Pure Albion Gentle Iron 25 mg Ingredients & Drug Interactions
by Emerald Labs
What is this page for?
First and foremost: checking Pure Albion Gentle Iron 25 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Pure Albion Gentle Iron 25 mg is a dietary supplement by Emerald Labs with 2 active ingredients. Its ingredients are commonly taken for iron-deficiency anemia, low iron stores during pregnancy, fatigue from iron deficiency.Based on those ingredients, 831 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Tocotriene Complex, Iron. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Pure Albion Gentle Iron 25 mg by Emerald Labs
Ask about any prescription or over-the-counter medication and we check it for interactions with Pure Albion Gentle Iron 25 mg by Emerald Labs — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Pure Albion Gentle Iron 25 mg by Emerald Labs
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains 2 active ingredients: iron (25 mg per capsule) and a tocotriene complex, which is a form of vitamin E. Iron is the main driver — it's a mineral your body needs to make red blood cells and prevent iron deficiency anemia.
The tocotriene complex is an antioxidant that supports cellular health. The capsule itself is a vegetable capsule, which is an inactive ingredient that holds everything together.
Does it work?
Strong evidence
Iron in this supplement is effective for treating iron deficiency anemia, anemia from chronic disease, and iron deficiency in pregnancy. It's also rated possibly effective for heart failure.
The tocotriene complex (vitamin E) is effective for vitamin E deficiency itself and for a rare inherited nerve disorder called AVED. For other conditions — Alzheimer's disease, thalassemia, G6PD deficiency, and brain bleeding — the evidence rates it as possibly effective.
If you're taking this for a specific condition, your doctor or pharmacist can tell you whether the evidence supports it for your situation.
How safe is it?
Well-documented data
Iron is generally well tolerated at recommended doses, but excess iron can be toxic — it should be used when there's a real medical need, not just as insurance. The most common side effects are gastrointestinal: abdominal pain, constipation, diarrhea, nausea, and vomiting.
Serious side effects like ulcers are rare. The vitamin E in this product is also generally well tolerated at typical doses, though high-dose supplements may increase bleeding risk over time.
During pregnancy, iron is often recommended, but your prenatal care provider should guide the dose. Both ingredients are considered acceptable while breastfeeding at appropriate doses, though you should confirm with your healthcare provider.
Meds to double-check
Moderate interaction found
Before taking this product, double-check if you're on levodopa for Parkinson's disease, any quinolone or tetracycline antibiotics, bisphosphonates for bone health, methyldopa for blood pressure, levothyroxine for thyroid disease, mycophenolate mofetil (an immunosuppressant), or penicillamine — iron reduces absorption of all of these. Also check for any blood thinners or antiplatelet drugs, chemotherapy (especially alkylating agents and antitumor antibiotics), cyclosporine, niacin, or selumetinib, because the vitamin E in this product may affect them.
Use the medication checker on this page to verify your exact prescriptions.
The bottom line
Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This product is straightforward if you have documented iron deficiency — it's an effective, well-tolerated way to correct it. But iron interacts with a lot of medications, so check your prescriptions here before you start.
If you take levodopa, antibiotics, thyroid medication, or blood thinners, you'll especially want to talk with your pharmacist about timing or whether this product is right for you.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Pure Albion Gentle Iron 25 mg, straight from the product label.
| Brand | Emerald Labs |
|---|---|
| Barcode (UPC) | 743650003532 |
| Net contents | 120 Vegetable Cap(s) |
| Market status | On market |
| Date entered into DSLD | Nov 22, 2024 |
| DSLD ID | 320037 |
| Product type | Single Vitamin And Mineral |
| Supplement form | Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Pure Albion Gentle Iron 25 mg by Emerald Labs, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Iron | 25 mg | 139% |
| Tocotriene Complex | 175 mg | -- |
Other ingredients: Vegetable Capsule
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Therapeutic amounts of 100% pure Albion Chelated "Gentle" Iron, considered to be the Gold-Standard in quality minerals, for maximum bioavailability.
General Statements
Emerald Labs is family owned and operated since our beginnings in 1996. We are committed to providing your family with additive-free formulas and superior nutrient forms in therapeutic amounts.
Value size! Doctor-formulated
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent disease.
