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Dietary supplement

High Strength Krill Oil 500 mg With Astaxanthin Ingredients & Drug Interactions

by Simply Supplements

High Strength Krill Oil 500 mg With Astaxanthin label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking High Strength Krill Oil 500 mg With Astaxanthin against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

High Strength Krill Oil 500 mg With Astaxanthin is a dietary supplement by Simply Supplements with 1 active ingredient. Its ingredients are commonly taken for heart and cholesterol support, high triglycerides, joint pain and inflammation.Based on those ingredients, 838 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Krill Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against High Strength Krill Oil 500 mg With Astaxanthin by Simply Supplements

Ask about any prescription or over-the-counter medication and we check it for interactions with High Strength Krill Oil 500 mg With Astaxanthin by Simply Supplements — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of High Strength Krill Oil 500 mg With Astaxanthin by Simply Supplements

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • “Krill Oil” is listed as a grouped ingredient — the label gives one combined amount (500 mg) without saying how much of each component you get.

This product contains 3 active ingredients: two omega-3 fatty acids from krill oil (eicosapentaenoic acid and docosahexaenoic acid) and astaxanthin, a carotenoid antioxidant. The krill oil provides the omega-3s EPA and DHA, the same long-chain fatty acids found in fish oil.

Astaxanthin is the pigment that gives krill and other marine life their reddish color and is included here as an added antioxidant component. The capsule also contains gelatin, glycerol, sorbitol, and purified water as inactive ingredients.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: heart health, blood pressure and triglyceride support.
  • We looked for evidence on: Cardiovascular disease (CVD), Hypertension, Hypertriglyceridemia, Hyperlipidemia, Heart failure, Stroke — and 2 related terms.
  • The closest evidence on file: Astaxanthin is rated "Insufficient Reliable Evidence To Rate" for Heart failure (Natural Medicines).
  • Also on file: Astaxanthin is rated "Insufficient Reliable Evidence To Rate" for Hyperlipidemia, Hypertension, Stroke.

The evidence for astaxanthin's effectiveness is limited. Our data shows insufficient reliable evidence to rate it for age-related cognitive decline, macular degeneration of the eye, aging skin, Alzheimer disease, athletic performance, or carpal tunnel syndrome.

We hold no effectiveness ratings for the krill oil's omega-3 content in this product.

The evidence, ingredient by ingredient Krill Oil Astaxanthin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Astaxanthin is generally well tolerated in studies, though long-term safety data are limited. The most common side effects reported orally are abdominal pain, diarrhea, and red-colored stools — a harmless color change from the astaxanthin itself.

At standard doses (around 6 mg daily), a small number of trial participants experienced increased bowel movements or red stools; at much higher doses (40 mg daily), severe stomach pain has been reported in a small number of people. Not enough safety data exist for astaxanthin during pregnancy or breastfeeding, so it's best to avoid it in both situations.

Talk with your doctor or pharmacist about whether this product is right for you if you're pregnant, planning to become pregnant, or nursing.

Side effects, ingredient by ingredient Krill Oil Astaxanthin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Astaxanthin.
  • The most serious interaction on file is rated Moderate.
  • For scale: 672 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start this product, check with your doctor or pharmacist if you take any drugs metabolized by the CYP3A4 liver enzyme (which includes statins, some blood pressure medications, some immunosuppressants, and many others) or the CYP2B6 enzyme. Astaxanthin may theoretically lower their blood levels and reduce effectiveness, though this hasn't been confirmed in humans.

Because we couldn't check the omega-3 fatty acids against our data, discuss the full product with your healthcare provider.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This krill oil supplement delivers omega-3 fatty acids (EPA and DHA) plus astaxanthin, though the evidence for astaxanthin's health benefits is currently weak. The main concern is whether astaxanthin may lower levels of certain medications processed by your liver.

If you take drugs broken down by CYP3A4 or CYP2B6 enzymes — or any prescription medication — check your exact medications with the tool on this page and talk with your doctor or pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 24, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about High Strength Krill Oil 500 mg With Astaxanthin, straight from the product label.

Brand Simply Supplements
Barcode (UPC) 5060370563821
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Feb 24, 2017
DSLD ID 70308
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses Nutrient, All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for High Strength Krill Oil 500 mg With Astaxanthin by Simply Supplements, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
UPC/BARCODE
5060370563821
IngredientAmount% DV
Eicosapentaenoic Acid60 mg--
Docosahexaenoic Acid30 mg--
Astaxanthin180 mcg--
Krill Oil500 mg--

Other ingredients: Gelatin, Glycerol, Sorbitol, purified Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

High Strength Krill Oil 500 mg With Astaxanthin Concentrated source of Omega 3

Product Information Krill Oil provides valuable levels of EPA and DHA, which contribute to the maintenance of healthy heart function, blood pressure and triglyceride levels. The ingredient which sets krill oil apart from other fish oils is astaxanthin, which may offer some defence against oxidative damage.

