Interactions on record — worth a quick check against your medications. Based on 5 of 6 ingredients. Check your meds →
Dietary supplement

Gut Soothe Ingredients & Drug Interactions

by Terry Naturally

Gut Soothe label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Gut Soothe against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Gut Soothe is a dietary supplement by Terry Naturally with 6 active ingredients. Its ingredients are commonly taken for sore throat and cough, heartburn and stomach upset, mouth ulcers and digestive complaints.Based on those ingredients, 1,186 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Deglycyrrhizinated Licorice (DGL) (Glycyrrhiza glabra) root extract, Bifidobacterium bifidum, Lactobacillus acidophilus. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Gut Soothe by Terry Naturally

Ask about any prescription or over-the-counter medication and we check it for interactions with Gut Soothe by Terry Naturally — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Gut Soothe by Terry Naturally

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 2 of its 6 active ingredients.
  • “Proprietary Probiotic Blend” is a proprietary blend — the label gives one combined amount (500 mg) without saying how much of each component you get.

Gut Soothe contains 6 active ingredients: three strains of beneficial bacteria (Bifidobacterium bifidum, Lactobacillus acidophilus, and Bifidobacterium longum), a prebiotic fiber called fructooligosaccharide (FOS) that feeds good bacteria, and deglycyrrhizinated licorice (DGL) — licorice root with the glycyrrhizin removed to reduce the risk of side effects from the whole plant. The proprietary blend container lists these bacteria together; their individual amounts are not broken out on the label.

The capsule also contains inactive ingredients: vegetable cellulose capsule material, rice dextrin, silicon dioxide, and vegetable-source magnesium stearate.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: supports healthy digestive function and stomach lining.
  • We looked for evidence on: Antibiotic-associated diarrhea, Diarrhea, Constipation, Dyspepsia, Helicobacter pylori, Clostridioides difficile infection — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Helicobacter pylori, Irritable bowel syndrome (IBS).
  • Also on file: Bifidobacterium Bifidum is rated "Possibly Effective" for Irritable bowel syndrome (IBS).

The probiotics in this formula — Bifidobacterium bifidum and Lactobacillus acidophilus — are possibly effective for irritable bowel syndrome (IBS). L. acidophilus is also possibly effective for antibiotic-associated diarrhea, Helicobacter pylori infection, and bacterial vaginosis, while B. longum and B. bifidum have insufficient evidence to rate for most of the conditions studied.

Fructooligosaccharide has insufficient evidence for the conditions on file. Deglycyrrhizinated licorice is possibly effective for eczema and canker sores.

For most other uses listed in the data, the evidence is too limited to say whether the ingredients work.

The evidence, ingredient by ingredient Licorice Bifidobacterium Bifidum Lactobacillus Acidophilus Bifidobacterium Longum Fructo-oligosaccharides (fos)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

The probiotics are generally well tolerated in healthy people, but those with weakened immune systems should be cautious, and you should check with your doctor before use since the safety data are limited. Rare cases of bacterial bloodstream infection (sepsis) have been reported in critically ill patients taking Bifidobacterium species, but these are uncommon.

The most frequent side effects from the probiotics and FOS are bloating, flatulence, and abdominal discomfort, though a meta-analysis of FOS studies showed these symptoms did not increase compared to placebo at doses up to 15 grams daily. Deglycyrrhizinated licorice is generally well tolerated in the amounts found in food, but the safety data advises against use in pregnancy, and there isn't enough reliable information to know if it's safe while breastfeeding — talk with your doctor or pharmacist if you're pregnant or nursing.

For Bifidobacterium animalis lactis, pregnancy and lactation safety data aren't on file.

Side effects, ingredient by ingredient Licorice Bifidobacterium Bifidum Lactobacillus Acidophilus Bifidobacterium Longum Fructo-oligosaccharides (fos)

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 5 matched ingredients can interact with medications — Lactobacillus Acidophilus, Licorice, Bifidobacterium Bifidum, Bifidobacterium Longum.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; heart-rhythm medications.
  • For scale: 1,187 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking Gut Soothe if you take antibiotics (the probiotics may lose potency if timed wrong), digoxin or other heart medications, warfarin or other blood thinners, loop diuretics (water pills), midazolam or other sedatives, or cancer drugs like cisplatin or paclitaxel. No interactions are documented for the ingredient we could not check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Gut Soothe may help with IBS and a few specific digestive concerns if the probiotics work for you, and it's generally well tolerated by healthy people. If you take any prescription medication — especially heart drugs, blood thinners, antibiotics, cancer treatments, or sedatives — check with your doctor or pharmacist before starting, because the licorice and probiotics can interact significantly.

Pregnant or breastfeeding people should talk with their healthcare provider first, since safety data are limited or advise against use.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 25, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Gut Soothe, straight from the product label.