Brand IP Statement(s)
Albion and TRAACS are registered trademarks of Albion Laboratories, Inc. U.S. Patent 7,838,042 is licensed by Albion Laboratories, Inc. Copyright 2021 Emerald Labs, Inc. Emerald Labs The Additive-Free Company
Formulation
Gold-standard bioavailability 100% chelated Non-constipating Clinical potency Easy-to-swallow capsule
Made with non-GMO ingredients No magnesium stearate Gluten-free
Vegan formula
This product is free of: Corn, milk, salt, soy, yeast, added sugar, wheat, artificial flavors and preservatives.
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Suggested use: Adults, take one (1) capsule daily with or without food or as directed by a health care practitioner.
Precautions
Keep out of reach of children.
Do not use if safety seal on cap or printed inner seal is missing or broken.
Consult a physician if pregnant, lactating, currently on prescription medication or diagnosed with a medical condition.
Iron warning: Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6. Keep out of reach of children. In case of accidental overdose, call a doctor or poison control center immediately.
Product is manufactured in a facility that processes milk, egg, soy, tree nuts, fish and shellfish.
Storage
Store in a cool, dry place.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Pure Albion Gentle Iron 25 mg by Emerald Labs label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Pure Albion Gentle Iron 25 mg by Emerald Labs
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container120 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Iron
Interacts with80 drugs
Iron is an essential mineral your body needs to make hemoglobin and carry oxygen in the blood. Supplements are mainly useful for treating or preventin...
Iron monograph & interactionsTocotriene Complex
Interacts with764 drugs
Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet. Supplements can help correc...
Tocotriene Complex monograph & interactionsOther (inactive) ingredients: Vegetable Capsule. These complete the product’s ingredient list but are not active constituents.
Pure Albion Gentle Iron 25 mg by Emerald Labs Drug Interactions
HelloPharmacist Interaction Report
Pure Albion Gentle Iron 25 mg contains two active ingredients — iron and a tocotriene complex (a form of vitamin E) — that together interact with a significant number of medications.
The most serious interaction involves iron and levodopa (used for Parkinson's disease): iron can reduce levodopa absorption by roughly half, which may lower its effectiveness at controlling your symptoms. You'd want to space these doses as far apart as possible.
Read the full breakdown — every affected drug type, severity by severity
Iron also interacts moderately with quinolone and tetracycline antibiotics, bisphosphonates (for bone health), methyldopa (a blood pressure medication), levothyroxine (thyroid hormone), mycophenolate mofetil (an immunosuppressant), and penicillamine (for Wilson's disease). In each case, iron binds to these drugs in your stomach and reduces how much gets absorbed.
Taking iron at least 2 hours away from these medications — or 4 hours for tetracyclines — helps, though your doctor may recommend different timing depending on your situation.
Vitamin E in this product interacts moderately with blood thinners and antiplatelet drugs (including warfarin), chemotherapy drugs, and cyclosporine, mainly through effects on bleeding risk and drug metabolism. It also has a minor interaction with niacin for cholesterol.
Altogether, these interactions span 820 individual medications. Before starting this product, use the medication checker on this page to verify your prescriptions against the full list.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Pure Albion Gentle Iron 25 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Pure Albion Gentle Iron 25 mg interact with 831 drugs. Click any drug to see the details.
2 of the 2 ingredients in Pure Albion Gentle Iron 25 mg interact with drugs. Each result below shows which ingredient is responsible. Tocotriene Complex Iron
Ado-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Pure Albion Gentle Iron 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Tocotriene ComplexCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.
Read the full Tocotriene Complex + Ado-trastuzumab Emtansine interactionAbciximabReoPro
How Abciximab interacts with Pure Albion Gentle Iron 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Tocotriene ComplexAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Concomitant use of vitamin E and anticoagulant or antiplatelet agents might increase the risk of bleeding.
Read the full Tocotriene Complex + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Pure Albion Gentle Iron 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Tocotriene ComplexCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.
Read the full Tocotriene Complex + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Pure Albion Gentle Iron 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Tocotriene ComplexCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.
Read the full Tocotriene Complex + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Pure Albion Gentle Iron 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Tocotriene ComplexCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.
Read the full Tocotriene Complex + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Pure Albion Gentle Iron 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Tocotriene ComplexAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Concomitant use of vitamin E and anticoagulant or antiplatelet agents might increase the risk of bleeding.
