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Dietary supplement

Hawaiian Noni Fruit Ingredients & Drug Interactions

by Earth's Bounty

Hawaiian Noni Fruit label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Hawaiian Noni Fruit against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Hawaiian Noni Fruit is a dietary supplement by Earth's Bounty with 1 active ingredient. Its ingredients are commonly taken for general wellness and energy, inflammation and joint pain, immune support.Based on those ingredients, 542 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Noni, Powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Hawaiian Noni Fruit by Earth's Bounty

Ask about any prescription or over-the-counter medication and we check it for interactions with Hawaiian Noni Fruit by Earth's Bounty — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Hawaiian Noni Fruit by Earth's Bounty

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: noni powder, derived from the noni fruit. Noni has been used traditionally in Pacific and Asian cultures, though modern evidence for its health claims remains limited.

The capsule also contains cellulose, an inactive ingredient that forms the capsule structure.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Noni's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: immune and digestive health, joints and skin support.
  • We looked for evidence on: Osteoarthritis, Rheumatoid arthritis (RA), Wound healing, Common cold, gastrointestinal health, inflammation — and 1 related terms.
  • The closest evidence on file: Noni is rated "Insufficient Reliable Evidence To Rate" for Common cold (Natural Medicines).
  • Also on file: Noni is rated "Insufficient Reliable Evidence To Rate" for Osteoarthritis, Rheumatoid arthritis (RA), Wound healing.

The effectiveness data we hold for noni rates it as having insufficient reliable evidence for asthma, atherosclerosis, athletic performance, burns, cancer, and cardiovascular disease. In plain terms, we don't have solid evidence that noni works reliably for these conditions.

Preliminary clinical research suggests noni juice can reduce blood pressure in people with high blood pressure, but that's not the same as proving it's an effective treatment you should rely on.

The evidence, ingredient by ingredient Noni

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Noni is generally well tolerated in moderate amounts, but there are two concerns worth knowing. First, rare cases of liver injury — sometimes severe, including liver failure — have been reported in people taking noni products, though it's unclear whether noni itself or contaminants in some products were responsible.

Second, noni is high in potassium, which matters if you have kidney disease or take medications that affect potassium levels. The most common side effects reported are nausea and abdominal discomfort.

Noni should not be used during pregnancy — it has been traditionally used to cause abortion, and there isn't enough safety information to know it's okay in pregnancy or while breastfeeding.

Side effects, ingredient by ingredient Noni

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Noni.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 543 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your pharmacist if you're on blood pressure medication, ACE inhibitors, ARBs, potassium-sparing diuretics, blood thinners like warfarin, seizure medications like phenytoin, ranitidine for acid reflux, or any drugs known to cause liver damage. All of these have documented interactions with noni.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you're on blood pressure medication, potassium-raising drugs, blood thinners, or seizure medication, talk to your pharmacist before taking noni. Even if you're not on those medications, the rare risk of liver damage and noni's high potassium content mean it's worth a quick check of your full medication list.

Do not use during pregnancy or while breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Hawaiian Noni Fruit, straight from the product label.

Brand Earth's Bounty
Barcode (UPC) 707990201003
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Jul 24, 2025
DSLD ID 334187
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Hawaiian Noni Fruit by Earth's Bounty, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
707990201003
IngredientAmount% DV
Noni, Powder500 mg--

Other ingredients: Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Take 1 or more capsules daily.

Storage

Best if taken 3 years from date on bottom.

Formulation

Benefits: Enzyme rich adaptogen Promotes immune and digestive health Supports healthy joints and skin

Discover the healing power of nature

V Vegan

Lifetime satisfaction guarantee

Non GMO

Formulated to be free from: Gluten Sugar Soy Preservatives

Precautions

Warning: Do not use if outer safety seal is broken or missing.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

Earth's Bounty Wellness from our family to yours Est 1991

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

V Vegan

GMP Certified

General Statements

2

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Hawaiian Noni Fruit by Earth's Bounty label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Hawaiian Noni Fruit label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Hawaiian Noni Fruit by Earth's Bounty

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Noni, Powder

Interacts with
542 drugs
500 mg per serving

Noni is a tropical fruit used widely in folk medicine and sold mostly as a juice or supplement, but solid human evidence for its many claimed benefits...

Noni, Powder monograph & interactions

Other (inactive) ingredients: Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Hawaiian Noni Fruit by Earth's Bounty Drug Interactions

Want to check YOUR meds against Hawaiian Noni Fruit?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
542Drugs
541 Moderate 1 Minor

Ingredients driving the most interactions

Noni, Powder 542

Individual Drug Interactions

The ingredients in Hawaiian Noni Fruit interact with 542 drugs. Click any drug to see the details.

