Interactions on record — worth a quick check against your medications. Based on 1 of 5 ingredients. Check your meds →
Dietary supplement

Histamine & Immune Ingredients & Drug Interactions

by Heart & Soil

Histamine & Immune label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Histamine & Immune against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Histamine & Immune is a dietary supplement by Heart & Soil with 5 active ingredients. Its ingredients are commonly taken for anemia and low iron, vitamin b12 support, general energy and fatigue.Based on those ingredients, 3 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Liver. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Histamine & Immune by Heart & Soil

Ask about any prescription or over-the-counter medication and we check it for interactions with Histamine & Immune by Heart & Soil — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Histamine & Immune by Heart & Soil

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product has 5 active ingredients: organ tissue extracts from Spleen, Liver, Kidney, Lung, and Thymus. The Liver extract is the one we have data on; it's included to support immune and energy function.

The others are dried organ tissues meant to offer similar support, though our monograph data covers only the liver component. The capsule itself is made from bovine gelatin.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Liver Extract product and its label doesn't state a use — see Liver Extract's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

For liver extract specifically, the evidence is mixed. It's rated possibly ineffective for chronic fatigue syndrome (CFS).

For hepatitis C, there isn't enough reliable evidence to say whether it helps or not. The effectiveness of the other four organ extracts — Spleen, Kidney, Lung, and Thymus — isn't established in our data.

The evidence, ingredient by ingredient Liver Extract

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Liver extract is generally low-risk in food amounts, but this product can deliver high levels of vitamin A and iron, which is worth knowing. Because liver products can contain very high vitamin A, they may harm a developing baby — the safety data advises against use in pregnancy unless your doctor says otherwise.

There's also a lingering concern about contamination: liver extract comes from raw animal liver sourced from slaughterhouses, potentially from sick or diseased animals. Additionally, some older reports raised the possibility of BSE (mad cow disease) contamination in products from certain countries, though no confirmed cases of BSE transfer from liver extract to humans have been reported.

Safety hasn't been thoroughly studied overall, so check with your doctor before starting.

Side effects, ingredient by ingredient Liver Extract

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Liver Extract.
  • The most serious interaction on file is rated Minor.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 3 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist if you take warfarin (Coumadin) — liver extract may affect how it works. Also flag iron supplements or iron-containing medications, as combining them with this product could increase your total iron intake.

Use the search tool on this page to verify your exact medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

This product is geared toward people looking to support immune function and energy with organ tissue extracts. If you take warfarin or iron supplements, talk with your pharmacist before adding this to your routine.

Pregnant women should avoid it unless their doctor approves. Anyone with iron-overload disorders or concerns about supplement sourcing should discuss it with their healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Histamine & Immune, straight from the product label.

Brand Heart & Soil
Barcode (UPC) 850018088046
Net contents 180 Capsule(s)
Market status On market
Date entered into DSLD Nov 22, 2022
DSLD ID 276351
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Histamine & Immune by Heart & Soil, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
6 Capsule(s)
Maximum serving Sizes:
6 Capsule(s)
Servings per container
30
UPC/BARCODE
850018088046
IngredientAmount% DV
Spleen600 mg--
Liver600 mg--
Kidney600 mg--
Lung600 mg--
Thymus600 mg--

Other ingredients: Bovine Gelatin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Reclaim your birthright to radical health. It breaks my heart to see how our families and our children struggle with fatigue, brain fog, mood issues, infertility, and autoimmunity. Is this the new normal that will become our future? Why have we forsaken the vitality that is our birthright and accepted this suffering as inescapable? I believe with all my soul that the solution is nose-to-tail nourishment. It starts with the soil and regenerative practices that heal the land, love, and nourish our animals so that we may be deeply nourished in turn. When we honor and consume animals nose-to-tail, we receive all of the nutrients needed to thrive, in the most bioavailable forms. This is my passion, my purpose, my entire heart & soul. Let me show you a brighter future. Visit us online at www.heartandsoil.co to start your journey today. Paul Saladino, M.D.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

3 g organs per serving

Histamine & Immune 500 mg ea 180 capsules

Formulation

Regenerative Small batch 100% grass-fed 100% grass-finished

Suggested/Recommended/Usage/Directions

Suggested Use: 6 capsules daily or as directed by a healthcare professional

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Histamine & Immune by Heart & Soil label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Histamine & Immune label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Histamine & Immune by Heart & Soil

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size6 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Spleen

600 mg per serving Form: Bovine

Liver

Interacts with
3 drugs
600 mg per serving Form: Bovine

Liver extract is a dried or concentrated form of animal liver that is naturally rich in iron, vitamin B12, vitamin A, and other nutrients. It was once...

