Major interaction on record — check this product against your medications before combining. Based on 4 of 8 ingredients. Check your meds →
Dietary supplement

Energy 28 Ingredients & Drug Interactions

by Natural Vitality

Energy 28 label
See full label image
Liquid Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Energy 28 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Energy 28 is a dietary supplement by Natural Vitality with 8 active ingredients. Its ingredients are commonly taken for energy and fatigue, athletic performance and recovery, fibromyalgia symptoms.Based on those ingredients, 1,542 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Rhodiola rosea extract, Golden Chlorella(TM) Omega, D-Ribose. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Energy 28 by Natural Vitality

Ask about any prescription or over-the-counter medication and we check it for interactions with Energy 28 by Natural Vitality — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Energy 28 by Natural Vitality

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 4 of its 28 active ingredients.
  • “Organic Natural Vitality Superfruit” is listed as a grouped ingredient — the label gives one combined amount (200 mg) without saying how much of each component you get.
  • “Organic superfruits” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Organic veggies / sprouts” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Energy 28 contains 28 active ingredients — a mix of nutrient-dense plant foods and herbal extracts. The lineup includes D-ribose (a sugar that may support energy production), noni fruit, broccoli, apple, blueberry, raspberry, strawberry, spinach, alfalfa, pumpkin, tart cherry, kale, carrot, tomato, acai, cranberry, pomegranate, aronia (chokeberry), sweet cherry, rhodiola rosea extract (an adaptogenic herb), maca root powder, chlorella (a microalga), and several others.

The inactive ingredients are purified water, vegetable glycerin, organic agave nectar, citric acid, natural colors, malic acid, natural flavors, potassium sorbate, sodium benzoate, organic stevia extract, guar gum, and xanthan gum.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Athletic performance — rated "Possibly Effective" (Sour Cherry) (Natural Medicines).
  • On file: Benign prostatic hyperplasia (BPH) — rated "Possibly Effective" (Pumpkin) (Natural Medicines).
  • On file: Colorectal cancer — rated "Possibly Effective" (Broccoli) (Natural Medicines).
  • On file: Diarrhea — rated "Possibly Effective" (Banana) (Natural Medicines).
  • On file: Hypertension — rated "Possibly Effective" (Pomegranate) (Natural Medicines).

The effectiveness evidence for Energy 28's ingredients is sparse and mixed. D-ribose is rated possibly ineffective for athletic performance and muscle recovery.

Broccoli shows possibly effective evidence for colorectal cancer prevention, while tart cherry is rated possibly effective for athletic performance recovery. Cranberry is possibly effective for urinary tract infections, and pumpkin is possibly effective for benign prostate enlargement.

For most other ingredients and conditions, the evidence in our data is insufficient to establish whether they work — which means clinical studies are lacking, not that they're proven ineffective. Pomegranate and apple have some ratings of possibly ineffective for certain conditions (blood sugar control, cholesterol).

The rest have insufficient evidence or no rating on file.

The evidence, ingredient by ingredient Ribose Rhodiola Maca Chlorella

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 23 of the 25 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 24 of 25.
  • General safety write-ups exist for 25 of 25.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of these ingredients are generally well tolerated when eaten as whole foods in normal amounts. However, several carry cautions or concerns in supplement form.

D-ribose can lower blood sugar and most common side effects include diarrhea, nausea, headache, and hypoglycemia; long-term safety isn't well studied. Noni is associated with rare but serious liver injury and has a high potassium content, which is a concern if you take certain blood pressure or heart medications.

Broccoli in concentrated supplement form may cause loose stools, diarrhea, and abdominal pain, especially at high doses. Apple, blueberry, strawberry, spinach, alfalfa, pumpkin, cranberry, pomegranate, aronia, and chlorella can all cause gastrointestinal upset (diarrhea, nausea, abdominal discomfort) in some people.

Chlorella has been reported to cause photosensitivity (sun-sensitive skin reactions) in rare cases. Rhodiola may cause dizziness and dry mouth or excessive saliva.

Maca can cause stomach pain if consumed raw or uncooked. None of these ingredients are rated safe for use during pregnancy or breastfeeding in supplement amounts — most are rated possibly unsafe, insufficient information, or best avoided, with the exception of a few (broccoli, spinach, kale, carrot, tomato, tart cherry, sweet cherry, blueberry, and cranberry) rated likely safe as foods.

Side effects, ingredient by ingredient Ribose Rhodiola Maca Chlorella

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 19 of the 25 matched ingredients can interact with medications — Alfalfa, Apple, Strawberry, Spinach, Pomegranate, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; lithium; Parkinson's medications.
  • For scale: 1,543 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Energy 28, double-check with your own doctor or pharmacist if you take any of these medication types: blood thinners like warfarin or antiplatelet drugs (apple, strawberry, aronia, noni, spinach, alfalfa, cranberry, pomegranate, chlorella); blood pressure medications or ACE inhibitors/ARBs (apple, noni, pomegranate, rhodiola); antidiabetes drugs or insulin (D-ribose, apple, blueberry, spinach, alfalfa, acai, chokeberry, rhodiola); drugs metabolized by the liver's CYP enzymes, including statins like atorvastatin (broccoli, cranberry, pomegranate, aronia, rhodiola); seizure drugs like phenytoin or carbamazepine (noni, pomegranate); or immunosuppressants (alfalfa, rhodiola). Lithium users should be cautious with apple, pumpkin, and their potassium and water-balance effects.

If you take fexofenadine (Allegra), atenolol (Tenormin), or aliskiren (Tekturna) — all substrates of OATP — apple in this product may significantly reduce their blood levels.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Major medication interactions have been identified, and safety information is well characterized.

Energy 28 is a broad-spectrum fruit and herb blend designed as a nutrient booster, but it carries significant interaction potential — particularly with blood thinners, blood pressure drugs, diabetes medications, and drugs processed by the liver — because of its 14 interacting ingredients. If you take any regular prescription medications, especially for your heart, blood sugar, blood clotting, or liver function, check each of your medications against this product's ingredients using the tool on this page before starting.

Even if no direct interactions appear, the high potassium and liver-processing burden of multiple botanical ingredients warrant a conversation with your own doctor or pharmacist about whether this supplement fits your health profile.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 26 of 28 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Energy 28, straight from the product label.

Brand Natural Vitality
Barcode (UPC) 875534001560
Net contents 15 Whole-Food Energizer Nutri Pack(s)
Market status On market
Date entered into DSLD Sep 25, 2013
DSLD ID 25708
Product type Other Combinations
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Energy 28 by Natural Vitality, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 fl. Oz.
Maximum serving Sizes:
1 fl. Oz.
UPC/BARCODE
875534001560
IngredientAmount% DV
Calories35 {Calories}1%
Total Carbohydrates4 Gram(s)1.4%
Sugar3 Gram(s)--
D-Ribose500 mg--
Noni0 NP--
Broccoli0 NP--
Apple0 NP--
Blueberry0 NP--
Raspberry0 NP--
Strawberry0 NP--
Spinach0 NP--
Alfalfa0 NP--
Pumpkin0 NP--
Tart Cherry0 NP--
Kale0 NP--
Carrot0 NP--
Tomato0 NP--
Acai0 NP--
Cranberry0 NP--
Pomegranate0 NP--
Aronia0 NP--
Sweet Cherry0 NP--
Rhodiola rosea extract250 mg--
Organic Maca root powder525 None--
Broccoli0 NP--
Golden Chlorella(TM) Omega1000 mg--
Organic Natural Vitality Superfruit200 mg--
Organic superfruits0 NP--
goji0 NP--
Organic veggies / sprouts0 NP--
onion0 NP--
peas0 NP--
Organic fruits0 NP--
Banana0 NP--
daikon radish0 NP--

Other ingredients: purified Water, vegetable-source Glycerin, organic agave nectar, Citric Acid, natural colors, Malic Acid, Natural flavors, Potassium Sorbate, sodium benzoate, organic Stevia extract, Guar Gum, Xanthan Gum

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

24 Organic superfruits, veggies, sprouts and fruits

Organic Maca

GLUTEN FREE * NON-GMO

ENERGIZE Naturally with 28 Organic and Natural Foods PLUS MORE

VEGAN

Formula

Golden Chlorella(TM) Omega A complete nutrient-dense green food

Bioenergy RIBOSE(TM)

Golden Chlorella(TM) Omega is an ultra-pure microalgae, sustainably grown in the USA without chemicals. It is a complete nutrient-dense green food: 1,000 mg contains 500 mg of heart-healthy omega 3-6-9 and 200 mg of fiber, along with naturally occurring vitamins, minerals, amino acids and micronutrients.

Rhodiola

General Statements

CONCENTRATED WHOLE-FOOD ENERGIZER

E-28 WHOLE-FOOD ENERGIZER

See more Natural Vitality products at www.naturalvitality.com

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: Shake before opening. As a dietary supplement, take one packet per day. Use Energy28 right from the pack or add to a water bottle, juice or a smoothie. May be taken more than once per day when you need a natural energy boost.

Seals/Symbols

deliciousliving SUPPLEMENT AWARD 2012

AKA(TM) Ashley Koff RD APPROVED

General

Product No. 3430

Brand IP Statement(s)

(C) 2012 Natural Vitality. All rights reserved.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Energy 28 by Natural Vitality label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Energy 28 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Energy 28 by Natural Vitality

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 fl. Oz. Dosage formLiquid Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

3 Gram(s) per serving

D-Ribose

Interacts with
86 drugs
500 mg per serving

Ribose (D-ribose) is a simple sugar your body makes naturally and uses to build energy molecules like ATP. Some people take it for fatigue, fibromyalg...

D-Ribose monograph & interactions

Rhodiola rosea extract

Interacts with
1,271 drugs
250 mg per serving

Rhodiola is an herb traditionally used to fight fatigue and help the body cope with stress. Some small studies suggest it may modestly reduce fatigue...

Rhodiola rosea extract monograph & interactions

Organic Maca root powder

No known
interactions
525 None per serving

Maca is a nutrient-rich Andean root often used for energy, libido, and menopause symptoms. Early studies suggest it may modestly help sexual desire an...

Organic Maca root powder monograph & interactions

Golden Chlorella(TM) Omega

Interacts with
337 drugs
1000 mg per serving

Chlorella is a nutrient-rich freshwater green algae taken as a supplement for general wellness, immune support, and 'detox.' Some small studies sugges...

Golden Chlorella(TM) Omega monograph & interactions

Organic Natural Vitality Superfruit

200 mg per serving
  • › Organic superfruits
  • › Organic veggies / sprouts
  • › Organic fruits

Other (inactive) ingredients: Purified Water, Vegetable-source Glycerin, Organic agave nectar, Citric Acid, Natural colors, Malic Acid, Natural flavors, Potassium Sorbate, Sodium benzoate, Organic Stevia extract, Guar Gum, Xanthan Gum. These complete the product’s ingredient list but are not active constituents.

Interaction report

Energy 28 by Natural Vitality Drug Interactions

Want to check YOUR meds against Energy 28?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,542Drugs
49 Major 1,400 Moderate 93 Minor

Ingredients driving the most interactions

Rhodiola rosea extract 1,271
Golden Chlorella(TM) Omega 337
D-Ribose 86

Individual Drug Interactions

The ingredients in Energy 28 interact with 1,542 drugs. Click any drug to see the details.

3 of the 8 ingredients in Energy 28 interact with drugs. Each result below shows which ingredient is responsible. Rhodiola rosea extract Golden Chlorella(TM) Omega D-Ribose

Each ingredient & the kinds of drugs it affects

For each ingredient in Energy 28 with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Rhodiola rosea extract10 drug types · 1,271 drugs

Antidiabetes Drugs

Theoretically, taking rhodiola with antidiabetes drugs might increase the risk of hypoglycemia.
In vitro and animal research shows that rhodiola extract can decrease blood glucose due to alpha-glucosidase activity.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking rhodiola with antihypertensive drugs might increase the risk of hypotension.
In vitro and animal research shows that rhodiola extract inhibits angiotensin-converting enzyme (ACE) and might lower blood pressure.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, rhodiola might increase levels of drugs metabolized by CYP2C9.
In vitro research shows that rhodiola inhibits CYP2C9. This effect is highly variable and appears to be dependent on the rhodiola product studied. Also, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days reduces the metabolism of losartan, a CYP2C9 substrate, by 21% after 4 hours.

Likelihood Possible Evidence B
Immunosuppressants

Theoretically, rhodiola use might interfere with immunosuppressive therapy.
In vitro and animal research show that rhodiola has immunostimulatory effects.

Likelihood Possible Evidence D
Losartan (Cozaar)

Rhodiola might increase the levels and adverse effects of losartan.
A clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days reduces the metabolism of losartan, a CYP2C9 substrate, by 21% after 4 hours.

Likelihood Probable Evidence B
P-Glycoprotein Substrates

Theoretically, rhodiola might increase levels of P-glycoprotein substrates.
In vitro research shows that rhodiola inhibits P-glycoprotein. Theoretically, using rhodiola with P-glycoprotein substrates might increase drug levels and potentially increase the risk of adverse effects.

Likelihood Possible Evidence D
Antidepressant Drugs

Theoretically, rhodiola might increase the risk of adverse effects when taken with antidepressants.
A review of adverse event reports in Poland identified cases of tachyarrhythmias, myalgia, arthralgia, gum pain, restless leg syndrome, swallowing disorders, and changes in consciousness when rhodiola was taken in combination with paroxetine, escitalopram, fluoxetine, sertraline, trazodone, and/or duloxetine.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, rhodiola might increase the risk of adverse effects when taken with CNS depressants.
A review of adverse event reports in Poland identified cases of excessive sedation, myoclonus, hypotension, and hallucinations when rhodiola was taken with haloperidol, diazepam, or alprazolam.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
In vitro research shows that rhodiola inhibits CYP1A2. This effect is highly variable and appears to be dependent on the rhodiola product studied. However, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days does not inhibit the metabolism of caffeine, a CYP1A2 substrate.

Likelihood Possible Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.
In vitro research shows that rhodiola inhibits CYP3A4. This effect is highly variable and appears to be dependent on the rhodiola product studied. However, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days does not inhibit the metabolism of midazolam, a CYP3A4 substrate.

Likelihood Possible Evidence B
Rhodiola rosea extract full monograph & interactions

Golden Chlorella(TM) Omega2 drug types · 337 drugs

Photosensitizing Drugs

Theoretically, chlorella might have additive effects with photosensitizing drugs.
Chlorella has been reported to cause photosensitization. In five case reports, patients who had ingested chlorella exhibited swelling followed by erythematopurpuric lesions on sun-exposed areas of the body. Theoretically, concomitant use with photosensitizing drugs may exacerbate effects.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, chlorella might reduce the clinical effects of warfarin.
Chlorella contains significant amounts of vitamin K. There is at least one case report of warfarin therapy becoming sub-therapeutic after initiation of chlorella supplements.

Likelihood Possible Evidence D
Golden Chlorella(TM) Omega full monograph & interactions

D-Ribose2 drug types · 86 drugs

Antidiabetes Drugs

Theoretically, taking ribose in combination with antidiabetes drugs might increase the risk of hypoglycemia.
In clinical research, ribose decreases serum glucose levels in a dose-dependent manner.

Likelihood Probable Evidence B
Insulin

Theoretically, taking ribose with insulin could increase the hypoglycemic effect of insulin.
In clinical pharmacokinetic studies, oral administration of ribose modestly increased serum insulin levels.

Likelihood Possible Evidence B
D-Ribose full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Energy 28, from the product label.

Natural Vitality

See all Natural Vitality products
Name
NATURAL VITALITY
Street Address
8500 Shoal Creek Blvd., Bldg. 4, Suite 208
City
Austin
State
TX
ZipCode
78757
Web Address
www.naturalvitality.com
Pharmacist Counseling Corner

Energy 28 by Natural Vitality: Common Questions

Does Energy 28 by Natural Vitality interact with any medications?
Yes. Based on its ingredients, Energy 28 has a known interaction with 1,542 medications, including 49 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Energy 28 contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is Energy 28 safe to take during pregnancy or breastfeeding?
No, not in supplement amounts. D-ribose, noni, alfalfa, rhodiola, maca, and chlorella are all rated unsafe or possibly unsafe, or lack enough safety data, in pregnancy and while nursing. A few ingredients like broccoli, spinach, and carrot are rated likely safe as foods, but this is a concentrated liquid supplement, not a food serving. Talk with your doctor or pharmacist about whether any component is safe for you at this dose before starting.
Does this supplement help with energy and athletic performance?
The evidence is limited. D-ribose and tart cherry are among the few with any effectiveness ratings — D-ribose is rated possibly ineffective for athletic performance, while tart cherry is possibly effective for exercise recovery. The rest either lack good clinical evidence or are unrated. If you're looking for energy support, the science here doesn't clearly back that claim across most ingredients.
What are the most common side effects?
Gastrointestinal upset — diarrhea, nausea, abdominal discomfort, and gas — is the most frequently reported adverse effect across multiple ingredients, especially at higher doses or in the first week or two of use. D-ribose can also cause headache and low blood sugar. Cranberry and blueberry in particular may cause loose stools or diarrhea. If you experience these symptoms, lower your dose or space doses further apart and contact your pharmacist.
Can I take this with blood pressure medications?
Not without checking first with your doctor. Apple, noni, pomegranate, and rhodiola all have documented interactions with blood pressure drugs or ACE inhibitors/ARBs — some can increase the effect and lower blood pressure further, others may interfere with the drug's work. Additionally, noni is high in potassium, which can be dangerous with certain heart and kidney medications. Always discuss this with your own pharmacist or doctor before starting.
Does this product contain any fillers or artificial ingredients?
The inactive ingredients are vegetable glycerin, organic agave nectar, citric acid, natural colors, malic acid, natural flavors, potassium sorbate, sodium benzoate, organic stevia extract, guar gum, and xanthan gum. Those last three are thickeners and binders common in liquid supplements, not 'fillers' in the sense of inert padding — they're necessary for the formula. There are also preservatives (potassium sorbate and sodium benzoate) to keep the liquid stable.
Can I take this if I'm on warfarin or another blood thinner?
No, not safely without medical approval. Noni, spinach, alfalfa, and chlorella all contain vitamin K or have anticoagulant effects and can interfere with warfarin's job. Apple, strawberry, and aronia may increase bleeding risk. And cranberry and pomegranate have conflicting evidence but raise concern. Before starting this product, talk with your doctor or pharmacist — your blood thinner dose may need adjustment, or you may need to avoid this supplement entirely.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Energy 28 label
Go deeper

