Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Hormone Balance + Probiotics Ingredients & Drug Interactions

by Rainbow Nutrients

Hormone Balance + Probiotics label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Hormone Balance + Probiotics against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Hormone Balance + Probiotics is a dietary supplement by Rainbow Nutrients with 5 active ingredients. Its ingredients are commonly taken for menopause symptoms, menstrual cramps and irregular periods, premenstrual syndrome (pms).Based on those ingredients, 925 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Black Cohosh, Probiotic Blend, Dong Quai root extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Hormone Balance + Probiotics by Rainbow Nutrients

Ask about any prescription or over-the-counter medication and we check it for interactions with Hormone Balance + Probiotics by Rainbow Nutrients — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Hormone Balance + Probiotics by Rainbow Nutrients

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 4 of its 9 active ingredients.
  • “Probiotic Blend” is a proprietary blend — the label gives one combined amount (50 mg) without saying how much of each component you get.

This product has 9 ingredients, including three live-organism probiotics: Lactobacillus acidophilus, Bifidobacterium animalis lactis, and Bacillus coagulans. It also contains Lactobacillus rhamnosus and Bifidobacterium breve — both probiotics that support gut health.

For hormone support, it includes Dong Quai root extract (traditionally used in Asian medicine), Black Cohosh (used for menopausal symptoms), Maca (a root supplement), and Chasteberry fruit extract. The capsules also contain inactive ingredients: hypromellose, magnesium stearate, silicon dioxide, and microcrystalline cellulose.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Hormone balance and probiotic digestive support.
  • We looked for evidence on: Menopausal symptoms, Dysmenorrhea, Amenorrhea, Constipation, Diarrhea, Irritable bowel syndrome (IBS) — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Irritable bowel syndrome (IBS).
  • Also on file: Black Cohosh is rated "Possibly Effective" for Menopausal symptoms.

Evidence for this product's ingredients is mixed. Lactobacillus acidophilus is possibly effective for irritable bowel syndrome, antibiotic-associated diarrhea, and bacterial vaginosis, though evidence remains limited.

Bacillus coagulans is possibly effective for constipation and irritable bowel syndrome. Black Cohosh is possibly effective for menopausal symptoms.

For the other active ingredients — Bifidobacterium breve, Bifidobacterium animalis lactis, Lactobacillus rhamnosus, Maca, Dong Quai, and Chasteberry — we have insufficient reliable evidence in our data to say whether they work for their stated purposes, or the evidence suggests they're ineffective. The evidence for 'hormone balance' as a whole isn't established in the data we hold.

The evidence, ingredient by ingredient Dong Quai Lactobacillus Acidophilus Bacillus Coagulans Bifidobacterium Breve Black Cohosh Maca Vitex Agnus-castus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 7 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

The probiotics are generally well tolerated in healthy adults, though live-organism supplements do carry a small theoretical risk of infection in severely ill or immunocompromised people — talk to your doctor if you fall into that group. Gastrointestinal side effects like bloating, flatulence, and stomach upset are uncommon but reported.

Black Cohosh is generally well tolerated at standard doses short-term, but rare cases of liver problems have been documented; medical guidance before use is wise. Dong Quai is generally well tolerated but can increase bleeding risk and cause sensitivity to sunlight.

Maca is well tolerated as a food but long-term supplement safety hasn't been studied. Pregnancy and breastfeeding safety data aren't on file for most of these ingredients; those with safety guidance advise against their use in pregnancy and lactation.

Talk with your doctor or pharmacist before use if you're pregnant or nursing.

Side effects, ingredient by ingredient Dong Quai Lactobacillus Acidophilus Bacillus Coagulans Bifidobacterium Breve Black Cohosh Maca Vitex Agnus-castus

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 6 of the 7 matched ingredients can interact with medications — Lactobacillus Acidophilus, Black Cohosh, Dong Quai, Vitex Agnus-castus, Bacillus Coagulans, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 926 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this, double-check if you're on warfarin or other blood thinners (anticoagulants or antiplatelet drugs) — Dong Quai increases bleeding risk significantly. Also check for estrogen therapy, serotonergic antidepressants (SSRIs, SNRIs, or others), hepatotoxic drugs, atorvastatin, cisplatin, or antibiotic medications, all of which have documented Moderate interactions with ingredients here.

