Glycine Ingredients & Drug Interactions
by SuperSmart
What is this page for?
First and foremost: checking Glycine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Glycine is a dietary supplement by SuperSmart with 1 active ingredient. Its ingredients are commonly taken for sleep quality and insomnia, relaxation, cognitive function.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Glycine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Glycine by SuperSmart
Ask about any prescription or over-the-counter medication and we check it for interactions with Glycine by SuperSmart — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Glycine by SuperSmart
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: L-glycine, a simple amino acid. There are no inactive ingredients or fillers in this powder.
Does it work?
Moderate evidence
Glycine is possibly effective for schizophrenia according to the evidence we hold. However, the interaction data above suggests adding it to clozapine may worsen symptoms rather than help — so effectiveness in that specific scenario is questionable.
For other conditions like ADHD, benign prostatic hyperplasia (enlarged prostate), cystic fibrosis, or 3-phosphoglycerate dehydrogenase deficiency, there isn't enough reliable evidence to say whether it works.
How safe is it?
Well-documented data
Glycine is generally well tolerated at typical doses, though long-term safety data are limited. Rarely, people report mild sedation, irritability, insomnia, fatigue, memory problems, headache, soft stools, nausea, vomiting, and upper digestive discomfort — these resolve quickly if you stop taking it.
There isn't enough safety data during pregnancy or while breastfeeding, so caution is advised and you should talk with your doctor before use in either situation.
Meds to double-check
Moderate interaction found
Check with your pharmacist before using this product if you take clozapine (Clozaril) for schizophrenia — a clinical study suggests it may reduce the drug's effectiveness and worsen symptoms.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
Glycine may help some people with schizophrenia, but the evidence is still building. If you take clozapine, it's a conversation starter with your psychiatrist, not something to add on your own.
For other uses, the science isn't there yet. Talk to your pharmacist before starting, especially if you're pregnant, breastfeeding, or on any medications.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 21, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Glycine, straight from the product label.
| Brand | SuperSmart |
|---|---|
| Barcode (UPC) | 5453003828051 |
| Net contents | 180 Gram(s) |
| Market status | On market |
| Date entered into DSLD | May 21, 2025 |
| DSLD ID | 332368 |
| Product type | Amino Acid/protein |
| Supplement form | Powder |
| Dietary claims / uses | Nutrient, All Other |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Glycine by SuperSmart, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| L-Glycine | 2.5 Gram(s) | -- |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Recommended use: Adults. Take half serving a day.
Formula
Each half serving contains 2.5 grams of L-glycine.
Precautions
Precautions: Do not exceed the recommended daily dose. This product is a nutritional supplement and should not replace a varied, balanced diet.
Keep out of childrens' reach.
As with any nutritional supplement, you should consult a health professional before taking this product if you are pregnant, breastfeeding or have a health problem.
Storage
Store away from direct light, heat and humidity.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Glycine by SuperSmart label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Glycine by SuperSmart
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size0.5 Serving(s) Dosage formPowder Servings per container72 Amounts shown are per serving.
L-Glycine
Interacts with1 drug
Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep q...
L-Glycine monograph & interactionsGlycine by SuperSmart Drug Interactions
HelloPharmacist Interaction Report
SuperSmart Glycine is a single-ingredient powder that does interact with one medication we've documented.
The concern is clozapine (Clozaril), an antipsychotic used for schizophrenia. A small clinical study showed that adding glycine to clozapine therapy actually worsened schizophrenia symptoms compared to clozapine alone — the interaction is rated Moderate severity, though the exact mechanism isn't fully understood.
Read the full breakdown — every affected drug type, severity by severity
If you take clozapine, do not start glycine without talking to your psychiatrist or pharmacist first. You'll want to check your exact medications with the search tool on this page to make sure nothing else applies to you.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Glycine?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Glycine interact with 1 drug. Click any drug to see the details.
1 of the 1 ingredient in Glycine interact with drugs. Each result below shows which ingredient is responsible. L-Glycine
ClozapineClozaril, Versacloz
How Clozapine interacts with Glycine — through 1 ingredient. Tap an ingredient for the detail:
L-glycineClozapine (clozaril) Moderate
Interaction Summary
Theoretically, glycine might decrease the effectiveness of clozapine.
Read the full L-glycine + Clozapine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Glycine with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
L-Glycine
Clozapine (Clozaril)
Theoretically, glycine might decrease the effectiveness of clozapine.
One small clinical study in patients with schizophrenia shows that adding glycine to clozapine therapy worsens symptoms of schizophrenia when compared with clozapine alone. The mechanism of this interaction is unclear.
Brand information
Manufacturer and brand details for Glycine, from the product label.
SuperSmart
See all SuperSmart products- Name
- SN Worldwide Unipessoal, LDA
- Street Address
- Avenida Do Infante 66 Edificio Quinta Avenida 1 C
- City
- Funchal
- ZipCode
- 9000-015
Glycine by SuperSmart: Common Questions
Does Glycine by SuperSmart interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm pregnant?
Is it safe to use while breastfeeding?
What's glycine actually for?
What side effects should I watch for?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Glycine is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Glycine’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Glycine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 5 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Glycine 5 references
- Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry 1999;56:29-36.. PubMed
- Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry 1999;156:145-7.. PubMed
- Gusev EI, Skvortsova VI, Dambinova SA, et al. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovasc Dis 2000;10:49-60. PubMed
- Inagawa K, Kawai N, Ono K, Sukegawa E, Tsubuku S, Takahashi M. Assessment of acute adverse effects of glycine ingestion at a high dose in human volunteers. Seikatsu Eisei. 2006; 50:27-32.
- Woods SW, Walsh BC, Hawkins KA, Miller TJ, Saksa JR, D'Souza DC, Pearlson GD, Javitt DC, McGlashan TH, Krystal JH. Glycine treatment of the risk syndrome for psychosis: report of two pilot studies. Eur Neuropsychopharmacol. 2013 Aug;23(8):931-40. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC