Skin Hair & Nails Ingredients & Drug Interactions
by Heart & Soil
What is this page for?
First and foremost: checking Skin Hair & Nails against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Skin Hair & Nails is a dietary supplement by Heart & Soil with 3 active ingredients. Its ingredients are commonly taken for anemia and low iron, vitamin b12 support, general energy and fatigue.Based on those ingredients, 3 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bovine Liver. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Skin Hair & Nails by Heart & Soil
Ask about any prescription or over-the-counter medication and we check it for interactions with Skin Hair & Nails by Heart & Soil — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Skin Hair & Nails by Heart & Soil
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
This 6-ingredient supplement centers on collagen and bone-derived compounds meant to support skin, hair, and nails. It contains chondroitin sulfate (a cartilage component often studied for joint health), bovine liver (organ meat concentrate), trachea collagen, scapula collagen, bovine cartilage, peptides, and bovine bone marrow.
The product comes in capsules with bovine gelatin as the inactive ingredient.
Does it work?
Not established
Chondroitin sulfate has possibly effective evidence for cataracts and osteoarthritis (joint wear-and-tear). For aging skin, osteoporosis (weak bones), high cholesterol (hyperlipidemia), and colorectal adenoma, the evidence is insufficient to rate it.
Bovine liver shows possibly ineffective evidence for chronic fatigue syndrome. The effectiveness of the collagen, cartilage, peptides, and bone marrow ingredients we hold in our data is not established.
How safe is it?
Well-documented data
Chondroitin sulfate is generally well tolerated for short-term use, though quality varies and benefits are uncertain. Most common side effects from oral use are stomach upset — abdominal pain, bloating, constipation, diarrhea, heartburn, nausea.
Rare serious effects include liver damage (hepatotoxicity). Skin symptoms like eyelid or leg swelling, hair loss, rash, and hives have been reported, and a case of worsened asthma occurred with a glucosamine-chondroitin product.
Bovine liver is generally low-risk for healthy adults in food amounts but can deliver high levels of vitamin A and iron; there's also concern about potential contamination from raw animal liver or BSE (mad cow disease) if sourced from affected countries, though no human cases from liver extract have been reported. Safety during breastfeeding hasn't been well studied.
During pregnancy, chondroitin should be avoided due to insufficient safety data, and liver products carry risk from high vitamin A, which may harm a developing baby.
Meds to double-check
Moderate interaction found
If you take warfarin (Coumadin) or any blood thinner, flag this product with your doctor or pharmacist before use — chondroitin plus glucosamine can increase warfarin's anticoagulant effect and raise INR, and even chondroitin alone's effect isn't fully clear. Similarly, if you're on iron supplements or iron-containing medications, check first because the bovine liver in this product adds heme iron.
Tell your provider right away if you start, stop, or change the amount you're taking.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
This product is built around collagen and organ extracts marketed for skin, hair, and nails support, but the evidence for most ingredients is limited or not established. If you take warfarin or iron supplements, you'll want to check with your doctor or pharmacist before starting — the interactions are real, though most are rated Moderate or Minor.
Pregnant people and those breastfeeding should talk with their healthcare provider first, especially given the vitamin A load in the liver component.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 21, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Skin Hair & Nails, straight from the product label.
| Brand | Heart & Soil |
|---|---|
| Barcode (UPC) | 850018088060 |
| Net contents | 180 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Apr 21, 2023 |
| DSLD ID | 276356 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Skin Hair & Nails by Heart & Soil, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Chondroitin Sulfate | 0 NP | -- |
| Bovine Liver | 600 mg | -- |
| Trachea collagen | 0 NP | -- |
| Scapula Collagen | 0 NP | -- |
| Bovine Cartilage | 1200 mg | -- |
| Peptides | 0 NP | -- |
| Bovine Bone Marrow | 1200 mg | -- |
Other ingredients: Bovine Gelatin
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Reclaim your birthright to radical health. It breaks my heart to see how our families and our children struggle with fatigue, brain fog, mood issues, infertility, and autoimmunity. Is this the new normal that will become our future? Why have we forsaken the vitality that is our birthright and accepted this suffering as inescapable? I believe with all my soul that the solution is nose-to-tail nourishment. It starts with the soil and regenerative practices that heal the land, love, and nourish our animals so that we may be deeply nourished in turn. When we honor and consume animals nose-to-tail, we receive all of the nutrients needed to thrive, in the most bioavailable forms. This is my passion, my purpose, my entire heart & soul. Let me show you a brighter future. Visit us online at www.heartandsoil.co to start your journey today. Paul Saladino, M.D.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Formula
3 g organs per serving
Skin Hair & Nails 500 mg ea 180 capsules
Formulation
Regenerative Small batch 100% grass-fed 100% grass-finished
Suggested/Recommended/Usage/Directions
Suggested Use: 6 capsules daily or as directed by a healthcare professional
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Skin Hair & Nails by Heart & Soil label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Skin Hair & Nails by Heart & Soil
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size6 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Bovine Liver
Interacts with3 drugs
Liver extract is a dried or concentrated form of animal liver that is naturally rich in iron, vitamin B12, vitamin A, and other nutrients. It was once...