CYP2D6 substrates and OATP2B1 substrates (you can search these terms with your pharmacist) also have interactions documented. Use the medication checker on this page with your complete drug list.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This is a multi-ingredient supplement with probiotics and herbal hormone support — but it has significant interactions with blood thinners, hormone therapy, liver-affecting drugs, and antidepressants. If you take any prescription medication, especially warfarin, estrogen therapy, cholesterol drugs, or serotonergic antidepressants, check your medications against the tool below before starting.

Even if you take antibiotics, you'll need to time them carefully away from the probiotics. Talk to your pharmacist before adding this to your regimen.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 9 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Hormone Balance + Probiotics, straight from the product label.

Brand Rainbow Nutrients
Barcode (UPC) X003OGXE5L
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Nov 22, 2024
DSLD ID 319991
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Girls: (All), Adult Female (18 - 50 Years), Menopause, Post-Menopause
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Hormone Balance + Probiotics by Rainbow Nutrients, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
X003OGXE5L
IngredientAmount% DV
Lactobacillus acidophilus0 NP--
Bifidobacterium animalis lactis0 NP--
Bacillus coagulans0 NP--
Dong Quai root extract300 mg--
Lactobacillus rhamnosus0 NP--
Bifidobacterium breve0 NP--
Probiotic Blend50 mg--
Black Cohosh100 mg--
Maca500 mg--
Chasteberry fruit extract400 mg--

Other ingredients: Hypromellose, Magnesium Stearate, Silicon Dioxide, Microcrystalline Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Keep out of reach of children.

Do not use if safety seal is damaged or missing.

Caution Pregnant or nursing mothers, children under the age of 18 and individuals with a known medical condition should consult with a physician before using this or any dietary supplement.

Pregnant or nursing mothers, children under the age of 18 and individuals with a known medical condition should consult with a physician before using this or any dietary supplement.

Storage

Store in a cool & dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

Our Quality Commitment Our proprietary hormone balance + probiotic formula uses the highest potency natural herbs available to ensure the right nutrients get into your body for a better you! It provides unique Chasteberry and Dong Quai 4:1 extracts combined with 5 strains of probiotics for maximum bioavailability to help with PMS, menopause, cramps, mood swings, night seats & more

Suggested/Recommended/Usage/Directions

Suggested use Take 2 capsules once a day or as directed by your healthcare professional. For best results, take daily for at least 15 consecutive days or results may diminish.

Formulation

Natural hormone balance Natural all-in-1 women relief PMS & menopause relief Manages mood & hot flashes

120 non-GMO V capsules Made with Non GMO ingredients

Vegan Friendly

Zero GMO's, antibiotics, preservatives, gluten, shellfish, dairy, soy & wheat, sugar, hormones, lactose, egg, peanuts, tree nuts

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Vegan Friendly LAB tested 3rd party certified for purity & potency Made in the USA with globally sourced ingredients GMPc Facility Good Manufacturing Practice-consistency quality

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Hormone Balance + Probiotics by Rainbow Nutrients label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Hormone Balance + Probiotics label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Hormone Balance + Probiotics by Rainbow Nutrients

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Dong Quai root extract

Interacts with
163 drugs
300 mg per serving

Dong Quai is a traditional Chinese herb often called "female ginseng" and is mostly used for menstrual and menopausal complaints. High-quality scienti...

Dong Quai root extract monograph & interactions

Probiotic Blend

Interacts with
182 drugs
50 mg per serving

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy p...

Probiotic Blend monograph & interactions

Black Cohosh

Interacts with
652 drugs
100 mg per serving

Black cohosh is a North American plant most often used to ease menopause symptoms like hot flashes, but the research is mixed and far from settled. It...

Black Cohosh monograph & interactions

Maca

No known
interactions
500 mg per serving

Maca is a nutrient-rich Andean root often used for energy, libido, and menopause symptoms. Early studies suggest it may modestly help sexual desire an...

