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Dietary supplement

HA Hyaluronic Acid Formula Ingredients & Drug Interactions

by California Natural

HA Hyaluronic Acid Formula label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking HA Hyaluronic Acid Formula against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

HA Hyaluronic Acid Formula is a dietary supplement by California Natural with 3 active ingredients. Its ingredients are commonly taken for skin hydration and aging, joint comfort and osteoarthritis, dry eyes.Based on those ingredients, 2 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Chrondroitin Sulfate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against HA Hyaluronic Acid Formula by California Natural

Ask about any prescription or over-the-counter medication and we check it for interactions with HA Hyaluronic Acid Formula by California Natural — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of HA Hyaluronic Acid Formula by California Natural

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This formula contains 3 active ingredients. Hyaluronic acid is a natural substance that helps retain moisture in tissues and skin.

Chondroitin sulfate is derived from cartilage and supports joint structure. Biocell Collagen Type II provides a collagen blend.

The capsules also contain rice powder, magnesium stearate, and a capsule shell as inactive ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: supports collagen production and joint health.
  • We looked for evidence on: Osteoarthritis, Aging skin, Dry eye, Wound healing, Gingivitis, Oral mucositis — and 2 related terms.
  • The strongest evidence on file: Chondroitin Sulfate is rated "Possibly Effective" for Osteoarthritis (Natural Medicines).
  • Also on file: Hyaluronic Acid is rated "Possibly Effective" for Dry eye.
  • Also on file: Chondroitin Sulfate is rated "Insufficient Reliable Evidence To Rate" for Aging skin, Dry eye.

Hyaluronic acid is possibly effective for dry eye and venous leg ulcers (slow-healing sores on the legs). For aging skin, hay fever, and sexual dysfunction, there isn't enough reliable evidence to rate how well it works.

Chondroitin sulfate is possibly effective for cataracts and osteoarthritis. For aging skin, weak bones (osteoporosis), high cholesterol (hyperlipidemia), and colorectal adenomas, the evidence is insufficient to know if it helps.

We hold no effectiveness data for Biocell Collagen Type II.

The evidence, ingredient by ingredient Hyaluronic Acid Chondroitin Sulfate

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Hyaluronic acid and chondroitin sulfate are generally well tolerated orally. With hyaluronic acid, the data notes that long-term safety of supplements isn't fully studied; some caution is advised.

Chondroitin sulfate may cause stomach upset—abdominal pain, bloating, constipation, diarrhea, heartburn, or nausea—and rare reports of liver damage exist. Skin symptoms such as swelling of the eyelids, lower leg swelling, hair loss, rash, or hives have been reported with chondroitin, especially in combinations with glucosamine.

A rare case of asthma worsening was reported with a glucosamine-chondroitin product. We hold no safety or adverse effect data for Biocell Collagen Type II.

Side effects, ingredient by ingredient Hyaluronic Acid Chondroitin Sulfate

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Chondroitin Sulfate.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 2 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Blood thinners like warfarin (Coumadin) are the main concern with this product—chondroitin sulfate may increase its blood-thinning effect, raising your bleeding risk. If you take warfarin or any anticoagulant, confirm with your doctor or pharmacist before adding this formula.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may work for dry eye or joint health concerns, though the evidence is mixed depending on which condition you're targeting. If you take warfarin or another blood thinner, you need to check with your doctor or pharmacist before starting it—chondroitin may boost the thinner's effects.

Watch for stomach upset or skin reactions, and keep in mind that long-term supplement safety isn't fully established. Talk it over with your own healthcare provider to see if it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 27, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about HA Hyaluronic Acid Formula, straight from the product label.

Brand California Natural
Barcode (UPC) 011821590090
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Jul 27, 2021
DSLD ID 251924
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for HA Hyaluronic Acid Formula by California Natural, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
90
UPC/BARCODE
011821590090
IngredientAmount% DV
Hyaluronic Acid50 mg--
Chrondroitin Sulfate100 mg--
Biocell Collagen Type II500 mg--

Other ingredients: Rice powder, Magnesium Stearate, Capsule shell

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

Made in the U.S.A.

Precautions

Do not use if tamper resistant seal is missing or broken

Keep out of reach of children.

