Interactions on record — worth a quick check against your medications. Based on 1 of 5 ingredients. Check your meds →
Dietary supplement

Gut & Digestion Ingredients & Drug Interactions

by Heart & Soil

Gut & Digestion label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Gut & Digestion against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Gut & Digestion is a dietary supplement by Heart & Soil with 5 active ingredients. Its ingredients are commonly taken for anemia and low iron, vitamin b12 support, general energy and fatigue.Based on those ingredients, 3 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Liver. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Gut & Digestion by Heart & Soil

Ask about any prescription or over-the-counter medication and we check it for interactions with Gut & Digestion by Heart & Soil — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Gut & Digestion by Heart & Soil

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains five active ingredients sourced from animal organs: spleen, liver, pancreas, tripe (stomach), and intestines. These are whole-food organ concentrates — sometimes called "nose-to-tail" supplements — meant to deliver naturally occurring nutrients from those tissues.

The product is supplied as capsules with bovine gelatin as an inactive ingredient.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: gut and digestion support.
  • We looked for evidence on: digestive health, intestinal function, microbiome health, nutrient absorption.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The evidence for liver extract is very limited. For chronic fatigue syndrome (CFS), it's rated possibly ineffective.

For hepatitis C, we don't have enough reliable evidence to rate it either way. The other organ ingredients in this product don't have established effectiveness ratings in our data.

The evidence, ingredient by ingredient Liver Extract

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Liver extract is generally well tolerated in food amounts, but the product facts point to a few cautions. Liver can deliver very high levels of vitamin A and iron — especially at supplement doses — and there are concerns about the source: liver extract comes from raw animal liver at slaughterhouses, which may come from sick or diseased animals.

There's also a theoretical risk of contamination with BSE (mad cow disease) if the source country has reported BSE, though no human cases from contaminated liver extract have ever been reported. The safety of this product hasn't been thoroughly studied, so check with your doctor before using it.

If you're pregnant, the high vitamin A in liver products could harm a developing baby, so avoid it unless your doctor advises otherwise. Safety data for breastfeeding isn't on file.

Side effects, ingredient by ingredient Liver Extract

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Liver Extract.
  • The most serious interaction on file is rated Minor.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 3 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take warfarin (Coumadin) or any blood thinner, or if you use iron supplements or iron-containing medications, check this product with your pharmacist first. Both interactions are rated Minor but are worth confirming against your specific drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

This is a whole-food organ-concentrate product with limited evidence for the conditions it may target. If you take warfarin or iron supplements, you'll want to talk to your pharmacist first — the interactions are documented but not yet proven in real people.

Anyone concerned about source quality, contamination risk, or high vitamin A and iron levels should discuss this with their doctor before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Gut & Digestion, straight from the product label.

Brand Heart & Soil
Barcode (UPC) 850018088022
Net contents 180 Capsule(s)
Market status On market
Date entered into DSLD Nov 22, 2022
DSLD ID 276349
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Gut & Digestion by Heart & Soil, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
6 Capsule(s)
Maximum serving Sizes:
6 Capsule(s)
Servings per container
30
UPC/BARCODE
850018088022
IngredientAmount% DV
Spleen300 mg--
Liver300 mg--
Pancreas800 mg--
Tripe/Stomach800 mg--
Intestines800 mg--

Other ingredients: Bovine Gelatin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Reclaim your birthright to radical health. It breaks my heart to see how our families and our children struggle with fatigue, brain fog, mood issues, infertility, and autoimmunity. Is this the new normal that will become our future? Why have we forsaken the vitality that is our birthright and accepted this suffering as inescapable? I believe with all my soul that the solution is nose-to-tail nourishment. It starts with the soil and regenerative practices that heal the land, love, and nourish our animals so that we may be deeply nourished in turn. When we honor and consume animals nose-to-tail, we receive all of the nutrients needed to thrive, in the most bioavailable forms. This is my passion, my purpose, my entire heart & soul. Let me show you a brighter future. Visit us online at www.heartandsoil.co to start your journey today. Paul Saladino, M.D.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

3 g organs per serving

Gut & digestion 500 mg ea 180 capsules

Formulation

Regenerative Small batch 100% grass-fed 100% grass-finished

Suggested/Recommended/Usage/Directions

Suggested Use: 6 capsules daily or as directed by a healthcare professional

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Gut & Digestion by Heart & Soil label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Gut & Digestion label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Gut & Digestion by Heart & Soil

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size6 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Spleen

300 mg per serving Form: Bovine

Liver

Interacts with
3 drugs
300 mg per serving Form: Bovine

Liver extract is a dried or concentrated form of animal liver that is naturally rich in iron, vitamin B12, vitamin A, and other nutrients. It was once...