Read the full Tocotriene Complex + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Pure Albion Gentle Iron 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Tocotriene ComplexCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.
Read the full Tocotriene Complex + Acalabrutinib interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Pure Albion Gentle Iron 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Tocotriene ComplexAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Concomitant use of vitamin E and anticoagulant or antiplatelet agents might increase the risk of bleeding.
Read the full Tocotriene Complex + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Pure Albion Gentle Iron 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Tocotriene ComplexAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Concomitant use of vitamin E and anticoagulant or antiplatelet agents might increase the risk of bleeding.
Read the full Tocotriene Complex + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Pure Albion Gentle Iron 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Tocotriene ComplexAnticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Concomitant use of vitamin E and anticoagulant or antiplatelet agents might increase the risk of bleeding.
Read the full Tocotriene Complex + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Pure Albion Gentle Iron 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Tocotriene ComplexCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.
Read the full Tocotriene Complex + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Pure Albion Gentle Iron 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Tocotriene ComplexCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.
Read the full Tocotriene Complex + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Pure Albion Gentle Iron 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Tocotriene ComplexCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.
Read the full Tocotriene Complex + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Pure Albion Gentle Iron 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Tocotriene ComplexCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.
Read the full Tocotriene Complex + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Pure Albion Gentle Iron 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Tocotriene ComplexCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.
Read the full Tocotriene Complex + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Pure Albion Gentle Iron 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Tocotriene ComplexCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.
Read the full Tocotriene Complex + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Pure Albion Gentle Iron 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Tocotriene ComplexCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.
Read the full Tocotriene Complex + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Pure Albion Gentle Iron 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Tocotriene ComplexCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.
Read the full Tocotriene Complex + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Pure Albion Gentle Iron 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Tocotriene ComplexCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.
Read the full Tocotriene Complex + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Pure Albion Gentle Iron 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Tocotriene ComplexCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.
Read the full Tocotriene Complex + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Pure Albion Gentle Iron 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Tocotriene ComplexCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.
Read the full Tocotriene Complex + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Pure Albion Gentle Iron 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Tocotriene ComplexCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.
Read the full Tocotriene Complex + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Pure Albion Gentle Iron 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Tocotriene ComplexCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.
Read the full Tocotriene Complex + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Pure Albion Gentle Iron 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Tocotriene ComplexCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.
Read the full Tocotriene Complex + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Pure Albion Gentle Iron 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Tocotriene ComplexCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.
Read the full Tocotriene Complex + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with Pure Albion Gentle Iron 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Tocotriene ComplexCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.
Read the full Tocotriene Complex + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with Pure Albion Gentle Iron 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Tocotriene ComplexCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.
Read the full Tocotriene Complex + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine interacts with Pure Albion Gentle Iron 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Tocotriene ComplexCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.
Read the full Tocotriene Complex + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with Pure Albion Gentle Iron 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Tocotriene ComplexCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.
Read the full Tocotriene Complex + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interacts with Pure Albion Gentle Iron 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Tocotriene ComplexCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.
Read the full Tocotriene Complex + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Pure Albion Gentle Iron 25 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Tocotriene Complex
Alkylating Agents
Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of alkylating agents.
There's concern that antioxidants could reduce the activity of chemotherapy drugs which generate free radicals, such as cyclophosphamide, chlorambucil, carmustine, busulfan, and thiotepa. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin E have on chemotherapy. Advise patients to consult their oncologist before using vitamin E supplements, especially in high doses.
Anticoagulant/Antiplatelet Drugs
Concomitant use of vitamin E and anticoagulant or antiplatelet agents might increase the risk of bleeding.
Vitamin E seems to inhibit of platelet aggregation and antagonize the effects of vitamin K-dependent clotting factors. These effects appear to be dose-dependent, and are probably only likely to be clinically significant with doses of at least 800 units daily. Mixed tocopherols, such as those found in food, might have a greater antiplatelet effect than alpha-tocopherol. RRR alpha-tocopherol (natural vitamin E) 1000 IU daily antagonizes vitamin K-dependent clotting factors. Advise patients to avoid high doses of vitamin E, especially in people with low vitamin K intake or other risk factors for bleeding.
Antitumor Antibiotics
Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of antitumor antibiotics.