Seek the advise of health care professional before using.

Formulation

Laboratory tested and approved. Potency guaranteed

Guaranteed not to contain: Sucrose, starch, yeast, wheat, corn, dairy products, preservatives, artificial colors or flavors

Supports collagen production

Brand IP Statement(s)

The BioCell Collagen II (and desire) is a trademark of BioCell Technology LLC, Anaheim, California USA.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Usage: 2 to 3 capsules a day with water or fruit juice, or as recommended by your health care practitioner.

Formula

Capsule shell: Gelatin & water

BioCell Collagen

General Statements

Patent # 6,025,327

FDA Disclaimer Statement

This statement has not been evaluated by the FDA. This product is not intended to diagnose, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

HA Hyaluronic Acid Formula by California Natural label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

HA Hyaluronic Acid Formula label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in HA Hyaluronic Acid Formula by California Natural

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Hyaluronic Acid

No known
interactions
50 mg per serving

Hyaluronic acid is a natural substance in the body that helps hold water in the skin, joints, and eyes. Oral and topical products are popular for skin...

Hyaluronic Acid monograph & interactions

Chrondroitin Sulfate

Interacts with
2 drugs
100 mg per serving

Chondroitin sulfate is a naturally occurring building block of cartilage that is widely taken, often with glucosamine, for osteoarthritis joint pain....

Chrondroitin Sulfate monograph & interactions

Biocell Collagen Type II

500 mg per serving

Other (inactive) ingredients: Rice powder, Magnesium Stearate, Capsule shell. These complete the product’s ingredient list but are not active constituents.

Interaction report

HA Hyaluronic Acid Formula by California Natural Drug Interactions

Want to check YOUR meds against HA Hyaluronic Acid Formula?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2Drugs
2 Moderate

Ingredients driving the most interactions

Chrondroitin Sulfate 2

Individual Drug Interactions

The ingredients in HA Hyaluronic Acid Formula interact with 2 drugs. Click any drug to see the details.

1 of the 3 ingredients in HA Hyaluronic Acid Formula interact with drugs. Each result below shows which ingredient is responsible. Chrondroitin Sulfate

Each ingredient & the kinds of drugs it affects

For each ingredient in HA Hyaluronic Acid Formula with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Chrondroitin Sulfate1 drug type · 2 drugs

Warfarin (Coumadin)

Taking chondroitin in combination with glucosamine might increase the anticoagulant effects of warfarin. However, the effect of chondroitin alone is unclear.
There have been multiple reports of increased international normalized ratio (INR) in patients taking warfarin with glucosamine, with or without chondroitin. The lack of reports with chondroitin alone seem to suggest that the interactions occurring in these reports may have been due to glucosamine. In two individual case reports, glucosamine/chondroitin combinations were associated with a significant increase in INR in patients previously stabilized on warfarin. Additionally, 20 voluntary case reports to the US Food & Drug Administration (FDA) have linked glucosamine plus chondroitin with increased INR, bruising, and bleeding in patients who were also taking warfarin. There have also been 20 additional case reports to the World Health Organization (WHO) that link glucosamine alone, without chondroitin, to increased INR in patients taking warfarin.

Likelihood Unlikely Evidence D
Chrondroitin Sulfate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for HA Hyaluronic Acid Formula, from the product label.

California Natural

See all California Natural products
Name
California Natural Vitamin Labs
City
Chatsworth
State
CA
ZipCode
91311
Phone Number
(888) 383-1212
Web Address
www.californianatural.net
Pharmacist Counseling Corner

