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Dietary supplement

GPC Liquid Glycerophosphocholine Ingredients & Drug Interactions

by Designs for Health

GPC Liquid Glycerophosphocholine label
See full label image
Liquid Category: Non-nutrient/non-botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking GPC Liquid Glycerophosphocholine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

GPC Liquid Glycerophosphocholine is a dietary supplement by Designs for Health with 1 active ingredient. Its ingredients are commonly taken for memory and learning support, age-related cognitive decline, alzheimer's disease and dementia (under study).Based on those ingredients, 16 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Glycerophosphocholine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against GPC Liquid Glycerophosphocholine by Designs for Health

Ask about any prescription or over-the-counter medication and we check it for interactions with GPC Liquid Glycerophosphocholine by Designs for Health — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of GPC Liquid Glycerophosphocholine by Designs for Health

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: glycerophosphocholine, also known as alpha-GPC. It's a naturally occurring compound in the body involved in cell membrane structure and signaling in the brain.

The liquid formulation also includes vegetable glycerin and deionized water as inactive ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: supports brain function.
  • We looked for evidence on: Cognitive function, Alzheimer disease, Vascular dementia, memory, learning, age-related cognitive decline.
  • The strongest evidence on file: Alpha-gpc is rated "Possibly Effective" for Alzheimer disease (Natural Medicines).
  • Also on file: Alpha-gpc is rated "Insufficient Reliable Evidence To Rate" for Cognitive function, Vascular dementia.

Alpha-GPC is possibly effective for Alzheimer disease based on available evidence. For cognitive function, vascular dementia, stroke, and brain tumors, the evidence isn't reliable enough to rate how well it works.

The data we hold doesn't establish how it performs for other claimed uses.

The evidence, ingredient by ingredient Alpha-gpc

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Alpha-GPC is generally well tolerated in studies, but long-term safety hasn't been fully established. Rare side effects from oral use include dizziness, headache, insomnia, excitement, diarrhea, heartburn, nausea, and vomiting.

Rarely, oral alpha-GPC has been associated with stroke, especially with use lasting 2 months or longer compared with non-users or shorter-term users. Because there isn't enough safety information for pregnancy and breastfeeding, talk with your doctor or pharmacist before taking this product if you're pregnant, planning to become pregnant, or nursing.

Side effects, ingredient by ingredient Alpha-gpc

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Alpha-gpc.
  • The most serious interaction on file is rated Minor.
  • For scale: 16 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you use a scopolamine patch (Transderm Scop), check with your doctor or pharmacist before taking this product, as alpha-GPC may theoretically reduce its effects. Although this is the only documented interaction in our data, run your full medication list through the search tool on this page to be sure.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

Alpha-GPC may help with Alzheimer disease symptoms, though evidence for other cognitive or brain conditions is weak. It's generally well tolerated, but long-term safety data is limited, and rare stroke risk has been reported with prolonged use.

If you take any medications—especially a scopolamine patch—or have concerns about stroke risk, talk with your doctor or pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about GPC Liquid Glycerophosphocholine, straight from the product label.

Brand Designs for Health
Barcode (UPC) 879452003330
Net contents 2 fl. Oz.; 59 mL
Market status On market
Date entered into DSLD Jun 25, 2013
DSLD ID 22668
Product type Non-nutrient/non-botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for GPC Liquid Glycerophosphocholine by Designs for Health, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 mL
Maximum serving Sizes:
2 mL
Servings per container
30
UPC/BARCODE
879452003330
IngredientAmount% DV
Glycerophosphocholine600 mg--

Other ingredients: Vegetable Glycerin, deionized Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

Manufactured in a GMP CERTIFIED Facility

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent disease.

Formulation

Does not contain gluten.

Storage

STORE IN A COOL, DRY PLACE.

Precautions

KEEP OUT OF REACH OF CHILDREN.

General Statements

Notice: This is a natural product that may exhibit color, taste and density variations from lot to lot.

Supports Brain Function

For Professional Use Only

General

GPC2OZ

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Recommended Use: As a dietary supplement, take 2 ml (approx. 2 droppers full) daily, or as directed by your health care practitioner.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

GPC Liquid Glycerophosphocholine by Designs for Health label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

GPC Liquid Glycerophosphocholine label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in GPC Liquid Glycerophosphocholine by Designs for Health

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 mL Dosage formLiquid Servings per container30 Amounts shown are per serving.

