Graviola 650 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Graviola 650 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Graviola 650 mg is a dietary supplement by Pure Naturals with 1 active ingredient. Its ingredients are commonly taken for cancer support (unproven), infections, inflammation.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Graviola. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Graviola 650 mg by Pure Naturals
Ask about any prescription or over-the-counter medication and we check it for interactions with Graviola 650 mg by Pure Naturals — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Graviola 650 mg by Pure Naturals
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient, graviola, a plant-based ingredient. Graviola is the ingredient the 650 mg capsule is built around, and its effects are what the ratings and safety notes on this page describe.
The capsule also contains inactive ingredients: gelatin, magnesium stearate, and stearic acid. These are included for the capsule and its manufacturing, not as active ingredients.
Does it work?
Couldn't assess
Every effectiveness rating we hold for graviola is Insufficient Reliable Evidence To Rate. These ratings cover uses including HPV, headache, insect repellent, and male infertility.
In other words, the evidence that graviola works for any of these uses isn't established in the data we hold.
How safe is it?
Well-documented data
Our safety notes say human safety data are limited, and lab studies raise concerns about possible nerve toxicity with long-term use. Common reported side effects include nausea and epigastrium pain (stomach-area pain).
Rare but serious effects include movement disorders and myeloneuropathy (nerve damage), with symptoms similar to Parkinson disease. Graviola is generally well tolerated in the data we hold only for short-term, low-dose use, and regular consumption may be unsafe.
The pregnancy and breastfeeding rating is Possibly Unsafe, and the safety notes advise against using it during pregnancy and while breastfeeding.
Meds to double-check
Moderate interaction found
Carbamazepine (Tegretol) is the medication to double-check before taking this product, and its interaction is rated Moderate. This is the only interaction documented in our data for graviola.
Please confirm any other prescriptions with your own doctor or pharmacist.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Graviola is an ingredient people may look into for the uses listed on this page, but the evidence for those uses isn't established. If you take carbamazepine (Tegretol), are pregnant or breastfeeding, or have concerns about nerve or movement symptoms, talk it over with your own doctor or pharmacist before taking this product.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Graviola 650 mg, straight from the product label.
| Brand | Pure Naturals |
|---|---|
| Barcode (UPC) | 816511021263 |
| Net contents | 120 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Feb 23, 2025 |
| DSLD ID | 323852 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Graviola 650 mg by Pure Naturals, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Graviola | 650 mg | -- |
Other ingredients: Gelatin, Magnesium Stearate, Stearic Acid
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested use: As a dietary supplement, adults take two (2) capsules daily or as directed by a healthcare professional.
Precautions
Caution: Not intended for use by pregnant or nursing women. If you are taking any medications, planning any medical procedure or have any medical condition, consult your doctor before use.
Discontinue use and consult your doctor if any adverse reactions occur.
Keep out of reach of children.
Do not use if safety seal is damaged or missing.
Storage
Store in a cool, dry place.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Formula
Annona muricata
Formulation
Supports immune function Promotes relaxation & positive mood Supports cardiovascular health
Contains no: Artificial flavor, sweetener, preservatives, sugar, starch, milk, lactose, soy, gluten, wheat, yeast, fish or sodium.
FDA Statement of Identity
Dietary Supplement
Seals/Symbols
Made in USA Sourced from a GMP Certified Facility Good Manufacturing Practice Quality Assured
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Graviola 650 mg by Pure Naturals label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Graviola 650 mg by Pure Naturals
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container120 Amounts shown are per serving.
Graviola
Interacts with1 drug
Graviola (soursop) is a tropical fruit tree whose leaves, fruit, and bark are used in traditional medicine, especially in parts of South America, Afri...
Graviola monograph & interactionsOther (inactive) ingredients: Gelatin, Magnesium Stearate, Stearic Acid. These complete the product’s ingredient list but are not active constituents.
Graviola 650 mg by Pure Naturals Drug Interactions
HelloPharmacist Interaction Report
Pure Naturals Graviola 650 mg can interact with carbamazepine (Tegretol), and this interaction is rated Moderate.
Graviola may lower how much carbamazepine your body absorbs, which could make the medication less effective. Theoretically, this is a possible interaction.
A study in rats found that graviola extract reduced carbamazepine's exposure by 46% and its peak concentration by 35% compared with carbamazepine alone.
Read the full breakdown — every affected drug type, severity by severity
Graviola is the only active ingredient in this product, so the interaction comes from graviola itself. Altogether, these interactions span 1 individual medications.
Use the search tool on this page to check your exact medications before you start this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Graviola 650 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Graviola 650 mg interact with 1 drug. Click any drug to see the details.
1 of the 1 ingredient in Graviola 650 mg interact with drugs. Each result below shows which ingredient is responsible. Graviola
CarbamazepineCarbatrol, Carnexiv, Equetro, Tegretol, Tegretol XR
How Carbamazepine interacts with Graviola 650 mg — through 1 ingredient. Tap an ingredient for the detail:
GraviolaCarbamazepine (tegretol) Moderate
Interaction Summary
Theoretically, graviola might decrease concentrations of carbamazepine when used concomitantly.
Read the full Graviola + Carbamazepine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Graviola 650 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Graviola
Carbamazepine (Tegretol)
Theoretically, graviola might decrease concentrations of carbamazepine when used concomitantly.
A study in rats shows that graviola extract reduces the area under the curve of carbamazepine by 46% and maximum concentration by 35% when compared with carbamazepine alone.
Brand information
Manufacturer and brand details for Graviola 650 mg, from the product label.
Pure Naturals
See all Pure Naturals products- Name
- Pure Naturals
- City
- Jersey City
- State
- NJ
- ZipCode
- 07310
- Web Address
- purenaturals.co
Graviola 650 mg by Pure Naturals: Common Questions
Does Graviola 650 mg by Pure Naturals interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take Graviola 650 mg while pregnant?
Is it okay to take while breastfeeding?
What side effects can graviola cause?
What is graviola used for?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Graviola 650 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Graviola 650 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Graviola 650 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 4 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Graviola 4 references
- Caparros-Lefebvre D, Elbaz A. Possible relation of atypical parkinsonism in the French West Indies with consumption of tropical plants: a case-control study. Caribbean Parkinsonism Study Group. Lancet 1999;354:281-6. PubMed
- Gavamukulya Y, Wamunyokoli F, El-Shemy HA. Annona muricata: Is the natural therapy to most disease conditions including cancer growing in our backyard? A systematic review of its research history and future prospects. Asian Pac J Trop Med. 2017;10(9):835- PubMed
- Abu Soukhon AA, Abu-Qatouseh L, Mansoor K, et al. Cytotoxicity Activity of Graviola Fruit Extract with Carbamazepine and Valproic Acid Show Antagonistic and Indifferent Effects. Asian Pac J Cancer Prev 2023;24(6):1869-1875. PubMed
- Cleret de Langavant L, Roze E, Petit A, et al. Annonaceae Consumption Worsens Disease Severity and Cognitive Deficits in Degenerative Parkinsonism. Mov Disord 2022;37(12):2355-2366. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC