Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

HoneyZest Soothing Blend Ingredients & Drug Interactions

by Amazing Herbs

HoneyZest Soothing Blend label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking HoneyZest Soothing Blend against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

HoneyZest Soothing Blend is a dietary supplement by Amazing Herbs with 5 active ingredients. Its ingredients are commonly taken for cough and sore throat, wound and burn care, soothing minor skin irritation.Based on those ingredients, 1,424 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Chamomile, Black Cumin Seed Oil Extract, raw Honey. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against HoneyZest Soothing Blend by Amazing Herbs

Ask about any prescription or over-the-counter medication and we check it for interactions with HoneyZest Soothing Blend by Amazing Herbs — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of HoneyZest Soothing Blend by Amazing Herbs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 5 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (7 Gram(s)) without saying how much of each component you get.

HoneyZest Soothing Blend contains 5 active ingredients: raw honey, hyssop, chamomile, black cumin seed oil extract, and thyme extract, delivered in powder form. There are no inactive ingredients listed for this product.

Raw honey has been studied for colds sores, cough, sore throat inflammation (oral mucositis), burns, and dry eye. Chamomile, hyssop, and thyme are traditional respiratory and throat-soothing herbs.

Black cumin seed oil extract has been studied for acne, allergies, asthma, and stomach bacteria.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Acne — rated "Possibly Effective" (Black Seed) (Natural Medicines).
  • On file: Allergic rhinitis (hay fever) — rated "Possibly Effective" (Black Seed) (Natural Medicines).
  • On file: Asthma — rated "Possibly Effective" (Black Seed) (Natural Medicines).
  • On file: Burns — rated "Possibly Effective" (Honey) (Natural Medicines).
  • On file: Chronic obstructive pulmonary disease (COPD) — rated "Possibly Effective" (Black Seed) (Natural Medicines).

Raw honey is possibly effective for cold sores, cough, sore throat inflammation, burns, and dry eye. The other four ingredients — hyssop, chamomile, thyme extract, and black cumin seed oil extract — all show insufficient reliable evidence for their traditional uses in our data.

Hyssop and thyme have not been reliably studied for respiratory tract infections or cough; chamomile has insufficient evidence for anxiety and attention issues; and while black cumin seed is possibly effective for acne, allergies, asthma, and diabetes, there's no established evidence for its role in this blend's soothing purpose.

The evidence, ingredient by ingredient Honey Hyssop German Chamomile Black Seed Thyme

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Raw honey is generally well tolerated and safe as a food for adults and children over 1 year old. Orally and topically it may cause nausea, stomach pain, vomiting, burning, pain, or stinging — usually minor.

Avoid honey from the Black Sea coast of Turkey, which can contain grayanotoxins and cause serious cardiac effects. Allergic reactions including anaphylaxis are rare but possible.

Chamomile is well tolerated for most adults but can trigger allergic reactions in people sensitive to ragweed; topically it may cause dermatitis or eczema. Thyme is safe as a food and tea; the concentrated essential oil is toxic if swallowed.

Black cumin seed is well tolerated in food amounts; common side effects with supplements are constipation, gastric discomfort, nausea, and vomiting. Hyssop in small amounts is low-risk, but the essential oil can cause seizures.

For pregnancy: raw honey and thyme are likely safe, but hyssop is likely unsafe and should be avoided — it's traditionally thought to stimulate the uterus. Black cumin seed supplement doses are likely unsafe in pregnancy.

Chamomile safety in pregnancy is unclear; talk with your doctor before using it medicinally. For breastfeeding: raw honey eaten by the mother is fine, but medicinal use should be discussed with your provider.

Hyssop and black cumin are best avoided while breastfeeding due to insufficient safety data. Chamomile has limited safety data — check with your doctor or pharmacist.

Side effects, ingredient by ingredient Honey Hyssop German Chamomile Black Seed Thyme

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 5 matched ingredients can interact with medications — Honey, Thyme, Black Seed, German Chamomile.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,425 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before taking this product if you use seizure medications (phenytoin), sedatives or sleep aids, antidepressants (especially SSRIs), blood thinners or antiplatelet drugs, blood pressure medications, diabetes medications, oral contraceptives or hormone replacement therapy, tamoxifen, diuretics, cyclosporine, or any drug metabolized by liver enzymes CYP2D6, CYP2C9, or CYP3A4 — a category that includes many common medications. Use the medication checker below to confirm your specific drugs before you start.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

HoneyZest Soothing Blend is built around raw honey, which has good evidence for cough and cold sores, plus traditional respiratory herbs. However, the blend carries multiple Moderate-severity interactions with common medications — especially blood pressure drugs, blood thinners, sedatives, antidepressants, diabetes and birth control medications, and several others.

