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Dietary supplement

i-flex Ingredients & Drug Interactions

by DSM Nutritional Products

i-flex label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking i-flex against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

i-flex is a dietary supplement by DSM Nutritional Products with 1 active ingredient. Its ingredients are commonly taken for joint pain and osteoarthritis, colds and flu, source of vitamin c.Based on those ingredients, 213 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Rosehip. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against i-flex by DSM Nutritional Products

Ask about any prescription or over-the-counter medication and we check it for interactions with i-flex by DSM Nutritional Products — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of i-flex by DSM Nutritional Products

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

i-flex contains one active ingredient: rosehip, a plant extract used in traditional and supplement medicine. The capsule itself is made from gelatin.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: joint relief and mobility improvement.
  • We looked for evidence on: Osteoarthritis, Rheumatoid arthritis (RA), Postoperative pain, Gout, Sciatica, Joint flexibility — and 2 related terms.
  • The strongest evidence on file: Rose Hip is rated "Possibly Effective" for Osteoarthritis (Natural Medicines).
  • Also on file: Rose Hip is rated "Possibly Effective" for Postoperative pain.
  • Also on file: Rose Hip is rated "Insufficient Reliable Evidence To Rate" for Rheumatoid arthritis (RA), Gout, Sciatica.

Rosehip is rated possibly effective for postoperative pain (pain after surgery) and osteoarthritis. For high cholesterol (hypoglycemia), the evidence isn't established in the data we hold.

The evidence, ingredient by ingredient Rose Hip

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Rosehip from the Rosa canina and Rosa damascena species is generally well tolerated as a food, though supplement safety is less well studied than food use. The most common side effects reported are flatulence and loose stools.

Rarely, vertigo and headache have been reported. A range of gastrointestinal reactions—including abdominal cramps, acid reflux, constipation, diarrhea, nausea, vomiting, and heartburn—have been reported, though in most cases these occurred at the same rate in people taking placebo.

Because reliable safety data on supplement doses is limited, use caution and avoid concentrated supplements unless your doctor approves.

Side effects, ingredient by ingredient Rose Hip

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Rose Hip.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; cancer treatments; lithium.
  • For scale: 213 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking i-flex, double-check with your pharmacist if you take estrogens (oral contraceptives or hormone replacement therapy), blood thinners (anticoagulants or antiplatelet drugs like warfarin or aspirin), lithium, chemotherapy drugs (alkylating agents or antitumor antibiotics), or aluminum-containing products.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

i-flex may be worth considering if you're looking at rosehip for postoperative pain or osteoarthritis and have no reason to avoid it. If you take estrogen-based medications, blood thinners, lithium, or chemotherapy drugs, talk to your pharmacist or doctor before adding this supplement.

Check your exact medications with the interaction tool on this page.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 22, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about i-flex, straight from the product label.

Brand DSM Nutritional Products
Barcode (UPC) 850146001030
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Oct 22, 2016
DSLD ID 65289
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for i-flex by DSM Nutritional Products, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
40
UPC/BARCODE
850146001030
IngredientAmount% DV
Rosehip2.25 Gram(s)--

Other ingredients: Gelatin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

-Clinically proven joint relief -All natural & Glucosamine-free -Improve mobility flexibility

100% Natural patented Rosehip

Helps your joints feel young again

Remember when you were a child and your body just seemed to "bounce back" from the everyday rigors of your active lifestyle? The reason your joints don't bounce back so quickly now is because those same joints have been stressed over time and are not getting the relief they deserve.

Published Scientific Studies: 1. K Winther, et al. Scand J Rheumatol, 2005, 34;302.308 2. E. Rein, et al. Phytomedicine, 2004, 11:383-391 3. O Warholm, et al. Current Therapeutic Research, 2003, 64 21-31. 4. S.N. Willich, ett al, Phytomedicina, 2010, 87-93. 5. A Kharazmi and K Winther, Inflammopharmacology, 1999, 7:377-386. 6. K Winther, et al. Inflammopharmacology, 1999, 7:63-68. 7. N Richad, et al. Osteoarthritis and Cartilage, 2006, 16:76.