Brand Terry Naturally
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Nov 25, 2014
DSLD ID 39750
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Gut Soothe by Terry Naturally, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
IngredientAmount% DV
Bifidobacterium bifidum0 NP--
Lactobacillus acidophilus0 NP--
Bifidobacterium animalis lactis0 NP--
Bifidobacterium longum0 NP--
Fructooligosaccharide50 mg--
Deglycyrrhizinated Licorice (DGL) (Glycyrrhiza glabra) root extract300 mg--
Proprietary Probiotic Blend500 mg--

Other ingredients: Vegetable Cellulose Capsule, Rice Dextrin, Silicon Dioxide, Vegetable Source Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

EuroPharma(R)

Terry Naturally(R)

Formulation

Contains no sugar, salt, yeast, wheat, gluten, soy, dairy products, artificial coloring, artificial flavoring, or preservatives.

General Statements

Made in the USA

UNCONDITIONALLY GUARANTEED

- Supports and promotes a healthy stomach lining - Provides antioxidant support to digestive tract - Helps to maintain healthy digestive function - Maintains healthy intestinal flora*

Clinically Studied Ingredients For Your Good Health

{signature} Terry

Suggested/Recommended/Usage/Directions

Recommendations: 2 capsules daily, may take as 1 capsule twice daily.

Precautions

If pregnant or nursing, consult a healthcare practitioner before using.

If pregnant or nursing, consult a healthcare practitioner before use.

Storage

No refrigeration necessary. Stable at room temperature (70°F).

FDA Disclaimer Statement

* THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE OR PREVENT ANY DISEASE.

General

JC 34 91 + 3(5,6)EP L40706.03

Formula

Probiotic with DGL For Healthy Intestinal Tract Support*

FDA Statement of Identity

DIETARY SUPPLEMENT

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Gut Soothe by Terry Naturally label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Gut Soothe label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Gut Soothe by Terry Naturally

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Deglycyrrhizinated Licorice (DGL) (Glycyrrhiza glabra) root extract

Interacts with
1,040 drugs
300 mg per serving Form: Glabridin, Total Flavonoids

Licorice root is a traditional remedy used for sore throats, coughs, and digestive complaints, but solid human evidence is limited for most uses. Regu...

Deglycyrrhizinated Licorice (DGL) (Glycyrrhiza glabra) root extract monograph & interactions

Proprietary Probiotic Blend

500 mg per serving

Other (inactive) ingredients: Vegetable Cellulose Capsule, Rice Dextrin, Silicon Dioxide, Vegetable Source Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Gut Soothe by Terry Naturally Drug Interactions

Want to check YOUR meds against Gut Soothe?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,186Drugs
1,124 Moderate 62 Minor

Ingredients driving the most interactions

Deglycyrrhizinated Licorice (DGL) (Glycyrrhiza glabra) root extract 1,040
Bifidobacterium bifidum 182
Lactobacillus acidophilus 182
Bifidobacterium longum 182

Individual Drug Interactions

The ingredients in Gut Soothe interact with 1,186 drugs. Click any drug to see the details.

4 of the 6 ingredients in Gut Soothe interact with drugs. Each result below shows which ingredient is responsible. Deglycyrrhizinated Licorice (DGL) (Glycyrrhiza glabra) root extract Bifidobacterium bifidum Lactobacillus acidophilus Bifidobacterium longum

Each ingredient & the kinds of drugs it affects

For each ingredient in Gut Soothe with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Deglycyrrhizinated Licorice (DGL) (Glycyrrhiza glabra) root extract18 drug types · 1,040 drugs

Antihypertensive Drugs

Theoretically, licorice might reduce the effects of antihypertensive drugs.
In human research, licorice increases blood pressure in a dose-dependent manner.

Likelihood Possible Evidence B
Cisplatin (Platinol-Aq)

Theoretically, licorice might reduce the effects of cisplatin.
In animal research, licorice diminished the therapeutic efficacy of cisplatin.

Likelihood Possible Evidence D
Corticosteroids

Theoretically, concomitant use of licorice and corticosteroids might increase the side effects of corticosteroids.
Case reports suggest that concomitant use of licorice and oral corticosteroids, such as hydrocortisone, can potentiate the duration of activity and increase blood levels of corticosteroids. Additionally, in one case report, a patient with neurogenic orthostatic hypertension stabilized on fludrocortisone 0.1 mg twice daily developed pseudohyperaldosteronism after recent consumption of large amounts of black licorice.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, licorice might increase levels of drugs metabolized by CYP2B6.
In vitro research shows that licorice extract and glabridin, a licorice constituent, inhibit CYP2B6 isoenzymes. Licorice extract from the species G. uralensis seems to inhibit CYP2B6 isoenzymes to a greater degree than G. glabra extract in vitro. Theoretically, these species of licorice might increase levels of drugs metabolized by CYP2B6; however, these interactions have not yet been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, licorice might increase levels of drugs metabolized by CYP2C19.
In vitro, licorice extracts from the species G. glabra and G. uralensis inhibit CYP2C19 isoenzymes in vitro. Theoretically, these species of licorice might increase levels of drugs metabolized by CYP2C19; however, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C8 (Cyp2C8) Substrates

