Interactions on record — worth a quick check against your medications. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

High Concentration Omega-3 Krill Oil 750 mg Ingredients & Drug Interactions

by Schiff MegaRed

High Concentration Omega-3 Krill Oil 750 mg label
See full label image
Softgel Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking High Concentration Omega-3 Krill Oil 750 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

High Concentration Omega-3 Krill Oil 750 mg is a dietary supplement by Schiff MegaRed with 3 active ingredients. Its ingredients are commonly taken for heart and cholesterol support, high triglycerides, joint pain and inflammation.Based on those ingredients, 838 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Astaxanthin, Krill Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against High Concentration Omega-3 Krill Oil 750 mg by Schiff MegaRed

Ask about any prescription or over-the-counter medication and we check it for interactions with High Concentration Omega-3 Krill Oil 750 mg by Schiff MegaRed — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of High Concentration Omega-3 Krill Oil 750 mg by Schiff MegaRed

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 2 of its 4 active ingredients.
  • “Krill Oil” is listed as a grouped ingredient — the label gives one combined amount (750 mg) without saying how much of each component you get.
  • “Total Omega-3 Fatty Acids” is listed as a grouped ingredient — the label gives one combined amount (225 mg) without saying how much of each component you get.
  • “Total EPA and DHA” is listed as a grouped ingredient — the label gives one combined amount (183 mg) without saying how much of each component you get.

This krill oil supplement has 4 active ingredients: krill oil (the whole ingredient blend), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and phospholipids. EPA and DHA are omega-3 fatty acids — the main reason people take krill oil.

Phospholipids are fat-like compounds that help the body absorb those omega-3s. Each softgel delivers 750 mg of the full krill oil blend.

The product also contains the antioxidant astaxanthin, which gives krill oil its red color. The inactive ingredients are gelatin, glycerin, water, ethyl vanillin (for flavor), sorbitol, and sulfur dioxide.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Astaxanthin's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Supports cardiovascular health and three markers.
  • We looked for evidence on: Cardiovascular disease (CVD), Hyperlipidemia, Hypertriglyceridemia, Heart failure, Hypertension, Stroke — and 3 related terms.
  • The closest evidence on file: Astaxanthin is rated "Insufficient Reliable Evidence To Rate" for Heart failure (Natural Medicines).
  • Also on file: Astaxanthin is rated "Insufficient Reliable Evidence To Rate" for Hyperlipidemia, Hypertension, Stroke.

We don't have reliable evidence to rate astaxanthin's effectiveness for any of its common uses — age-related cognitive decline, macular degeneration, aging skin, Alzheimer disease, athletic performance, or carpal tunnel syndrome. That means the research so far hasn't been strong enough to say whether it works for these purposes.

The evidence, ingredient by ingredient Krill Oil Astaxanthin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Astaxanthin is generally well tolerated, though long-term safety data are limited. The most common side effects from oral use are abdominal pain, diarrhea, and red-colored stool.

In trial doses of 6 mg daily, a small number of participants reported increased bowel movements and red stool. At higher doses (40 mg daily), severe stomach or abdominal pain occurred in a small number of cases.

The safety data advises against taking this product during pregnancy or while breastfeeding, because there isn't enough information to know whether it's safe for the baby.

Side effects, ingredient by ingredient Krill Oil Astaxanthin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Astaxanthin.
  • The most serious interaction on file is rated Moderate.
  • For scale: 672 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, check with your doctor or pharmacist if you take any medications processed through the CYP3A4 or CYP2B6 pathways in your liver — astaxanthin may theoretically lower their blood levels. Use the interaction checker on this page to look up your exact medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you don't take medications broken down by CYP3A4 or CYP2B6 enzymes in your liver, this product has no documented interactions. Even so, because astaxanthin's safety in the long term is still being studied, talk it over with your doctor or pharmacist before starting — especially if you're pregnant, breastfeeding, or take any regular medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 22, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about High Concentration Omega-3 Krill Oil 750 mg, straight from the product label.