HA Hyaluronic Acid Formula by California Natural: Common Questions

Does HA Hyaluronic Acid Formula by California Natural interact with any medications?
Yes. Based on its ingredients, HA Hyaluronic Acid Formula has a known interaction with 2 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
HA Hyaluronic Acid Formula contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on warfarin?
Not without checking first. Chondroitin sulfate in this formula may boost how much warfarin thins your blood, which could raise your bleeding risk. Talk with your doctor or pharmacist before starting—they'll tell you whether it's safe for you or if you need closer monitoring.
What stomach side effects might I get?
Chondroitin sulfate can cause abdominal pain, bloating, constipation, diarrhea, heartburn, or nausea. These are the most common effects reported. If they don't settle or get worse, stop and talk with your pharmacist.
Is this safe long-term?
We don't have full data on how safe these ingredients are over a long time. The product facts note that long-term safety of supplements isn't fully studied. If you're thinking about taking this for months or years, bring that up with your doctor.
Can I take this while pregnant or breastfeeding?
Not enough safety information is available for either chondroitin sulfate or hyaluronic acid during pregnancy and breastfeeding. Talk with your doctor before starting if you're pregnant, planning to become pregnant, or nursing.
What does Biocell Collagen Type II do?
We hold no effectiveness or safety data for Biocell Collagen Type II in our monographs, so we can't tell you what role it plays in this formula. Your pharmacist or the product label may have more details.
Does this really help with aging skin?
There isn't enough reliable evidence yet to know whether hyaluronic acid or chondroitin work for aging skin. Both ingredients are possibly effective for other uses—hyaluronic acid for dry eye, chondroitin for joint health—but skin aging is still uncertain.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if HA Hyaluronic Acid Formula is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

HA Hyaluronic Acid Formula label
Go deeper

The Full Monographs Behind HA Hyaluronic Acid Formula’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Hyaluronic Acid

Hyaluronic acid is a natural substance in the body that helps hold water in the skin, joints, and eyes. Oral and topical products are popular for skin moisture and joint comfort, and the evi...

Read the full Hyaluronic Acid monograph → Herb & supplement monograph

Chondroitin Sulfate

Interacts with 2 drugs

Chondroitin sulfate is a naturally occurring building block of cartilage that is widely taken, often with glucosamine, for osteoarthritis joint pain. The evidence is mixed—some people report...

Read the full Chondroitin Sulfate monograph →
Sources

Sources & How We Checked

HA Hyaluronic Acid Formula's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 26 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Hyaluronic Acid 4 references
  1. Park Y, Song JS, Choi CY, Yoon KC, Lee HK, Kim HS. A randomized multicenter study comparing 0.1%, 0.15%, and 0.3% sodium hyaluronate with 0.05% cyclosporine in the treatment of dry eye. J Ocul Pharmacol Ther. 2017;33(2):66-72. PubMed
  2. U.S. Food and Drug Administration. Do Not Use Needle-Free Devices for Injection of Dermal Fillers - FDA Safety Communication. October 8, 2021. Available at: https://www.fda.gov/medical-devices/safety-communications/do-not-use-needle-free-devices-injection
  3. Disphanurat W, Srisantithum B. Efficacy and safety of 0.15% isobutylamido thiazolyl resorcinol combined with hyaluronic acid vs 0.15% isobutylamido thiazolyl resorcinol or hyaluronic acid alone in melasma treatment: A randomized evaluator-blind trial. J C PubMed
  4. Humbert P, Mikosinki J, Benchikhi H, Allaert FA. Efficacy and safety of a gauze pad containing hyaluronic acid in treatment of leg ulcers of venous or mixed origin: a double-blind, randomised, controlled trial. Int Wound J 2013;10(2):159-66. PubMed

