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Dietary supplement

Longevitrol Ingredients & Drug Interactions

by Earth's Bounty

Longevitrol label
See full label image
Liquid Category: Non-nutrient/non-botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Longevitrol against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Longevitrol is a dietary supplement by Earth's Bounty with 1 active ingredient. Its ingredients are commonly taken for athletic performance and strength, energy and fatigue, joint health and arthritis.Based on those ingredients, 52 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Velvet Antler extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Longevitrol by Earth's Bounty

Ask about any prescription or over-the-counter medication and we check it for interactions with Longevitrol by Earth's Bounty — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Longevitrol by Earth's Bounty

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.

Longevitrol is a one-ingredient liquid supplement built around velvet antler extract — the soft tissue covering that grows on deer antlers. The extract is mixed with purified water, vegetable glycerin, vitamin C (ascorbic acid), a trace mineral blend, maca root extract, green tea leaf extract, natural flavors, and citric acid to deliver it in liquid form.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Deer Velvet's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Anti-aging formula.
  • We looked for evidence on: Aging, longevity, age-related decline, aging-related conditions.
  • The closest evidence on file: Deer Velvet is rated "Insufficient Reliable Evidence To Rate" for Aging (Natural Medicines).

The evidence for velvet antler extract doesn't yet support its use for any of the conditions it's marketed for. Our data rates it as having insufficient reliable evidence for wound healing, cardiovascular disease, high blood pressure, bone strength, sexual desire, and slowing aging.

That doesn't mean it doesn't work — it means the studies aren't there yet to prove it does.

The evidence, ingredient by ingredient Deer Velvet

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Velvet antler extract appears generally well tolerated in short-term use, but we don't have solid long-term safety data or good information on product quality across brands. The safety information isn't adequate for pregnancy or breastfeeding, so the data advises against use in both.

If you're pregnant, nursing, or planning to become pregnant, talk with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Deer Velvet

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Deer Velvet.
  • The most serious interaction on file is rated Minor.
  • For scale: 52 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Longevitrol, run your birth control pills and any estrogen medications (including hormone replacement therapy) through the interaction checker on this page. Both carry Minor-severity concerns with the velvet antler extract in this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Only minor medication interactions are documented, and some safety-information gaps remain.

Longevitrol is a single-ingredient liquid built on velvet antler extract, a substance with very limited research backing its claimed benefits. If you take birth control pills or estrogen-based hormone therapy, you'll want to confirm with your own doctor or pharmacist that this product won't interfere before you start.

For anyone else, the main caution is that long-term safety hasn't been established.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 22, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Longevitrol, straight from the product label.

Brand Earth's Bounty
Net contents 1 Ounce(s); 30 mL
Market status On market
Date entered into DSLD Dec 22, 2019
DSLD ID 208749
Product type Non-nutrient/non-botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Longevitrol by Earth's Bounty, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Spray(s)
Maximum serving Sizes:
3 Spray(s)
Servings per container
61
IngredientAmount% DV
Velvet Antler extract0 NP--

Other ingredients: purified Water, deionized Water, Vegetable Glycerin, Ascorbic Acid, Trace Mineral Complex, Maca root extract, Green Tea Leaf Extract, Natural Flavors, Polymer Matrix, Citric Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Anti-aging formula

FDA Statement of Identity

Liquid Dietary Supplement

General Statements

Oral polymer matrix spray

Suggested/Recommended/Usage/Directions

Suggested use: 3 sprays 2-3 times daily into your mouth.

Precautions

Do not use if outer safety seal is broken or missing.

Not recommended if pregnant or nursing.

Keep out of reach of children.

Storage

Store at room temperature. Keep out of direct sunlight.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Longevitrol by Earth's Bounty label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Longevitrol label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Longevitrol by Earth's Bounty

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size3 Spray(s) Dosage formLiquid Servings per container61 Amounts shown are per serving.

Velvet Antler extract

Interacts with
52 drugs
0 NP per serving

Deer velvet is a traditional remedy made from the soft, growing antlers of deer or elk, and it is most often promoted for energy, athletic performance...