If you take any prescription medication, check it against the list on this page before starting. Pregnant or breastfeeding people should talk with their doctor or pharmacist, since hyssop and black cumin are not recommended in pregnancy and several ingredients lack safety data in lactation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about HoneyZest Soothing Blend, straight from the product label.

Brand Amazing Herbs
Barcode (UPC) 665231841169
Net contents 16 Ounce(s); 1 Pound(s); 454 Gram(s)
Market status On market
Date entered into DSLD Jun 16, 2022
DSLD ID 272860
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for HoneyZest Soothing Blend by Amazing Herbs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
7 Gram(s)
Maximum serving Sizes:
7 Gram(s)
Servings per container
65
UPC/BARCODE
665231841169
IngredientAmount% DV
Calories20 Calorie(s)--
Total Carbohydrates6 Gram(s)2%
Total Sugars5 Gram(s)--
Proprietary Blend7 Gram(s)--
added Sugars5 Gram(s)10%
raw Honey0 NP--
Hyssop0 NP--
Chamomile0 NP--
Black Cumin Seed Oil Extract0 NP--
Thyme extract0 NP--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

Formula

Herbal honey Raw natural honey infused with hyssop, chamomile, thyme extracts and pure black seed oil.

Suggested/Recommended/Usage/Directions

Suggested Use One teaspoon Add to tea, milk, juice

Formulation

Made in the USA

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

HoneyZest Soothing Blend by Amazing Herbs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

HoneyZest Soothing Blend label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in HoneyZest Soothing Blend by Amazing Herbs

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size7 Gram(s) Dosage formPowder Servings per container65 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

7 Gram(s) per serving
Interaction report

HoneyZest Soothing Blend by Amazing Herbs Drug Interactions

Want to check YOUR meds against HoneyZest Soothing Blend?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,424Drugs
1,397 Moderate 27 Minor

Ingredients driving the most interactions

Chamomile 960
Black Cumin Seed Oil Extract 912
raw Honey 736
Thyme extract 379

Individual Drug Interactions

The ingredients in HoneyZest Soothing Blend interact with 1,424 drugs. Click any drug to see the details.

4 of the 5 ingredients in HoneyZest Soothing Blend interact with drugs. Each result below shows which ingredient is responsible. Chamomile Black Cumin Seed Oil Extract raw Honey Thyme extract

Each ingredient & the kinds of drugs it affects

For each ingredient in HoneyZest Soothing Blend with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Chamomile9 drug types · 960 drugs

Cns Depressants

Theoretically, German chamomile might have additive effects when used with CNS depressants.
German chamomile has mild sedative effects. Theoretically, concomitant use with drugs with sedative properties can cause additive effects and side effects.

Likelihood Possible Evidence D
Contraceptive Drugs

Theoretically, large amounts of German chamomile might reduce the effectiveness of oral contraceptives.
In vitro, German chamomile has demonstrated antiestrogenic activity. Theoretically, concomitant use of large amounts of German chamomile might interfere with contraceptive drugs through competition for estrogen receptors.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, German chamomile might inhibit CYP2C9 and increase levels of drugs metabolized by these enzymes.
In vitro evidence shows that German chamomile might inhibit CYP2C9. So far, this interaction has not been reported in humans. However, there might be an increase in the levels of drugs metabolized by CYP2C9 in patients taking German chamomile.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, German chamomile might inhibit CYP2D6 and increase levels of drugs metabolized by these enzymes.
In vitro evidence shows that German chamomile might inhibit CYP2D6. So far, this interaction has not been reported in humans. However, there might be an increase in the levels of drugs metabolized by CYP2D6 in patients taking German chamomile.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.
In vitro evidence shows that German chamomile might inhibit CYP3A4. So far, this interaction has not been reported in humans. However, there might be an increase in the levels of drugs metabolized by CYP3A4 in patients taking German chamomile.