Seals/Symbols

Quality Assured

Suggested/Recommended/Usage/Directions

Suggested Daily Intake Take one to three capsules daily as a food supplement or as directed by a healthcare professional.

Precautions

Important Information If you are taking any prescription medication, you have a medical condition or you have specific concerns about the suitability of our products, always consult your GP or Pharmacist prior to taking supplements.

Do not exceed stated dose.

Keep away from children at all times.

Do not use if seal is broken.

Pregnant or lactating women should consult a Doctor before using this product.

Food supplement: This product should not be used as a substitute for a varied diet.

For Allergens see ingredients in bold.

Storage

Store in a cool dry place.

General Statements

Image is for illustration purposes only.

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General

E391

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

High Strength Krill Oil 500 mg With Astaxanthin by Simply Supplements label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

High Strength Krill Oil 500 mg With Astaxanthin label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in High Strength Krill Oil 500 mg With Astaxanthin by Simply Supplements

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Krill Oil

Interacts with
208 drugs
500 mg per serving Form: Crustaceans

Krill oil is a source of omega-3 fatty acids (EPA and DHA) bound to phospholipids, which may help absorption. It is most studied for lowering triglyce...

Krill Oil monograph & interactions
  • › Eicosapentaenoic Acid
  • › Docosahexaenoic Acid
  • › Astaxanthin

Other (inactive) ingredients: Gelatin, Glycerol, Sorbitol, Purified Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

High Strength Krill Oil 500 mg With Astaxanthin by Simply Supplements Drug Interactions

Want to check YOUR meds against High Strength Krill Oil 500 mg With Astaxanthin?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
838Drugs
838 Moderate

Ingredients driving the most interactions

Krill Oil 208

Individual Drug Interactions

The ingredients in High Strength Krill Oil 500 mg With Astaxanthin interact with 838 drugs. Click any drug to see the details.

1 of the 1 ingredient in High Strength Krill Oil 500 mg With Astaxanthin interact with drugs. Each result below shows which ingredient is responsible. Krill Oil

Each ingredient & the kinds of drugs it affects

For each ingredient in High Strength Krill Oil 500 mg With Astaxanthin with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Krill Oil2 drug types · 208 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, krill oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Taking high doses of omega-3 fatty acids from fish oil can modestly decrease platelet aggregation. Since krill oil also contains these fatty acids, taking high doses of krill oil might also inhibit platelet aggregation. Theoretically, taking high doses of krill oil with antiplatelet or anticoagulant drugs might increase the risk of bleeding. However, the omega-3 content of krill oil is much lower than that of fish oil.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking krill oil with antidiabetes drugs might increase the risk of hypoglycemia.
Some research in animals and humans shows that krill oil might lower blood glucose levels. However, a small study shows that taking krill oil does not reduce blood glucose levels in patients with type 2 diabetes, most of whom were taking antidiabetes drugs.

Likelihood Possible Evidence B
Krill Oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for High Strength Krill Oil 500 mg With Astaxanthin, from the product label.

Simply Supplements

See all Simply Supplements products
Name
Simply Supplements
Street Address
PO Box 1330
City
Peterborough
ZipCode
PE2 2PW
Phone Number
0800 988 0292
Pharmacist Counseling Corner

High Strength Krill Oil 500 mg With Astaxanthin by Simply Supplements: Common Questions

Does High Strength Krill Oil 500 mg With Astaxanthin by Simply Supplements interact with any medications?
Yes. Based on its ingredients, High Strength Krill Oil 500 mg With Astaxanthin has a known interaction with 838 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
High Strength Krill Oil 500 mg With Astaxanthin contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What are EPA and DHA, and why are they in krill oil?
EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) are long-chain omega-3 fatty acids naturally found in krill and other marine sources. They're the same beneficial omega-3s you'd get from fish oil. We don't have effectiveness data on file for these ingredients in this specific product.
What is astaxanthin, and why is it added to krill oil?
Astaxanthin is a carotenoid pigment — a natural compound that gives krill and salmon their reddish color — included here as an antioxidant. The evidence for its health benefits is currently too weak to rate for most conditions.
Will this product turn my stool red?
Red-colored stools are a common and harmless side effect of astaxanthin. It's just the pigment passing through; it doesn't mean anything is wrong. This color change has been reported in trial participants and is not a sign of an adverse effect.
Is this safe to take if I'm pregnant or breastfeeding?
No — there isn't enough safety data on astaxanthin in pregnancy or breastfeeding, so it's best to avoid it in both situations. Talk with your doctor or pharmacist about what's right for you.
Are there any common side effects I should know about?
Most people tolerate astaxanthin well. The most common side effects are abdominal pain, diarrhea, and red stools. At very high doses (much higher than this product), severe stomach pain has been reported in a small number of people.
Why does the interaction report mention 672 medications?
That number reflects the total of individual medications affected by all the ingredients we could check — in this case, astaxanthin's theoretical effect on two liver enzymes that process hundreds of different drugs. You may not take any of them, so use the search tool to check your exact medications.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if High Strength Krill Oil 500 mg With Astaxanthin is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

