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Dietary supplement

Riboflavin 400 mg Ingredients & Drug Interactions

by Pure Naturals

Riboflavin 400 mg label
See full label image
Capsule Category: Vitamin
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Oct 7, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Riboflavin 400 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Riboflavin 400 mg is a dietary supplement by Pure Naturals with 1 active ingredient. Its ingredients are commonly taken for riboflavin deficiency, migraine prevention, general energy and metabolism support.Based on those ingredients, 20 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Riboflavin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Riboflavin 400 mg by Pure Naturals

Ask about any prescription or over-the-counter medication and we check it for interactions with Riboflavin 400 mg by Pure Naturals — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Riboflavin 400 mg by Pure Naturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Oct 8, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This capsule contains one active ingredient, riboflavin, at 400 mg. Riboflavin's role is the reason most people take it, and the effectiveness notes below describe what the evidence shows for its uses.

The inactive ingredients are gelatin, microcrystalline cellulose, magnesium stearate, and silicon dioxide. These are the capsule material and processing agents that hold the product together.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Nervous system, protein metabolism, red blood cell support.
  • We looked for evidence on: Anemia, Nervous system disorders.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The evidence for riboflavin is strongest for ariboflavinosis, which is rated Effective. It is rated Possibly Effective for hyperhomocysteinemia (high levels of homocysteine in the blood) and for migraine headache.

These ratings are the most we can say from the data we hold. Possibly Effective is not the same as proven, so talk with your doctor about whether it fits your situation.

The evidence, ingredient by ingredient Riboflavin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

In the adverse effect data we hold, riboflavin is generally well tolerated. The most common effects are nausea that increases with the dose and urine that turns bright yellow, which is harmless but can be surprising.

Rare diarrhea has also been reported, and a small number of trial participants reported increased urination. For pregnancy, our data rates riboflavin as Likely Safe, and its safety notes say it is needed during pregnancy and generally safe at recommended amounts.

Our notes advise checking with your provider before using high-dose supplements. For breastfeeding, the notes say it is generally safe at recommended amounts, and to ask your provider about higher doses.

Side effects, ingredient by ingredient Riboflavin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Riboflavin.
  • The most serious interaction on file is rated Moderate.
  • For scale: 20 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check tetracycline antibiotics before taking this product, since the interaction is rated Moderate. The effect is theoretical and has not been reported in humans, but it is worth confirming with your own doctor or pharmacist.

No other medication types are documented for this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may be worth discussing if you are looking at riboflavin for one of the uses rated in our data. If you take tetracycline antibiotics, be careful and confirm with your own doctor or pharmacist before combining them.

If you are pregnant, breastfeeding, or considering higher doses, have that conversation with your own healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Riboflavin 400 mg, straight from the product label.

Brand Pure Naturals
Barcode (UPC) 816511023281
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Mar 25, 2025
DSLD ID 323872
Product type Vitamin
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Riboflavin 400 mg by Pure Naturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
120
UPC/BARCODE
816511023281
IngredientAmount% DV
Riboflavin400 mg23529%

Other ingredients: Gelatin, Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, adults take one (1) capsule daily, preferably with a meal or as directed by a health care professional.

Precautions

Caution: If you are pregnant, nursing, taking any medication(s) or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur. Do not use and consult your doctor if any adverse reactions occur.

Keep out of reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

Vitamin B12

Formulation

Supports nervous system health Promotes metabolism of proteins Supports red blood cell formation

Contains no: Preservatives, artificial colors, flavors or sweeteners, sugar, milk, lactose, gluten, wheat, yeast, fish or sodium.

Pure Naturals An FDA regulated facility

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Made in USA Sourced from a GMP Certified Facility Good Manufacturing Practice Quality Assured

Storage

Store in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Riboflavin 400 mg by Pure Naturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Riboflavin 400 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Riboflavin 400 mg by Pure Naturals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container120 Amounts shown are per serving.