Likelihood Possible Evidence D
Estrogens

Theoretically, large amounts of German chamomile might reduce the effectiveness of estrogens.
In vitro, German chamomile has demonstrated antiestrogenic activity. Theoretically, large amounts of German chamomile might interfere with hormone replacement therapy through competition for estrogen receptors.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, large amounts of German chamomile might interfere with the activity of tamoxifen.
In vitro, German chamomile has demonstrated antiestrogenic activity.

Likelihood Possible Evidence D
Warfarin (Coumadin)

German chamomile might increase the effects of warfarin and increase the risk of bleeding.
In one case, a 70-year-old female taking warfarin developed retroperitoneal hematoma and bilateral recti muscle bleeding along with an INR of 7.9 following ingestion of German chamomile tea 4-5 cups daily and use of a topical chamomile-based lotion applied 4-5 times daily.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, German chamomile might inhibit CYP1A2 and increase levels of drugs metabolized by these enzymes.
In vitro and animal research shows that German chamomile might inhibit CYP1A2. So far, this interaction has not been reported in humans. However, there might be an increase in the levels of drugs metabolized by CYP1A2 in patients taking German chamomile.

Likelihood Possible Evidence D
Chamomile full monograph & interactions

Black Cumin Seed Oil Extract14 drug types · 912 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, black seed may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that black seed extract can inhibit platelet aggregation and clotting, and increase bleeding time. In addition, decreased platelet counts have occurred in a human case report and in animal research.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking black seed with antidiabetes drugs might increase the risk of hypoglycemia.
Some clinical research and numerous animal studies suggest that black seed, especially its constituent thymoquinone, can have hypoglycemic effects.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking black seed with antihypertensive drugs might increase the risk of hypotension.
Clinical research suggests that black seed powder and oil might reduce blood pressure by 2-3 mmHg. In animal research, black seed modestly reduces blood pressure and concomitant use of black seed and amlodipine (Norvasc) or metoprolol (Lopressor) increased the blood pressure lowering effects of these drugs.

Likelihood Possible Evidence B
Clopidogrel (Plavix)

Theoretically, black seed may increase the risk of bleeding if used with clopidogrel.
Animal research shows that taking black seed extract daily for 2 weeks prior to a single dose of clopidogrel increases maximum concentrations of clopidogrel by approximately 31% and modestly decreases oral clearance. Furthermore, bleeding time was increased by 12%. This has not been shown in humans.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.
Animal research suggests that black seed may have CNS depressant effects.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically taking black seed might reduce the levels and clinical effects of cyclosporine.
In animal research, black seed extract decreased the maximal levels of cyclosporine in the blood by 35.5%. This has not been shown in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, black seed might increase levels of drugs metabolized by CYP2C9.
In vitro research suggests that thymoquinone, a constituent of black seed, can decrease the metabolism of phenytoin by a mechanism possibly related to the inhibition of CYP2C9. The effect of black seed on CYP2C9 is unclear. This has not been shown in humans.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, taking black seed with diuretic drugs might increase potassium loss and the risk of hypokalemia.
Black seed extract has shown diuretic effects in animals, which could theoretically increase potassium loss. This has not been shown in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, black seed might interfere with immunosuppressive therapy.
Animal and in vitro studies suggest that black seed might stimulate immune function. However, other animal studies suggest that black seed may suppress immune function.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

Theoretically, black seed might increase or decrease levels and effects of phenytoin.
In vitro research suggests that thymoquinone, a constituent of black seed, can decrease the metabolism of phenytoin. This effect may be due to inhibition of cytochrome P450 2C9 (CYP2C9). However, animal research shows that black seed decreases the maximum concentration of and total systemic exposure to phenytoin by 57% and 87%, respectively. This seems to be related to increased clearance and steady state volume of distribution. This interaction has not been shown in humans.

Likelihood Possible Evidence D
Serotonergic Drugs

Theoretically, combining serotonergic drugs with black seed might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders.
Animal research suggests that black seed can increase brain serotonin levels. In one case report, a 35-year-old man undergoing endoscopic surgery experienced immediate postoperative serotonin syndrome that was likely associated with the use of black seed oil 600 mg daily starting 4 days before surgery, and precipitated by the use of serotonergic pain medications, including fentanyl and oxycodone. Monitor patients for signs of serotonin syndrome and other serotonergic side effects if using black seed with serotonergic drugs.