Maca monograph & interactions

Chasteberry fruit extract

Interacts with
121 drugs
400 mg per serving

Vitex (chasteberry) is an herbal remedy most often used for PMS and menstrual cycle problems, and the strongest evidence is for easing some PMS sympto...

Chasteberry fruit extract monograph & interactions

Other (inactive) ingredients: Hypromellose, Magnesium Stearate, Silicon Dioxide, Microcrystalline Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Hormone Balance + Probiotics by Rainbow Nutrients Drug Interactions

Want to check YOUR meds against Hormone Balance + Probiotics?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
925Drugs
2 Major 912 Moderate 11 Minor

Ingredients driving the most interactions

Black Cohosh 652
Probiotic Blend 182
Dong Quai root extract 163
Chasteberry fruit extract 121

Individual Drug Interactions

The ingredients in Hormone Balance + Probiotics interact with 925 drugs. Click any drug to see the details.

4 of the 5 ingredients in Hormone Balance + Probiotics interact with drugs. Each result below shows which ingredient is responsible. Black Cohosh Probiotic Blend Dong Quai root extract Chasteberry fruit extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Hormone Balance + Probiotics with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Black Cohosh7 drug types · 652 drugs

Atorvastatin (Lipitor)

Taking black cohosh with atorvastatin might increase the risk for elevated liver function tests.
In one case report, a patient taking atorvastatin (Lipitor) developed significantly elevated liver function enzymes after starting black cohosh 100 mg four times daily. Liver enzymes returned to normal when black cohosh was discontinued. It is unclear whether the elevated liver enzymes were due to black cohosh itself or an interaction between atorvastatin and black cohosh.

Likelihood Possible Evidence D
Cisplatin (Platinol-Aq)

Theoretically, black cohosh may reduce the clinical effects of cisplatin.
Animal research suggests that black cohosh might decrease the cytotoxic effect of cisplatin on breast cancer cells.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Some research suggests that black cohosh might inhibit CYP2D6, but there is conflicting evidence.
Some clinical research suggests that black cohosh might modestly inhibit CYP2D6 and increase levels of drugs metabolized by this enzyme. However, contradictory clinical research shows a specific black cohosh product (Remifemin, Enzymatic Therapy) 40 mg twice daily does not significantly inhibit metabolism of a CYP2D6 substrate in healthy study volunteers. Until more is known, use black cohosh cautiously in patients taking drugs metabolized by CYP2D6.

Likelihood Possible Evidence B
Estrogens

Theoretically, black cohosh may alter the effects of estrogen therapy.
Some research suggests that black cohosh has estrogenic effects. This may enhance or inhibit the effects of estrogen therapy.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking black cohosh with hepatotoxic drugs may increase the risk of liver damage.
There is concern that black cohosh might be linked to cases of liver failure and autoimmune hepatitis.

Likelihood Possible Evidence D
Serotonergic Drugs

Combining serotonergic drugs with black cohosh might cause additive serotonergic effects.
Black cohosh might increase the risk of serotonin syndrome when combined with other serotonergic drugs. Black cohosh acts as an agonist at several serotonin receptor subtypes and might interact with other serotonergic medications. In one case, a 55-year-old female who had been on stable treatment with sertraline 50 mg and duloxetine 60 mg daily developed serotonin syndrome after taking black cohosh extract 40 mg daily for 3 days.

Likelihood Possible Evidence D
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Black cohosh may inhibit one form of OATP, OATP2B1, which could reduce the bioavailability and clinical effects of OATP2B1 substrates.
In vitro research shows that black cohosh modestly inhibits OATP2B1. OATPs are expressed in the small intestine and liver and are responsible for the uptake of drugs and other compounds into the body. Inhibition of OATP may reduce the bioavailability of oral drugs that are substrates of OATP.