Liver monograph & interactions

Kidney

600 mg per serving Form: Bovine

Lung

600 mg per serving Form: Bovine

Thymus

600 mg per serving Form: Bovine, Ovine

Other (inactive) ingredients: Bovine Gelatin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Histamine & Immune by Heart & Soil Drug Interactions

Want to check YOUR meds against Histamine & Immune?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
3Drugs
3 Minor

Ingredients driving the most interactions

Liver 3

Individual Drug Interactions

The ingredients in Histamine & Immune interact with 3 drugs. Click any drug to see the details.

1 of the 5 ingredients in Histamine & Immune interact with drugs. Each result below shows which ingredient is responsible. Liver

Each ingredient & the kinds of drugs it affects

For each ingredient in Histamine & Immune with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Liver2 drug types · 3 drugs

Iron

Liver extract can contain heme iron. Taking liver extract with iron-containing medications or supplements may increase total iron intake and could increase the risk of gastrointestinal adverse effects or excessive iron accumulation. The risk is greater with high doses, prolonged use, or in individuals with hemochromatosis or another iron-overload disorder. Review the iron content of the liver extract and the total elemental iron dose. Avoid unnecessary duplicate iron supplementation and consider monitoring ferritin and transferrin saturation when clinically appropriate.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Liver extract products may contain small and variable amounts of vitamin K. Theoretically, starting, stopping, or substantially changing the amount of liver extract used could reduce the anticoagulant effect of warfarin and lower the INR. However, this interaction has not been directly studied or reported in humans, and the vitamin K content of liver extract products is generally not standardized. Consider monitoring the INR after a meaningful change in liver extract use.

Likelihood Possible Evidence C
Liver full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Histamine & Immune, from the product label.

Heart & Soil

See all Heart & Soil products
Name
Heart & Soil, LLC.
City
Austin
State
TX
ZipCode
78746
Web Address
www.heartandsoil.co
Pharmacist Counseling Corner

Histamine & Immune by Heart & Soil: Common Questions

Does Histamine & Immune by Heart & Soil interact with any medications?
Yes. Based on its ingredients, Histamine & Immune has a known interaction with 3 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Histamine & Immune contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take while I'm pregnant?
The safety data advises against liver extract in pregnancy because it can contain very high amounts of vitamin A, which may harm a developing baby. Talk with your doctor before using this product if you're pregnant or planning to become pregnant.
What are these organ extracts supposed to do?
They're included to support immune function and energy. That said, the evidence for liver extract in chronic fatigue syndrome is rated possibly ineffective, and we don't have established effectiveness data for the other four organ tissues in our files.
I've heard about BSE in some supplements. Should I worry?
There is a historical concern that liver extracts from cows in countries where BSE (mad cow disease) has been reported could theoretically carry contaminated tissue. However, no confirmed cases of BSE transfer to humans from liver extract products have been reported. If you're concerned about sourcing, ask the brand which countries their liver comes from.
Can I take this with my iron supplement?
Liver extract contains heme iron, so taking it alongside iron supplements might increase your total iron intake and could cause stomach upset or iron buildup, especially over time or at higher doses. Check with your pharmacist about the best way to combine them, or whether you should space them out.
What's in the capsule itself?
The capsule is made from bovine gelatin, which is derived from cattle.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Histamine & Immune is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Histamine & Immune label
Go deeper

The Full Monographs Behind Histamine & Immune’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Liver Extract

Interacts with 3 drugs

Liver extract is a dried or concentrated form of animal liver that is naturally rich in iron, vitamin B12, vitamin A, and other nutrients. It was once used to treat certain anemias before pu...

Read the full Liver Extract monograph →
Sources

Sources & How We Checked

Histamine & Immune's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Liver Extract 4 references
  1. Lewis CJ. Letter to reiterate certain public health and safety concerns to firms manufacturing or importing dietary supplements that contain specific bovine tissues. FDA. Available at: www.cfsan.fda.gov/~dms/dspltr05.html.
  2. Kaslow JE, Rucker L, Onishi R. Liver extract-folic acid-cyanocobalamin vs placebo for chronic fatigue syndrome. Arch Intern Med 1989;149:2501-3. DOI
  3. Ebinuma, H., Saito, H., Tada, S., Masuda, T., Kamiya, T., Nishida, J., Yoshioka, M., and Ishii, H. Additive therapeutic effects of the liver extract preparation mixture adelavin-9 on interferon-beta treatment for chronic hepatitis C. Hepatogastroenterolog
  4. Saito, H., Ebinuma, H., Tada, S., Tsunematsu, S., Atsukawa, K., Masuda, T., Tsuchiya, M., and Ishii, H. Enhancing effect of the liver extract and flavin adenin dinucleotide mixture on anti-viral efficacy of interferon in patients with chronic hepatitis C. PubMed

See these in context on the Liver Extract monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team