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Dietary supplement

Skin Hair & Nails Ingredients & Drug Interactions

by Heart & Soil

Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Skin Hair & Nails is a dietary supplement by Heart & Soil with 3 active ingredients. Its ingredients are commonly taken for anemia and low iron, vitamin b12 support, general energy and fatigue.Based on those ingredients, 3 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bovine Liver. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Skin Hair & Nails by Heart & Soil

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 2 of its 6 active ingredients.
  • “Bovine Cartilage” is listed as a grouped ingredient — the label gives one combined amount (1,200 mg) without saying how much of each component you get.

This 6-ingredient supplement centers on collagen and bone-derived compounds meant to support skin, hair, and nails. It contains chondroitin sulfate (a cartilage component often studied for joint health), bovine liver (organ meat concentrate), trachea collagen, scapula collagen, bovine cartilage, peptides, and bovine bone marrow.

The product comes in capsules with bovine gelatin as the inactive ingredient.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: skin, hair, and nails health.
  • We looked for evidence on: Aging skin, Psoriasis, Wound healing, hair loss, nail brittleness.
  • The closest evidence on file: Chondroitin Sulfate is rated "Insufficient Reliable Evidence To Rate" for Aging skin (Natural Medicines).
  • Also on file: Chondroitin Sulfate is rated "Insufficient Reliable Evidence To Rate" for Psoriasis.

Chondroitin sulfate has possibly effective evidence for cataracts and osteoarthritis (joint wear-and-tear). For aging skin, osteoporosis (weak bones), high cholesterol (hyperlipidemia), and colorectal adenoma, the evidence is insufficient to rate it.

Bovine liver shows possibly ineffective evidence for chronic fatigue syndrome. The effectiveness of the collagen, cartilage, peptides, and bone marrow ingredients we hold in our data is not established.

The evidence, ingredient by ingredient Liver Extract Bovine Cartilage Chondroitin Sulfate

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Chondroitin sulfate is generally well tolerated for short-term use, though quality varies and benefits are uncertain. Most common side effects from oral use are stomach upset — abdominal pain, bloating, constipation, diarrhea, heartburn, nausea.

Rare serious effects include liver damage (hepatotoxicity). Skin symptoms like eyelid or leg swelling, hair loss, rash, and hives have been reported, and a case of worsened asthma occurred with a glucosamine-chondroitin product.

Bovine liver is generally low-risk for healthy adults in food amounts but can deliver high levels of vitamin A and iron; there's also concern about potential contamination from raw animal liver or BSE (mad cow disease) if sourced from affected countries, though no human cases from liver extract have been reported. Safety during breastfeeding hasn't been well studied.

During pregnancy, chondroitin should be avoided due to insufficient safety data, and liver products carry risk from high vitamin A, which may harm a developing baby.

Side effects, ingredient by ingredient Liver Extract Bovine Cartilage Chondroitin Sulfate

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Chondroitin Sulfate, Liver Extract.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 3 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take warfarin (Coumadin) or any blood thinner, flag this product with your doctor or pharmacist before use — chondroitin plus glucosamine can increase warfarin's anticoagulant effect and raise INR, and even chondroitin alone's effect isn't fully clear. Similarly, if you're on iron supplements or iron-containing medications, check first because the bovine liver in this product adds heme iron.

Tell your provider right away if you start, stop, or change the amount you're taking.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product is built around collagen and organ extracts marketed for skin, hair, and nails support, but the evidence for most ingredients is limited or not established. If you take warfarin or iron supplements, you'll want to check with your doctor or pharmacist before starting — the interactions are real, though most are rated Moderate or Minor.

Pregnant people and those breastfeeding should talk with their healthcare provider first, especially given the vitamin A load in the liver component.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 21, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Skin Hair & Nails, straight from the product label.

