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Dietary supplement

Graviola Leaf Ingredients & Drug Interactions

by Herb Stop

Graviola Leaf label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Graviola Leaf against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Graviola Leaf is a dietary supplement by Herb Stop with 1 active ingredient. Its ingredients are commonly taken for cancer support (unproven), infections, inflammation.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Graviola. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Graviola Leaf by Herb Stop

Ask about any prescription or over-the-counter medication and we check it for interactions with Graviola Leaf by Herb Stop — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Graviola Leaf by Herb Stop

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: graviola leaf extract in capsule form. Graviola is a tropical plant traditionally used for various purposes, though the scientific evidence for most of those uses is weak.

The capsule also contains inactive ingredients — hydroxypropyl methylcellulose and purified water — which are standard binders and fillers.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: supports health cell and immune function.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The evidence for graviola is insufficient for the conditions listed in the research we hold: human papillomavirus (HPV), headache, and insect repellent use. That means we don't have enough reliable studies to say whether it works or doesn't.

If you're considering this supplement for one of those reasons, the data we have simply isn't strong enough to make a confident claim either way.

The evidence, ingredient by ingredient Graviola

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Regular graviola use comes with real safety concerns you should know about. The most common side effects are stomach pain and nausea, reported in a study at a dose of 300 mg daily.

More seriously, long-term use has been linked to movement disorders and nerve damage (myeloneuropathy) — symptoms that can look like Parkinson disease. One large study even found that people with Parkinson disease who had consumed graviola fruit, juice, or tea experienced worsening of their motor and thinking symptoms.

Graviola is rated possibly unsafe in pregnancy and should be avoided while breastfeeding — there simply isn't enough safety data. Lab studies also raise concerns about possible nerve toxicity with long-term use, so this isn't a supplement to take indefinitely without professional guidance.

Side effects, ingredient by ingredient Graviola

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Graviola.
  • The most serious interaction on file is rated Moderate.
  • For scale: 1 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take carbamazepine (Tegretol) for seizures, this supplement may reduce how well it works — graviola can lower the drug's blood levels significantly. Talk with your doctor before combining them.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Graviola Leaf may appeal to someone looking for a traditional remedy, but the evidence that it actually works is weak, and the safety profile has real red flags — especially the potential for nerve damage and movement problems with regular use. If you take carbamazepine or any other medication, check with your doctor or pharmacist before starting.

Given the safety concerns and lack of proven benefit, pregnant people and those breastfeeding should avoid it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Graviola Leaf, straight from the product label.

Brand Herb Stop
Net contents 300 Veggie Capsule(s)
Market status On market
Date entered into DSLD Oct 24, 2023
DSLD ID 297318
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Graviola Leaf by Herb Stop, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
150
IngredientAmount% DV
Graviola560 mg--

Other ingredients: Hydroxypropyl Methylcellulose, Water, Purified

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: Take 2 capsules 2 to 3 times per day with water, or as directed by your qualified healthcare professional.

Precautions

Safety Guideline: Do not take this product if you have any neuro-degenerative disorders, Parkinson's Disease, or are taking any anti-hypertensive or MAO inhibitor medications. Not to be used during pregnancy or lactation. If you have a medical condition or take pharmaceutical drugs, please consult with your doctor before use.

Keep away from children.

Use only as directed on label.

Brand IP Statement(s)

Herb Stop Health In Your Own Hands

Formula

Herbal Capsule

Formulation

Supports health cell & immune function

Vegan & Cruelty-Free

Vegan & Cruelty-Free Made in the USA.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Graviola Leaf by Herb Stop label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Graviola Leaf label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Graviola Leaf by Herb Stop

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container150 Amounts shown are per serving.

Graviola

Interacts with
1 drug
560 mg per serving Form: Soursop

Graviola (soursop) is a tropical fruit tree whose leaves, fruit, and bark are used in traditional medicine, especially in parts of South America, Afri...

