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Dietary supplement

Horse Chestnut Extract 300 mg Ingredients & Drug Interactions

by Meijer

Horse Chestnut Extract 300 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Horse Chestnut Extract 300 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Horse Chestnut Extract 300 mg is a dietary supplement by Meijer with 1 active ingredient. Its ingredients are commonly taken for chronic venous insufficiency, leg swelling and heaviness, varicose veins.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Horse Chestnut seed extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Horse Chestnut Extract 300 mg by Meijer

Ask about any prescription or over-the-counter medication and we check it for interactions with Horse Chestnut Extract 300 mg by Meijer — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Horse Chestnut Extract 300 mg by Meijer

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This supplement contains a single active ingredient: horse chestnut seed extract at 300 mg per capsule. The extract has been processed to remove esculin, a toxic constituent found in the raw plant.

The capsule itself is made from gelatin and filled with inactive ingredients including rice powder, cellulose, magnesium stearate, and silica.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Horse Chestnut's overall clinical evidence instead.

Moderate

Some clinical evidence supports Horse Chestnut for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Chronic venous insufficiency (CVI) — rated "Possibly Effective" (Natural Medicines).

Horse chestnut extract is possibly effective for chronic venous insufficiency (CVI)—the condition where veins in your legs don't pump blood back to your heart as well as they should, often causing swelling and discomfort. For hemorrhoids, irritable bowel syndrome, and kidney stones, the evidence isn't strong enough yet for us to rate how well it works.

The evidence, ingredient by ingredient Horse Chestnut

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

When properly processed (with the toxic esculin removed), horse chestnut seed extract is generally well tolerated. The most common side effects are dizziness, stomach upset, headache, and itching.

Raw or unprocessed plant parts are toxic and should be avoided. The safety data advises against use during pregnancy and breastfeeding.

A rare case of a serious heart condition has been reported, though it's unclear whether horse chestnut caused it or contributed to it.

Side effects, ingredient by ingredient Horse Chestnut

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Horse Chestnut.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs—warfarin, dabigatran, apixaban, aspirin, clopidogrel, or similar medications. Horse chestnut may increase your bleeding risk with these drugs (Moderate severity).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

If you have chronic venous insufficiency and want to try horse chestnut extract, it's worth a conversation with your doctor or pharmacist—especially if you take any blood thinners or antiplatelet medications. This isn't the right choice if you're pregnant or breastfeeding.

Make sure any horse chestnut product you use is properly processed and comes from a reputable source.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Horse Chestnut Extract 300 mg, straight from the product label.

Brand Meijer
Barcode (UPC) 886926473957
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Aug 23, 2022
DSLD ID 271847
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Horse Chestnut Extract 300 mg by Meijer, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
886926473957
IngredientAmount% DV
Horse Chestnut seed extract300 mg--

Other ingredients: Gelatin, Water, Rice powder, Cellulose, Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Standardized extract

General health

No sugar, salt, dairy, yeast, wheat, gluten, corn, soy, preservatives, artificial colors or flavors.

Natural color variations may occur in this product.

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

This statements has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

Our standardized Horse Chestnut Extract is produced by a European phytopharmaceutical company and is manufactured under strict European quality control standards without the use of harsh solvents. It is meticulously extracted to provide the optimal level of 20% natural occurring Aescin.

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, adults take one (1) capsule, three (3) times daily with meals or, as directed by a health care professional.

Storage

Store in a cool, dry place and away from direct light.

Precautions

Keep out of reach of children.

General Statements

Questions or comments? 1-800-879-8623

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Horse Chestnut Extract 300 mg by Meijer label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Horse Chestnut Extract 300 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Horse Chestnut Extract 300 mg by Meijer

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Horse Chestnut seed extract

Interacts with
122 drugs
300 mg per serving Form: Aescin

Horse chestnut seed extract is most often used for chronic venous insufficiency, where standardized products may help reduce leg swelling, pain, and h...

Horse Chestnut seed extract monograph & interactions

Other (inactive) ingredients: Gelatin, Water, Rice powder, Cellulose, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Horse Chestnut Extract 300 mg by Meijer Drug Interactions

Want to check YOUR meds against Horse Chestnut Extract 300 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

Horse Chestnut seed extract 122

Individual Drug Interactions

The ingredients in Horse Chestnut Extract 300 mg interact with 122 drugs. Click any drug to see the details.

1 of the 1 ingredient in Horse Chestnut Extract 300 mg interact with drugs. Each result below shows which ingredient is responsible. Horse Chestnut seed extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Horse Chestnut Extract 300 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Horse Chestnut seed extract1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Horse chestnut may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Horse chestnut contains the constituent esculin which has been shown to have antithrombotic effects. Therefore, horse chestnut might have antiplatelet effects. This has not been shown in humans.

Likelihood Possible Evidence D
Horse Chestnut seed extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Horse Chestnut Extract 300 mg, from the product label.

Meijer

See all Meijer products
Name
Meijer Distribution, Inc.
City
Grand Rapids
State
MI
ZipCode
49544
Phone Number
1-800-879-8623
Web Address
www.meijer.com
Pharmacist Counseling Corner

Horse Chestnut Extract 300 mg by Meijer: Common Questions

Does Horse Chestnut Extract 300 mg by Meijer interact with any medications?
Yes. Based on its ingredients, Horse Chestnut Extract 300 mg has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Horse Chestnut Extract 300 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on aspirin or another blood thinner?
Not without checking first. Horse chestnut may increase bleeding risk when combined with blood thinners or antiplatelet drugs. Talk to your doctor or pharmacist before taking this supplement if you're on any of these medications.
What's horse chestnut extract actually used for?
It's possibly effective for chronic venous insufficiency (CVI)—swelling and discomfort in your legs from poor circulation. For hemorrhoids, IBS, and kidney stones, the evidence isn't solid enough yet to say how well it works.
Is it safe to take during pregnancy or while breastfeeding?
No. The safety data advises against it during pregnancy and breastfeeding. If you're pregnant, planning to become pregnant, or nursing, skip this supplement and talk with your doctor about other options.
What side effects should I expect?
The most common are dizziness, stomach upset, headache, and itching. Most people tolerate the properly processed extract well, but a thorough safety review hasn't been done.
Does it matter if the product is 'raw' or 'processed'?
Yes. This product uses processed seed extract with the toxic compound esculin removed. Raw or unprocessed horse chestnut parts are toxic and shouldn't be taken as a supplement.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Horse Chestnut Extract 300 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Horse Chestnut Extract 300 mg label
Go deeper

The Full Monographs Behind Horse Chestnut Extract 300 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Horse Chestnut

Interacts with 122 drugs

Horse chestnut seed extract is most often used for chronic venous insufficiency, where standardized products may help reduce leg swelling, pain, and heaviness. Raw, unprocessed horse chestnu...

Read the full Horse Chestnut monograph →
Sources

Sources & How We Checked

Horse Chestnut Extract 300 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Horse Chestnut 21 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  3. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  4. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  5. Greeske K, Pohlmann BK. Horse chestnut seed extract-an effective therapy principle in general practice. Drug therapy of chronic venous insufficiency. Fortschr Med 1996;114:196-200.
  6. Robbers JE, Tyler VE. Tyler's Herbs of Choice: The Therapeutic Use of Phytomedicinals. New York, NY: The Haworth Herbal Press, 1999.
  7. Takegoshi K, Tohyama T, Okuda K, et al. A case of Venoplant-induced hepatic injury. Gastroenterol Jpn 1986;21:62-5.
  8. Jaspersen-Schib R, Theus L, Guirguis-Oeschger M, et al. [Serious plant poisonings in Switzerland 1966-1994. Case analysis from the Swiss Toxicology Information Center]. Schweiz Med Wochenschr 1996;126:1085-98.
  9. Popp W, Horak F, Jager S, et al. Horse chestnut (Aesculus hippocastanum) pollen: a frequent cause of allergic sensitization in urban children. Allergy 1992;47:380-3.
  10. Diaz-Perales A, Collada C, Blanco C, et al. Cross-reactions in the latex-fruit syndrome: A relevant role of chitinases but not of complex asparagine-linked glycans. J Allergy Clin Immunol 1999;104:681-7. PubMed
  11. Blanco C, Diaz-Perales A, Collada C, et al. Class I chitinases as potential panallergens involved in the latex-fruit syndrome. J Allergy Clin Immunol 1999;103:507-13. PubMed
  12. Comaish JS, Kersey PJ. Contact dermatitis to extract of horse chestnut (esculin). Contact Dermatitis 1980;6:150-1. PubMed
  13. Pittler MH, Ernst E. Horse chestnut seed extract for chronic venous insufficiency (Cochrane Review). In: The Cochrane Library, Issue 3, 2004. Chichester, UK: John Wiley & Sons, Ltd. PubMed
  14. Ottillinger, B. and Greeske, K. Rational therapy of chronic venous insufficiency--chances and limits of the therapeutic use of horse-chestnut seeds extract. BMC.Cardiovasc.Disord. 2001;1(1):5. PubMed
  15. Pittler, M. H. and Ernst, E. Horse chestnut seed extract for chronic venous insufficiency. Cochrane.Database.Syst.Rev. 2004;(2):CD003230. PubMed
  16. Fang, Y., Zhao, L., Yan, F., Xia, X., Xu, D., and Cui, X. Escin improves sperm quality in male patients with varicocele-associated infertility. Phytomedicine. 2010;17(3-4):192-196. PubMed
  17. De Smet, P. A., Van den Eertwegh, A. J., Lesterhuis, W., and Stricker, B. H. Hepatotoxicity associated with herbal tablets. BMJ 7-13-1996;313(7049):92.
  18. Rehn, D., Unkauf, M., Klein, P., Jost, V., and Lucker, P. W. Comparative clinical efficacy and tolerability of oxerutins and horse chestnut extract in patients with chronic venous insufficiency. Arzneimittelforschung 1996;46(5):483-487.
  19. Edem E, Kahyaoglu B, Çakar MA. Acute Effusive Pericarditis due to Horse Chestnut Consumption. Am J Case Rep. 2016;17:305-8. PubMed
  20. Costa Santos D, Lérias G, Madruga I. Drug-induced Liver Injury Due to a Horse Chestnut Dietary Supplement. Eur J Case Rep Intern Med 2021;8(3):002389. PubMed
  21. Yi HY, Lee JY. Poisoning due to consumption of horse chestnut seed. Clin Exp Emerg Med 2021;8(4):333-335. PubMed

See these in context on the Horse Chestnut monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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