Bovine Liver monograph & interactionsBovine Cartilage
No knowninteractions
Bovine cartilage is an animal-derived supplement that some people use for joint health, inflammation, and as an unproven cancer aid. The scientific ev...
Bovine Cartilage monograph & interactions- › Chondroitin Sulfate
- › Trachea collagen
- › Scapula Collagen
- › Peptides
Bovine Bone Marrow
Other (inactive) ingredients: Bovine Gelatin. These complete the product’s ingredient list but are not active constituents.
Skin Hair & Nails by Heart & Soil Drug Interactions
HelloPharmacist Interaction Report
Heart & Soil's Skin Hair & Nails interacts with medications through its chondroitin sulfate and bovine liver content.
The most serious concern is a Moderate interaction with warfarin (Coumadin), a blood thinner (anticoagulant): chondroitin combined with glucosamine may increase warfarin's blood-thinning effect and raise your INR (a measure of how thin your blood is), though chondroitin alone is less clear. There have been multiple reports of this with the combination.
Read the full breakdown — every affected drug type, severity by severity
Bovine liver poses two Minor interactions. It contains small amounts of vitamin K, which could theoretically reduce warfarin's effect if you start, stop, or significantly change how much of this product you take — though this hasn't been directly studied in people.
Liver also contains heme iron (a form of iron from animal sources), so taking it alongside iron supplements or iron-containing medications may increase your total iron intake and raise the risk of stomach upset or iron buildup, especially at high doses or with prolonged use.
We couldn't find interaction data for trachea collagen, scapula collagen, peptides, or bovine bone marrow. Altogether, these interactions span 3 individual medications.
Check your exact medications with the tool on this page before starting.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Skin Hair & Nails?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Skin Hair & Nails interact with 3 drugs. Click any drug to see the details.
1 of the 3 ingredients in Skin Hair & Nails interact with drugs. Each result below shows which ingredient is responsible. Bovine Liver
WarfarinWarfarin
How Warfarin interacts with Skin Hair & Nails — through 2 ingredients. Tap an ingredient for the detail:
Chondroitin SulfateWarfarin (coumadin) Moderate
Interaction Summary
Taking chondroitin in combination with glucosamine might increase the anticoagulant effects of warfarin.
Read the full Chondroitin Sulfate + Warfarin interactionBovine LiverWarfarin (coumadin) Minor
Interaction Summary
Liver extract products may contain small and variable amounts of vitamin K.
Read the full Bovine Liver + Warfarin interactionWarfarin SodiumCoumadin, Panwarfin, Sofarin
How Warfarin Sodium interacts with Skin Hair & Nails — through 2 ingredients. Tap an ingredient for the detail:
Chondroitin SulfateWarfarin (coumadin) Moderate
Interaction Summary
Taking chondroitin in combination with glucosamine might increase the anticoagulant effects of warfarin.
Read the full Chondroitin Sulfate + Warfarin Sodium interactionBovine LiverWarfarin (coumadin) Minor
Interaction Summary
Liver extract products may contain small and variable amounts of vitamin K.
Read the full Bovine Liver + Warfarin Sodium interactionFerrous SulfateFeosol
How Ferrous Sulfate interacts with Skin Hair & Nails — through 1 ingredient. Tap an ingredient for the detail:
Bovine LiverIron Minor
Interaction Summary
Liver extract can contain heme iron.
Read the full Bovine Liver + Ferrous Sulfate interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Skin Hair & Nails with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Bovine Liver
Iron
Liver extract can contain heme iron. Taking liver extract with iron-containing medications or supplements may increase total iron intake and could increase the risk of gastrointestinal adverse effects or excessive iron accumulation. The risk is greater with high doses, prolonged use, or in individuals with hemochromatosis or another iron-overload disorder. Review the iron content of the liver extract and the total elemental iron dose. Avoid unnecessary duplicate iron supplementation and consider monitoring ferritin and transferrin saturation when clinically appropriate.