Riboflavin

Interacts with
20 drugs
400 mg per serving Form: Vitamin B2

Riboflavin (vitamin B2) is an essential nutrient your body needs to turn food into energy and to keep skin, eyes, and nerves healthy. It is generally...

Riboflavin monograph & interactions

Other (inactive) ingredients: Gelatin, Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Riboflavin 400 mg by Pure Naturals Drug Interactions

Want to check YOUR meds against Riboflavin 400 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
20Drugs
20 Moderate

Ingredients driving the most interactions

Riboflavin 20

Individual Drug Interactions

The ingredients in Riboflavin 400 mg interact with 20 drugs. Click any drug to see the details.

1 of the 1 ingredient in Riboflavin 400 mg interact with drugs. Each result below shows which ingredient is responsible. Riboflavin

Each ingredient & the kinds of drugs it affects

For each ingredient in Riboflavin 400 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Riboflavin1 drug type · 20 drugs

Tetracycline Antibiotics

Theoretically, taking riboflavin with tetracycline antibiotics may decrease the potency of these antibiotics.
In vitro research suggests that riboflavin may inhibit the potency of tetracycline antibiotics. It is not clear if this effect is clinically significant, as this interaction has not been reported in humans.

Likelihood Possible Evidence D
Riboflavin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Riboflavin 400 mg, from the product label.

Pure Naturals

See all Pure Naturals products
Name
Pure Naturals
City
Jersey City
State
NJ
ZipCode
07310
Web Address
purenaturals.co
Pharmacist Counseling Corner

Riboflavin 400 mg by Pure Naturals: Common Questions

Does Riboflavin 400 mg by Pure Naturals interact with any medications?
Yes. Based on its ingredients, Riboflavin 400 mg has a known interaction with 20 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Riboflavin 400 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is Riboflavin 400 mg safe during pregnancy?
Our data rates riboflavin as Likely Safe in pregnancy, and its safety notes say it is generally safe at recommended amounts. The notes advise checking with your provider before using high-dose supplements, so talk with your own doctor or pharmacist for advice about your situation.
What side effects can riboflavin cause?
The most common effects are nausea that increases with the dose and bright yellow urine. Rare diarrhea has been reported, and a small number of trial participants reported increased urination.
Does riboflavin work for migraines?
Our data rates riboflavin as Possibly Effective for migraine headache. That is less than proven, so discuss it with your own doctor if you are considering it for this purpose.
What is riboflavin used for?
Our data rates riboflavin as Effective for ariboflavinosis and Possibly Effective for hyperhomocysteinemia, meaning high levels of homocysteine in the blood.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Riboflavin 400 mg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Riboflavin 400 mg label
Go deeper

The Full Monographs Behind Riboflavin 400 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Riboflavin

Interacts with 20 drugs

Riboflavin (vitamin B2) is an essential nutrient your body needs to turn food into energy and to keep skin, eyes, and nerves healthy. It is generally very safe at typical doses, and the stro...

Read the full Riboflavin monograph →
Sources

Sources & How We Checked

Riboflavin 400 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Riboflavin 5 references
  1. Schoenen J, Jacquy J, Lenaerts M. Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial. Neurology 1998;50:466-70. PubMed
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Leeson LJ, Weidenheimer JF. Stability of tetracycline and riboflavin. J Pharm Sci. 1969;58(3):355-7. PubMed
  4. MacLennan, S. C., Wade, F. M., Forrest, K. M., Ratanayake, P. D., Fagan, E., and Antony, J. High-dose riboflavin for migraine prophylaxis in children: a double-blind, randomized, placebo-controlled trial. J Child Neurol. 2008;23(11):1300-1304.
  5. Dietary reference intakes (DRIs): estimated average requirements. Food and Nutrition Board, Institute of Medicine, National Academics. https://www.nal.usda.gov/sites/default/files/fnic_uploads//recommended_intakes_individuals.pdf Accessed July 24, 2017.

See these in context on the Riboflavin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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