1 of the 1 ingredient in Hawaiian Noni Fruit interact with drugs. Each result below shows which ingredient is responsible. Noni, Powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Hawaiian Noni Fruit with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Noni, Powder8 drug types · 542 drugs

Ace Inhibitors (Aceis)

Theoretically, combining noni and ACE inhibitors might increase the risk of hyperkalemia.
Noni juice contains significant amounts of potassium, about 6 mEq/100 mL juice. This may increase the risk for hyperkalemia when used in conjunction with ACE inhibitors, which can also increase potassium levels.

Likelihood Possible Evidence D
Angiotensin Receptor Blockers (Arbs)

Theoretically, combining noni and ARBs might increase the risk of hyperkalemia.
Noni juice contains significant amounts of potassium, about 6 mEq/100 mL juice. This may increase the risk for hyperkalemia when used in conjunction with ARBs, which can also increase potassium levels.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, noni may increase the risk of hypotension when used in combination with antihypertensive drugs.
Preliminary clinical research suggests that drinking noni juice can reduce blood pressure in individuals with hypertension.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking noni with hepatotoxic drugs might increase the risk of liver damage.
There is concern that noni might cause hepatotoxicity in some patients. Advise patients against combining noni with potentially hepatotoxic drugs.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

Theoretically, taking noni fruit juice concomitantly with phenytoin may lower phenytoin levels and increase the risk of seizures.
In one case report, an adult taking phenytoin for partial seizures experienced low serum phenytoin levels while taking noni juice 90-200 mL daily. Serum phenytoin levels increased after decreasing noni juice consumption; similarly, serum phenytoin levels decreased after increasing noni juice consumption. Some researchers believe noni juice may induce cytochrome P450 2C9 enzymes, which would decrease phenytoin levels, but this has not been well studied. Patients may need additional monitoring when starting or stopping noni juice supplementation.

Likelihood Possible Evidence D
Potassium-Sparing Diuretics

Theoretically, combing noni and a potassium-sparing diuretic might increase the risk of hyperkalemia.
Noni juice contains significant amounts of potassium, about 6 mEq/100 mL juice. This may increase the risk for hyperkalemia when used in conjunction with potassium-sparing diuretics, which can also increase potassium levels.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, taking noni juice concomitantly with warfarin might decrease the effectiveness of warfarin.
In one case, a 41-year-old patient stabilized on warfarin had a decreased international normalized ratio (INR) following consumption of a specific commercial noni juice product (Noni juice 4 Everything). While the patient was still taking noni juice, an increase in warfarin dose did not produce an increase in INR. However, it should be noted that this particular product contained extracts and derivatives from more than 115 components, many of which contained vitamin K. Furthermore, vitamin K was listed as a separate ingredient of the product, suggesting that the product was possibly fortified with vitamin K. It has not been verified that noni fruit alone contains a significant amount of vitamin K or interacts with warfarin.

Likelihood Possible Evidence D
Ranitidine (Zantac)

Taking noni fruit with ranitidine might increase the levels and clinical effects of ranitidine.
Clinical evidence shows that taking an aqueous extract of noni fruit 30 minutes prior to taking a single oral dose of ranitidine can increase the rate of absorption and plasma concentration of ranitidine.

Likelihood Possible Evidence B
Noni, Powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Hawaiian Noni Fruit, from the product label.

Earth's Bounty

See all Earth's Bounty products
Name
Earth's Bounty
City
Flagler Beach
State
FL
ZipCode
32136
Phone Number
(800) 736-5609
Web Address
earthsbounty.com
Pharmacist Counseling Corner

Hawaiian Noni Fruit by Earth's Bounty: Common Questions

Does Hawaiian Noni Fruit by Earth's Bounty interact with any medications?
Yes. Based on its ingredients, Hawaiian Noni Fruit has a known interaction with 542 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Hawaiian Noni Fruit contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
No. Noni has been traditionally used to cause abortion, so it should not be taken during pregnancy. There also isn't enough safety information to know whether it's okay while breastfeeding. Talk to your doctor or pharmacist if you're pregnant, planning to become pregnant, or nursing.
What side effects should I watch for?
The most common side effects are nausea and abdominal discomfort. Rarely, noni has been linked to liver injury, including serious cases of liver failure, though it's unclear whether noni itself or contaminants in some products were responsible. If you develop yellowing of the skin or eyes, dark urine, or unexplained fatigue, stop taking it and see a doctor right away.
Does noni actually work for any health condition?
The evidence we hold doesn't establish that noni reliably works for asthma, atherosclerosis, athletic performance, burns, cancer, or heart disease. Preliminary research suggests noni juice might lower blood pressure in people with high blood pressure, but that's not the same as proven effectiveness.
Why does noni interact with so many blood pressure and kidney medications?
Noni is very high in potassium. Medications like ACE inhibitors, ARBs, and potassium-sparing diuretics also raise potassium levels. When you combine them, your potassium can climb to a dangerous level (hyperkalemia). Noni itself can also lower blood pressure, so it may compound the effect of blood pressure drugs.
What's in the capsule besides noni?
The capsule contains cellulose, which is an inactive ingredient used to form the capsule shell. There are no other active ingredients.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Hawaiian Noni Fruit is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Hawaiian Noni Fruit label
Go deeper