Warfarin (Coumadin)
Liver extract products may contain small and variable amounts of vitamin K. Theoretically, starting, stopping, or substantially changing the amount of liver extract used could reduce the anticoagulant effect of warfarin and lower the INR. However, this interaction has not been directly studied or reported in humans, and the vitamin K content of liver extract products is generally not standardized. Consider monitoring the INR after a meaningful change in liver extract use.
Brand information
Manufacturer and brand details for Skin Hair & Nails, from the product label.
Heart & Soil
See all Heart & Soil products- Name
- Heart & Soil, LLC.
- City
- Austin
- State
- TX
- ZipCode
- 78746
- Web Address
- www.heartandsoil.co
Skin Hair & Nails by Heart & Soil: Common Questions
Does Skin Hair & Nails by Heart & Soil interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will this help my skin, hair, and nails?
Can I take this while I'm pregnant or breastfeeding?
What are the most common side effects?
Where does the liver come from, and is it safe?
What if I take warfarin or iron supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Skin Hair & Nails is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Skin Hair & Nails’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Liver Extract
Interacts with 3 drugsLiver extract is a dried or concentrated form of animal liver that is naturally rich in iron, vitamin B12, vitamin A, and other nutrients. It was once used to treat certain anemias before pu...
Read the full Liver Extract monograph → Herb & supplement monographBovine Cartilage
Bovine cartilage is an animal-derived supplement that some people use for joint health, inflammation, and as an unproven cancer aid. The scientific evidence supporting these uses is weak and...
Read the full Bovine Cartilage monograph → Herb & supplement monographChondroitin Sulfate
Interacts with 2 drugsChondroitin sulfate is a naturally occurring building block of cartilage that is widely taken, often with glucosamine, for osteoarthritis joint pain. The evidence is mixed—some people report...
Read the full Chondroitin Sulfate monograph →Sources & How We Checked
Skin Hair & Nails's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 32 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Chondroitin Sulfate 22 references
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
- Tallia AF, Cardone DA. Asthma exacerbation associated with glucosamine-chondroitin supplement. J Am Board Fam Pract 2002;15:481-4..
- Danao-Camara T. Potential side effects of treatment with glucosamine and chondroitin. Arthritis Rheum 2000;43:2853. PubMed
- Rozenfeld V, Crain JL, Callahan AK. Possible augmentation of warfarin effect by glucosamine-chondroitin. Am J Health Syst Pharm 2004;61:306-307. PubMed
- Clegg DO, Reda DJ, Harris CL, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med 2006;354:795-808. DOI
- Knudsen J, Sokol GH. Potential glucosamine-warfarin interaction resulting in increased international normalized ratio: Case report and review of the literature and MedWatch database. Pharmacotherapy 2008;28:540-8. PubMed
- Yue QY, Strandell J, Myrberg O. Concomitant use of glucosamine potentiates the effect of warfarin. Jan 2006. Drug Safety 29(10):911-1010. DOI
- Nordling, J. and van, Ophoven A. Intravesical glycosaminoglycan replenishment with chondroitin sulphate in chronic forms of cystitis. A multi-national, multi-centre, prospective observational clinical trial. Arzneimittelforschung. 2008;58(7):328-335. PubMed
- Nickel, J. C., Egerdie, B., Downey, J., Singh, R., Skehan, A., Carr, L., and Irvine-Bird, K. A real-life multicentre clinical practice study to evaluate the efficacy and safety of intravesical chondroitin sulphate for the treatment of interstitial cystit
- Oliviero, U., Sorrentino, G. P., De Paola, P., Tranfaglia, E., D'Alessandro, A., Carifi, S., Porfido, F. A., Cerio, R., Grasso, A. M., Policicchio, D., and . Effects of the treatment with matrix on elderly people with chronic articular degeneration. Drug
- Crowley, D. C., Lau, F. C., Sharma, P., Evans, M., Guthrie, N., Bagchi, M., Bagchi, D., Dey, D. K., and Raychaudhuri, S. P. Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial. Int.J.Med.Sc PubMed
- Nickel, J. C., Egerdie, R. B., Steinhoff, G., Palmer, B., and Hanno, P. A multicenter, randomized, double-blind, parallel group pilot evaluation of the efficacy and safety of intravesical sodium chondroitin sulfate versus vehicle control in patients with
- Sawitzke, A. D., Shi, H., Finco, M. F., Dunlop, D. D., Harris, C. L., Singer, N. G., Bradley, J. D., Silver, D., Jackson, C. G., Lane, N. E., Oddis, C. V., Wolfe, F., Lisse, J., Furst, D. E., Bingham, C. O., Reda, D. J., Moskowitz, R. W., Williams, H. J.
