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Dietary supplement

Graviola 650 mg Ingredients & Drug Interactions

by Pure Naturals

Graviola 650 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Graviola 650 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Graviola 650 mg is a dietary supplement by Pure Naturals with 1 active ingredient. Its ingredients are commonly taken for cancer support (unproven), infections, inflammation.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Graviola. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Graviola 650 mg by Pure Naturals

Ask about any prescription or over-the-counter medication and we check it for interactions with Graviola 650 mg by Pure Naturals — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Graviola 650 mg by Pure Naturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product has one active ingredient: graviola (also called soursop), a tropical fruit extract at 650 mg per capsule. The capsule itself is made from gelatin, and the remaining ingredients—magnesium stearate and stearic acid—are inactive binders and flow agents.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Graviola product and its label doesn't state a use — see Graviola's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for graviola is not yet established for any of its traditional uses. Our data shows insufficient reliable evidence to rate it for human papillomavirus (HPV) infection, headache, acting as an insect repellent, or male infertility.

That doesn't mean it doesn't work—it means large, well-designed human studies haven't confirmed its effects yet.

The evidence, ingredient by ingredient Graviola

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Graviola is generally well tolerated, but regular use comes with caution flags. The most common side effects reported in trials are stomach pain and nausea.

Rare but serious concerns include movement disorders and nerve damage (myeloneuropathy) with long-term consumption. People with Parkinson disease or a family history of it should be especially careful, since even small amounts of graviola fruit or herbal tea have been linked to worsening motor and thinking symptoms in observational studies.

Safety data in pregnancy and breastfeeding are too limited. The facts advise against use during both—talk with your doctor or pharmacist for personalized guidance before taking this if you're pregnant or nursing.

Side effects, ingredient by ingredient Graviola

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Graviola.
  • The most serious interaction on file is rated Moderate.
  • For scale: 1 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take carbamazepine (Tegretol) or any other seizure medication, check with your pharmacist or doctor before starting this product—graviola may lower drug levels and reduce seizure control.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Graviola has traditional uses, but human evidence is lacking for the conditions it's marketed for. The main red flag is a documented interaction with carbamazepine (a seizure drug) that could reduce its effectiveness.

If you take any medications—especially seizure meds—check with us or your doctor first. Otherwise, be aware of the rare but serious risk of nerve damage with regular long-term use.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Graviola 650 mg, straight from the product label.

Brand Pure Naturals
Barcode (UPC) 816511021263
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Feb 23, 2025
DSLD ID 323852
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Graviola 650 mg by Pure Naturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
120
UPC/BARCODE
816511021263
IngredientAmount% DV
Graviola650 mg--

Other ingredients: Gelatin, Magnesium Stearate, Stearic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, adults take two (2) capsules daily or as directed by a healthcare professional.

Precautions

Caution: Not intended for use by pregnant or nursing women. If you are taking any medications, planning any medical procedure or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of reach of children.

Do not use if safety seal is damaged or missing.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

Annona muricata

Formulation

Supports immune function Promotes relaxation & positive mood Supports cardiovascular health

Contains no: Artificial flavor, sweetener, preservatives, sugar, starch, milk, lactose, soy, gluten, wheat, yeast, fish or sodium.

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Made in USA Sourced from a GMP Certified Facility Good Manufacturing Practice Quality Assured

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Graviola 650 mg by Pure Naturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Graviola 650 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Graviola 650 mg by Pure Naturals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container120 Amounts shown are per serving.

Graviola

Interacts with
1 drug
650 mg per serving Form: Graviola, Graviola

Graviola (soursop) is a tropical fruit tree whose leaves, fruit, and bark are used in traditional medicine, especially in parts of South America, Afri...

Graviola monograph & interactions

Other (inactive) ingredients: Gelatin, Magnesium Stearate, Stearic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Graviola 650 mg by Pure Naturals Drug Interactions

Want to check YOUR meds against Graviola 650 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1Drugs
1 Moderate

Ingredients driving the most interactions

Graviola 1

Individual Drug Interactions

The ingredients in Graviola 650 mg interact with 1 drug. Click any drug to see the details.