Likelihood Possible Evidence D
Sildenafil (Viagra)

Theoretically, black seed might reduce plasma levels and the therapeutic effects of sildenafil.
Animal research shows that black seed reduces the total systemic exposure to sildenafil by 43%. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, black seed might increase levels of warfarin and increase the risk of bleeding.
In vitro research suggests that thymoquinone, a constituent of black seed, can decrease the metabolism of warfarin. This effect may be due to inhibition of cytochrome P450 2C9 (CYP2C9). The effect of black seed on warfarin metabolism is unclear. This has not been shown in humans.

Likelihood Possible Evidence D
Prednisolone

Theoretically black seed might reduce plasma levels and therapeutic effects of prednisolone.
In animal research, oral administration of a single dose of black seed oil 15 minutes prior to oral prednisolone decreases the prednisolone maximum plasma concentration by 65% and area under the curve by 25%. This has not been shown in humans.

Likelihood Possible Evidence D
Black Cumin Seed Oil Extract full monograph & interactions

raw Honey3 drug types · 736 drugs

Phenytoin (Dilantin)

Theoretically, honey might increase levels of phenytoin.
In an animal model, the rate and extent of absorption of phenytoin was increased by honey. This effect has not been reported in humans.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, honey may increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
In vitro, honey inhibits platelet aggregation and increases the time to clotting. Furthermore, animal research suggests that feeding mice large doses of honey for 12 days increases bleeding time when compared with no intervention. However, these effects have not been reported in humans.

Likelihood Unlikely Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Some clinical research shows that honey induces CYP3A4. However, other clinical studies found no effect on CYP3A4 activity. Different honey preparations may have different effects on CYP3A4.

Likelihood Possible Evidence B
raw Honey full monograph & interactions

Thyme extract4 drug types · 379 drugs

Anticholinergic Drugs

Theoretically, concurrent use of anticholinergic drugs and thyme essential oil might reduce the effects of anticholinergic drugs.
In vitro evidence suggests that thyme essential oil and specific essential oil constituents like thymohydroquinone and carvacrol can inhibit acetylcholinesterase (AChE). However, this effect has not been observed in humans.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, thyme leaf extract might have additive effects with anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that thyme leaf extract has antiplatelet effects. However, this effect has not been observed in humans.

Likelihood Possible Evidence D
Cholinergic Drugs

Theoretically, concurrent use of cholinergic drugs and thyme essential oil might cause additive cholinergic effects.
In vitro evidence suggests that thyme essential oil and specific essential oil constituents like thymohydroquinone and carvacrol can inhibit acetylcholinesterase (AChE). However, this effect has not been observed in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, thyme might competitively inhibit the effects of estrogen replacement therapy.
In vitro research shows that thyme has estrogen receptor-binding activity and phytoestrogen content. However, this effect has not been observed in humans.

Likelihood Possible Evidence D
Thyme extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for HoneyZest Soothing Blend, from the product label.

Amazing Herbs

See all Amazing Herbs products
Name
Amazing Herbs
City
Buford
State
GA
ZipCode
30518
Phone Number
1-800-241-9138
Pharmacist Counseling Corner

HoneyZest Soothing Blend by Amazing Herbs: Common Questions

Does HoneyZest Soothing Blend by Amazing Herbs interact with any medications?
Yes. Based on its ingredients, HoneyZest Soothing Blend has a known interaction with 1,424 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
HoneyZest Soothing Blend contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is it safe to take this while pregnant?
The blend contains hyssop, which is likely unsafe in pregnancy because it's traditionally thought to stimulate the uterus — you should avoid it. Raw honey and thyme are likely safe, but black cumin supplement doses and chamomile's medicinal use lack clear safety data in pregnancy. Talk with your doctor or pharmacist before taking this blend.
Can I take this while breastfeeding?
Raw honey eaten by a nursing mother is generally considered fine, but medicinal use should be discussed with your provider. Hyssop and black cumin are best avoided while breastfeeding due to insufficient safety data, and chamomile has limited safety information — check with your doctor or pharmacist.
What is raw honey in this blend actually used for?
Honey is possibly effective for cough, cold sores, sore throat inflammation, burns, and dry eye. That's where the evidence is strongest. The other ingredients are traditional respiratory and soothing herbs, but they haven't been reliably studied for their specific uses.
Are there any common side effects from this powder?
Honey may cause nausea, stomach pain, or vomiting; chamomile and thyme can cause nausea, heartburn, or diarrhea; and black cumin commonly causes constipation, gastric discomfort, or nausea. Most are mild, but if you have a sensitivity to ragweed plants, chamomile could trigger an allergic reaction.
Does black cumin seed in here actually work for anything?
Black cumin is possibly effective for acne, allergies, asthma, and stomach bacteria in clinical studies. But in this soothing blend, there's no established evidence that it plays a role in the product's respiratory or throat benefits.
Should I worry about the hyssop in this blend?
In small culinary or tea amounts, hyssop is generally low-risk. However, the essential oil can be toxic and cause seizures, so avoid concentrated forms. If you're pregnant or breastfeeding, skip this product due to hyssop alone.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