Theoretically, licorice might increase levels of drugs metabolized by CYP2C8.
In vitro, licorice extract from the species G. glabra and G. uralensis inhibits CYP2C8 isoenzymes. Theoretically, these species of licorice might increase levels of drugs metabolized by CYP2C8; however, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP2C9.
There is conflicting evidence about the effect of licorice on CYP2C9 enzyme activity. In vitro research shows that extracts from the licorice species G. glabra and G. uralensis moderately inhibit CYP2C9 isoenzymes. However, evidence from an animal model shows that licorice extract from the species G. uralensis can induce hepatic CYP2C9 activity. Until more is known, licorice should be used cautiously in people taking CYP2C9 substrates.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Pharmacokinetic research shows that the licorice constituent glycyrrhizin, taken in a dosage of 150 mg orally twice daily for 14 days, modestly decreases the area under the concentration-time curve of midazolam by about 20%. Midazolam is a substrate of CYP3A4, suggesting that glycyrrhizin modestly induces CYP3A4 activity. Animal research also shows that licorice extract from the species G. uralensis induces CYP3A4 activity. However, licorice extract from G. glabra species appear to inhibit CYP3A4-induced metabolism of testosterone in vitro. It is thought that the G. glabra inhibits CYP3A4 due to its constituent glabridin, which is a moderate CYP3A4 inhibitor in vitro and not present in other licorice species. Until more is known, licorice should be used cautiously in people taking CYP3A4 substrates.

Likelihood Possible Evidence B
Digoxin (Lanoxin)

Theoretically, concomitant use of licorice with digoxin might increase the risk of cardiac toxicity.
Overuse or misuse of licorice with cardiac glycoside therapy might increase the risk of cardiac toxicity due to potassium loss.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, concomitant use of licorice with diuretic drugs might increase the risk of hypokalemia.
Overuse of licorice might compound diuretic-induced potassium loss. In one case report, a 72-year-old male with a past medical history of hypertension, type 2 diabetes, hyperlipidemia, arrhythmia, stroke, and hepatic dysfunction was hospitalized with severe hypokalemia and uncontrolled hypertension due to pseudohyperaldosteronism. This was thought to be provoked by concomitant daily consumption of a product containing 225 mg of glycyrrhizin, a constituent of licorice, and hydrochlorothiazide 12.5 mg for 1 month.

Likelihood Possible Evidence D
Estrogens

Theoretically, licorice might increase or decrease the effects of estrogen therapy.
Theoretically, licorice might interfere with estrogen therapy due to estrogenic and anti-estrogenic effects.

Likelihood Possible Evidence D
Loop Diuretics

Theoretically, loop diuretics might increase the mineralocorticoid effects of licorice.
Theoretically, loop diuretics might enhance the mineralocorticoid effects of licorice by inhibiting the enzyme that converts cortisol to cortisone; however, bumetanide (Bumex) does not appear to have this effect.

Likelihood Possible Evidence D
Midazolam (Versed)

Theoretically, licorice might decrease levels of midazolam.
In humans, the licorice constituent glycyrrhizin appears to moderately induce the metabolism of midazolam. This is likely due to induction of cytochrome P450 3A4 by licorice. Until more is known, licorice should be used cautiously in people taking midazolam.

Likelihood Possible Evidence B
P-Glycoprotein Substrates

Theoretically, licorice might decrease the absorption of P-glycoprotein substrates.
In vitro research shows that licorice can increase P-glycoprotein activity.

Likelihood Possible Evidence D
Paclitaxel (Abraxane, Onxol)

Theoretically, licorice might decrease plasma levels and clinical effects of paclitaxel.
Multiple doses of licorice taken concomitantly with paclitaxel might reduce the effectiveness of paclitaxel. Animal research shows that licorice 3 grams/kg given orally for 14 days before intravenous administration of paclitaxel decreases the exposure to paclitaxel and increases its clearance. Theoretically, this occurs because licorice induces cytochrome P450 3A4 enzymes, which metabolize paclitaxel. Notably, a single dose of licorice did not affect exposure or clearance of paclitaxel.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, licorice might decrease plasma levels and clinical effects of warfarin.
Licorice seems to increase metabolism and decrease levels of warfarin in animal models. This is likely due to induction of cytochrome P450 2C9 (CYP2C9) metabolism by licorice. Advise patients taking warfarin to avoid taking licorice.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that licorice induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Methotrexate (Trexall, Others)

Theoretically, licorice might increase levels of methotrexate.
Animal research suggests that intravenous administration of glycyrrhizin, a licorice constituent, and high-dose methotrexate may delay methotrexate excretion and increase systemic exposure, leading to transient elevations in liver enzymes and total bilirubin. This interaction has not yet been reported in humans.