Brand Schiff MegaRed
Barcode (UPC) 020525957139
Net contents 80 Softgel(s)
Market status On market
Date entered into DSLD Oct 22, 2016
DSLD ID 65417
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for High Concentration Omega-3 Krill Oil 750 mg by Schiff MegaRed, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
UPC/BARCODE
020525957139
IngredientAmount% DV
Calories5 Calorie(s)--
Krill Oil750 mg--
Calories from Fat5 Calorie(s)--
Eicosapentaenoic Acid0 NP--
Docosahexaenoic Acid0 NP--
Phospholipids262 mg--
Cholesterol15 mg4%
Total Fat0.5 Gram(s)1%
Total Omega-3 Fatty Acids225 mg--
Total EPA and DHA183 mg--
Astaxanthin225 mcg--

Other ingredients: Gelatin, Glycerin, Water, Ethyl Vanillin, Sorbitol, Sulfur Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Since 1936

New High Concentration

Heart health

To open tear here

Supports the 3 markers of Cardiovascular Health: Omega-3 index1, Triglycerides2 & CRP3

One Pill, No Fishy Aftertaste

Actual size

A healthy and active life begins with a healthy heart. And eating healthy, staying active and taking omega-3 supplements can help support your heart health.

rb Health Hygiene Home

Gelatin is derived from bovine sources.

2 Based on 15 randomized controlled trials assessing the impact of Omega-3 fatty acid intake on serum triglyceride levels. 3 Based on 30 day randomized, double blind, placebo controlled trial measuring the effect of 300mg krill oil on CRP levels.

Eco-Friendly. Krill is one of earth’s most abundant and sustainable organisms. The harvest of krill is well below conservative international catch guidelines.

GUARANTEED for purity, freshness and labeled potency.

Formula

30% More Omega-3s per mg vs. standard pure Krill Oil 100% Pure High Absorption Krill Oil

MegaRed High Concentration Krill Oil contains ingredients to support three markers of cardiovascular health: ~ Omega-3 index: The amount of omega-3 fatty acids EPA DHA in blood cells1 ~ Triglycerides: A type of fat measured in the blood2 ~ C-reactive Protein (CRP): An important marker of systemic inflammation3

Besides, MegaRed is the first to give you 30% more Omega-3s per milligram compared to what you can find in standard pure krill oil supplements. All in just one, easy to swallow pill.

It also contains astaxanthin, a naturally occurring antioxidant.

Contains shellfish (krill)

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Why is MegaRed High Concentration Krill Oil superior?

MegaRed High Concentration Krill Oil carries its omegas in a phospholipid form for easy absorption and uses 100% pure Antarctic Krill, tiny crustaceans that thrive in the frigid waters of the Antarctic.

2015 RB

1 Proprietary controlled human clinical study of 300mg MegaRed for improving Omega-3 Index.

More Omega-3 in one pill One 750 mg MegaRed High Concentration pill = Two 500 mg standard pure Krill Oil pills

MegaRed goes a step further by only sourcing krill from the Antarctic where krill is most abundant. This helps the ecosystem maintain a healthy, sustainable krill population.

Suggested/Recommended/Usage/Directions

DIRECTIONS: Adults take one (1) softgel daily.

Precautions

Contains shellfish (krill)

WARNING: People with shellfish allergy, coagulopathy or taking anticoagulants or other medications should notify their physician and be tested prior to taking dietary supplements.

WARNING: People with shellfish allergy, coagulopathy or taking anticoagulants or other medications should notify their physician and be tested prior to taking dietary supplements. Note: If pregnant, breastfeeding, or on prescribed medication, consult your physician before using this product.

Keep out of reach of children.

Protected with a tamper evident seal. Do not use if seal under cap is broken or missing.

Storage

Store in a cool, dry place with lid tightly closed.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Schiff Quality Guarantee

Formulation

GUARANTEED: No added sugar (sucrose, fructose, lactose), salt (sodium chloride), yeast, wheat, gluten or milk. No preservatives or artificial colors.

General

072215 8199993

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

High Concentration Omega-3 Krill Oil 750 mg by Schiff MegaRed label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

High Concentration Omega-3 Krill Oil 750 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in High Concentration Omega-3 Krill Oil 750 mg by Schiff MegaRed

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Krill Oil

Interacts with
208 drugs
750 mg per serving

Krill oil is a source of omega-3 fatty acids (EPA and DHA) bound to phospholipids, which may help absorption. It is most studied for lowering triglyce...