1 of the 1 ingredient in Graviola 650 mg interact with drugs. Each result below shows which ingredient is responsible. Graviola

Each ingredient & the kinds of drugs it affects

For each ingredient in Graviola 650 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Graviola1 drug type · 1 drug

Carbamazepine (Tegretol)

Theoretically, graviola might decrease concentrations of carbamazepine when used concomitantly.
A study in rats shows that graviola extract reduces the area under the curve of carbamazepine by 46% and maximum concentration by 35% when compared with carbamazepine alone.

Likelihood Possible Evidence D
Graviola full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Graviola 650 mg, from the product label.

Pure Naturals

See all Pure Naturals products
Name
Pure Naturals
City
Jersey City
State
NJ
ZipCode
07310
Web Address
purenaturals.co
Pharmacist Counseling Corner

Graviola 650 mg by Pure Naturals: Common Questions

Does Graviola 650 mg by Pure Naturals interact with any medications?
Yes. Based on its ingredients, Graviola 650 mg has a known interaction with 1 medication. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Graviola 650 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is graviola and why is it in this supplement?
Graviola is a tropical fruit extract traditionally used for several conditions, including HPV infection, headache, and male infertility. However, reliable human evidence for these uses hasn't been established yet.
What are the side effects?
The most common side effects are nausea and stomach pain. Rarely, long-term use can cause movement disorders or nerve damage (myeloneuropathy) with symptoms similar to Parkinson disease. If you have Parkinson disease or family history of it, this product isn't a good fit for you.
Is it safe to take graviola while pregnant or breastfeeding?
No—safety data are too limited. The evidence advises against use in both pregnancy and breastfeeding. Talk with your doctor or pharmacist before using this if you're pregnant, planning to become pregnant, or nursing.
Can I take this with my seizure medication?
No—not without checking with your doctor first. Graviola may lower blood levels of carbamazepine (Tegretol) and other seizure drugs, making them less effective. Your doctor may need to adjust your dose or monitor you more closely.
How much graviola is in each capsule?
Each capsule contains 650 mg of graviola extract. The capsule itself is gelatin with magnesium stearate and stearic acid as inactive binders—no fillers beyond those.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Graviola 650 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Graviola 650 mg label
Go deeper

The Full Monographs Behind Graviola 650 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Graviola

Interacts with 1 drug

Graviola (soursop) is a tropical fruit tree whose leaves, fruit, and bark are used in traditional medicine, especially in parts of South America, Africa, and Asia. Despite popular online cla...

Read the full Graviola monograph →
Sources

Sources & How We Checked

Graviola 650 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Graviola 4 references
  1. Caparros-Lefebvre D, Elbaz A. Possible relation of atypical parkinsonism in the French West Indies with consumption of tropical plants: a case-control study. Caribbean Parkinsonism Study Group. Lancet 1999;354:281-6. PubMed
  2. Gavamukulya Y, Wamunyokoli F, El-Shemy HA. Annona muricata: Is the natural therapy to most disease conditions including cancer growing in our backyard? A systematic review of its research history and future prospects. Asian Pac J Trop Med. 2017;10(9):835- PubMed
  3. Abu Soukhon AA, Abu-Qatouseh L, Mansoor K, et al. Cytotoxicity Activity of Graviola Fruit Extract with Carbamazepine and Valproic Acid Show Antagonistic and Indifferent Effects. Asian Pac J Cancer Prev 2023;24(6):1869-1875. PubMed
  4. Cleret de Langavant L, Roze E, Petit A, et al. Annonaceae Consumption Worsens Disease Severity and Cognitive Deficits in Degenerative Parkinsonism. Mov Disord 2022;37(12):2355-2366. PubMed

See these in context on the Graviola monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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