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Dietary supplement

Graviola Extract Ingredients & Drug Interactions

by Paradise

Graviola Extract label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Graviola Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Graviola Extract is a dietary supplement by Paradise with 1 active ingredient. Its ingredients are commonly taken for cancer support (unproven), infections, inflammation.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Graviola leaf extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Graviola Extract by Paradise

Ask about any prescription or over-the-counter medication and we check it for interactions with Graviola Extract by Paradise — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Graviola Extract by Paradise

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: graviola leaf extract. Graviola is a tropical plant that's been used traditionally in herbal medicine.

The capsules also contain plant cellulose as an inactive ingredient.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Graviola product and its label doesn't state a use — see Graviola's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for graviola's effectiveness isn't established in the data we hold. Studies have looked at it for human papillomavirus (HPV) infection, headache, insect repellent, and male infertility, but none of these uses have sufficient reliable evidence to make a confident rating.

Talk with your pharmacist about whether this supplement matches what you're hoping it will do.

The evidence, ingredient by ingredient Graviola

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Regular use of graviola raises some safety concerns. The most common side effects reported in studies are nausea and burning pain in the upper belly, though these occur in a small number of people.

More seriously, long-term use has been linked in rare cases to movement disorders and nerve damage (myeloneuropathy) — symptoms that can resemble Parkinson disease. Lab studies also suggest possible nerve toxicity with long-term use, so caution is advised.

Graviola is not recommended during pregnancy or breastfeeding due to insufficient safety data.

Side effects, ingredient by ingredient Graviola

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Graviola.
  • The most serious interaction on file is rated Moderate.
  • For scale: 1 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take carbamazepine (Tegretol) for seizures, check with your pharmacist before starting this product — graviola may significantly lower the drug's effectiveness. Even though carbamazepine is the only medication with documented interaction data, always review your full medication list with your pharmacist before adding any new supplement.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Graviola extract may work for some traditional uses, but the evidence isn't clear, and regular use comes with safety cautions — especially the rare risk of movement and nerve problems over time. If you take carbamazepine (a seizure medication), you'll need to check with your pharmacist before using this.

Talk with your doctor or pharmacist about whether graviola is right for you, particularly if you're pregnant, breastfeeding, or taking seizure medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Graviola Extract, straight from the product label.

Brand Paradise
Barcode (UPC) 601944778118
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Aug 22, 2025
DSLD ID 336863
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), No Allergies, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Graviola Extract by Paradise, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
Servings per container
60
UPC/BARCODE
601944778118
IngredientAmount% DV
Graviola leaf extract250 mg--

Other ingredients: Plant Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Quality-purity-potency We are dedicated to sourcing premium ultra pure ingredients that meet the highest standards of excellence.

We never add unnecessary fillers, binders, preservatives or flow agents to our encapsulation process. Our active whole spectrum extracts contain a full profile of naturally occurring constituents and are extracted without the use of toxic solvents and/or harsh chemicals.

Vegan

Non-GMO Gluten free

Contains no common allergens. Made without fillers.

Manufactured in the USA. GMP Quality Assured & FDA Registered.

General Statements

Paradise products have won over a decade of Best of Supplements Awards.

Formula

Active whole spectrum difference Our active whole spectrum extracts contain a full profile of naturally occurring constituents and are extracted without the use of toxic solvents and/or harsh chemicals. This unique method captures the true essence of the whole herb while still retaining a highly active and bioavailable concentration of phyto nutrients.

Graviola Extract AKA Soursop Antioxidant superfood

Raw Material: Graviola leaf extract naturally containing a full spectrum of active and synergistic constituents including annonaceous acetogenins.

Precautions

Warning: Keep in a cool dry place, out of the reach of children.

If pregnant, nursing, or using any prescription medication consult your health care professional before using this product.

Storage

Warning: Keep in a cool dry place, out of the reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

Paradise Enhancing Nature's Miracles Since 1994 Paradise EST. 1994

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: Take 1 vegetarian capsule 1-2 times daily or as directed a qualified health care professional.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Graviola Extract by Paradise label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Graviola Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Graviola Extract by Paradise

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Graviola leaf extract

Interacts with
1 drug
250 mg per serving

Graviola (soursop) is a tropical fruit tree whose leaves, fruit, and bark are used in traditional medicine, especially in parts of South America, Afri...