Velvet Antler extract monograph & interactions

Other (inactive) ingredients: Purified Water, Deionized Water, Vegetable Glycerin, Ascorbic Acid, Trace Mineral Complex, Maca root extract, Green Tea Leaf Extract, Natural Flavors, Polymer Matrix, Citric Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Longevitrol by Earth's Bounty Drug Interactions

Want to check YOUR meds against Longevitrol?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
52Drugs
52 Minor

Ingredients driving the most interactions

Velvet Antler extract 52

Individual Drug Interactions

The ingredients in Longevitrol interact with 52 drugs. Click any drug to see the details.

1 of the 1 ingredient in Longevitrol interact with drugs. Each result below shows which ingredient is responsible. Velvet Antler extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Longevitrol with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Velvet Antler extract2 drug types · 52 drugs

Contraceptive Drugs

Theoretically, deer velvet might interfere with the effectiveness of contraceptive drugs.
Laboratory research shows that deer velvet contains small quantities of estradiol and testosterone. While clinical research shows that taking deer velvet extract does not raise testosterone levels, estradiol levels were not measured.

Likelihood Unlikely Evidence D
Estrogens

Theoretically, deer velvet might increase the effects and side effects of estrogens.
Laboratory evidence shows that deer velvet contains small quantities of estradiol and testosterone. While clinical research shows that taking deer velvet extract does not raise testosterone levels, estradiol levels were not measured.

Likelihood Unlikely Evidence D
Velvet Antler extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Longevitrol, from the product label.

Earth's Bounty

See all Earth's Bounty products
Name
Earth's Bounty
City
Vancouver
State
WA
ZipCode
98682
Phone Number
800-736-5609
Web Address
www.earthsbounty.com
Pharmacist Counseling Corner

Longevitrol by Earth's Bounty: Common Questions

Does Longevitrol by Earth's Bounty interact with any medications?
Yes. Based on its ingredients, Longevitrol has a known interaction with 52 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Longevitrol contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does velvet antler extract really work for any of the things Longevitrol claims?
According to our data, we don't have enough reliable evidence to say yes for any of them — not for wound healing, heart health, blood pressure, bones, sexual function, or anti-aging. That's different from saying it doesn't work; it means the studies haven't been done or published yet.
Is it safe if I'm trying to get pregnant?
There isn't enough safety information to know either way. Talk with your doctor or pharmacist about whether to use it while you're trying to conceive.
Can I take this while breastfeeding?
No — there isn't enough safety data, so it's best avoided while breastfeeding. Check with your doctor or pharmacist if you have questions about what you can take during nursing.
What exactly is velvet antler extract?
It's an extract made from the soft tissue that covers a deer's antlers before they harden. That tissue contains small amounts of estradiol and testosterone, which is why the product can interact with hormonal medications.
Are there any side effects listed for this product?
Our data doesn't have documented side effects for velvet antler extract. The main caution is that long-term safety hasn't been well studied.
What are all the other ingredients in the bottle?
The other ingredients are water, vegetable glycerin, vitamin C, a trace mineral complex, maca root extract, green tea leaf extract, natural flavors, a polymer matrix, and citric acid. These are inactive ingredients that help preserve and flavor the liquid.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Longevitrol is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Longevitrol label
Go deeper

The Full Monographs Behind Longevitrol’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Deer Velvet

Interacts with 52 drugs

Deer velvet is a traditional remedy made from the soft, growing antlers of deer or elk, and it is most often promoted for energy, athletic performance, and joint health. Good-quality human e...

Read the full Deer Velvet monograph →
Sources

Sources & How We Checked

Longevitrol's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Deer Velvet 2 references
  1. Sleivert, G., Burke, V., Palmer, C., Walmsley, A., Gerrard, D., Haines, S., and Littlejohn, R. The effects of deer antler velvet extract or powder supplementation on aerobic power, erythropoiesis, and muscular strength and endurance characteristics. Int PubMed
  2. Bubenik, G. A., Miller, K. V., Lister, A. L., Osborn, D. A., Bartos, L., and van der Kraak, G. J. Testosterone and estradiol concentrations in serum, velvet skin, and growing antler bone of male white-tailed deer. J Exp Zoolog.A Comp Exp Biol 3-1-2005;30 PubMed

See these in context on the Deer Velvet monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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