Interactions on record — worth a quick check against your medications. Based on 2 of 4 ingredients. Check your meds →
Dietary supplement

HLC Neonate Ingredients & Drug Interactions

by Pharmax

HLC Neonate label
See full label image
Powder Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking HLC Neonate against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

HLC Neonate is a dietary supplement by Pharmax with 4 active ingredients. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus acidophilus (CUL-21), Bifidobacterium animalis subsp. lactis (CUL-62). Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against HLC Neonate by Pharmax

Ask about any prescription or over-the-counter medication and we check it for interactions with HLC Neonate by Pharmax — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of HLC Neonate by Pharmax

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 4 active ingredients.
  • “HLC Consortium” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

HLC Neonate is a powder containing 4 active probiotic ingredients: two strains of Lactobacillus acidophilus (CUL-21 and CUL-60), Lactobacillus paracasei (CUL-08), and Bifidobacterium animalis subsp. lactis (CUL-62)—all live, beneficial bacteria meant to support gut health. The inactive ingredients include lactose monohydrate.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Digestive health and immune support for infants.
  • We looked for evidence on: Antibiotic-associated diarrhea, Colic, Constipation, Lactose intolerance, Necrotizing enterocolitis (NEC), Rotaviral diarrhea — and 3 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Bifidobacterium Animalis Subsp. Lactis is rated "Possibly Effective" for Constipation, Colic.
  • Also on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Constipation, Lactose intolerance, Necrotizing enterocolitis (NEC), Rotaviral diarrhea.

These probiotics have been studied for several digestive and immune conditions. Both Lactobacillus acidophilus strains and Bifidobacterium animalis subsp. lactis are rated possibly effective for irritable bowel syndrome (IBS) and antibiotic-associated diarrhea, and both L. acidophilus strains also show possibly effective evidence for Helicobacter pylori and bacterial vaginosis.

B. lactis is additionally rated possibly effective for respiratory tract infections and constipation. L. acidophilus is rated possibly ineffective for atopic disease, and evidence is insufficient to rate it for acute respiratory distress syndrome.

We hold no effectiveness data for Lactobacillus paracasei.

The evidence, ingredient by ingredient Lactobacillus Acidophilus Bifidobacterium Animalis Subsp. Lactis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

These probiotics are generally well tolerated in healthy adults and children. In clinical trials, gastrointestinal side effects like abdominal discomfort, bloating, flatulence, and diarrhea were reported in a small number of participants, though these events are uncommon.

Rare cases of rash and itching have been noted in trial data, though it's unclear whether they were due to L. acidophilus, B. lactis, the combination, or individual sensitivity. Since these contain live organisms, there is a theoretical concern of infection in some patients, though most documented cases appear linked to bacteria translocation from other body sites.

Your own healthcare provider can weigh whether this product is right for your specific situation.

Side effects, ingredient by ingredient Lactobacillus Acidophilus Bifidobacterium Animalis Subsp. Lactis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Lactobacillus Acidophilus, Bifidobacterium Animalis Subsp. Lactis.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking HLC Neonate, double-check the timing with your doctor or pharmacist if you're on antibiotic drugs. Antibiotics taken at the same time as this product may reduce how well the probiotics work.

We have no documented interactions with other medication types for the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

HLC Neonate is a multi-strain probiotic powder aimed at digestive and immune support, with possibly effective evidence for IBS, antibiotic-associated diarrhea, and respiratory health. The main consideration is timing around antibiotics—you'll want to separate doses by a few hours.

If you take any medications or have concerns about safety, talk it over with your doctor or pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about HLC Neonate, straight from the product label.

Brand Pharmax
Barcode (UPC) 88319620630
Net contents 0.2 Oz(s); 6 Gram(s)
Market status On market
Date entered into DSLD Mar 24, 2020
DSLD ID 215379
Product type Non-nutrient/non-botanical
Supplement form Powder
Dietary claims / uses All Other
Intended target group(s) Children more than 1 but less than 4
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for HLC Neonate by Pharmax, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Children less than 4 years of age
Minimum serving Sizes:
0.1 Gram(s)
Maximum serving Sizes:
0.1 Gram(s)
Servings per container
60
UPC/BARCODE
88319620630
IngredientAmount% DV
Lactobacillus acidophilus (CUL-21)0 NP--
HLC Consortium0 NP--
Lactobacillus acidophilus (CUL-60)0 NP--
Lactobacillus paracasei (CUL-08)0 NP--
Bifidobacterium animalis subsp. lactis (CUL-62)0 NP--

Other ingredients: Lactose Monohydrate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Recommended intake: Children (1-4 years): added one level scoop (100 mg) of HLC neonate powder into a single daily feeding of expressed breast or formula milk or as professionally directed.

Take at least 2-3 hours before or after taking antibiotics.

Precautions

Risk information: If you have an immune compromised condition, do not use. If you are experiencing nausea, fever, vomiting, bloody diarrhea or severe abdominal pain, consult your healthcare practitioner prior to use. If symptoms of digestive upset occur, worsen or persist beyond three days, discontinue use and consult your healthcare practitioner. Safety-sealed for your protection and for product freshness. Do not use if out seal is missing or broken.

Keep out of reach of children.

Storage

Store under refrigeration (below 46 degrees F).