Likelihood Possible Evidence D
Black Cohosh full monograph & interactions

Probiotic Blend1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Probiotic Blend full monograph & interactions

Dong Quai root extract3 drug types · 163 drugs

Warfarin (Coumadin)

Dong quai may increase the risk of bleeding when used with warfarin.
Case reports suggest that concomitant use of dong quai with warfarin can increase the anticoagulant effects of warfarin and increase the risk of bleeding. In one case, after 4 weeks of taking dong quai 565 mg once or twice daily, the international normalized ratio (INR) increased to 4.9. The INR normalized 4 weeks after discontinuation of dong quai.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, dong quai may increase the risk of bleeding when used with anticoagulant or antiplatelet drugs; however, research is conflicting.
Animal studies suggest that dong quai has antithrombin activity and inhibits platelet aggregation due to its coumarin components. Additionally, some case reports in humans suggest that dong quai can increase the anticoagulant effects of warfarin. However, clinical research in healthy adults shows that taking 1 gram of dong quai root daily for 3 weeks does not significantly inhibit platelet aggregation or cause bleeding. Until more is known, use dong quai with caution in patients taking antiplatelet/anticoagulant drugs.

Likelihood Possible Evidence D
Estrogens

Theoretically, dong quai may reduce the effects of estrogens.
Dong quai has estrogenic effects. Theoretically, concomitant use of large amounts of dong quai might interfere with hormone replacement therapy due to competition for estrogen receptors.

Likelihood Possible Evidence D
Dong Quai root extract full monograph & interactions

Chasteberry fruit extract5 drug types · 121 drugs

Antipsychotic Drugs

Theoretically, vitex agnus-castus could interfere with the activity of antipsychotic drugs.
Vitex agnus-castus might interfere with the action of dopamine antagonists such as antipsychotic drugs due to its dopamine agonist effects.

Likelihood Possible Evidence D
Contraceptive Drugs

Theoretically, vitex agnus-castus could interfere with oral contraceptives.
Vitex agnus-castus might interfere with the efficacy of oral contraceptives due to possible hormone modulating activity.

Likelihood Possible Evidence B
Dopamine Agonists

Theoretically, vitex agnus-castus could interfere with dopamine agonists.
Vitex agnus-castus might potentiate the actions of dopaminergic agonists due to possible dopaminergic effects.

Likelihood Possible Evidence D
Estrogens

Theoretically, vitex agnus-castus could interfere with the activity of estrogens.
Vitex agnus-castus has hormone modulating activity that can interfere with the efficacy of hormone replacement therapy.

Likelihood Probable Evidence D
Metoclopramide (Reglan)

Theoretically, dopaminergic effects of vitex agnus-castus could interfere with metoclopramide.
Vitex agnus-castus might interfere with the action of dopamine antagonists such as metoclopramide due to its possible dopaminergic effects.

Likelihood Possible Evidence D
Chasteberry fruit extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Hormone Balance + Probiotics, from the product label.

Rainbow Nutrients

See all Rainbow Nutrients products
Name
Rainbow Nutrients
City
Seattle
State
WA
ZipCode
98188
Web Address
www.rainbownutrients.com
Pharmacist Counseling Corner

Hormone Balance + Probiotics by Rainbow Nutrients: Common Questions

Does Hormone Balance + Probiotics by Rainbow Nutrients interact with any medications?
Yes. Based on its ingredients, Hormone Balance + Probiotics has a known interaction with 925 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Hormone Balance + Probiotics contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this with antibiotics?
Not at the same time. Three of the probiotics in this product — Lactobacillus acidophilus, Bacillus coagulans, and Bifidobacterium breve — contain live organisms that antibiotics can kill, making both less effective. Ask your doctor or pharmacist to space them out, usually several hours apart.
Is this safe during pregnancy?
Safety data aren't on file for most of these ingredients. Dong Quai and Black Cohosh have guidance advising against pregnancy use. Because the evidence is incomplete, talk with your doctor or pharmacist for personalized advice before taking it while pregnant.
What are the probiotics in here for?
Probiotics support gut health and digestion. Lactobacillus acidophilus is possibly effective for irritable bowel syndrome, antibiotic-associated diarrhea, and bacterial vaginosis. Bacillus coagulans is possibly effective for constipation and irritable bowel syndrome. The others may help overall gut function, though evidence is less established.
Does this actually help with hormone balance?
Black Cohosh is possibly effective for menopausal symptoms. For the other ingredients — Dong Quai, Maca, and Chasteberry — we don't have enough reliable evidence in our data to say whether they work for hormone support. Talk to your doctor about your specific needs.
What side effects might I get?
Gastrointestinal effects like bloating, flatulence, and stomach upset are uncommon but possible with probiotics. Black Cohosh can cause breast tenderness, dizziness, headache, or rash. Dong Quai can cause burping and flatulence. These are generally mild, but talk to your pharmacist if they concern you.
Why is there a warning about my liver with this product?
Black Cohosh is rarely linked to liver problems, and one case report showed elevated liver enzymes when combined with atorvastatin (a cholesterol drug). The risk is small but real, especially if you already take medications that affect your liver. Your doctor can advise if it's right for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Hormone Balance + Probiotics is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Hormone Balance + Probiotics label
Go deeper

