Graviola Fruit 450 mg 4:1 Extract Ingredients & Drug Interactions
by TerraVita Premium Collection
What is this page for?
First and foremost: checking Graviola Fruit 450 mg 4:1 Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Graviola Fruit 450 mg 4:1 Extract is a dietary supplement by TerraVita Premium Collection with 1 active ingredient. Its ingredients are commonly taken for cancer support (unproven), infections, inflammation.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Graviola Fruit Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Graviola Fruit 450 mg 4:1 Extract by TerraVita Premium Collection
Ask about any prescription or over-the-counter medication and we check it for interactions with Graviola Fruit 450 mg 4:1 Extract by TerraVita Premium Collection — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Graviola Fruit 450 mg 4:1 Extract by TerraVita Premium Collection
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: Graviola Fruit Extract, supplied as a 4:1 concentrate (meaning the extract is concentrated from four parts of the fruit down to one part). The capsule itself is made from gelatin and water, which are inactive ingredients that hold the extract.
Does it work?
Couldn't assess
The evidence we hold doesn't establish that graviola works for the conditions listed — human papillomavirus (HPV), headache, insect repellent, or male infertility all carry insufficient reliable evidence ratings. That doesn't mean it doesn't work; it means the clinical studies strong enough to prove effectiveness aren't yet on file in our data.
How safe is it?
Well-documented data
Regular use of graviola fruit may be unsafe. The most common side effects reported in studies are stomach pain (epigastrium pain) and nausea, typically from daily doses.
Rarely, longer-term use raises concerns about nerve toxicity — specifically movement disorders and a type of nerve damage called myeloneuropathy, with symptoms similar to Parkinson disease. A large observational study in people with Parkinson disease suggests even small cumulative amounts of graviola may worsen motor and thinking symptoms.
The safety data advises against use during pregnancy and breastfeeding. Because human safety information is limited and lab findings raise concerns, it's best to avoid this product if you're pregnant, planning to become pregnant, or breastfeeding.
Meds to double-check
Moderate interaction found
If you take carbamazepine (Tegretol) for seizures, check with your doctor or pharmacist before using this product—graviola may lower the drug's effectiveness by reducing its blood levels.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Graviola fruit extract may help with certain conditions, but the evidence we hold isn't established yet. The more pressing concern is safety: regular use carries a real risk of stomach upset and, with longer-term use, rare but serious nerve problems.
If you take carbamazepine for seizures, you'll need to clear this with your doctor or pharmacist before starting. Talk with your own healthcare provider about whether this product is right for you, especially if you have any nerve disorders or are pregnant or breastfeeding.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 21, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Graviola Fruit 450 mg 4:1 Extract, straight from the product label.
| Brand | TerraVita Premium Collection |
|---|---|
| Barcode (UPC) | 064435203573 |
| Net contents | 100 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Apr 21, 2023 |
| DSLD ID | 289018 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Graviola Fruit 450 mg 4:1 Extract by TerraVita Premium Collection, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Graviola Fruit Extract | 450 mg | -- |
Other ingredients: Gelatin, Water
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity
A Dietary Supplement
Brand IP Statement(s)
Copyright 2017 TerraVita - Distributed by ZooScape LLC, All Rights Reserved.
Suggested/Recommended/Usage/Directions
Directions Take 1 capsule, 3 times daily, with meals.
General Statements
TerraVita is an exclusive line of premium natural products that use the finest, purest and most potent ingredients in the world. TerraVita's hallmarks are the highest possible standards of purity, potency, stability and freshness. All products are prepared with the greatest quality control, from raw materials through the entire manufacturing process, right up to the moment your product is sealed for freshness and shipped to you.
Please recycle!
FDA Disclaimer Statement
Statements not evaluated by FDA. Product not intended to diagnose, treat, cure, or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Graviola Fruit 450 mg 4:1 Extract by TerraVita Premium Collection label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Graviola Fruit 450 mg 4:1 Extract by TerraVita Premium Collection
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.
Graviola Fruit Extract
Interacts with1 drug
Graviola (soursop) is a tropical fruit tree whose leaves, fruit, and bark are used in traditional medicine, especially in parts of South America, Afri...