Brand Heart & Soil
Barcode (UPC) 850018088060
Net contents 180 Capsule(s)
Market status On market
Date entered into DSLD Apr 21, 2023
DSLD ID 276356
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Skin Hair & Nails by Heart & Soil, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
6 Capsule(s)
Maximum serving Sizes:
6 Capsule(s)
Servings per container
30
UPC/BARCODE
850018088060
IngredientAmount% DV
Chondroitin Sulfate0 NP--
Bovine Liver600 mg--
Trachea collagen0 NP--
Scapula Collagen0 NP--
Bovine Cartilage1200 mg--
Peptides0 NP--
Bovine Bone Marrow1200 mg--

Other ingredients: Bovine Gelatin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Reclaim your birthright to radical health. It breaks my heart to see how our families and our children struggle with fatigue, brain fog, mood issues, infertility, and autoimmunity. Is this the new normal that will become our future? Why have we forsaken the vitality that is our birthright and accepted this suffering as inescapable? I believe with all my soul that the solution is nose-to-tail nourishment. It starts with the soil and regenerative practices that heal the land, love, and nourish our animals so that we may be deeply nourished in turn. When we honor and consume animals nose-to-tail, we receive all of the nutrients needed to thrive, in the most bioavailable forms. This is my passion, my purpose, my entire heart & soul. Let me show you a brighter future. Visit us online at www.heartandsoil.co to start your journey today. Paul Saladino, M.D.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

3 g organs per serving

Skin Hair & Nails 500 mg ea 180 capsules

Formulation

Regenerative Small batch 100% grass-fed 100% grass-finished

Suggested/Recommended/Usage/Directions

Suggested Use: 6 capsules daily or as directed by a healthcare professional

See for yourself

Skin Hair & Nails by Heart & Soil label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Skin Hair & Nails by Heart & Soil

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size6 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Bovine Liver

Interacts with
3 drugs
600 mg per serving

Liver extract is a dried or concentrated form of animal liver that is naturally rich in iron, vitamin B12, vitamin A, and other nutrients. It was once...

Bovine Liver monograph & interactions

Bovine Cartilage

No known
interactions
1200 mg per serving

Bovine cartilage is an animal-derived supplement that some people use for joint health, inflammation, and as an unproven cancer aid. The scientific ev...

Bovine Cartilage monograph & interactions

Bovine Bone Marrow

1200 mg per serving

Other (inactive) ingredients: Bovine Gelatin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Skin Hair & Nails by Heart & Soil Drug Interactions

Want to check YOUR meds against Skin Hair & Nails?

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Go to the checker
3Drugs
2 Moderate 1 Minor

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Skin Hair & Nails with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bovine Liver2 drug types · 3 drugs

Iron

Liver extract can contain heme iron. Taking liver extract with iron-containing medications or supplements may increase total iron intake and could increase the risk of gastrointestinal adverse effects or excessive iron accumulation. The risk is greater with high doses, prolonged use, or in individuals with hemochromatosis or another iron-overload disorder. Review the iron content of the liver extract and the total elemental iron dose. Avoid unnecessary duplicate iron supplementation and consider monitoring ferritin and transferrin saturation when clinically appropriate.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Liver extract products may contain small and variable amounts of vitamin K. Theoretically, starting, stopping, or substantially changing the amount of liver extract used could reduce the anticoagulant effect of warfarin and lower the INR. However, this interaction has not been directly studied or reported in humans, and the vitamin K content of liver extract products is generally not standardized. Consider monitoring the INR after a meaningful change in liver extract use.

Likelihood Possible Evidence C
The maker

Brand information

Manufacturer and brand details for Skin Hair & Nails, from the product label.

Heart & Soil

See all Heart & Soil products
Name
Heart & Soil, LLC.
City
Austin
State
TX
ZipCode
78746
Web Address
www.heartandsoil.co
Pharmacist Counseling Corner

Skin Hair & Nails by Heart & Soil: Common Questions

Does Skin Hair & Nails by Heart & Soil interact with any medications?
Yes. Based on its ingredients, Skin Hair & Nails has a known interaction with 3 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Skin Hair & Nails contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my skin, hair, and nails?
The collagen and organ extracts are marketed for that purpose, but the evidence in our data is limited. Chondroitin has possibly effective evidence for cataracts and osteoarthritis, not skin or nails. The effectiveness of the collagen, cartilage, peptides, and bone marrow components isn't established in the data we hold. Talk with your doctor or pharmacist about whether it's right for your goals.
Can I take this while I'm pregnant or breastfeeding?
No — chondroitin sulfate should be avoided during pregnancy because there isn't enough safety data. The bovine liver is also a concern during pregnancy due to high vitamin A, which may harm a developing baby. Safety during breastfeeding hasn't been well studied. Talk with your doctor before use if you're pregnant, planning to become pregnant, or breastfeeding.
What are the most common side effects?
Chondroitin sulfate can cause stomach upset — abdominal pain, bloating, constipation, diarrhea, heartburn, or nausea. Skin symptoms like swelling, rash, or hair loss have also been reported. Rare serious effects include liver damage. If you notice any of these, stop and tell your doctor.
Where does the liver come from, and is it safe?
The facts don't specify the source, but bovine liver products carry concerns about potential contamination from raw animal tissue or BSE (mad cow disease) if sourced from certain countries. No human BSE cases from liver extract have been reported, but the facts advise checking the country of origin with the manufacturer. Liver also delivers very high levels of vitamin A and iron, which can build up with long-term use.
What if I take warfarin or iron supplements?
Do not start this product without checking with your doctor or pharmacist. Chondroitin may increase warfarin's blood-thinning effect, and the bovine liver adds vitamin K (which can lower warfarin's effect) and heme iron, which can add to iron from supplements. These interactions need professional review for your specific situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Skin Hair & Nails is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Skin Hair & Nails label
Sources