The Full Monographs Behind Hormone Balance + Probiotics’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Dong Quai

Interacts with 163 drugs

Dong Quai is a traditional Chinese herb often called "female ginseng" and is mostly used for menstrual and menopausal complaints. High-quality scientific evidence that it works for these use...

Read the full Dong Quai monograph → Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph → Herb & supplement monograph

Bacillus Coagulans

Interacts with 182 drugs

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, and certain types of diarrhea. The eviden...

Read the full Bacillus Coagulans monograph → Herb & supplement monograph

Bifidobacterium Breve

Interacts with 182 drugs

Bifidobacterium breve is a 'friendly' gut bacterium taken as a probiotic, most often to support digestion and balance the gut microbiome. Some studies suggest possible benefits for certain d...

Read the full Bifidobacterium Breve monograph → Herb & supplement monograph

Black Cohosh

Interacts with 652 drugs

Black cohosh is a North American plant most often used to ease menopause symptoms like hot flashes, but the research is mixed and far from settled. It is generally well tolerated for short-t...

Read the full Black Cohosh monograph → Herb & supplement monograph

Maca

Maca is a nutrient-rich Andean root often used for energy, libido, and menopause symptoms. Early studies suggest it may modestly help sexual desire and some menopause symptoms, but the evide...

Read the full Maca monograph → Herb & supplement monograph

Vitex Agnus-castus

Interacts with 121 drugs

Vitex (chasteberry) is an herbal remedy most often used for PMS and menstrual cycle problems, and the strongest evidence is for easing some PMS symptoms. It is generally well tolerated by ma...

Read the full Vitex Agnus-castus monograph →
Sources

Sources & How We Checked

Hormone Balance + Probiotics's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 155 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
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Dong Quai 19 references
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Bifidobacterium Breve 9 references
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Black Cohosh 68 references
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Maca 1 reference
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  19. Van Die MD, Burger HC, Teede HG, Bone KM. Vitex agnus castus extracts for female reproductive disorders: a systematic review of clinical trials. Planta Med 2013:79:562-575. PubMed
  20. Ooi SL, Watts S, McClean R, Pak SC. Vitex agnus-castus for the treatment of cyclic mastalgia: A systematic review and meta-analysis. J Womens Health (Larchmt). 2020;29(2):262-278. PubMed
  21. Mollazadeh S, Mirghafourvand M, Abdollahi NG. The effects of Vitex agnus-castus on menstrual bleeding: A systematic review and meta-analysis. J Complement Integr Med. 2019;17(1). pii: /j/jcim.2019.17.issue-1/jcim-2018-0053/jcim-2018-0053.xml.
  22. Najib FS, Poordast T, Mahmudi MS, Shiravani Z, Namazi N, Omrani GR. Does Vitex Agnus-Castus L. Have Deleterious Effect on Fertility and Pregnancy Outcome? An Experimental Study on Rats for Prediction of Its Safety. J Pharmacopuncture 2022;25(2):106-113. PubMed
  23. Somuncu E, Solak IHA. Colonic Obstruction Secondary to Phytobezoar Caused by Vitex Agnus-Castus Seeds: A Case Report. J Coll Physicians Surg Pak 2022;32(8):S115-S117. PubMed

See these in context on the Vitex Agnus-castus monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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