Graviola monograph & interactions

Other (inactive) ingredients: Hydroxypropyl Methylcellulose, Water, Purified. These complete the product’s ingredient list but are not active constituents.

Interaction report

Graviola Leaf by Herb Stop Drug Interactions

Want to check YOUR meds against Graviola Leaf?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1Drugs
1 Moderate

Ingredients driving the most interactions

Graviola 1

Individual Drug Interactions

The ingredients in Graviola Leaf interact with 1 drug. Click any drug to see the details.

1 of the 1 ingredient in Graviola Leaf interact with drugs. Each result below shows which ingredient is responsible. Graviola

Each ingredient & the kinds of drugs it affects

For each ingredient in Graviola Leaf with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Graviola1 drug type · 1 drug

Carbamazepine (Tegretol)

Theoretically, graviola might decrease concentrations of carbamazepine when used concomitantly.
A study in rats shows that graviola extract reduces the area under the curve of carbamazepine by 46% and maximum concentration by 35% when compared with carbamazepine alone.

Likelihood Possible Evidence D
Graviola full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Graviola Leaf, from the product label.

Herb Stop

See all Herb Stop products
Name
The Herb Stop
Street Address
PO Box 673
City
Pine
State
AZ
ZipCode
85544
Phone Number
877.345.4372
Web Address
www.herbstop.com
Pharmacist Counseling Corner

Graviola Leaf by Herb Stop: Common Questions

Does Graviola Leaf by Herb Stop interact with any medications?
Yes. Based on its ingredients, Graviola Leaf has a known interaction with 1 medication. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Graviola Leaf contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What's graviola actually for?
Traditionally, people use graviola for HPV, headache, and as an insect repellent, but the research evidence for any of those uses is too weak to say it actually works.
What are the side effects?
The most common ones are stomach pain and nausea. More seriously, regular long-term use has been linked to movement disorders and nerve damage that can mimic Parkinson disease symptoms.
Is it safe to take while pregnant or breastfeeding?
No — graviola is rated possibly unsafe in pregnancy and should be avoided while breastfeeding due to insufficient safety data.
Can I take this if I'm on seizure medication?
Not without checking with your doctor first. Graviola may lower carbamazepine (Tegretol) levels by nearly half, which could make the medication less effective.
How much is considered safe to take long-term?
The data we hold raises concerns about nerve toxicity with long-term use, so there's no amount we'd call safe indefinitely without professional monitoring. Talk with your doctor before taking it regularly.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Graviola Leaf is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Graviola Leaf label
Go deeper

The Full Monographs Behind Graviola Leaf’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Graviola

Interacts with 1 drug

Graviola (soursop) is a tropical fruit tree whose leaves, fruit, and bark are used in traditional medicine, especially in parts of South America, Africa, and Asia. Despite popular online cla...

Read the full Graviola monograph →
Sources

Sources & How We Checked

Graviola Leaf's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Graviola 4 references
  1. Caparros-Lefebvre D, Elbaz A. Possible relation of atypical parkinsonism in the French West Indies with consumption of tropical plants: a case-control study. Caribbean Parkinsonism Study Group. Lancet 1999;354:281-6. PubMed
  2. Gavamukulya Y, Wamunyokoli F, El-Shemy HA. Annona muricata: Is the natural therapy to most disease conditions including cancer growing in our backyard? A systematic review of its research history and future prospects. Asian Pac J Trop Med. 2017;10(9):835- PubMed
  3. Abu Soukhon AA, Abu-Qatouseh L, Mansoor K, et al. Cytotoxicity Activity of Graviola Fruit Extract with Carbamazepine and Valproic Acid Show Antagonistic and Indifferent Effects. Asian Pac J Cancer Prev 2023;24(6):1869-1875. PubMed
  4. Cleret de Langavant L, Roze E, Petit A, et al. Annonaceae Consumption Worsens Disease Severity and Cognitive Deficits in Degenerative Parkinsonism. Mov Disord 2022;37(12):2355-2366. PubMed

See these in context on the Graviola monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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