Sources & How We Checked

Skin Hair & Nails's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 32 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Chondroitin Sulfate 22 references
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  2. Tallia AF, Cardone DA. Asthma exacerbation associated with glucosamine-chondroitin supplement. J Am Board Fam Pract 2002;15:481-4..
  3. Danao-Camara T. Potential side effects of treatment with glucosamine and chondroitin. Arthritis Rheum 2000;43:2853. PubMed
  4. Rozenfeld V, Crain JL, Callahan AK. Possible augmentation of warfarin effect by glucosamine-chondroitin. Am J Health Syst Pharm 2004;61:306-307. PubMed
  5. Clegg DO, Reda DJ, Harris CL, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med 2006;354:795-808. DOI
  6. Knudsen J, Sokol GH. Potential glucosamine-warfarin interaction resulting in increased international normalized ratio: Case report and review of the literature and MedWatch database. Pharmacotherapy 2008;28:540-8. PubMed
  7. Yue QY, Strandell J, Myrberg O. Concomitant use of glucosamine potentiates the effect of warfarin. Jan 2006. Drug Safety 29(10):911-1010. DOI
  8. Nordling, J. and van, Ophoven A. Intravesical glycosaminoglycan replenishment with chondroitin sulphate in chronic forms of cystitis. A multi-national, multi-centre, prospective observational clinical trial. Arzneimittelforschung. 2008;58(7):328-335. PubMed
  9. Nickel, J. C., Egerdie, B., Downey, J., Singh, R., Skehan, A., Carr, L., and Irvine-Bird, K. A real-life multicentre clinical practice study to evaluate the efficacy and safety of intravesical chondroitin sulphate for the treatment of interstitial cystit
  10. Oliviero, U., Sorrentino, G. P., De Paola, P., Tranfaglia, E., D'Alessandro, A., Carifi, S., Porfido, F. A., Cerio, R., Grasso, A. M., Policicchio, D., and . Effects of the treatment with matrix on elderly people with chronic articular degeneration. Drug
  11. Crowley, D. C., Lau, F. C., Sharma, P., Evans, M., Guthrie, N., Bagchi, M., Bagchi, D., Dey, D. K., and Raychaudhuri, S. P. Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial. Int.J.Med.Sc PubMed
  12. Nickel, J. C., Egerdie, R. B., Steinhoff, G., Palmer, B., and Hanno, P. A multicenter, randomized, double-blind, parallel group pilot evaluation of the efficacy and safety of intravesical sodium chondroitin sulfate versus vehicle control in patients with
  13. Sawitzke, A. D., Shi, H., Finco, M. F., Dunlop, D. D., Harris, C. L., Singer, N. G., Bradley, J. D., Silver, D., Jackson, C. G., Lane, N. E., Oddis, C. V., Wolfe, F., Lisse, J., Furst, D. E., Bingham, C. O., Reda, D. J., Moskowitz, R. W., Williams, H. J.
  14. Wildi, L. M., Raynauld, J. P., Martel-Pelletier, J., Beaulieu, A., Bessette, L., Morin, F., Abram, F., Dorais, M., and Pelletier, J. P. Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starti
  15. Pavelka and et al. Double-blind, dose effect study of oral cs 4 & 6 1200mg, 800mg, 200mg against placebo in the treatment of femorotibial osteoarthritis. Wular Rheumatol Liter 1998;27(suppl 2):63.
  16. Cerda C, Bruguera M, Parés A. Hepatotoxicity associated with glucosamine and chondroitin sulfate in patients with chronic liver disease. World J Gastroenterol 2013;19(32):5381-4. PubMed
  17. von Felden J, Montani M, Kessebohm K, Stickel F. Drug-induced acute liver injury mimicking autoimmune hepatitis after intake of dietary supplements containing glucosamine and chondroitin sulfate. Int J Clin Pharmacol Ther 2013;51(3):219-23. PubMed
  18. Provenza JR, Shinjo SK, Silva JM, Peron CR, Rocha FA. Combined glucosamine and chondroitin sulfate, once or three times daily, provides clinically relevant analgesia in knee osteoarthritis. Clin Rheumatol 2015;34:1455-62. PubMed
  19. Ossendza RA, Grandval P, Chinoune F, Rocher F, Chapel F, Bernardini D. [Acute cholestatic hepatitis due to glucosamine forte]. Gastroenterol Clin Biol. 2007 Apr;31(4):449-50.
  20. Greenlee H, Crew KD, Shao T, Kranwinkel G, Kalinsky K, Maurer M, Brafman L, Insel B, Tsai WY, Hershman DL. Phase II study of glucosamine with chondroitin on aromatase inhibitor-associated joint symptoms in women with breast cancer. Support Care Cancer 201 PubMed
  21. Chu EC, Huang KHK, Cheung G, Ng G, Lin A. Delayed Skin Allergy to Glucosamine Chondroitin Supplement. Cureus 2023;15(3):e36310. PubMed
  22. Lila AM, Alekseeva LI, Baranov AA, et al. Chondroitin sulfate and glucosamine combination in patients with knee and hip osteoarthritis: A long-term observational study in Russia. World J Orthop 2023;14(6):443-457. PubMed