Krill Oil monograph & interactions
  • › Total Omega-3 Fatty Acids

Phospholipids

262 mg per serving

Astaxanthin

Interacts with
671 drugs
225 mcg per serving Form: Krill Oil

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise...

Astaxanthin monograph & interactions

Other (inactive) ingredients: Gelatin, Glycerin, Water, Ethyl Vanillin, Sorbitol, Sulfur Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

High Concentration Omega-3 Krill Oil 750 mg by Schiff MegaRed Drug Interactions

Want to check YOUR meds against High Concentration Omega-3 Krill Oil 750 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
838Drugs
838 Moderate

Ingredients driving the most interactions

Astaxanthin 671
Krill Oil 208

Individual Drug Interactions

The ingredients in High Concentration Omega-3 Krill Oil 750 mg interact with 838 drugs. Click any drug to see the details.

2 of the 3 ingredients in High Concentration Omega-3 Krill Oil 750 mg interact with drugs. Each result below shows which ingredient is responsible. Astaxanthin Krill Oil

Each ingredient & the kinds of drugs it affects

For each ingredient in High Concentration Omega-3 Krill Oil 750 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Astaxanthin2 drug types · 671 drugs

Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP2B6.
In vitro research shows that astaxanthin induces cytochrome CYP2B6 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
In vitro research shows that astaxanthin induces CYP3A4 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Astaxanthin full monograph & interactions

Krill Oil2 drug types · 208 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, krill oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Taking high doses of omega-3 fatty acids from fish oil can modestly decrease platelet aggregation. Since krill oil also contains these fatty acids, taking high doses of krill oil might also inhibit platelet aggregation. Theoretically, taking high doses of krill oil with antiplatelet or anticoagulant drugs might increase the risk of bleeding. However, the omega-3 content of krill oil is much lower than that of fish oil.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking krill oil with antidiabetes drugs might increase the risk of hypoglycemia.
Some research in animals and humans shows that krill oil might lower blood glucose levels. However, a small study shows that taking krill oil does not reduce blood glucose levels in patients with type 2 diabetes, most of whom were taking antidiabetes drugs.

Likelihood Possible Evidence B
Krill Oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for High Concentration Omega-3 Krill Oil 750 mg, from the product label.

Schiff MegaRed

See all Schiff MegaRed products
Name
Reckitt Benckiser
City
Parsippany
State
NJ
ZipCode
07054-0224
Phone Number
1-800-526-6251
Web Address
www.megared.com
Pharmacist Counseling Corner

High Concentration Omega-3 Krill Oil 750 mg by Schiff MegaRed: Common Questions

Does High Concentration Omega-3 Krill Oil 750 mg by Schiff MegaRed interact with any medications?
Yes. Based on its ingredients, High Concentration Omega-3 Krill Oil 750 mg has a known interaction with 838 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
High Concentration Omega-3 Krill Oil 750 mg contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What exactly is krill oil?
Krill oil is made from tiny shrimp-like creatures called krill. It's rich in omega-3 fatty acids (EPA and DHA) and phospholipids, which help your body absorb them. It also contains astaxanthin, a natural red antioxidant.
Can I take this while pregnant or breastfeeding?
The safety data advise against it — there isn't enough information to know whether it's safe for your baby during pregnancy or while nursing. Talk with your doctor or pharmacist about whether it's right for you in those situations.
What side effects might I notice?
The most common ones are mild abdominal pain, diarrhea, and red-colored stool. In trials, a small number of people had increased bowel movements or stomach pain, especially at higher doses.
Is there evidence this works for memory or brain health?
We don't have reliable evidence yet to say astaxanthin works for age-related cognitive decline, Alzheimer disease, or any other brain-health condition. The research hasn't been strong enough to draw a conclusion.
Why is my stool red after taking this?
That's the astaxanthin — the red antioxidant in krill oil. It comes through unchanged in your stool. It's harmless, just a visual side effect.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if High Concentration Omega-3 Krill Oil 750 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

High Concentration Omega-3 Krill Oil 750 mg label
Go deeper

The Full Monographs Behind High Concentration Omega-3 Krill Oil 750 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Krill Oil

Interacts with 208 drugs

Krill oil is a source of omega-3 fatty acids (EPA and DHA) bound to phospholipids, which may help absorption. It is most studied for lowering triglycerides and supporting heart health, but t...