The Full Monographs Behind Energy 28’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Ribose

Interacts with 86 drugs

Ribose (D-ribose) is a simple sugar your body makes naturally and uses to build energy molecules like ATP. Some people take it for fatigue, fibromyalgia, exercise recovery, or heart conditio...

Read the full Ribose monograph → Herb & supplement monograph

Rhodiola

Interacts with 1,271 drugs

Rhodiola is an herb traditionally used to fight fatigue and help the body cope with stress. Some small studies suggest it may modestly reduce fatigue and improve mood, but the evidence is li...

Read the full Rhodiola monograph → Herb & supplement monograph

Maca

Maca is a nutrient-rich Andean root often used for energy, libido, and menopause symptoms. Early studies suggest it may modestly help sexual desire and some menopause symptoms, but the evide...

Read the full Maca monograph → Herb & supplement monograph

Chlorella

Interacts with 337 drugs

Chlorella is a nutrient-rich freshwater green algae taken as a supplement for general wellness, immune support, and 'detox.' Some small studies suggest possible benefits for cholesterol, blo...

Read the full Chlorella monograph →
Sources

Sources & How We Checked

Energy 28's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 292 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Ribose 8 references
  1. Segal S, Foley J. The metabolism of D-ribose in man. J Clin Invest 1958;37:719-35. PubMed
  2. Perlmutter NS, Wilson RA, Angello DA, et al. Ribose facilitates thallium-201 redistribution in patients with coronary artery disease. J Nucl Med 1991;32:193-200.
  3. Hegewald MG, Palac RT, Angello DA, et al. Ribose infusion accelerates thallium redistribution with early imaging compared with late 24-hour imaging without ribose. J Am Coll Cardiol 1991;18:1671-81. PubMed
  4. Pliml W, von Arnim T, Stalein A, et al. Effects of ribose on excercise-induced ischaemia in stable coronary artery disease. Lancet 1992;340:507-10.
  5. Burke ER. D-Ribose What You Need To Know. Garden City Park, NY: Avery Publishing Group 1999;1-43.
  6. Gross M, Reiter S, Zollner N. Metabolism of D-ribose administered continuously to healthy persons and to patients with myoadenylate deaminase deficiency. Klin Wochenschr 1989;67:1205-13. PubMed
  7. Teitelbaum JE, Johnson C, St Cyr J. The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study. J Altern Complement Med 2006;12:857-62. PubMed
  8. Thompson J, Neutel J, Homer K, Tempero K, Shah A, Khankari R. Evaluation of D-ribose pharmacokinetics, dose proportionality, food effect, and pharmacodynamics after oral solution administration in healthy male and female subjects. J Clin Pharmacol 2014;54 PubMed