Likelihood Unlikely Evidence D
Deglycyrrhizinated Licorice (DGL) (Glycyrrhiza glabra) root extract full monograph & interactions

Bifidobacterium bifidum1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium. bifidum with antibiotic drugs might decrease the effectiveness of B. bifidum.
Since B. bifidum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. bifidum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium bifidum full monograph & interactions

Lactobacillus acidophilus1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus full monograph & interactions

Bifidobacterium longum1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B. longum.
Since B. longum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. longum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium longum full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Gut Soothe, from the product label.

Terry Naturally

See all Terry Naturally products
Name
EuroPharma, Inc.
City
Green Bay
State
WI
ZipCode
54311
Phone Number
(866) 807-2731
Web Address
www.EuroPharmaUSA.com
Pharmacist Counseling Corner

Gut Soothe by Terry Naturally: Common Questions

Does Gut Soothe by Terry Naturally interact with any medications?
Yes. Based on its ingredients, Gut Soothe has a known interaction with 1,186 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Gut Soothe contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this work if I'm on antibiotics?
The probiotics in Gut Soothe may lose effectiveness if you take them at the same time as antibiotics, because antibiotics can kill the live bacteria in the capsules. Space them out — take your antibiotic and the probiotic several hours apart, or ask your doctor or pharmacist for the best timing.
What's in the capsule besides the probiotics?
The formula includes a prebiotic fiber called fructooligosaccharide (FOS) that feeds the beneficial bacteria, and deglycyrrhizinated licorice (DGL), which is licorice root stripped of glycyrrhizin to reduce potential side effects. The capsule itself is made from vegetable cellulose, and the other inactive ingredients are rice dextrin, silicon dioxide, and magnesium stearate.
Is it safe to take while pregnant?
The probiotics are possibly safe in pregnancy, but the licorice in this formula is considered unsafe during pregnancy because of possible harmful effects from glycyrrhizin, even though the DGL form has most of it removed. Talk with your doctor before taking Gut Soothe if you're pregnant.
Can it cause bloating or gas?
Yes — bloating, flatulence, and abdominal discomfort are the most common side effects from both the probiotics and the FOS prebiotic. These tend to be mild, and a large review of studies showed they don't occur more often than placebo at typical doses, so they often settle as your gut adjusts.
Does this formula actually help with IBS?
The two main probiotics in Gut Soothe — Bifidobacterium bifidum and Lactobacillus acidophilus — are possibly effective for IBS based on available evidence. Results vary between people, so it may help you, but it's not guaranteed.
Is it safe if I have a weak immune system?
The probiotics should be used cautiously if you have a weakened immune system, and you should check with your doctor before taking Gut Soothe. Although serious infections from these bacteria are rare, they have been reported in critically ill or immune-compromised patients.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Gut Soothe label
Go deeper

The Full Monographs Behind Gut Soothe’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Licorice

Interacts with 1,040 drugs

Licorice root is a traditional remedy used for sore throats, coughs, and digestive complaints, but solid human evidence is limited for most uses. Regular licorice contains glycyrrhizin, whic...

Read the full Licorice monograph → Herb & supplement monograph

Bifidobacterium Bifidum

Interacts with 182 drugs

Bifidobacterium bifidum is a 'friendly' bacteria (probiotic) that naturally lives in the human gut and is taken to support digestion and gut balance. Some evidence suggests probiotics may he...

Read the full Bifidobacterium Bifidum monograph → Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph → Herb & supplement monograph

Bifidobacterium Longum

Interacts with 182 drugs

Bifidobacterium longum is a 'friendly' bacterium found naturally in the human gut and used as a probiotic. It is generally well tolerated and is most studied for digestive issues, though evi...

Read the full Bifidobacterium Longum monograph → Herb & supplement monograph

Fructo-oligosaccharides (fos)

Fructo-oligosaccharides (FOS) are a type of soluble fiber that acts as a prebiotic, meaning they feed the helpful bacteria in your gut. They are generally considered safe for most people in...

Read the full Fructo-oligosaccharides (fos) monograph →
Sources

Sources & How We Checked

Gut Soothe's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 141 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bifidobacterium Bifidum 7 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Rerksuppaphol S, Rerksuppaphol L. Randomized controlled trial of probiotics to reduce common cold in schoolchildren. Pediatr Int. 2012;54(5):682-7. PubMed
  4. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  5. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  6. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  7. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed

See these in context on the Bifidobacterium Bifidum monograph →

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
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  91. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
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See these in context on the Licorice monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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