- Wildi, L. M., Raynauld, J. P., Martel-Pelletier, J., Beaulieu, A., Bessette, L., Morin, F., Abram, F., Dorais, M., and Pelletier, J. P. Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starti
- Pavelka and et al. Double-blind, dose effect study of oral cs 4 & 6 1200mg, 800mg, 200mg against placebo in the treatment of femorotibial osteoarthritis. Wular Rheumatol Liter 1998;27(suppl 2):63.
- Cerda C, Bruguera M, Parés A. Hepatotoxicity associated with glucosamine and chondroitin sulfate in patients with chronic liver disease. World J Gastroenterol 2013;19(32):5381-4. PubMed
- von Felden J, Montani M, Kessebohm K, Stickel F. Drug-induced acute liver injury mimicking autoimmune hepatitis after intake of dietary supplements containing glucosamine and chondroitin sulfate. Int J Clin Pharmacol Ther 2013;51(3):219-23. PubMed
- Provenza JR, Shinjo SK, Silva JM, Peron CR, Rocha FA. Combined glucosamine and chondroitin sulfate, once or three times daily, provides clinically relevant analgesia in knee osteoarthritis. Clin Rheumatol 2015;34:1455-62. PubMed
- Ossendza RA, Grandval P, Chinoune F, Rocher F, Chapel F, Bernardini D. [Acute cholestatic hepatitis due to glucosamine forte]. Gastroenterol Clin Biol. 2007 Apr;31(4):449-50.
- Greenlee H, Crew KD, Shao T, Kranwinkel G, Kalinsky K, Maurer M, Brafman L, Insel B, Tsai WY, Hershman DL. Phase II study of glucosamine with chondroitin on aromatase inhibitor-associated joint symptoms in women with breast cancer. Support Care Cancer 201 PubMed
- Chu EC, Huang KHK, Cheung G, Ng G, Lin A. Delayed Skin Allergy to Glucosamine Chondroitin Supplement. Cureus 2023;15(3):e36310. PubMed
- Lila AM, Alekseeva LI, Baranov AA, et al. Chondroitin sulfate and glucosamine combination in patients with knee and hip osteoarthritis: A long-term observational study in Russia. World J Orthop 2023;14(6):443-457. PubMed
Liver Extract 4 references
- Lewis CJ. Letter to reiterate certain public health and safety concerns to firms manufacturing or importing dietary supplements that contain specific bovine tissues. FDA. Available at: www.cfsan.fda.gov/~dms/dspltr05.html.
- Kaslow JE, Rucker L, Onishi R. Liver extract-folic acid-cyanocobalamin vs placebo for chronic fatigue syndrome. Arch Intern Med 1989;149:2501-3. DOI
- Ebinuma, H., Saito, H., Tada, S., Masuda, T., Kamiya, T., Nishida, J., Yoshioka, M., and Ishii, H. Additive therapeutic effects of the liver extract preparation mixture adelavin-9 on interferon-beta treatment for chronic hepatitis C. Hepatogastroenterolog
- Saito, H., Ebinuma, H., Tada, S., Tsunematsu, S., Atsukawa, K., Masuda, T., Tsuchiya, M., and Ishii, H. Enhancing effect of the liver extract and flavin adenin dinucleotide mixture on anti-viral efficacy of interferon in patients with chronic hepatitis C. PubMed
Bovine Cartilage 6 references
- Prudden JF, Balassa LL. The biological activity of bovine cartilage preparations. Clinical demonstration of their potent anti-inflammatory capacity with supplementary notes on certain relevant fundamental supportive studies. Semin Arthritis Rheum 1974;3:2 PubMed
- Prudden JF. The treatment of human cancer with agents prepared from bovine cartilage. J Biol Response Mod 1985;4:551-84.
- Durk, H., Haase, K., Saal, J., Becker, W., and Berg, P. A. Nephrotic syndrome after injections of bovine cartilage and marrow extract. Lancet 3-18-1989;1(8638):614. PubMed
- Schacht, E. and Roetz, R. Nephrotic syndrome after injections of bovine cartilage and marrow extract. Lancet 4-29-1989;1(8644):963. PubMed
- Berg, P. A., Durk, H., Saal, J., and Hopf, G. Bovine cartilage and marrow extract. Lancet 6-3-1989;1(8649):1275. PubMed
- Pavelka K, Gatterova J, Gollerova V, et al. A 5-year randomized controlled, double-blind study of glycosaminoglycan polysulphuric acid complex (Rumalon) as a structure modifying therapy in osteoarthritis of the hip and knee. Osteoarthritis Cartilage 2000; PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC