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Dietary supplement

Glycine 500 mg Ingredients & Drug Interactions

by Solgar

Glycine 500 mg label
See full label image
Capsule Category: Amino Acid/protein
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Glycine 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Glycine 500 mg is a dietary supplement by Solgar with 1 active ingredient. Its ingredients are commonly taken for sleep quality and insomnia, relaxation, cognitive function.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Glycine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Glycine 500 mg by Solgar

Ask about any prescription or over-the-counter medication and we check it for interactions with Glycine 500 mg by Solgar — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Glycine 500 mg by Solgar

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This supplement contains one active ingredient: glycine, a simple amino acid your body naturally makes and uses in many cellular functions. The capsule also contains vegetable cellulose, microcrystalline cellulose, vegetable magnesium stearate, and stearic acid as inactive binders and capsule material.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Glycine's overall clinical evidence instead.

Moderate

Some clinical evidence supports Glycine for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Schizophrenia — rated "Possibly Effective" (Natural Medicines).

The evidence shows glycine is possibly effective for schizophrenia. However, the data we hold don't support reliable rating for its use in 3-phosphoglycerate dehydrogenase (3-PGDH) deficiency, attention deficit-hyperactivity disorder (ADHD), benign prostatic hyperplasia (enlarged prostate), or cystic fibrosis—there isn't enough evidence to say whether it works for those.

The evidence, ingredient by ingredient Glycine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Glycine is generally well tolerated at typical doses, though long-term safety data are limited. Rarely, mild sedation, irritability, insomnia, fatigue, memory impairment, headache, sensory impairment, soft stools, nausea, vomiting, upper gastrointestinal discomfort, and dry mouth have been reported, though it's unclear whether glycine is the cause; symptoms resolve quickly if you stop taking it.

Not enough reliable safety data exist for pregnancy or while breastfeeding, so if either applies to you, talk with your doctor or pharmacist before taking this supplement.

Side effects, ingredient by ingredient Glycine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Glycine.
  • The most serious interaction on file is rated Moderate.
  • For scale: 1 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take clozapine (Clozaril) for schizophrenia, you'll want to check with your doctor or pharmacist before adding glycine—this supplement may worsen your symptoms on that medication. No other medication interactions are documented for the ingredients we have data on.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Glycine may help with schizophrenia, but it can make clozapine less effective or worsen symptoms, so that's the main caution. If you take clozapine or any other prescription medications, check them against this product with your doctor or pharmacist before you start.

For most other uses listed here, the evidence isn't strong enough yet to say whether it works.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 21, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Glycine 500 mg, straight from the product label.

Brand Solgar
Barcode (UPC) 033984013704
Net contents 100 Vegetable Capsule(s)
Market status On market
Date entered into DSLD Oct 21, 2017
DSLD ID 79631
Product type Amino Acid/protein
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Glycine 500 mg by Solgar, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetable Capsule(s)
Maximum serving Sizes:
1 Vegetable Capsule(s)
UPC/BARCODE
033984013704
IngredientAmount% DV
Glycine500 mg--

Other ingredients: Vegetable Cellulose, Microcrystalline Cellulose, Vegetable Magnesium Stearate, Stearic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Glycine is a non-essential amino acid that is synthesized by the body and is used to form protein. It is a naturally sweet-tasting amino acid.

Since 1947 Free form

Formula

This formulation provides Free Form Glycine to promote optimal absorption and assimilation.

Solgar’s KOF-K certification #K-1250

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

2016 Solgar, Inc.

General

SOLGB71370 02C

Formulation

Non-GMO Gluten, wheat & dairy free

Suitable for vegans

Free Of: Gluten, wheat, dairy, soy, yeast, sugar, sodium, artificial flavor, sweetener, preservatives and color.

Seals/Symbols

GF Certified Gluten-free

K Parve

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement for adults, take one (1) vegetable capsule two times daily, between meals or as directed by a healthcare practitioner.

Precautions

If you are pregnant, nursing, taking any medications or have any medical condition, please consult your healthcare practitioner before taking any dietary supplement.

Discontinue use and consult your healthcare practitioner if any adverse reactions occur.

Keep out of reach of children.