Glycerophosphocholine

Interacts with
16 drugs
600 mg per serving Form: Soy Lecithin

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition...

Glycerophosphocholine monograph & interactions

Other (inactive) ingredients: Vegetable Glycerin, Deionized Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

GPC Liquid Glycerophosphocholine by Designs for Health Drug Interactions

Want to check YOUR meds against GPC Liquid Glycerophosphocholine?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
16Drugs
16 Minor

Ingredients driving the most interactions

Glycerophosphocholine 16

Individual Drug Interactions

The ingredients in GPC Liquid Glycerophosphocholine interact with 16 drugs. Click any drug to see the details.

1 of the 1 ingredient in GPC Liquid Glycerophosphocholine interact with drugs. Each result below shows which ingredient is responsible. Glycerophosphocholine

Each ingredient & the kinds of drugs it affects

For each ingredient in GPC Liquid Glycerophosphocholine with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Glycerophosphocholine1 drug type · 16 drugs

Scopolamine (Transderm Scop)

Theoretically, alpha-GPC might decrease the effects of scopolamine.
A small clinical study shows that alpha-GPC can partially counteract the attention and memory impairment effects caused by scopolamine given intramuscularly. Whether alpha-GPC can decrease the beneficial anti-motion sickness effects of the scopolamine patch (Transderm Scop) is unclear.

Likelihood Possible Evidence B
Glycerophosphocholine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for GPC Liquid Glycerophosphocholine, from the product label.

Designs for Health

See all Designs for Health products
Name
Designs for Health, Inc.
Street Address
980 South Street
City
Suffield
State
CT
ZipCode
06078
Web Address
www.designsforhealth.com
Pharmacist Counseling Corner

GPC Liquid Glycerophosphocholine by Designs for Health: Common Questions

Does GPC Liquid Glycerophosphocholine by Designs for Health interact with any medications?
Yes. Based on its ingredients, GPC Liquid Glycerophosphocholine has a known interaction with 16 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
GPC Liquid Glycerophosphocholine contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does alpha-GPC actually improve memory or brain function?
The evidence suggests it may help with Alzheimer disease, but for general cognitive function or memory in healthy people, we don't have reliable data. Talk with your doctor about whether it's right for your specific situation.
Is it safe to take long-term?
It's generally well tolerated in studies, but long-term safety hasn't been fully established. One concern: rare cases of stroke have been reported with use lasting 2 months or longer. Ask your doctor whether long-term use is appropriate for you.
What if I'm pregnant or nursing?
There isn't enough safety information for pregnancy or breastfeeding. Talk with your doctor or pharmacist for personalized advice before taking it.
Can I use this with my motion sickness patch?
Alpha-GPC may theoretically reduce how well a scopolamine patch works, though we're not certain it affects the patch itself. Check with your doctor or pharmacist before combining them.
What are the common side effects?
Most people tolerate it well. Rare side effects include headache, insomnia, dizziness, nausea, heartburn, diarrhea, and excitation. Serious adverse effects are very rare.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if GPC Liquid Glycerophosphocholine is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

GPC Liquid Glycerophosphocholine label
Go deeper

The Full Monographs Behind GPC Liquid Glycerophosphocholine’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Alpha-gpc

Interacts with 16 drugs

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition in people with dementia, but evidence i...

Read the full Alpha-gpc monograph →
Sources

Sources & How We Checked

GPC Liquid Glycerophosphocholine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Alpha-gpc 4 references
  1. Di Perri R, Coppola G, Ambrosio LA, et al. A multicentre trial to the evaluate the efficacy and tolerability of alpha-glycerylphosphorylcholine versus cytosine diphosphocholine in patients with vascular dementia. J Int Med Res 1991;19:330-41.
  2. Barbagallo Sangiorgi G, Barbagallo M, Giordano M, et al. Alpha-glycerophosphocholine in the mental recovery of cerebral ischemic attacks: An Italian multicenter clinical trial. Ann N Y Acad Sci 1994;717:253-69. PubMed
  3. Canal N, Franceschi M, Alberoni M, et al. Effect of L-alpha-glyceryl-phosphorylcholine on amnesia caused by scopolamine. Int J Clin Pharmacol Ther Toxicol 1991;29:103-7.
  4. Lee G, Choi S, Chang J, et al. Association of L-a glycerylphosphorylcholine with subsequent stroke risk after 10 Years. JAMA Netw Open 2021;4(11):e2136008.

See these in context on the Alpha-gpc monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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