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Dietary supplement

GPC GlyceroPhosphoCholine Ingredients & Drug Interactions

by Designs for Health

GPC GlyceroPhosphoCholine label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking GPC GlyceroPhosphoCholine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

GPC GlyceroPhosphoCholine is a dietary supplement by Designs for Health with 1 active ingredient. Its ingredients are commonly taken for memory and learning support, age-related cognitive decline, alzheimer's disease and dementia (under study).Based on those ingredients, 16 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Glycerophosphocholine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against GPC GlyceroPhosphoCholine by Designs for Health

Ask about any prescription or over-the-counter medication and we check it for interactions with GPC GlyceroPhosphoCholine by Designs for Health — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of GPC GlyceroPhosphoCholine by Designs for Health

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: glycerophosphocholine (also called alpha-GPC). The capsule also contains microcrystalline cellulose, dicalcium phosphate, silicon dioxide, and magnesium stearate as inactive ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: supports brain function.
  • We looked for evidence on: Cognitive function, Alzheimer disease, Vascular dementia, memory, learning, age-related cognitive decline.
  • The strongest evidence on file: Alpha-gpc is rated "Possibly Effective" for Alzheimer disease (Natural Medicines).
  • Also on file: Alpha-gpc is rated "Insufficient Reliable Evidence To Rate" for Cognitive function, Vascular dementia.

The evidence for alpha-GPC is mixed and depends on the condition. It's rated possibly effective for Alzheimer disease.

For brain tumor, cognitive function, vascular dementia, and stroke, there isn't enough reliable evidence in our data to rate how well it works.

The evidence, ingredient by ingredient Alpha-gpc

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Alpha-GPC is generally well tolerated in studies, though long-term safety hasn't been fully established. Rarely, it's been associated with dizziness, headache, insomnia, excitation, nausea, heartburn, diarrhea, and vomiting.

There's a rare but important concern: oral use for at least 2 months has been associated with an elevated stroke risk compared with non-users or those who used it for less than 2 months. Very rarely, stroke itself has been reported.

There isn't enough safety information to use this supplement in pregnancy or while breastfeeding unless your doctor directs it.

Side effects, ingredient by ingredient Alpha-gpc

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Alpha-gpc.
  • The most serious interaction on file is rated Minor.
  • For scale: 16 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you use a scopolamine patch (Transderm Scop) for motion sickness, check with your pharmacist or doctor before starting—alpha-GPC may reduce its effectiveness. No other medication interactions are documented in our data for the ingredients we hold.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

Alpha-GPC may help with Alzheimer disease, but the evidence for other uses is unclear. If you use a scopolamine patch, check with your doctor or pharmacist before taking this.

The long-term safety profile isn't fully known, and there's a rare stroke signal with extended use—discuss this product with your healthcare provider to see if it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about GPC GlyceroPhosphoCholine, straight from the product label.

Brand Designs for Health
Barcode (UPC) 879452000797
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jul 25, 2013
DSLD ID 23518
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for GPC GlyceroPhosphoCholine by Designs for Health, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
879452000797
IngredientAmount% DV
Glycerophosphocholine300 mg--

Other ingredients: Microcrystalline Cellulose, Dicalcium Phosphate, Silicon Dioxide, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

STORE IN A COOL, DRY PLACE.

Precautions

KEEP OUT OF REACH OF CHILDREN.

General Statements

NOTICE: Color, size or shape may appear different between lots.

This product is manufactured in a NSF GMP registered facility

SUPPORTS BRAIN FUNCTION

Seals/Symbols

GMP 800.847.8302 For details on DFH GMPs

GPC(TM) Mental Performance

General

GPC060

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Recommended Use: As a dietary supplement, take one or more capsules daily or as directed by your health care practitioner.

Formulation

This product does not contain wheat, yeast, eggs, dairy products, corn, or animal products, and is suitable for vegetarians. It is free of artificial colors, flavors and preservatives.

This product does not contain wheat, yeast, eggs, dairy products, corn, or animal products, and is suitable for vegetarians.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

GPC GlyceroPhosphoCholine by Designs for Health label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

GPC GlyceroPhosphoCholine label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in GPC GlyceroPhosphoCholine by Designs for Health

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Glycerophosphocholine

Interacts with
16 drugs
300 mg per serving

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition...