Do not use if outer bottle seal is missing or damaged.

Storage

Store at room temperature.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Glycine 500 mg by Solgar label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Glycine 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Glycine 500 mg by Solgar

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Vegetable Capsule(s) Dosage formCapsule Amounts shown are per serving.

Glycine

Interacts with
1 drug
500 mg per serving

Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep q...

Glycine monograph & interactions

Other (inactive) ingredients: Vegetable Cellulose, Microcrystalline Cellulose, Vegetable Magnesium Stearate, Stearic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Glycine 500 mg by Solgar Drug Interactions

Want to check YOUR meds against Glycine 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1Drugs
1 Moderate

Ingredients driving the most interactions

Glycine 1

Individual Drug Interactions

The ingredients in Glycine 500 mg interact with 1 drug. Click any drug to see the details.

1 of the 1 ingredient in Glycine 500 mg interact with drugs. Each result below shows which ingredient is responsible. Glycine

Each ingredient & the kinds of drugs it affects

For each ingredient in Glycine 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Glycine1 drug type · 1 drug

Clozapine (Clozaril)

Theoretically, glycine might decrease the effectiveness of clozapine.
One small clinical study in patients with schizophrenia shows that adding glycine to clozapine therapy worsens symptoms of schizophrenia when compared with clozapine alone. The mechanism of this interaction is unclear.

Likelihood Probable Evidence B
Glycine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Glycine 500 mg, from the product label.

Solgar

See all Solgar products
Name
Solgar, Inc.
Street Address
500 Willow Tree Road
City
Leonia
State
NJ
ZipCode
07605
Phone Number
1-877-765-4274
Web Address
www.solgar.com
Pharmacist Counseling Corner

Glycine 500 mg by Solgar: Common Questions

Does Glycine 500 mg by Solgar interact with any medications?
Yes. Based on its ingredients, Glycine 500 mg has a known interaction with 1 medication. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Glycine 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
There isn't enough reliable safety data to know whether glycine is safe in pregnancy or while breastfeeding. Talk with your doctor or pharmacist before taking it if either applies to you—they can help you weigh the risks and benefits in your situation.
What side effects might I notice?
Side effects are rare, but mild sedation, irritability, insomnia, nausea, soft stools, and dry mouth have been reported. It's unclear whether glycine caused them, and they resolve quickly if you stop taking it. If anything bothers you, stop and let your pharmacist know.
Does glycine actually work for schizophrenia?
The evidence suggests it's possibly effective for schizophrenia, but there's a catch: adding it to clozapine may actually worsen symptoms. Talk with your prescriber before using this alongside any antipsychotic medication.
What is glycine and why is it in supplements?
Glycine is an amino acid your body makes naturally and uses in many processes. People take supplements for various conditions, though evidence is strong only for schizophrenia and limited for other uses.
Is this safe to take long-term?
Glycine is generally well tolerated at typical doses, but long-term safety data are limited—we don't have enough information about what happens with years of use. If you're thinking of taking it long-term, check in with your pharmacist or doctor first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Glycine 500 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Glycine 500 mg label
Go deeper

The Full Monographs Behind Glycine 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glycine

Interacts with 1 drug

Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep quality, where early research is promisin...

Read the full Glycine monograph →
Sources

Sources & How We Checked

Glycine 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glycine 5 references
  1. Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry 1999;56:29-36.. PubMed
  2. Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry 1999;156:145-7.. PubMed
  3. Gusev EI, Skvortsova VI, Dambinova SA, et al. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovasc Dis 2000;10:49-60. PubMed
  4. Inagawa K, Kawai N, Ono K, Sukegawa E, Tsubuku S, Takahashi M. Assessment of acute adverse effects of glycine ingestion at a high dose in human volunteers. Seikatsu Eisei. 2006; 50:27-32.
  5. Woods SW, Walsh BC, Hawkins KA, Miller TJ, Saksa JR, D'Souza DC, Pearlson GD, Javitt DC, McGlashan TH, Krystal JH. Glycine treatment of the risk syndrome for psychosis: report of two pilot studies. Eur Neuropsychopharmacol. 2013 Aug;23(8):931-40. PubMed

See these in context on the Glycine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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