allicin constituent induced CYP3A4 in the gut mucosa. Another study shows that giving docetaxel intravenously, bypassing the CYP3A4 enzymes in the gut mucosa, along with the same specific garlic product for 12 consecutive days, does not affect docetaxel levels. Conversely, there is concern that garlic may inhibit HEPATIC CYP3A4. In a single case report, increased tacrolimus levels and liver injury occurred in a liver transplant patient after taking a specific garlic supplement (Garlicin Cardio, Nature's Way) at up to three times the manufacturer recommended dose for 7 days. Several other studies have evaluated the impact of other garlic formulations on CYP3A4 substrates and have found no effect. Most of the products in these studies provided little or no allicin.
Isoniazid
Theoretically, garlic might decrease levels of isoniazid.
Animal research suggests that an aqueous extract of garlic reduces isoniazid levels by about 65%. Garlic reduced the maximum concentration (Cmax) and area under the curve (AUC), but not the half-life, of isoniazid. This suggests that garlic extract might inhibit isoniazid absorption across the intestinal mucosa; however, the exact mechanism of this potential interaction is not known.
Protease Inhibitors (Pis)
Theoretically, garlic products containing allicin might decrease levels of PIs.
Protease inhibitors are metabolized by cytochrome P450 3A4 (CYP3A4) isoenzymes. There is concern that garlic products containing allicin might induce intestinal CYP3A4, reducing plasma levels of protease inhibitors. This is primarily based on a study showing that taking a specific garlic product (GarliPure Maximum Allicin Formula, Natrol Inc.) twice daily for 3 days reduces levels of saquinavir, a PI, by approximately 50%. It is speculated that the allicin constituent induce CYP3A4 in the gut mucosa. Several studies have evaluated the impact of other garlic formulations on CYP3A4 substrates and have found no effect. Most of the products in these studies provided little or no allicin.
Saquinavir (Fortovase, Invirase)
Theoretically, garlic containing allicin might decrease levels of saquinavir.
Saquinavir is a substrate of cytochrome P450 3A4 (CYP3A4) isoenzymes. There is concern that garlic products containing allicin might induce intestinal CYP3A4 and cause subtherapeutic levels of saquinavir. This is primarily based on a pharmacokinetic study showing that taking a specific garlic product (GarliPure Maximum Allicin Formula, Natrol Inc.) twice daily for 3 days reduces saquinavir levels by approximately 50%. It is speculated that the allicin constituent induces CYP3A4 in the gut mucosa. Several pharmacokinetic studies have evaluated the impact of other garlic formulations on CYP3A4 substrates and have found no effect. Most of the products in these studies provided little or no allicin. Until more is known about this potential interaction, use garlic containing allicin cautiously in patients taking saquinavir.
Sofosbuvir (Sovaldi)
Theoretically, taking garlic with sofosbuvir might decrease its effectiveness.
Animal research in rats shows that giving aged garlic extract 120 mg/kg orally daily for 14 days decreases the area under the concentration time curve (AUC) after a single sofosbuvir dose of 40 mg/kg by 36%, increases the clearance by 63%, and decreases the plasma concentrations at 1 and 8 hours by 35% and 58%, respectively. This interaction is hypothesized to be due to induction of intestinal P-glycoprotein expression by garlic.
Tacrolimus (Prograf)
Theoretically, garlic might increase levels of tacrolimus.
In one case report, a liver transplant patient taking tacrolimus experienced increased tacrolimus levels and liver injury after taking a specific garlic supplement (Garlicin Cardio, Nature's Way) at up to three times the manufacturer recommended dose for 7 days. It is speculated that garlic inhibited hepatic cytochrome P450 3A4 (CYP3A4), which increased plasma levels of tacrolimus.
Warfarin (Coumadin)
Theoretically, garlic might increase the risk of bleeding with warfarin.
Raw garlic and a variety of garlic extracts have antiplatelet activity and can increase prothrombin time. In addition, there is a report of two patients who experienced an increase in a previously stabilized international normalized ratio (INR) with concomitant garlic and warfarin use. However, this report has been subsequently debated due to limited clinical information. Other clinical studies have not identified an effect of garlic on INR, warfarin pharmacokinetics, or bleeding risk. More evidence is needed to determine the safety of using garlic with warfarin.