All natural & clinically effective formula

Europe's best kept secret on joint relief The secret to i-flex's joint relief action is patented, Danish-processed rosehips. Europeans have relied on this ingredient for years to soothe their sore joints.

for younger feeling joints

FDA Statement of Identity

Dietary Supplement

General

Rev. 04/11

Brand IP Statement(s)

In-vitro studies show that the antioxidant action and unique activity of i-flex may prevent the damaging cell reactions caused by chemokines and interleukins in your joints. these studies also found that i-lex helps reduce the oxidative activity that speeds the deterioration of your joints.

i-flex restores comfort where it matters most. With i-flex you won't miss a beat, taking on the activities you enjoy...being with the people you love.

More on i-flex and joint health at www.i-flextoday.com

Protected by U.S. Patent 6,024,960

i-flex is a registered trademark of DSM

The i-flex formula has been tested in 4 placebo controlled joint relief clinical studies and used by thousands around the globe to relieve their joint discomfort.

i-flex is the only joint product that features these specialized rosehips.

Unlike glucosamine-based joint products, which are commonly sourced from shellfish, i-flex is a 100% natural supplement made exclusively from patented Danish-processed rosehips.

If you have been suffering with aching joints, your new solution is here...i-flex for younger feeling joints.

Suggested/Recommended/Usage/Directions

Directions: Take three (3) capsules twice per day. With first signs of relief, consider taking two (2) capsules twice per day.

Formula

-100% natural Rosehip!

Formulation

-Glucosamine free! -No Dairy! -No Sugar! -No Gluten! -No fillers or binders! -Non GMO!

Glucosamine-free!

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

i-flex by DSM Nutritional Products label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

i-flex label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in i-flex by DSM Nutritional Products

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container40 Amounts shown are per serving.

Rosehip

Interacts with
213 drugs
2.25 Gram(s) per serving

Rose hip is the vitamin C–rich fruit of the wild rose, used traditionally for colds and joint pain. A standardized rose hip powder has some research s...

Rosehip monograph & interactions

Other (inactive) ingredients: Gelatin. These complete the product’s ingredient list but are not active constituents.

Interaction report

i-flex by DSM Nutritional Products Drug Interactions

Want to check YOUR meds against i-flex?

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213Drugs
213 Moderate

Ingredients driving the most interactions

Rosehip 213

Individual Drug Interactions

The ingredients in i-flex interact with 213 drugs. Click any drug to see the details.

1 of the 1 ingredient in i-flex interact with drugs. Each result below shows which ingredient is responsible. Rosehip

Each ingredient & the kinds of drugs it affects

For each ingredient in i-flex with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Rosehip8 drug types · 213 drugs

Alkylating Agents

Theoretically, the antioxidant effects of rose hip might reduce the effectiveness of alkylating agents but might also reduce the oxidative damage caused by certain alkylating agents.
Rose hip contains vitamin C. The use of antioxidants like vitamin C during chemotherapy is controversial. There is concern that antioxidants could reduce the activity of chemotherapy drugs that generate free radicals, such as cyclophosphamide, chlorambucil, carmustine, busulfan, and thiotepa. In contrast, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. Further, some animal research suggests that the antioxidant effects of rose hip might attenuate cyclophosphamide-induced testicular toxicity. More evidence is needed to determine what effect, if any, antioxidants found in rose hip, such as vitamin C, have on the effectiveness and adverse effects of chemotherapy.

Likelihood Possible Evidence D
Aluminum

Theoretically, rose hip might increase the amount of aluminum absorbed from aluminum compounds.
Rose hip contains vitamin C. Theoretically, vitamin C increases the absorption of aluminum. Concomitant use might increase aluminum absorption, but the clinical significance of this is unknown. Administer rose hip two hours before or four hours after antacids.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, rose hip might reduce the effectiveness of anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that a constituent of rose hip, rugosin E, can induce platelet aggregation. This has not been shown in humans. Theoretically, concomitant use of rose hip might reduce the effectiveness of antiplatelet or anticoagulant drugs.

Likelihood Possible Evidence D
Antitumor Antibiotics

Theoretically, the antioxidant effects of rose hip might reduce the effectiveness of antitumor antibiotics.
Rose hip contains the antioxidant vitamin C. There is concern that antioxidants might reduce the activity of chemotherapy drugs that generate free radicals, such as antitumor antibiotics. In contrast, other researchers theorize that antioxidants might make antitumor antibiotic chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effects, if any, antioxidants such as vitamin C have on antitumor antibiotic chemotherapy.