FDA Statement of Identity

Dietary Supplement

Probiotic Supplement

General Statements

see www.pharmaxllc.com for details

Nutraceutical & Biophysical Systems

Formula

Contains clinically proven strains

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

HLC Neonate by Pharmax label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

HLC Neonate label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in HLC Neonate by Pharmax

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size0.1 Gram(s) Dosage formPowder Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

HLC Consortium

0 NP per serving

Other (inactive) ingredients: Lactose Monohydrate. These complete the product’s ingredient list but are not active constituents.

Interaction report

HLC Neonate by Pharmax Drug Interactions

Want to check YOUR meds against HLC Neonate?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Lactobacillus acidophilus (CUL-21) 182
Bifidobacterium animalis subsp. lactis (CUL-62) 182

Individual Drug Interactions

The ingredients in HLC Neonate interact with 182 drugs. Click any drug to see the details.

2 of the 4 ingredients in HLC Neonate interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus acidophilus (CUL-21) Bifidobacterium animalis subsp. lactis (CUL-62)

Each ingredient & the kinds of drugs it affects

For each ingredient in HLC Neonate with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus acidophilus (CUL-21)1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus (CUL-21) full monograph & interactions

Bifidobacterium animalis subsp. lactis (CUL-62)1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium lactis with antibiotic drugs might decrease the effectiveness of B. lactis.
Since B. lactis preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. lactis preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium animalis subsp. lactis (CUL-62) full monograph & interactions
The maker

Brand information

Manufacturer and brand details for HLC Neonate, from the product label.

Pharmax

See all Pharmax products
Name
Seroyal USA
City
Pittsburgh
State
PA
ZipCode
15275
Phone Number
1-888-737-6925
Web Address
www.pharmaxllc.com
Pharmacist Counseling Corner

HLC Neonate by Pharmax: Common Questions

Does HLC Neonate by Pharmax interact with any medications?
Yes. Based on its ingredients, HLC Neonate has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
HLC Neonate contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm on an antibiotic?
Not at the same time. Since HLC Neonate contains live probiotic bacteria, antibiotics will kill them off and make the probiotics less effective. Ask your doctor or pharmacist how many hours apart you should take them—usually a few hours works well.
Is this safe during pregnancy?
Lactobacillus acidophilus is rated possibly safe in pregnancy, but data are limited. The safety profile for the other ingredients during pregnancy isn't on file. Talk with your doctor or pharmacist about whether it's right for you during pregnancy.
What are the common side effects?
Most people tolerate it well. A small number of trial participants reported mild digestive discomfort—bloating, gas, abdominal pain, or diarrhea—but these are uncommon. Rash has been reported rarely in combination probiotic trials, though it's unclear what caused it.
Will this help my IBS?
Both Lactobacillus acidophilus strains and Bifidobacterium lactis in this product are rated possibly effective for IBS. That means evidence suggests they may help, but results vary. Whether they'll work for you is an individual call worth discussing with your doctor.
Does this have any fillers or additives I should know about?
The powder contains lactose monohydrate as an inactive ingredient. If you're lactose intolerant or allergic, check with your doctor or pharmacist before use.
Can I take this while breastfeeding?
Safety data for breastfeeding isn't on file for the ingredients in this product. Talk with your doctor or pharmacist for personalized advice about whether it's appropriate for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if HLC Neonate is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

HLC Neonate label
Go deeper

The Full Monographs Behind HLC Neonate’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph → Herb & supplement monograph

Bifidobacterium Animalis Subsp. Lactis

Interacts with 182 drugs

Bifidobacterium animalis subsp. lactis is a well-studied probiotic bacterium commonly added to supplements and yogurts to support digestion and gut health. It appears generally safe for most...

Read the full Bifidobacterium Animalis Subsp. Lactis monograph →
Sources

Sources & How We Checked

HLC Neonate's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 23 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Bifidobacterium Animalis Subsp. Lactis 8 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Phuapradit P, Varavithya W, Vathanophas K, et al. Reduction of rotavirus infection in children receiving bifidobacteria-supplemented formula. J Med Assoc Thai 1999;82:S43-8.
  3. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  4. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  5. Taipale TJ, Pienihäkkinen K, Isolauri E, Jokela JT, Söderling EM. Bifidobacterium animalis subsp. lactis BB-12 in reducing the risk of infections in early childhood. Pediatr Res. 2016;79(1-1):65-9. PubMed
  6. Amat-Bou M, Garcia-Ribera S, Climent E, et al. Effects of Bifidobacterium animalis Subsp. lactis (BPL1) supplementation in children and adolescents with prader-willi syndrome: A randomized crossover trial. Nutrients. 2020;12(10):3123. PubMed
  7. Mäkelä SM, Forssten SD, Kailajärvi M, et al. Effects of Bifidobacterium animalis ssp. lactis 420 on gastrointestinal inflammation induced by a nonsteroidal anti-inflammatory drug: A randomized, placebo-controlled, double-blind clinical trial. Br J Clin Ph
  8. Wildt S, Munck LK, Vinter-Jensen L, et al. Probiotic treatment of collagenous colitis: a randomized, double-blind, placebo-controlled trial with Lactobacillus acidophilus and Bifidobacterium animalis subsp. Lactis. Inflamm Bowel Dis 2006;12(5):395-401. PubMed

See these in context on the Bifidobacterium Animalis Subsp. Lactis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team