High Strength Krill Oil 500 mg With Astaxanthin label
Go deeper

The Full Monographs Behind High Strength Krill Oil 500 mg With Astaxanthin’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Krill Oil

Interacts with 208 drugs

Krill oil is a source of omega-3 fatty acids (EPA and DHA) bound to phospholipids, which may help absorption. It is most studied for lowering triglycerides and supporting heart health, but t...

Read the full Krill Oil monograph → Herb & supplement monograph

Astaxanthin

Interacts with 671 drugs

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise benefits. Early human studies are promis...

Read the full Astaxanthin monograph →
Sources

Sources & How We Checked

High Strength Krill Oil 500 mg With Astaxanthin's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Astaxanthin 3 references
  1. Kupcinskas L, Lafolie P, Lignell A, et al. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled
  2. Kistler, A., Liechti, H., Pichard, L., Wolz, E., Oesterhelt, G., Hayes, A., and Maurel, P. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. Arch.Toxicol. 2002;75(11-12):665-675. PubMed
  3. Choi HD, Youn YK, Shin WG. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods Hum Nutr. 2011;66:363-369. PubMed

See these in context on the Astaxanthin monograph →

Krill Oil 13 references
  1. Leaf A. On the reanalysis of the GISSI-Prevenzione. Circulation 2002;105:1874-5. PubMed
  2. Connor WE. n-3 Fatty acids from fish and fish oil: panacea or nostrum? Am J Clin Nutr 2001;74;415-6. PubMed
  3. Calder PC. N-3 polyunsaturated fatty acids, inflammation and immunity: pouring oil on troubled waters or another fishy tale? Nutr Res 2001;21:309-41. DOI
  4. Bunea R, El Farrah K, Deutsch L. Evaluation of the effects of Neptune Krill Oil on the clinical course of hyperlipidemia. Altern Med Rev 2004;9:420-8.
  5. Sampalis F, Bunea R, Pelland MF, et al. Evaluation of the effects of Neptune Krill Oil on the management of premenstrual syndrome and dysmenorrhea. Altern Med Rev 2003;8:171-9.
  6. Harris WS, Miller M, Tighe AP, et al. Omega-3 fatty acids and coronary heart disease risk: clinical and mechanistic perspectives. Atherosclerosis 2008;197:12-24. PubMed
  7. Tandy S, Chung RW, Wat E, et al. Dietary krill oil supplementation reduces hepatic steatosis, glycemia, and hypercholesterolemia in high-fat-fed mice. J Agric Food Chem 10-14-2009;57:9339-45. PubMed
  8. Maki, K. C., Reeves, M. S., Farmer, M., Griinari, M., Berge, K., Vik, H., Hubacher, R., and Rains, T. M. Krill oil supplementation increases plasma concentrations of eicosapentaenoic and docosahexaenoic acids in overweight and obese men and women. Nutr.R PubMed
  9. Albert BB, Derraik JG, Brennan CM, et al. Supplementation with a blend of krill and salmon oil is associated with increased metabolic risk in overweight men. Am J Clin Nutr 2015;102(1):49-57.
  10. Berge K, Musa-Veloso K, Harwood M, Hoem N, Burri L. Krill oil supplementation lowers serum triglycerides without increasing low-density lipoprotein cholesterol in adults with borderline high or high triglyceride levels. Nutr Res 2014;34(2):126-33. PubMed
  11. Lobraico JM, DiLello LC, Butler AD, Cordisco ME, Petrini JR, Ahmadi R. Effects of krill oil on endothelial function and other cardiovascular risk factors in participants with type 2 diabetes, a randomized controlled trial. BMJ Open Diabetes Res Care. 2015 PubMed
  12. van der Wurff ISM, von Schacky C, Bergeland T, Zeegers MP, Kirschner PA, de Groot RHM. Krill oil supplementation's effect on school grades in typically developing adolescents. Prostaglandins Leukot Essent Fatty Acids 2023;191:102553. PubMed
  13. van der Wurff ISM, von Schacky C, Bergeland T, et al. Effect of 1 year krill oil supplementation on cognitive achievement of Dutch adolescents: A double-blind randomized controlled trial. Nutrients. 2019;11(6):1230. PubMed

See these in context on the Krill Oil monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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