Likelihood Possible Evidence D
Estrogens

Theoretically, rose hip might increase blood levels of estrogens.
Rose hip contains vitamin C. Increases in plasma estrogen levels of up to 55% have occured under some circumstances when vitamin C is taken concurrently with oral contraceptives or hormone replacement therapy, including topical products. It is suggested that vitamin C prevents oxidation of estrogen in the tissues, regenerates oxidized estrogen, and reduces sulfate conjugation of estrogen in the gut wall. When tissue levels of vitamin C are high, these processes are already maximized and supplemental vitamin C does not have any effect on estrogen levels. However, increases in plasma estrogen levels may occur when women who are deficient in vitamin C take supplements.

Likelihood Possible Evidence D
Lithium

Theoretically, rose hip might increase blood levels of lithium.
Rose hip is thought to have diuretic properties. Theoretically, due to these potential diuretic effects, rose hip might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Aspirin

Theoretically, rose hip might reduce the clearance of aspirin; however, its vitamin C content is likely too low to produce clinically significant effects.
Rose hip contains vitamin C. It has been suggested that acidification of the urine by vitamin C can decrease the urinary excretion of salicylates, increasing plasma salicylate levels. However, short-term use of up to 6 grams daily of vitamin C does not seem to affect urinary pH or salicylate excretion. The vitamin C content of rose hip is typically about 500 mg per 100 grams. Thus, a clinically significant interaction between rose hip and aspirin is unlikely.

Likelihood Unlikely Evidence B
Warfarin (Coumadin)

Theoretically, rose hip might reduce the effectiveness of warfarin; however, its vitamin C content is likely too low to produce clinically significant effects.
Rose hip contains vitamin C. High doses of vitamin C may reduce the response to warfarin, possibly by causing diarrhea and reducing warfarin absorption. This occurred in two people who took up to 16 grams daily of vitamin C, and resulted in decreased prothrombin time. Lower doses of 5-10 grams daily of vitamin C can also reduce warfarin absorption, but this does not seem to be clinically significant. The vitamin C content of rose hip is typically about 500 mg per 100 grams. Thus, a clinically significant interaction between rose hip and warfarin is unlikely.

Likelihood Unlikely Evidence D
Rosehip full monograph & interactions
The maker

Brand information

Manufacturer and brand details for i-flex, from the product label.

DSM Nutritional Products

See all DSM Nutritional Products products
Name
DSM Nutritional Products, Inc.
Street Address
45 Waterview Blvd
City
Parsippany
State
NJ
ZipCode
07054
Web Address
www.i-flextoday.com
Pharmacist Counseling Corner

i-flex by DSM Nutritional Products: Common Questions

Does i-flex by DSM Nutritional Products interact with any medications?
Yes. Based on its ingredients, i-flex has a known interaction with 213 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
i-flex contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is rosehip and what is it used for?
Rosehip is a plant extract that's been used in traditional medicine. In this product, it's included for postoperative pain and osteoarthritis, where the evidence suggests it may help, though more research would strengthen that case.
What side effects might I have?
Flatulence and loose stools are the most commonly reported side effects. Vertigo and headache have been reported rarely. Various gastrointestinal effects like nausea, heartburn, and abdominal discomfort have been reported, though studies show they often occur at the same rate in people taking placebo.
Is rosehip safe to take long-term?
Rosehip from Rosa canina and Rosa damascena species is generally well tolerated as a food, but supplement safety data is more limited. Because reliable safety information on concentrated supplement doses isn't extensive, it's smart to use caution and check with your doctor before taking it long-term.
Can I take this if I'm pregnant or breastfeeding?
The product facts don't include safety data for pregnancy or breastfeeding. Talk to your doctor or pharmacist for personalized advice on whether i-flex is right for you in those situations.
Does this contain any fillers or other ingredients besides rosehip?
The capsule itself is made of gelatin. Rosehip is the active ingredient.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

i-flex label
Go deeper

The Full Monographs Behind i-flex’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Rose Hip

Interacts with 213 drugs

Rose hip is the vitamin C–rich fruit of the wild rose, used traditionally for colds and joint pain. A standardized rose hip powder has some research support for easing osteoarthritis symptom...

Read the full Rose Hip monograph →
Sources

Sources & How We Checked

i-flex's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 24 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Rose Hip 24 references
  1. Foster S, Tyler VE. Tyler's Honest Herbal: A Sensible Guide to the Use of Herbs and Related Remedies. 3rd ed., Binghamton, NY: Haworth Herbal Press, 1993.
  2. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  3. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  4. Back DJ, Breckenridge AM, MacIver M, et al. Interaction of ethinyloestradiol with ascorbic acid in man. Br Med J (Clin Res Ed) 1981;282:1516.
  5. Morris JC, Beeley L, Ballantine N. Interaction of ethinyloestradiol with ascorbic acid in man [letter]. Br Med J (Clin Res Ed) 1981;283:503.
  6. Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8.
  7. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  8. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: National Academy Press, 2000. Available at: http://www.nap.edu/books/0309069351/html/.
  9. Rosenthal G. Interaction of ascorbic acid and warfarin. JAMA 1971;215:1671. DOI
  10. Hume R, Johnstone JM, Weyers E. Interaction of ascorbic acid and warfarin. JAMA 1972;219:1479. DOI
  11. Smith EC, Skalski RJ, Johnson GC, Rossi GV. Interaction of ascorbic acid and warfarin. JAMA 1972;221:1166. DOI
  12. Mc Leod DC, Nahata MC. Inefficacy of ascorbic acid as a urinary acidifier (letter). N Engl J Med 1977;296:1413. DOI
  13. Hansten PD, Hayton WL. Effect of antacid and ascorbic acid on serum salicylate concentration. J Clin Pharmacol 1980;20:326-31. PubMed
  14. Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
  15. Feetam CL, Leach RH, Meynell MJ. Lack of a clinically important interaction between warfarin and ascorbic acid. Toxicol Appl Pharmacol 1975;31:544-7. PubMed
  16. Weintraub M, Griner PF. Warfarin and ascorbic acid: lack of evidence for a drug interaction. Toxicol Appl Pharmacol 1974;28:53-6. PubMed
  17. Prasad KN. Rationale for using high-dose multiple dietary antioxidants as an adjunct to radiation therapy and chemotherapy. J Nutr 2004;134:3182S-3S. PubMed
  18. Conklin KA. Cancer chemotherapy and antioxidants. J Nutr 2004;134:3201S-3204S. PubMed
  19. Andersson U, Berger K, Hogberg A, et al. Effects of rose hip intake on risk markers of type 2 diabetes and cardiovascular disease: a randomized, double-blind, cross-over investigation in obese persons. Eur J Clin Nutr 2012;66:585-90. PubMed
  20. Rein, E., Kharazmi, A., and Winther, K. A herbal remedy, Hyben Vital (stand. powder of a subspecies of Rosa canina fruits), reduces pain and improves general wellbeing in patients with osteoarthritis--a double-blind, placebo-controlled, randomised trial. PubMed
  21. Winther, K., Apel, K., and Thamsborg, G. A powder made from seeds and shells of a rose-hip subspecies (Rosa canina) reduces symptoms of knee and hip osteoarthritis: a randomized, double-blind, placebo-controlled clinical trial. Scand J Rheumatol. 2005;34
  22. Teng, C. M., Kang, Y. F., Chang, Y. L., Ko, F. N., Yang, S. C., and Hsu, F. L. ADP-mimicking platelet aggregation caused by rugosin E, an ellagitannin isolated from Rosa rugosa Thunb. Thromb.Haemost. 1997;77(3):555-561. DOI
  23. Seifi M, Abbasalizadeh S, Mohammad-Alizadeh-Charandabi S, Khodaie L, Mirghafourvand M. The effect of Rosa (L. Rosa canina) on the incidence of urinary tract infection in the puerperium: a randomized placebo-controlled trial. Phytother Res 2018;32(1):76-83
  24. Parandin R, Ghowsi M, Dadbod A. Protective effects of hydroalcoholic extract of Rosa canina L. fruit on cyclophosphamide-induced testicular toxicity in mice. Avicenna J Phytomed 2023;13(1):7-17.

See these in context on the Rose Hip monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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