See these in context on the Ribose monograph →

Noni 16 references
  1. Mueller BA, Scott MK, Sowinski KM, Prag KA. Noni juice (Morinda citrifolia): hidden potential for hyperkalemia? Am J Kidney Dis 2000;35:310-2. PubMed
  2. Millonig G, Stadlmann S, Vogel W. Herbal hepatotoxicity: acute hepatitis caused by a Noni preparation (Morinda citrifolia). Eur J Gastroenterol Hepatol 2005;17:445-7. PubMed
  3. Stadlbauer V, Fickert P, Lackner C, et al. Hepatotoxicity of NONI juice: report of two cases. World J Gastroenterol 2005;11:4758-60. PubMed
  4. Carr ME, Klotz J, Bergeron M. Coumadin resistance and the vitamin supplement "Noni". Am J Hematol 2004;77:103. PubMed
  5. Jensen CJ, Westendorf J, Wang MY, Wadsworth DP. Noni juice protects the liver. Eur J Gastroenterol Hepatol 2006;18:575-7. PubMed
  6. Yuce B, Gulberg V, Diebold J, Gerbes AL. Hepatitis induced by noni juice from morinda citrifolia: a rare cause of hepatotoxicity or the tip of the iceberg? Digestion 2006;73:167-70.
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Broccoli 5 references
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Apple 16 references
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Blueberry 7 references
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Strawberry 18 references
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Spinach 6 references
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Alfalfa 32 references
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Pumpkin 5 references
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Sour Cherry 4 references
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Kale 2 references
  1. Vitamin K - Health Professional Fact Sheet — NIH Office of Dietary Supplements Source
  2. Lutein and Zeaxanthin — NIH Office of Dietary Supplements Source

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Carrot 14 references
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Tomato 3 references
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Acai 2 references
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Cranberry 33 references
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Chokeberry 8 references
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Sweet Cherry 3 references
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Rhodiola 13 references
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Banana 11 references
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  3. Nieman DC, Gillitt ND, Sha W, et al. Metabolomics-Based Analysis of Banana and Pear Ingestion on Exercise Performance and Recovery. J Proteome Res 2015;14(12):5367-77. doi: 10.1021/acs.jproteome.5b00909. PubMed
  4. Rabbani GH, Ahmed S, Hossain I, Islam R, Marni F, Akhtar M, Majid N. Green banana reduces clinical severity of childhood shigellosis: a double-blind, randomized, controlled clinical trial. Pediatr Infect Dis J. 2009 May;28(5):420-5. PubMed
  5. Schoeffl V, Varatorn R, Blinnikov O, Vidamaly V. Intestinal obstruction due to phytobezoars of banana seeds: a case report. Asian J Surg. 2004 Oct;27(4):348-51. PubMed
  6. Don M, Longo G. Food protein-induced enterocolitis syndrome due to banana: an uncommon entity. Eur Ann Allergy Clin Immunol. 2013 Apr;45(2):61-2.
  7. Tazoe M, Narita M, Sakuta R, Nagai T, Narita N. Hyperkalemia and hyperdopaminemia induced by an obsessive eating of banana in an anorexia nervosa adolescent. Brain Dev. 2007 Jul;29(6):369-72. PubMed
  8. Meynadier J, Meynadier JM, Guilhou JJ. [Contact urticaria in atopic patients. Apropos of 2 cases]. Ann Dermatol Venereol. 1982;109(10):871-4.
  9. Hauswirth DW, Burks AW. Banana anaphylaxis with a negative commercial skin test. J Allergy Clin Immunol. 2005 Mar;115(3):632-3. PubMed
  10. Hotozuka S, Yasu T, Hikita E, Shirota M. Interaction Between Levodopa and Banana in a Patient With Parkinson's Disease. Am J Ther 2022;29(4):465-467. PubMed
  11. Arias-Córdova Y, Ble-Castillo JL, García-Vázquez C, et al. Resistant Starch Consumption Effects on Glycemic Control and Glycemic Variability in Patients with Type 2 Diabetes: A Randomized Crossover Study. Nutrients 2021;13(11):4052. PubMed

See these in context on the Banana monograph →

Radish 5 references
  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Damiani E, Aloia AM, Priore MG, Nardulli S, Ferrannini A. Generalized urticaria after ingestion of Raphanus sativus. Ann Allergy Asthma Immunol. 2011 Feb;106(2):168. PubMed
  3. Evans M, Paterson E, Barnes DM. An open label pilot study to evaluate the efficacy of Spanish black radish on the induction of phase I and phase II enzymes in healthy male subjects. BMC Complement Altern Med. 2014 Dec 9;14:475. PubMed
  4. Banihani SA. Radish (Raphanus sativus) and diabetes. Nutrients. 2017;9(9). pii: E1014. PubMed
  5. Shukla S, Chatterji S, Mehta S, Rai PK, Singh RK, Yadav DK, Watal G. Antidiabetic effect of Raphanus sativus root juice. Pharm Biol. 2011 Jan;49(1):32-7.

See these in context on the Radish monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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