HoneyZest Soothing Blend label
Go deeper

The Full Monographs Behind HoneyZest Soothing Blend’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Honey

Interacts with 736 drugs

Honey is a natural food with some real, modest evidence for easing coughs and helping certain wounds, especially when special medical-grade or Manuka honey is used. It is generally safe for...

Read the full Honey monograph → Herb & supplement monograph

Hyssop

Hyssop is a Mediterranean mint-family herb traditionally used for coughs, colds, and digestive complaints, but solid human evidence for these uses is lacking. The dried herb in tea is genera...

Read the full Hyssop monograph → Herb & supplement monograph

German Chamomile

Interacts with 960 drugs

German chamomile is a widely used herbal remedy taken mainly as a tea for calming, sleep, and digestive complaints. Early research suggests possible benefits for mild anxiety and some skin o...

Read the full German Chamomile monograph → Herb & supplement monograph

Black Seed

Interacts with 912 drugs

Black seed (Nigella sativa) is a traditional spice and remedy that has been studied for asthma, blood sugar, cholesterol, and blood pressure, with early research showing some promise but no...

Read the full Black Seed monograph → Herb & supplement monograph

Thyme

Interacts with 379 drugs

Thyme is a common kitchen herb that has long been used for coughs, sore throats, and digestive complaints. It is generally safe in the amounts found in food, and some cough products that com...

Read the full Thyme monograph →
Sources

Sources & How We Checked

HoneyZest Soothing Blend's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 134 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Honey 40 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. Bose B. Honey or sugar in treatment of infected wounds? Lancet 1982;1:963. PubMed
  4. Ozhan H, Akdemir R, Yazici M, et al. Cardiac emergencies caused by honey ingestion: a single centre experience. Emerg Med J 2004;21:742-4. PubMed
  5. Centers for Disease Control. Botulism in the Unites Sates, 1899-1996. Handbook for epidemiologists, clinicians, and laboratory workers, 1998. Available online: http://www.cdc.gov/ncidod/dbmd/diseaseinfo/botulism.PDF.
  6. Simon A, Traynor K, Santos K, et al. Medical honey for wound care - still the 'latest resort'? Evid Based Complement Alternat Med 2009;6:165-73. PubMed
  7. Gethin G, Cowman S. Case series of use of Manuka honey in leg ulceration. Int Wound J 2005;2:10-15. PubMed
  8. Ingle R, Levin J, Polinder K. Wound healing with honey - a randomised controlled trial. S Afr Med J 2006;96:831-5.
  9. Johnson DW, van Eps C, Mudge DW, et al. Randomized, controlled trial of topical exit-site application of honey (Medihoney) versus mupirocin for the prevention of catheter-associated infections in hemodialysis patients. J Am Soc Nephrol 2005;16:1456-62. PubMed
  10. Sukriti and Garg, S. K. Influence of honey on the pharmacokinetics of phenytoin in rabbits. Ind J Pharmacol 2002;34(147).
  11. Jung, A. and Ottosson, J. [Infantile botulism caused by honey]. Ugeskr Laeger 2001;163(2):169.
  12. Gunduz, A., Turedi, S., Uzun, H., and Topbas, M. Mad honey poisoning. Am J Emerg.Med 2006;24(5):595-598.
  13. van der Vorst, M. M., Jamal, W., Rotimi, V. O., and Moosa, A. Infant botulism due to consumption of contaminated commercially prepared honey. First report from the Arabian Gulf States. Med Princ.Pract. 2006;15(6):456-458. PubMed
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Hyssop 1 reference
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Black Seed 60 references
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Thyme 18 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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