Liver monograph & interactions

Pancreas

800 mg per serving Form: Bovine

Tripe/Stomach

800 mg per serving Form: Bovine

Intestines

800 mg per serving Form: Bovine

Other (inactive) ingredients: Bovine Gelatin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Gut & Digestion by Heart & Soil Drug Interactions

Want to check YOUR meds against Gut & Digestion?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
3Drugs
3 Minor

Ingredients driving the most interactions

Liver 3

Individual Drug Interactions

The ingredients in Gut & Digestion interact with 3 drugs. Click any drug to see the details.

1 of the 5 ingredients in Gut & Digestion interact with drugs. Each result below shows which ingredient is responsible. Liver

Each ingredient & the kinds of drugs it affects

For each ingredient in Gut & Digestion with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Liver2 drug types · 3 drugs

Iron

Liver extract can contain heme iron. Taking liver extract with iron-containing medications or supplements may increase total iron intake and could increase the risk of gastrointestinal adverse effects or excessive iron accumulation. The risk is greater with high doses, prolonged use, or in individuals with hemochromatosis or another iron-overload disorder. Review the iron content of the liver extract and the total elemental iron dose. Avoid unnecessary duplicate iron supplementation and consider monitoring ferritin and transferrin saturation when clinically appropriate.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Liver extract products may contain small and variable amounts of vitamin K. Theoretically, starting, stopping, or substantially changing the amount of liver extract used could reduce the anticoagulant effect of warfarin and lower the INR. However, this interaction has not been directly studied or reported in humans, and the vitamin K content of liver extract products is generally not standardized. Consider monitoring the INR after a meaningful change in liver extract use.

Likelihood Possible Evidence C
Liver full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Gut & Digestion, from the product label.

Heart & Soil

See all Heart & Soil products
Name
Heart & Soil, LLC.
City
Austin
State
TX
ZipCode
78746
Web Address
www.heartandsoil.co
Pharmacist Counseling Corner

Gut & Digestion by Heart & Soil: Common Questions

Does Gut & Digestion by Heart & Soil interact with any medications?
Yes. Based on its ingredients, Gut & Digestion has a known interaction with 3 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Gut & Digestion contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What are these organ ingredients supposed to do?
These are whole-food concentrates from animal organs — the idea is that you're getting naturally occurring nutrients from liver, pancreas, spleen, and digestive tissues. The liver ingredient is the one with some research attached, though the evidence for most uses is sparse or limited. The other organs in the formula don't have established effectiveness data in our records.
Is it safe if I'm pregnant?
Liver extract can contain very high vitamin A, which may harm a developing baby. The product facts advise against it unless your doctor says otherwise. If you're thinking about taking this while pregnant, talk to your doctor before you start.
Where does the liver come from, and is it safe?
Liver extract comes from raw animal liver sourced at slaughterhouses — which may come from sick or diseased animals. There's also a theoretical contamination risk with BSE (mad cow disease) if the source country has reported BSE cases. No human BSE cases from liver extract have been reported, but safety hasn't been thoroughly studied, so check with your doctor first.
Can I take this with my iron supplement?
Not without checking first. Liver extract naturally contains heme iron, so taking it alongside iron supplements could increase your total iron intake and raise the risk of stomach upset or iron buildup — especially at high doses or over long periods. Talk to your pharmacist about whether it's okay for you.
Will this affect my warfarin?
Possibly. Liver extract may contain small amounts of vitamin K, which theoretically could reduce warfarin's effectiveness, but this interaction hasn't been directly studied in humans, so the real-world risk is unclear. If you take warfarin, mention this product to your pharmacist before you start.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Gut & Digestion label
Go deeper

The Full Monographs Behind Gut & Digestion’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Liver Extract

Interacts with 3 drugs

Liver extract is a dried or concentrated form of animal liver that is naturally rich in iron, vitamin B12, vitamin A, and other nutrients. It was once used to treat certain anemias before pu...

Read the full Liver Extract monograph →
Sources

Sources & How We Checked

Gut & Digestion's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Liver Extract 4 references
  1. Lewis CJ. Letter to reiterate certain public health and safety concerns to firms manufacturing or importing dietary supplements that contain specific bovine tissues. FDA. Available at: www.cfsan.fda.gov/~dms/dspltr05.html.
  2. Kaslow JE, Rucker L, Onishi R. Liver extract-folic acid-cyanocobalamin vs placebo for chronic fatigue syndrome. Arch Intern Med 1989;149:2501-3. DOI
  3. Ebinuma, H., Saito, H., Tada, S., Masuda, T., Kamiya, T., Nishida, J., Yoshioka, M., and Ishii, H. Additive therapeutic effects of the liver extract preparation mixture adelavin-9 on interferon-beta treatment for chronic hepatitis C. Hepatogastroenterolog
  4. Saito, H., Ebinuma, H., Tada, S., Tsunematsu, S., Atsukawa, K., Masuda, T., Tsuchiya, M., and Ishii, H. Enhancing effect of the liver extract and flavin adenin dinucleotide mixture on anti-viral efficacy of interferon in patients with chronic hepatitis C. PubMed

See these in context on the Liver Extract monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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