The Full Monographs Behind Hawaiian Noni Fruit’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Noni

Interacts with 542 drugs

Noni is a tropical fruit used widely in folk medicine and sold mostly as a juice or supplement, but solid human evidence for its many claimed benefits is limited. While moderate juice intake...

Read the full Noni monograph →
Sources

Sources & How We Checked

Hawaiian Noni Fruit's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Noni 16 references
  1. Mueller BA, Scott MK, Sowinski KM, Prag KA. Noni juice (Morinda citrifolia): hidden potential for hyperkalemia? Am J Kidney Dis 2000;35:310-2. PubMed
  2. Millonig G, Stadlmann S, Vogel W. Herbal hepatotoxicity: acute hepatitis caused by a Noni preparation (Morinda citrifolia). Eur J Gastroenterol Hepatol 2005;17:445-7. PubMed
  3. Stadlbauer V, Fickert P, Lackner C, et al. Hepatotoxicity of NONI juice: report of two cases. World J Gastroenterol 2005;11:4758-60. PubMed
  4. Carr ME, Klotz J, Bergeron M. Coumadin resistance and the vitamin supplement "Noni". Am J Hematol 2004;77:103. PubMed
  5. Jensen CJ, Westendorf J, Wang MY, Wadsworth DP. Noni juice protects the liver. Eur J Gastroenterol Hepatol 2006;18:575-7. PubMed
  6. Yuce B, Gulberg V, Diebold J, Gerbes AL. Hepatitis induced by noni juice from morinda citrifolia: a rare cause of hepatotoxicity or the tip of the iceberg? Digestion 2006;73:167-70.
  7. Koch E, Biber A. Treatment of rats with the Pelargonium sidoides extract EPs 7630 has no effect on blood coagulation parameters or on the pharmacokinetics of warfarin. Phytomedicine 2007;14 Suppl 6:40-5. PubMed
  8. Yu EL, Sivagnanam M, Ellis L, Huang JS. Acute hepatotoxicity after ingestion of Morinda citrifolia (noni berry) juice in a 14-year-old boy. J Pediatr Gastroenterol Nutr 2011;52:222-4.
  9. Stadlbauer V, Weiss S, Payer F, Stauber RE. Herbal does not at all mean innocuous: the sixth case of hepatotoxicity associated with morinda citrifolia (noni). Am J Gastroenterol 2008;103:2406-7. PubMed
  10. López-Cepero Andrada JM, Lerma Castilla S, Fernández Olvera MD, Amaya Vidal A. [Hepatotoxicity caused by a noni (Morinda citrifolia) preparation]. [Article in Spanish] Rev Esp Enferm Dig 2007;99:179-81.
  11. Nima S, Kasiwong S, Ridtitid W, et al. Gastrokinetic activity of Morinda citrifolia aqueous fruit extract and its possible mechanism of action in human and rat models. J Ethnopharmacol. 2012;142(2):354-61. PubMed
  12. Issell, B. F., Gotay, C. C., Pagano, I., and Franke, A. A. Using quality of life measures in a Phase I clinical trial of noni in patients with advanced cancer to select a Phase II dose. J.Diet.Suppl 2009;6(4):347-359. PubMed
  13. Palu AK, Santiago RA West B Kaluhiokalani N Jensen J. The Effects of Morillda citrifolia L. Noni on High Blood Pressure: A Mechanistic Investigation and Case Study. ACS SYMPOSIUM SERIES 993 2008;
  14. Jiménez-Encarnación E, Ríos G, Muñoz-Mirabal A, Vilá LM. Euforia-induced acute hepatitis in a patient with scleroderma. BMJ Case Rep 2012;2012. PubMed
  15. Bussmann RW, Hennig L, Giannis A, Ortwein J, Kutchan TM, Feng X. Anthraquinone Content in Noni (Morinda citrifolia L.). Evid Based Complement Alternat Med. 2013;2013:208378.
  16. Yu-Chan Kang, Ming-Hong Chen, Shung-Lon Lai. Potentially Unsafe Herb-drug Interactions Between a Commercial Product of Noni Juice and Phenytoin- A Case Report. Acta Neurol Taiwan. 2015 Jun;24(2):43-6.

See these in context on the Noni monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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