There's concern that antioxidants could reduce the activity of antitumor antibiotic drugs such as doxorubicin, which generate free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin E have on chemotherapy involving antitumor antibiotics. Advise patients to consult their oncologist before using vitamin E supplements, especially in high doses.
Cyclosporine (Neoral, Sandimmune)
A specific form of vitamin E might increase absorption and levels of cyclosporine.
There is some evidence that one specific formulation of vitamin E (D-alpha-tocopheryl-polyethylene glycol-1000 succinate, TPGS, tocophersolan, Liqui-E) might increase absorption of cyclosporine. This vitamin E formulation forms micelles which seems to increase absorption of cyclosporine by 40% to 72% in some patients. However, this interaction is unlikely to occur with the usual forms of vitamin E.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.
Vitamin E appears to bind with the nuclear receptor, pregnane X receptor (PXR), which results in increased expression of CYP3A4. Although the clinical significance of this is not known, use caution when considering concomitant use of vitamin E and other drugs affected by these enzymes.
Selumetinib (Koselugo)
Taking selumetinib with vitamin E can result in a total daily dose of vitamin E that exceeds safe limits and therefore might increase the risk of bleeding.
Selumetinib contains 48-54 IU vitamin E per capsule. The increased risk of bleeding with vitamin E appears to be dose-dependent. Be cautious when using selumetinib in combination with supplemental vitamin E, especially in patients at higher risk of bleed, such as those with chronic conditions and those taking antiplatelet drugs.
Warfarin (Coumadin)
Using vitamin E with warfarin might increase the risk of bleeding.
Due to interference with production of vitamin K-dependent clotting factors, use of more than 400 IU of vitamin E daily with warfarin might increase prothrombin time (PT), INR, and the risk of bleeding,. At a dose of 1000 IU per day, vitamin E can antagonize vitamin K-dependent clotting factors even in people not taking warfarin. Limited clinical evidence suggests that doses up to 1200 IU daily may be used safely by patients taking warfarin, but this may not be applicable in all patient populations.
Niacin
Vitamin E might decrease the beneficial effects of niacin on high-density lipoprotein (HDL) cholesterol levels.
A combination of niacin and simvastatin (Zocor) effectively raises high-density lipoprotein (HDL) cholesterol levels in people with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50%. Vitamin E alone combined with a statin does not seem to decrease HDL levels. It is not known whether the adverse effect on HDL is due to one of the other antioxidants or to the combination. It also is not known whether it will occur in other patient populations.
Iron
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)
Iron might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and iron can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, iron containing products.
Bisphosphonates
Iron reduces the absorption of bisphosphonates.
Advise patients that doses of bisphosphonates should be separated by at least two hours from doses of all other medications, including supplements such as iron. Divalent cations, including iron, can decrease absorption of bisphosphonates by forming insoluble complexes in the gastrointestinal tract.
Denosumab (Prolia, Others)
Administration of intravenous iron within one month of denosumab administration might increase the risk of severe hypophosphatemia and hypocalcemia.
A case of severe hypocalcemia (albumin corrected calcium 6.88 mg/dL, ionized calcium 3.68 mg/dL) and hypophosphatemia (<0.5 mg/dL) with respiratory acidosis, QT interval prolongation, and nonsustained ventricular tachycardia was reported in a 76-year-old male who had received an iron polymaltose infusion within 2 weeks of a subcutaneous injection of denosumab. Serum parathyroid hormone was also elevated (348 pg/mL). Subsequent iron infusions with iron polymaltose and ferric carboxymaltose were followed by transient hypophosphatemia, but without hypocalcemia. Additionally, a literature review describes 6 additional cases of hypophosphatemia and hypocalcemia in patients 52-92 years of age who had been administered intravenous iron as either ferric carboxymaltose or iron polymaltose and subcutaneous denosumab within 1-4 weeks of each other.
Dolutegravir (Tivicay)
Iron might decrease dolutegravir levels by reducing its absorption.
Advise patients to take dolutegravir at least 2 hours before or 6 hours after taking iron. Pharmacokinetic research shows that iron can decrease the absorption of dolutegravir from the gastrointestinal tract through chelation. When taken under fasting conditions, a single dose of ferrous fumarate 324 mg orally along with dolutegravir 50 mg reduces overall exposure to dolutegravir by 54%.