Graviola Fruit Extract monograph & interactionsOther (inactive) ingredients: Gelatin, Water. These complete the product’s ingredient list but are not active constituents.
Graviola Fruit 450 mg 4:1 Extract by TerraVita Premium Collection Drug Interactions
HelloPharmacist Interaction Report
Graviola Fruit 450 mg 4:1 Extract by TerraVita Premium Collection interacts with carbamazepine (Tegretol), a seizure medication.
The concern is moderate in severity: graviola may lower the concentration of carbamazepine in your bloodstream, potentially reducing how well it controls seizures. Animal studies show the extract can decrease carbamazepine levels by roughly a third to nearly half.
Read the full breakdown — every affected drug type, severity by severity
If you take carbamazepine, don't start this product without talking to your doctor or pharmacist first. They may need to adjust your dose or monitor your seizure control more closely.
Altogehter, these interactions span 1 individual medication. Use the search tool below to check your other drugs, though no other interactions are documented in our data for this ingredient.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Graviola Fruit 450 mg 4:1 Extract?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Graviola Fruit 450 mg 4:1 Extract interact with 1 drug. Click any drug to see the details.
1 of the 1 ingredient in Graviola Fruit 450 mg 4:1 Extract interact with drugs. Each result below shows which ingredient is responsible. Graviola Fruit Extract
CarbamazepineCarbatrol, Carnexiv, Equetro, Tegretol, Tegretol XR
How Carbamazepine interacts with Graviola Fruit 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Graviola Fruit ExtractCarbamazepine (tegretol) Moderate
Interaction Summary
Theoretically, graviola might decrease concentrations of carbamazepine when used concomitantly.
Read the full Graviola Fruit Extract + Carbamazepine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Graviola Fruit 450 mg 4:1 Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Graviola Fruit Extract
Carbamazepine (Tegretol)
Theoretically, graviola might decrease concentrations of carbamazepine when used concomitantly.
A study in rats shows that graviola extract reduces the area under the curve of carbamazepine by 46% and maximum concentration by 35% when compared with carbamazepine alone.
Brand information
Manufacturer and brand details for Graviola Fruit 450 mg 4:1 Extract, from the product label.
TerraVita Premium Collection
See all TerraVita Premium Collection products- Name
- TerraVita Fine Whole Herbs
- City
- Brampton
- State
- Ontario
Graviola Fruit 450 mg 4:1 Extract by TerraVita Premium Collection: Common Questions
Does Graviola Fruit 450 mg 4:1 Extract by TerraVita Premium Collection interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm pregnant or breastfeeding?
What are the side effects I should watch for?
Does graviola actually work for HPV, headaches, or the other conditions listed?
What is the '4:1 Extract' on the label?
Are there any fillers in this product?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Graviola Fruit 450 mg 4:1 Extract is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Graviola Fruit 450 mg 4:1 Extract’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Graviola Fruit 450 mg 4:1 Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 4 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Graviola 4 references
- Caparros-Lefebvre D, Elbaz A. Possible relation of atypical parkinsonism in the French West Indies with consumption of tropical plants: a case-control study. Caribbean Parkinsonism Study Group. Lancet 1999;354:281-6. PubMed
- Gavamukulya Y, Wamunyokoli F, El-Shemy HA. Annona muricata: Is the natural therapy to most disease conditions including cancer growing in our backyard? A systematic review of its research history and future prospects. Asian Pac J Trop Med. 2017;10(9):835- PubMed
- Abu Soukhon AA, Abu-Qatouseh L, Mansoor K, et al. Cytotoxicity Activity of Graviola Fruit Extract with Carbamazepine and Valproic Acid Show Antagonistic and Indifferent Effects. Asian Pac J Cancer Prev 2023;24(6):1869-1875. PubMed
- Cleret de Langavant L, Roze E, Petit A, et al. Annonaceae Consumption Worsens Disease Severity and Cognitive Deficits in Degenerative Parkinsonism. Mov Disord 2022;37(12):2355-2366. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC