Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Fadogia agrestis with Tongkat Ali Ingredients & Drug Interactions

by Rainbow Nutrients

Fadogia agrestis with Tongkat Ali label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Fadogia agrestis with Tongkat Ali against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Fadogia agrestis with Tongkat Ali is a dietary supplement by Rainbow Nutrients with 3 active ingredients. Its ingredients are commonly taken for flavoring and culinary use, digestive complaints like bloating and indigestion, boosting absorption of other supplements.Based on those ingredients, 1,034 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bioperine, Tongkat Ali Root Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Fadogia agrestis with Tongkat Ali by Rainbow Nutrients

Ask about any prescription or over-the-counter medication and we check it for interactions with Fadogia agrestis with Tongkat Ali by Rainbow Nutrients — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Fadogia agrestis with Tongkat Ali by Rainbow Nutrients

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This supplement has three active ingredients. Bioperine is black pepper extract, added here to help your body absorb other compounds.

Tongkat Ali root extract is a traditional herbal used in Southeast Asia. Fadogia agrestis stem extract is a plant material with limited research in humans.

The capsule also contains two inactive ingredients: cellulose (a filler) and magnesium stearate (a lubricant).

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Male sexual function and athletic performance.
  • We looked for evidence on: Age-related testosterone deficiency, Athletic performance, Erectile dysfunction (ED), Male Infertility, Muscle strength, Sexual desire — and 3 related terms.
  • The strongest evidence on file: Eurycoma Longifolia is rated "Possibly Effective" for Sexual desire (Natural Medicines).
  • Also on file: Eurycoma Longifolia is rated "Possibly Ineffective" for Athletic performance.
  • Also on file: Black Pepper is rated "Insufficient Reliable Evidence To Rate" for Athletic performance, Sexual desire.

The evidence on these ingredients is sparse. Tongkat Ali is possibly effective for sexual desire based on clinical study data.

Black pepper and Fadogia agrestis have been studied for athletic performance, erectile dysfunction, and other uses, but we don't hold evidence strong enough to rate them one way or another — the research is insufficient. None of these ingredients are established as effective for the conditions listed.

The evidence, ingredient by ingredient Black Pepper Eurycoma Longifolia Fadogia Agrestis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Black pepper at food-spice levels is generally well tolerated. Concentrated black pepper supplements should be used more cautiously because long-term safety isn't well studied.

The most common side effects from oral black pepper are burning aftertaste, indigestion, and reduced taste perception; allergic reactions are rare. Tongkat Ali is generally tolerated in the short term in studies, but long-term safety and product quality are uncertain.

Because it may raise testosterone, there's a theoretical risk of testosterone-related side effects — acne, insulin resistance, and liver damage — if levels go too high. Fadogia agrestis has very limited human safety data, and animal studies raise concern about possible toxicity to the testicles, liver, and kidneys.

During pregnancy, avoid both Tongkat Ali and Fadogia agrestis; black pepper is likely safe in pregnancy. During breastfeeding, avoid both Tongkat Ali and Fadogia agrestis; black pepper is likely safe.

Side effects, ingredient by ingredient Black Pepper Eurycoma Longifolia Fadogia Agrestis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Black Pepper, Eurycoma Longifolia.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; lithium.
  • For scale: 1,035 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before using this product if you take propranolol (Inderal) or other heart medications, seizure medications like phenytoin (Dilantin), HIV drugs like nevirapine (Viramune), tuberculosis drugs like rifampin (Rifadin), immunosuppressants like cyclosporine (Neoral, Sandimmune), sedatives like pentobarbital (Nembutal), cholesterol medications like atorvastatin (Lipitor), or asthma medications like theophylline. Also double-check if you're on testosterone replacement.

The severity is Moderate for most of these, Minor for liver-enzyme substrates.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a multi-ingredient product with a notable number of documented drug interactions, mostly from black pepper. If you take any heart, seizure, HIV, tuberculosis, immunosuppressant, cholesterol, or asthma medications, check your exact prescriptions with the tool on this page before starting.

Talk with your pharmacist about whether this product fits your health situation, especially regarding testosterone and long-term safety of the other ingredients.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Fadogia agrestis with Tongkat Ali, straight from the product label.