See these in context on the Hyaluronic Acid monograph →

Chondroitin Sulfate 22 references
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  2. Tallia AF, Cardone DA. Asthma exacerbation associated with glucosamine-chondroitin supplement. J Am Board Fam Pract 2002;15:481-4..
  3. Danao-Camara T. Potential side effects of treatment with glucosamine and chondroitin. Arthritis Rheum 2000;43:2853. PubMed
  4. Rozenfeld V, Crain JL, Callahan AK. Possible augmentation of warfarin effect by glucosamine-chondroitin. Am J Health Syst Pharm 2004;61:306-307. PubMed
  5. Clegg DO, Reda DJ, Harris CL, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med 2006;354:795-808. DOI
  6. Knudsen J, Sokol GH. Potential glucosamine-warfarin interaction resulting in increased international normalized ratio: Case report and review of the literature and MedWatch database. Pharmacotherapy 2008;28:540-8. PubMed
  7. Yue QY, Strandell J, Myrberg O. Concomitant use of glucosamine potentiates the effect of warfarin. Jan 2006. Drug Safety 29(10):911-1010. DOI
  8. Nordling, J. and van, Ophoven A. Intravesical glycosaminoglycan replenishment with chondroitin sulphate in chronic forms of cystitis. A multi-national, multi-centre, prospective observational clinical trial. Arzneimittelforschung. 2008;58(7):328-335. PubMed
  9. Nickel, J. C., Egerdie, B., Downey, J., Singh, R., Skehan, A., Carr, L., and Irvine-Bird, K. A real-life multicentre clinical practice study to evaluate the efficacy and safety of intravesical chondroitin sulphate for the treatment of interstitial cystit
  10. Oliviero, U., Sorrentino, G. P., De Paola, P., Tranfaglia, E., D'Alessandro, A., Carifi, S., Porfido, F. A., Cerio, R., Grasso, A. M., Policicchio, D., and . Effects of the treatment with matrix on elderly people with chronic articular degeneration. Drug
  11. Crowley, D. C., Lau, F. C., Sharma, P., Evans, M., Guthrie, N., Bagchi, M., Bagchi, D., Dey, D. K., and Raychaudhuri, S. P. Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial. Int.J.Med.Sc PubMed
  12. Nickel, J. C., Egerdie, R. B., Steinhoff, G., Palmer, B., and Hanno, P. A multicenter, randomized, double-blind, parallel group pilot evaluation of the efficacy and safety of intravesical sodium chondroitin sulfate versus vehicle control in patients with
  13. Sawitzke, A. D., Shi, H., Finco, M. F., Dunlop, D. D., Harris, C. L., Singer, N. G., Bradley, J. D., Silver, D., Jackson, C. G., Lane, N. E., Oddis, C. V., Wolfe, F., Lisse, J., Furst, D. E., Bingham, C. O., Reda, D. J., Moskowitz, R. W., Williams, H. J.
  14. Wildi, L. M., Raynauld, J. P., Martel-Pelletier, J., Beaulieu, A., Bessette, L., Morin, F., Abram, F., Dorais, M., and Pelletier, J. P. Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starti
  15. Pavelka and et al. Double-blind, dose effect study of oral cs 4 & 6 1200mg, 800mg, 200mg against placebo in the treatment of femorotibial osteoarthritis. Wular Rheumatol Liter 1998;27(suppl 2):63.
  16. Cerda C, Bruguera M, Parés A. Hepatotoxicity associated with glucosamine and chondroitin sulfate in patients with chronic liver disease. World J Gastroenterol 2013;19(32):5381-4. PubMed
  17. von Felden J, Montani M, Kessebohm K, Stickel F. Drug-induced acute liver injury mimicking autoimmune hepatitis after intake of dietary supplements containing glucosamine and chondroitin sulfate. Int J Clin Pharmacol Ther 2013;51(3):219-23. PubMed
  18. Provenza JR, Shinjo SK, Silva JM, Peron CR, Rocha FA. Combined glucosamine and chondroitin sulfate, once or three times daily, provides clinically relevant analgesia in knee osteoarthritis. Clin Rheumatol 2015;34:1455-62. PubMed
  19. Ossendza RA, Grandval P, Chinoune F, Rocher F, Chapel F, Bernardini D. [Acute cholestatic hepatitis due to glucosamine forte]. Gastroenterol Clin Biol. 2007 Apr;31(4):449-50.
  20. Greenlee H, Crew KD, Shao T, Kranwinkel G, Kalinsky K, Maurer M, Brafman L, Insel B, Tsai WY, Hershman DL. Phase II study of glucosamine with chondroitin on aromatase inhibitor-associated joint symptoms in women with breast cancer. Support Care Cancer 201 PubMed
  21. Chu EC, Huang KHK, Cheung G, Ng G, Lin A. Delayed Skin Allergy to Glucosamine Chondroitin Supplement. Cureus 2023;15(3):e36310. PubMed
  22. Lila AM, Alekseeva LI, Baranov AA, et al. Chondroitin sulfate and glucosamine combination in patients with knee and hip osteoarthritis: A long-term observational study in Russia. World J Orthop 2023;14(6):443-457. PubMed

See these in context on the Chondroitin Sulfate monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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