Graviola leaf extract monograph & interactions

Other (inactive) ingredients: Plant Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Graviola Extract by Paradise Drug Interactions

Want to check YOUR meds against Graviola Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1Drugs
1 Moderate

Ingredients driving the most interactions

Graviola leaf extract 1

Individual Drug Interactions

The ingredients in Graviola Extract interact with 1 drug. Click any drug to see the details.

1 of the 1 ingredient in Graviola Extract interact with drugs. Each result below shows which ingredient is responsible. Graviola leaf extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Graviola Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Graviola leaf extract1 drug type · 1 drug

Carbamazepine (Tegretol)

Theoretically, graviola might decrease concentrations of carbamazepine when used concomitantly.
A study in rats shows that graviola extract reduces the area under the curve of carbamazepine by 46% and maximum concentration by 35% when compared with carbamazepine alone.

Likelihood Possible Evidence D
Graviola leaf extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Graviola Extract, from the product label.

Paradise

See all Paradise products
Name
Paradise Herbs & Essentials, Inc.
Street Address
19051 Goldenwest St. #106-304
City
Huntington Beach
State
CA
ZipCode
92648
Web Address
www.paradiseherbs.com
Pharmacist Counseling Corner

Graviola Extract by Paradise: Common Questions

Does Graviola Extract by Paradise interact with any medications?
Yes. Based on its ingredients, Graviola Extract has a known interaction with 1 medication. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Graviola Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
No — there isn't enough safety information about graviola during pregnancy and breastfeeding, and the safety data we have advises against it. Talk with your doctor or pharmacist about whether this is right for you.
What are the side effects?
The most common ones are nausea and burning pain in the upper belly. More rarely, long-term use has been linked to movement disorders and nerve damage that can feel like Parkinson disease, so regular use needs caution.
Does graviola actually work for HPV, headaches, or anything else?
The evidence we hold doesn't establish that graviola is effective for HPV, headache, insect repellent, or male infertility. The data isn't clear enough to say it works. Talk with your pharmacist about what you're trying to treat.
What's in this capsule besides the graviola?
Just plant cellulose, which is the capsule material itself. There are no other active ingredients.
I take seizure medication — is this safe for me?
Not without checking first. Graviola may lower carbamazepine (Tegretol) blood levels by almost half, which could make the seizure medication less effective. Talk with your pharmacist before you start.
How long can I safely take this?
The safety data we hold raises concerns about nerve toxicity with long-term use, so this isn't something to take indefinitely without talking to your pharmacist or doctor first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Graviola Extract is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Graviola Extract label
Go deeper

The Full Monographs Behind Graviola Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Graviola

Interacts with 1 drug

Graviola (soursop) is a tropical fruit tree whose leaves, fruit, and bark are used in traditional medicine, especially in parts of South America, Africa, and Asia. Despite popular online cla...

Read the full Graviola monograph →
Sources

Sources & How We Checked

Graviola Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Graviola 4 references
  1. Caparros-Lefebvre D, Elbaz A. Possible relation of atypical parkinsonism in the French West Indies with consumption of tropical plants: a case-control study. Caribbean Parkinsonism Study Group. Lancet 1999;354:281-6. PubMed
  2. Gavamukulya Y, Wamunyokoli F, El-Shemy HA. Annona muricata: Is the natural therapy to most disease conditions including cancer growing in our backyard? A systematic review of its research history and future prospects. Asian Pac J Trop Med. 2017;10(9):835- PubMed
  3. Abu Soukhon AA, Abu-Qatouseh L, Mansoor K, et al. Cytotoxicity Activity of Graviola Fruit Extract with Carbamazepine and Valproic Acid Show Antagonistic and Indifferent Effects. Asian Pac J Cancer Prev 2023;24(6):1869-1875. PubMed
  4. Cleret de Langavant L, Roze E, Petit A, et al. Annonaceae Consumption Worsens Disease Severity and Cognitive Deficits in Degenerative Parkinsonism. Mov Disord 2022;37(12):2355-2366. PubMed

See these in context on the Graviola monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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