Integrase Inhibitors
Theoretically, taking iron along with integrase inhibitors might decrease the levels and clinical effects of these drugs.
Iron is a divalent cation. There is concern that iron may decrease the absorption of integrase inhibitors from the gastrointestinal tract through chelation. One pharmacokinetic study shows that iron can decrease blood levels of the specific integrase inhibitor dolutegravir through chelation. Also, other pharmacokinetic research shows that other divalent cations such as calcium can decrease the absorption and levels of some integrase inhibitors through chelation.
Levodopa
Iron might decrease levodopa levels by reducing its absorption.
Advise patients to separate doses of levodopa and iron as much as possible. There is some evidence in healthy people that iron forms chelates with levodopa, reducing the amount of levodopa absorbed by around 50%. The clinical significance of this hasn't been determined.
Levothyroxine (Synthroid, Others)
Iron might decrease levothyroxine levels by reducing its absorption.
Advise patients to separate levothyroxine and iron doses by at least 2 hours. Iron can decrease the absorption and efficacy of levothyroxine by forming insoluble complexes in the gastrointestinal tract.
Methyldopa (Aldomet)
Iron might decrease methyldopa levels by reducing its absorption.
Advise patients to separate methyldopa and iron doses by at least 2 hours. Iron can decrease the absorption of methyldopa from the gastrointestinal tract through chelation, resulting in increases in blood pressure.
Mycophenolate Mofetil (Cellcept)
Theoretically, iron might decrease mycophenolate mofetil levels by reducing its absorption.
Advise patients to take iron 4-6 hours before, or 2 hours after, mycophenolate mofetil. It has been suggested that a decrease of absorption is possible, probably by forming nonabsorbable chelates. However, mycophenolate pharmacokinetics are not affected by iron supplementation in available clinical research.
Penicillamine (Cuprimine, Depen)
Iron might decrease penicillamine levels by reducing its absorption.
Advise patients to separate penicillamine and iron doses by at least 2 hours. Oral iron supplements can reduce absorption of penicillamine by 30% to 70%, probably due to chelate formation. In people with Wilson's disease, this interaction has led to reduced efficacy of penicillamine.
Quinolone Antibiotics
Iron might decrease levels of quinolone antibiotics by reducing their absorption.
Advise patients to separate quinolone antibiotics and iron doses by at least 2 hours. Iron decreases the absorption of quinolones due to formation of insoluble complexes in the gastrointestinal tract.
Tetracycline Antibiotics
Iron might decrease levels of tetracycline antibiotics by reducing their absorption.
Advise patients to take iron at least 2 hours before or 4 hours after tetracycline antibiotics. Concomitant use can decrease absorption of tetracycline antibiotics from the gastrointestinal tract by 50% to 90%.
Chloramphenicol
Theoretically, taking chloramphenicol with iron might reduce the response to iron therapy in iron deficiency anemia.
Chloramphenicol interferes with erythrocyte maturation. However, since chloramphenicol isn't usually taken for prolonged periods, this isn't likely to be clinically significant.
Brand information
Manufacturer and brand details for Pure Albion Gentle Iron 25 mg, from the product label.
Emerald Labs
See all Emerald Labs products- Name
- Emerald Labs
- Street Address
- 20600 Belshaw Ave.
- City
- Carson
- State
- CA
- ZipCode
- 90746
- Phone Number
- 800-436-4366
- Web Address
- www.emeraldlabs.com
Pure Albion Gentle Iron 25 mg by Emerald Labs: Common Questions
Does Pure Albion Gentle Iron 25 mg by Emerald Labs interact with any medications?
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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The Full Monographs Behind Pure Albion Gentle Iron 25 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Iron
Interacts with 80 drugsIron is an essential mineral your body needs to make hemoglobin and carry oxygen in the blood. Supplements are mainly useful for treating or preventing iron deficiency and iron-deficiency an...
Read the full Iron monograph → Herb & supplement monographVitamin E
Interacts with 764 drugsVitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet. Supplements can help correct a true deficiency, but high-dose vitam...
Read the full Vitamin E monograph →Sources & How We Checked
Pure Albion Gentle Iron 25 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 136 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Iron 72 references
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Vitamin E 64 references
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