Glycerophosphocholine monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Dicalcium Phosphate, Silicon Dioxide, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

GPC GlyceroPhosphoCholine by Designs for Health Drug Interactions

Want to check YOUR meds against GPC GlyceroPhosphoCholine?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
16Drugs
16 Minor

Ingredients driving the most interactions

Glycerophosphocholine 16

Individual Drug Interactions

The ingredients in GPC GlyceroPhosphoCholine interact with 16 drugs. Click any drug to see the details.

1 of the 1 ingredient in GPC GlyceroPhosphoCholine interact with drugs. Each result below shows which ingredient is responsible. Glycerophosphocholine

Each ingredient & the kinds of drugs it affects

For each ingredient in GPC GlyceroPhosphoCholine with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Glycerophosphocholine1 drug type · 16 drugs

Scopolamine (Transderm Scop)

Theoretically, alpha-GPC might decrease the effects of scopolamine.
A small clinical study shows that alpha-GPC can partially counteract the attention and memory impairment effects caused by scopolamine given intramuscularly. Whether alpha-GPC can decrease the beneficial anti-motion sickness effects of the scopolamine patch (Transderm Scop) is unclear.

Likelihood Possible Evidence B
Glycerophosphocholine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for GPC GlyceroPhosphoCholine, from the product label.

Designs for Health

See all Designs for Health products
Phone Number
800.847.8302
Pharmacist Counseling Corner

GPC GlyceroPhosphoCholine by Designs for Health: Common Questions

Does GPC GlyceroPhosphoCholine by Designs for Health interact with any medications?
Yes. Based on its ingredients, GPC GlyceroPhosphoCholine has a known interaction with 16 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
GPC GlyceroPhosphoCholine contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
There isn't enough safety information to know whether alpha-GPC is safe in pregnancy or while breastfeeding. Talk with your doctor or pharmacist about your specific situation before taking it.
What are the most common side effects?
Alpha-GPC is generally well tolerated. Rarely, people have reported dizziness, headache, insomnia, nausea, heartburn, and diarrhea.
Does it actually work for memory and cognitive function?
There's evidence it may help with Alzheimer disease. For general cognitive function, brain tumor, vascular dementia, and stroke, we don't have enough reliable evidence to say how well it works.
Is there a long-term safety concern I should know about?
Yes. Use of alpha-GPC orally for at least 2 months has been associated with a higher stroke risk compared with people who didn't use it or used it for shorter periods. Long-term safety overall hasn't been fully established, so discuss this with your doctor.
How many active ingredients are in this product?
One: glycerophosphocholine (alpha-GPC). The rest are inactive ingredients used to make the capsule.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if GPC GlyceroPhosphoCholine is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

GPC GlyceroPhosphoCholine label
Go deeper

The Full Monographs Behind GPC GlyceroPhosphoCholine’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Alpha-gpc

Interacts with 16 drugs

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition in people with dementia, but evidence i...

Read the full Alpha-gpc monograph →
Sources

Sources & How We Checked

GPC GlyceroPhosphoCholine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Alpha-gpc 4 references
  1. Di Perri R, Coppola G, Ambrosio LA, et al. A multicentre trial to the evaluate the efficacy and tolerability of alpha-glycerylphosphorylcholine versus cytosine diphosphocholine in patients with vascular dementia. J Int Med Res 1991;19:330-41.
  2. Barbagallo Sangiorgi G, Barbagallo M, Giordano M, et al. Alpha-glycerophosphocholine in the mental recovery of cerebral ischemic attacks: An Italian multicenter clinical trial. Ann N Y Acad Sci 1994;717:253-69. PubMed
  3. Canal N, Franceschi M, Alberoni M, et al. Effect of L-alpha-glyceryl-phosphorylcholine on amnesia caused by scopolamine. Int J Clin Pharmacol Ther Toxicol 1991;29:103-7.
  4. Lee G, Choi S, Chang J, et al. Association of L-a glycerylphosphorylcholine with subsequent stroke risk after 10 Years. JAMA Netw Open 2021;4(11):e2136008.

See these in context on the Alpha-gpc monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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