Brand information
Manufacturer and brand details for Garlic Oil, from the product label.
Nature's Sunshine
See all Nature's Sunshine products- Name
- Nature's Sunshine Products, Inc.
- City
- Spanish Fork
- State
- UT
- ZipCode
- 84660
- Phone Number
- 1-800-223-8225
- Web Address
- www.naturessunshine.com
Garlic Oil by Nature's Sunshine: Common Questions
Does Garlic Oil by Nature's Sunshine interact with any medications?
How can one product interact with so many drugs?
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Does garlic actually lower blood pressure or blood sugar?
What is soybean oil doing in a garlic product?
Can raw garlic cause an allergic reaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Garlic Oil’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Soybean Oil
Soybean oil is a common edible vegetable oil rich in polyunsaturated fats, including omega-6 and some omega-3 fatty acids. As part of a balanced diet it may help support healthy cholesterol...
Read the full Soybean Oil monograph → Herb & supplement monographGarlic
Interacts with 989 drugsGarlic is a common food and supplement that may modestly help with blood pressure and cholesterol, though the evidence is mixed and effects are usually small. It is generally safe in food am...
Read the full Garlic monograph →Sources & How We Checked
Garlic Oil's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 165 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Soybean Oil 11 references
- Eigenmann PA, Burks AW, Bannon GA, et al. Identification of unique peanut and soy allergens in sera adsorbed with cross-reacting antibodies. J Allergy Clin Immunol 1996;98:969-78. PubMed
- Bardare M, Magnolfi C, Zani G. Soy sensitivity: personal observation on 71 children with food intolerance. Allerg Immunol (Paris) 1988;20:63-6.
- Fradin MS, Day JF. Comparative efficacy of insect repellents against mosquito bites. N Engl J Med 2002;347:13-8. PubMed
- Public Health Agency of Canada. Canadian Recommendations for the Prevention and Treatment of Malaria Among International Travellers. Available at: http://www.phac-aspc.gc.ca/publicat/ccdr-rmtc/04vol30/30s1/page2_e.html (Accessed 24 May 2005).
- Duenas-Laita A, Pineda F, Armentia A. Hypersensitivity to generic drugs with soybean oil. N Engl J Med 2009;361(13):1317-8. PubMed
- Karupaiah T, Chuah KA, Chinna K, et al. Comparing effects of soybean oil- and palm olein-based mayonnaise consumption on the plasma lipid and lipoprotein profiles in human subjects: a double-blind randomized controlled trial with cross-over design. Lipids PubMed
- FDA completes review of qualified health claim petition for oleic acid and the risk of coronary heart disease. November 2018. Available at: www.fda.gov/Food/NewsEvents/ConstituentUpdates/ucm624758.htm. Accessed January 25, 2019.
- FDA. RE: Qualified Health Claim Petition - Soybean Oil and Reduced Risk of Coronary Heart Disease (Docket No. FDA-2016-Q-0995). July 2017. Available at: https://www.fda.gov/media/106649/download. Accessed on March 16, 2020.
- Stonehouse W, Sergi D, Benassi-Evans B, et al. Eucaloric diets enriched in palm olein, cocoa butter, and soybean oil did not differentially affect liver fat concentration in healthy participants: a 16-week randomized controlled trial. Am J Clin Nutr 2021; PubMed
- Wu MY, Du MH, Wen H, Wang WQ, Tang J, Shen LR. Effects of n-6 PUFA-rich soybean oil, MUFA-rich olive oil and camellia seed oil on weight and cardiometabolic profiles among Chinese women: a 3-month double-blind randomized controlled-feeding trial. Food Fun PubMed
- Peppone LJ, Inglis JE, Mustian KM, et al. Multicenter randomized controlled trial of omega-3 fatty acids versus omega-6 fatty acids for the control of cancer-related fatigue among breast cancer survivors. JNCI Cancer Spectr. 2019;3(2):pkz005. PubMed
Garlic 154 references
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- Garty BZ. Garlic burns. Pediatrics 1993;91:658-9.
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- Burnham BE. Garlic as a possible risk for postoperative bleeding. Plast Reconstr Surg 1995;95:213.
- Sunter WH. Warfarin and garlic. Pharm J 1991;246:722.
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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