Brand Rainbow Nutrients
Barcode (UPC) X003BTGIT5
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Oct 24, 2024
DSLD ID 319989
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Fadogia agrestis with Tongkat Ali by Rainbow Nutrients, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
40
UPC/BARCODE
X003BTGIT5
IngredientAmount% DV
Bioperine10 mg--
Tongkat Ali Root Extract500 mg--
Fadogia agrestis Stem Extract1500 mg--

Other ingredients: Cellulose, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Keep out of reach of children.

Do not use if safety seal is damaged or missing.

Caution Pregnant or nursing mothers, children under the age of 18 and individuals with a known medical condition should consult with a physician before using this or any dietary supplement.

Caution Pregnant or nursing mothers, children under the age of 18 and individuals with a known medical condition should consult with a physician before using this or any dietary supplement.

Storage

Store in a cool & dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

Our Quality Commitment Our proprietary fadogia agrestis with Tongkat Ali performance formula provides a unique 10:1 fadogia agrestis extract & 200:1 Tongkat Ali extract which is equivalent to a total of 115,000 mg per serving for maximum results! Our formula includes patented BioPerine for max bioavailability to support energy, muscle recovery, athletic performance & more.

BioPerine for enhanced absorption

Fadogia agrestis with Tongkat Ali 2010 mg

Suggested/Recommended/Usage/Directions

Suggested use Take 2-3 capsules once a day, 30 minutes before activity or as directed by your healthcare professional. For best results, take daily for at least 21 consecutive days or more. Otherwise results may diminish.

Brand IP Statement(s)

BioPerine is a registered trademark of Sabinsa corporation.

Formulation

Supports energy Promotes muscle health and strength

Vegan Friendly

Made with Non GMO Ingredients Zero added GMO's, antibiotics, preservatives, gluten, hormones, sugars, nuts, dioxides, shellfish, diary, soy & wheat

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Vegan Friendly Lab Tested 3rd Party Certified for Purity & Potency Made in USA with Globally Sourced Ingredients GMPc Facility Good Manufacturing Practice-Consistency Quality

General Statements

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Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Fadogia agrestis with Tongkat Ali by Rainbow Nutrients label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Fadogia agrestis with Tongkat Ali label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Fadogia agrestis with Tongkat Ali by Rainbow Nutrients

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container40 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Bioperine

Interacts with
1,019 drugs
10 mg per serving Form: Black Pepper Fruit Extract

Black pepper is a common kitchen spice that is generally safe in the amounts used in food. Its extract, piperine, is mostly added to supplements to he...

Bioperine monograph & interactions

Tongkat Ali Root Extract

Interacts with
248 drugs
500 mg per serving

Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small huma...

Tongkat Ali Root Extract monograph & interactions

Fadogia agrestis Stem Extract

No known
interactions
1500 mg per serving

Fadogia agrestis is a West African shrub marketed as a testosterone booster, but human evidence is essentially nonexistent and what we know comes most...

Fadogia agrestis Stem Extract monograph & interactions

Other (inactive) ingredients: Cellulose, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Fadogia agrestis with Tongkat Ali by Rainbow Nutrients Drug Interactions

Want to check YOUR meds against Fadogia agrestis with Tongkat Ali?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,034Drugs
976 Moderate 58 Minor

Ingredients driving the most interactions

Bioperine 1,019
Tongkat Ali Root Extract 248

Individual Drug Interactions

The ingredients in Fadogia agrestis with Tongkat Ali interact with 1,034 drugs. Click any drug to see the details.

2 of the 3 ingredients in Fadogia agrestis with Tongkat Ali interact with drugs. Each result below shows which ingredient is responsible. Bioperine Tongkat Ali Root Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Fadogia agrestis with Tongkat Ali with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Bioperine17 drug types · 1,019 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, black pepper might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
In vitro research shows that piperine, a constituent of black pepper, seems to inhibit platelet aggregation. This has not been reported in humans.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, black pepper might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research shows that piperine, a constituent of black pepper, can reduce blood glucose levels. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence D
Atorvastatin (Lipitor)

Theoretically, black pepper might increase blood levels of atorvastatin.
Animal research shows that taking piperine, a constituent of black pepper, 35 mg/kg can increase the maximum serum concentration of atorvastatin three-fold. This has not been reported in humans.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically, black pepper might increase the effects and side effects of cyclosporine.
In vitro research shows that piperine, a constituent of black pepper, increases the bioavailability of cyclosporine. This has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, black pepper might increase levels of drugs metabolized by CYP2D6.
In vitro research suggests that some constituents of black pepper inhibit CYP2D6. This has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.
In vitro research and pharmacokinetic simulation data suggest that piperine, a constituent of black pepper, as well as the pepper fruit seem to inhibit CYP3A4. This has not been reported in humans.

Likelihood Possible Evidence D
Lithium

Theoretically, black pepper might increase blood levels of lithium due to its diuretic effects. The dose of lithium might need to be reduced.
Black pepper is thought to have diuretic properties.

Likelihood Probable Evidence D
Nevirapine (Viramune)

Black pepper might increase blood levels of nevirapine.
Clinical research shows that piperine, a constituent of black pepper, increases the plasma concentration of nevirapine. However, no adverse effects were observed in this study.

Likelihood Probable Evidence D
P-Glycoprotein Substrates

Theoretically, black pepper might increase levels of P-glycoprotein substrates.
In vitro research shows that piperine, a constituent of black pepper, seems to inhibit P-glycoprotein.

Likelihood Possible Evidence D
Pentobarbital (Nembutal)

Theoretically, black pepper might increase the sedative effects of pentobarbital.
Animal research shows that piperine, a constituent of black pepper, increases pentobarbital-induced sleeping time.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

Black pepper might increase blood levels of phenytoin.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption, slow elimination, and increase levels of phenytoin. Taking a single dose of black pepper 1 gram along with phenytoin seems to double the serum concentration of phenytoin. Consuming a soup with black pepper providing piperine 44 mg/200 mL of soup along with phenytoin also seems to increase phenytoin levels when compared with consuming the same soup without black pepper.

Likelihood Possible Evidence B
Propranolol (Inderal)

Black pepper might increase blood levels of propranolol.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and slow elimination of propranolol.

Likelihood Possible Evidence B
Rifampin (Rifadin)

Black pepper might increase blood levels of rifampin.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and serum levels of rifampin.

Likelihood Possible Evidence B
Theophylline

Black pepper might increase blood levels of theophylline.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and slow elimination of theophylline.

Likelihood Possible Evidence D
Amoxicillin (Amoxil, Trimox)

Theoretically, black pepper might increase the effects and side effects of amoxicillin.
Animal research shows that taking piperine, a constituent of black pepper, with amoxicillin increases plasma levels of amoxicillin. This has not been reported in humans.

Likelihood Possible Evidence D
Carbamazepine (Tegretol)

Theoretically, black pepper might increase blood levels of carbamazepine, potentially increasing the effects and side effects of carbamazepine.
One clinical study in patients taking carbamazepine 300 mg or 500 mg twice daily shows that taking a single 20 mg dose of purified piperine, a constituent of black pepper, increases carbamazepine levels. Piperine may increase carbamazepine absorption by increasing blood flow to the GI tract, increasing the surface area of the small intestine, or inhibiting cytochrome P450 3A4 (CYP3A4) in the gut wall. Absorption was significantly increased by 7-10 mcg/mL/hour. The time to eliminate carbamazepine was also increased by 4-8 hours. Although carbamazepine levels were increased, this did not appear to increase side effects. In vitro research also shows that piperine can increase carbamazepine levels by 11% in a time-dependent manner.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, black pepper might decrease levels and clinical effects of drugs metabolized by CYP1A2.
In vitro research suggests that black pepper induces CYP1A2. This has not been reported in humans.

Likelihood Possible Evidence D
Bioperine full monograph & interactions

Tongkat Ali Root Extract5 drug types · 248 drugs

Propranolol (Inderal)

Eurycoma longifolia can reduce the levels and clinical effects of propranolol.
A small clinical study in healthy persons shows that taking a single dose of a water-based Eurycoma longifolia extract 200 mg, in combination with a single dose of propranolol 80 mg, reduces the propranolol area under the curve (AUC) by 29%, reduces the peak concentration by 42%, and increases time to peak concentration by 86% when compared with control. Since the elimination half-life of propranolol did not change, it seems that Eurycoma longifolia alters the kinetics of propranolol by decreasing its absorption in the gut, and not by altering its metabolism. It is not known if separating administration will prevent this interaction.