See these in context on the Chondroitin Sulfate monograph →

Liver Extract 4 references
  1. Lewis CJ. Letter to reiterate certain public health and safety concerns to firms manufacturing or importing dietary supplements that contain specific bovine tissues. FDA. Available at: www.cfsan.fda.gov/~dms/dspltr05.html.
  2. Kaslow JE, Rucker L, Onishi R. Liver extract-folic acid-cyanocobalamin vs placebo for chronic fatigue syndrome. Arch Intern Med 1989;149:2501-3. DOI
  3. Ebinuma, H., Saito, H., Tada, S., Masuda, T., Kamiya, T., Nishida, J., Yoshioka, M., and Ishii, H. Additive therapeutic effects of the liver extract preparation mixture adelavin-9 on interferon-beta treatment for chronic hepatitis C. Hepatogastroenterolog
  4. Saito, H., Ebinuma, H., Tada, S., Tsunematsu, S., Atsukawa, K., Masuda, T., Tsuchiya, M., and Ishii, H. Enhancing effect of the liver extract and flavin adenin dinucleotide mixture on anti-viral efficacy of interferon in patients with chronic hepatitis C. PubMed

See these in context on the Liver Extract monograph →

Bovine Cartilage 6 references
  1. Prudden JF, Balassa LL. The biological activity of bovine cartilage preparations. Clinical demonstration of their potent anti-inflammatory capacity with supplementary notes on certain relevant fundamental supportive studies. Semin Arthritis Rheum 1974;3:2 PubMed
  2. Prudden JF. The treatment of human cancer with agents prepared from bovine cartilage. J Biol Response Mod 1985;4:551-84.
  3. Durk, H., Haase, K., Saal, J., Becker, W., and Berg, P. A. Nephrotic syndrome after injections of bovine cartilage and marrow extract. Lancet 3-18-1989;1(8638):614. PubMed
  4. Schacht, E. and Roetz, R. Nephrotic syndrome after injections of bovine cartilage and marrow extract. Lancet 4-29-1989;1(8644):963. PubMed
  5. Berg, P. A., Durk, H., Saal, J., and Hopf, G. Bovine cartilage and marrow extract. Lancet 6-3-1989;1(8649):1275. PubMed
  6. Pavelka K, Gatterova J, Gollerova V, et al. A 5-year randomized controlled, double-blind study of glycosaminoglycan polysulphuric acid complex (Rumalon) as a structure modifying therapy in osteoarthritis of the hip and knee. Osteoarthritis Cartilage 2000; PubMed

See these in context on the Bovine Cartilage monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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