Read the full Krill Oil monograph → Herb & supplement monograph

Astaxanthin

Interacts with 671 drugs

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise benefits. Early human studies are promis...

Read the full Astaxanthin monograph →
Sources

Sources & How We Checked

High Concentration Omega-3 Krill Oil 750 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Krill Oil 13 references
  1. Leaf A. On the reanalysis of the GISSI-Prevenzione. Circulation 2002;105:1874-5. PubMed
  2. Connor WE. n-3 Fatty acids from fish and fish oil: panacea or nostrum? Am J Clin Nutr 2001;74;415-6. PubMed
  3. Calder PC. N-3 polyunsaturated fatty acids, inflammation and immunity: pouring oil on troubled waters or another fishy tale? Nutr Res 2001;21:309-41. DOI
  4. Bunea R, El Farrah K, Deutsch L. Evaluation of the effects of Neptune Krill Oil on the clinical course of hyperlipidemia. Altern Med Rev 2004;9:420-8.
  5. Sampalis F, Bunea R, Pelland MF, et al. Evaluation of the effects of Neptune Krill Oil on the management of premenstrual syndrome and dysmenorrhea. Altern Med Rev 2003;8:171-9.
  6. Harris WS, Miller M, Tighe AP, et al. Omega-3 fatty acids and coronary heart disease risk: clinical and mechanistic perspectives. Atherosclerosis 2008;197:12-24. PubMed
  7. Tandy S, Chung RW, Wat E, et al. Dietary krill oil supplementation reduces hepatic steatosis, glycemia, and hypercholesterolemia in high-fat-fed mice. J Agric Food Chem 10-14-2009;57:9339-45. PubMed
  8. Maki, K. C., Reeves, M. S., Farmer, M., Griinari, M., Berge, K., Vik, H., Hubacher, R., and Rains, T. M. Krill oil supplementation increases plasma concentrations of eicosapentaenoic and docosahexaenoic acids in overweight and obese men and women. Nutr.R PubMed
  9. Albert BB, Derraik JG, Brennan CM, et al. Supplementation with a blend of krill and salmon oil is associated with increased metabolic risk in overweight men. Am J Clin Nutr 2015;102(1):49-57.
  10. Berge K, Musa-Veloso K, Harwood M, Hoem N, Burri L. Krill oil supplementation lowers serum triglycerides without increasing low-density lipoprotein cholesterol in adults with borderline high or high triglyceride levels. Nutr Res 2014;34(2):126-33. PubMed
  11. Lobraico JM, DiLello LC, Butler AD, Cordisco ME, Petrini JR, Ahmadi R. Effects of krill oil on endothelial function and other cardiovascular risk factors in participants with type 2 diabetes, a randomized controlled trial. BMJ Open Diabetes Res Care. 2015 PubMed
  12. van der Wurff ISM, von Schacky C, Bergeland T, Zeegers MP, Kirschner PA, de Groot RHM. Krill oil supplementation's effect on school grades in typically developing adolescents. Prostaglandins Leukot Essent Fatty Acids 2023;191:102553. PubMed
  13. van der Wurff ISM, von Schacky C, Bergeland T, et al. Effect of 1 year krill oil supplementation on cognitive achievement of Dutch adolescents: A double-blind randomized controlled trial. Nutrients. 2019;11(6):1230. PubMed

See these in context on the Krill Oil monograph →

Astaxanthin 3 references
  1. Kupcinskas L, Lafolie P, Lignell A, et al. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled
  2. Kistler, A., Liechti, H., Pichard, L., Wolz, E., Oesterhelt, G., Hayes, A., and Maurel, P. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. Arch.Toxicol. 2002;75(11-12):665-675. PubMed
  3. Choi HD, Youn YK, Shin WG. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods Hum Nutr. 2011;66:363-369. PubMed

See these in context on the Astaxanthin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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