Likelihood Probable Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP1A2 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2A6 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2A6 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2C19 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2C19 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Testosterone

Theoretically, Eurycoma longifolia may further increase levels of testosterone.
A clinical study in aging males with testosterone levels below 300 ng/dL shows that taking a specific water extract of Eurycoma longifolia roots (Physta; Biotropics Malaysia) 100-200 mg daily with breakfast for 12 weeks increases total testosterone levels by 8% to 11% when compared with placebo. It is unclear whether this increase would occur in individuals with normal testosterone levels.

Likelihood Possible Evidence D
Tongkat Ali Root Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Fadogia agrestis with Tongkat Ali, from the product label.

Rainbow Nutrients

See all Rainbow Nutrients products
Name
Rainbow Nutrients
City
Seattle
State
WA
ZipCode
98188
Web Address
www.rainbownutrients.com
Pharmacist Counseling Corner

Fadogia agrestis with Tongkat Ali by Rainbow Nutrients: Common Questions

Does Fadogia agrestis with Tongkat Ali by Rainbow Nutrients interact with any medications?
Yes. Based on its ingredients, Fadogia agrestis with Tongkat Ali has a known interaction with 1,034 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Fadogia agrestis with Tongkat Ali contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant?
Black pepper is likely safe in pregnancy, but the safety data advises against Tongkat Ali and Fadogia agrestis during pregnancy because the research is insufficient or suggests potential risk. Talk with your doctor or pharmacist before using this product while pregnant.
Can I take this while breastfeeding?
Black pepper is likely safe while breastfeeding. However, there is no reliable safety information for Tongkat Ali or Fadogia agrestis while breastfeeding, so the data advises against both. Talk with your doctor or pharmacist for personalized advice.
What is Bioperine, and why is it in this product?
Bioperine is black pepper extract. It's included because it's believed to help your body absorb and use other compounds in the supplement more effectively.
Does this product actually work for sexual performance?
Tongkat Ali is possibly effective for sexual desire based on clinical research, but the evidence for black pepper and Fadogia agrestis isn't strong enough to say. The research is still insufficient for most of these ingredients.
What are the side effects of black pepper in this supplement?
Black pepper is well tolerated at food-spice amounts. Common mild effects include a burning aftertaste, indigestion, and reduced taste perception. Allergic reactions are rare. Concentrated supplements should be used more cautiously because long-term safety is not well studied.
Is it safe to take this long term?
Tongkat Ali is generally tolerated in short-term studies, but long-term safety and product quality are uncertain. Fadogia agrestis has very limited human safety data and animal studies raise concerns about possible toxicity to the testicles, liver, and kidneys. Talk with your pharmacist before taking it long term.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Fadogia agrestis with Tongkat Ali label
Go deeper

The Full Monographs Behind Fadogia agrestis with Tongkat Ali’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Black Pepper

Interacts with 1,019 drugs

Black pepper is a common kitchen spice that is generally safe in the amounts used in food. Its extract, piperine, is mostly added to supplements to help the body absorb other ingredients (li...

Read the full Black Pepper monograph → Herb & supplement monograph

Eurycoma Longifolia

Interacts with 248 drugs

Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small human studies suggesting possible benefits....

Read the full Eurycoma Longifolia monograph → Herb & supplement monograph

Fadogia Agrestis

Fadogia agrestis is a West African shrub marketed as a testosterone booster, but human evidence is essentially nonexistent and what we know comes mostly from a few small rat studies. Animal...

Read the full Fadogia Agrestis monograph →
Sources

Sources & How We Checked

Fadogia agrestis with Tongkat Ali's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 35 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Black Pepper 29 references
  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. Bano G, Amla V, Raina RK, et al. The effect of piperine on pharmacokinetics of phenytoin in healthy volunteers. Planta Med 1987;53:568-9. PubMed
  4. Bano G, et al. Effect of piperine on bioavailability and pharmacokinetics of propranolol and theophylline in healthy volunteers. Eur J Clin Pharmacol 1991;41;615-7. PubMed
  5. Cohle SD, Trestrail JD III, Graham MA, et al. Fatal pepper aspiration. Am J Dis Child 1988;142:633-6. PubMed
  6. Bhardwaj RK, Glaeser H, Becquemont L, et al. Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4. J Pharmacol Exp Ther 2002;302:645-50. PubMed
  7. Velpandian T, Jasuja R, Bhardwaj RK, et al. Piperine in food: interference in the pharmacokinetics of phenytoin. Eur J Drug Metab Pharmacokinet 2001;26:241-7. PubMed
  8. Pattanaik S, Hota D, Prabhakar S, et al. Pharmacokinetic interaction of a single dose of piperine with steady-state carbamazepine in epilepsy patients. Phytother Res 2009;23:1281-6.
  9. Munakata, M., Kobayashi, K., Niisato-Nezu, J., Tanaka, S., Kakisaka, Y., Ebihara, T., Ebihara, S., Haginoya, K., Tsuchiya, S., and Onuma, A. Olfactory stimulation using black pepper oil facilitates oral feeding in pediatric patients receiving long-term en
  10. Myers, B. M., Smith, J. L., and Graham, D. Y. Effect of red pepper and black pepper on the stomach. Am J Gastroenterol 1987;82(3):211-214.
  11. Raghavendra, R. H. and Naidu, K. A. Spice active principles as the inhibitors of human platelet aggregation and thromboxane biosynthesis. Prostaglandins Leukot.Essent.Fatty Acids 2009;81(1):73-78. PubMed
  12. Subehan, Usia, T., Kadota, S., and Tezuka, Y. Mechanism-based inhibition of human liver microsomal cytochrome P450 2D6 (CYP2D6) by alkamides of Piper nigrum. Planta Med 2006;72(6):527-532.
  13. Kasibhatta, R. and Naidu, M. U. Influence of piperine on the pharmacokinetics of nevirapine under fasting conditions: a randomised, crossover, placebo-controlled study. Drugs R.D. 2007;8(6):383-391. PubMed
  14. Usia, T., Iwata, H., Hiratsuka, A., Watabe, T., Kadota, S., and Tezuka, Y. CYP3A4 and CYP2D6 inhibitory activities of Indonesian medicinal plants. Phytomedicine. 2006;13(1-2):67-73. PubMed
  15. Mujumdar, A. M., Dhuley, J. N., Deshmukh, V. K., Raman, P. H., Thorat, S. L., and Naik, S. R. Effect of piperine on pentobarbitone induced hypnosis in rats. Indian J Exp.Biol. 1990;28(5):486-487.
  16. Panda, S. and Kar, A. Piperine lowers the serum concentrations of thyroid hormones, glucose and hepatic 5'D activity in adult male mice. Horm.Metab Res. 2003;35(9):523-526. PubMed
  17. Lawless, H. and Stevens, D. A. Effects of oral chemical irritation on taste. Physiol Behav. 1984;32(6):995-998. PubMed
  18. Hiwale, A. R., Dhuley, J. N., and Naik, S. R. Effect of co-administration of piperine on pharmacokinetics of beta-lactam antibiotics in rats. Indian J Exp.Biol. 2002;40(3):277-281.
  19. Han, Y., Chin Tan, T. M., and Lim, L. Y. In vitro and in vivo evaluation of the effects of piperine on P-gp function and expression. Toxicol.Appl.Pharmacol. 8-1-2008;230(3):283-289. PubMed
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See these in context on the Black Pepper monograph →

Eurycoma Longifolia 4 references
  1. Salman SA, Amrah S, Wahab MS, et al. Modification of propranolol's bioavailability by Eurycoma longifolia water-based extract. J Clin Pharm Ther 2010;35:691-6. PubMed
  2. Tambi MI, Imran MK, Henkel RR. Standardised water-soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late-onset hypogonadism? Andrologia 2011 Jun 15. doi: 10.1111/j.1439-0272.2011.01168.x. [Epub ahead of pri PubMed
  3. Han YM, Kim IS, Rehman SU, Choe K, Yoo HH. In vitro evaluation of the effects of Eurycoma longifolia extract on CYP-mediated drug metabolism. Evid Based Complement Alternat Med 2015;2015:631329.
  4. Chinnappan SM, George A, Pandey P, Narke G, Choudhary YK. Effect of Eurycoma longifolia standardised aqueous root extract-Physta ® on testosterone levels and quality of life in ageing male subjects: a randomised, double-blind, placebo-controlled multicent

See these in context on the Eurycoma Longifolia monograph →

Fadogia Agrestis 2 references
  1. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source
  2. Using Dietary Supplements Wisely — NIH NCCIH Source

See these in context on the Fadogia Agrestis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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