Idebenone 45 Ingredients & Drug Interactions
by LifeLink
What is this page for?
First and foremost: checking Idebenone 45 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Idebenone 45 is a dietary supplement by LifeLink with 1 active ingredient. Its ingredients are commonly taken for antioxidant support, brain and memory health, mitochondrial disorders.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Idebenone 45 by LifeLink
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Idebenone 45 contains one active ingredient: idebenone, a compound studied for its potential effects on nerve and muscle function. The capsule also contains magnesium stearate and gelatin as inactive ingredients (binders and capsule material).
Does it work?
Moderate evidence
Idebenone is possibly effective for Alzheimer disease, muscular dystrophy, and Leber hereditary optic neuropathy — meaning there's some evidence supporting its use, but the research isn't conclusive. For Friedreich ataxia, the evidence suggests it's possibly ineffective.
The data we hold doesn't cover other conditions this product might be marketed for.
How safe is it?
Well-documented data
Idebenone is generally well tolerated in studies. Uncommon side effects include nausea, vomiting, abdominal pain, elevated alkaline phosphatase (a liver enzyme), and loose stools.
One person reported a faster heart rate (tachycardia) in a trial, but it didn't require treatment. High doses up to 2,250 mg daily have been well tolerated without a significant increase in side effects.
There is a case report of an allergic skin reaction (contact dermatitis) from topical use of a cream containing idebenone. There is not enough safety information to use idebenone during pregnancy or while breastfeeding — the data advises against it.
Talk with your doctor or pharmacist about whether this product is right for you if you are pregnant, planning pregnancy, or nursing.
Meds to double-check
No known interactions
No interactions are documented for idebenone in our data. That said, run your exact medications through the checker on this page or confirm with your own pharmacist — absence of documented interactions isn't proof none exist.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. No medication interactions are currently documented, and safety information is well characterized.
Idebenone 45 may be worth considering if you're interested in the possibility of support for Alzheimer disease, muscular dystrophy, or Leber hereditary optic neuropathy, though the evidence is not conclusive. If you're pregnant, breastfeeding, or take any medications, talk it over with your own doctor or pharmacist first.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 1, 2012.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Idebenone 45, straight from the product label.
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Idebenone 45 by LifeLink, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Idebenone | 45 mg | -- |
Other ingredients: Magnesium Stearate, Gelatin
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested Use: 1 to 3 capsules daily in divided doses or as directed by a health care professional.
General Statements
Advanced CoQ10 analog
Idebenone is an enhanced form of Coenzyme Q10 that has been studied since 1982 as a cognitive enhancer - particularly in cases of brain injury due to stroke, aging, or Alzheimer's Disease.
FDA Statement of Identity
DIETARY SUPPLEMENT
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Idebenone 45 by LifeLink label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Idebenone 45 by LifeLink
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.
Idebenone
No knowninteractions
Idebenone is a synthetic, lab-made antioxidant related to coenzyme Q10. It has been studied mostly as a prescription drug for certain rare mitochondri...
Idebenone monograph & interactionsOther (inactive) ingredients: Magnesium Stearate, Gelatin. These complete the product’s ingredient list but are not active constituents.
Idebenone 45 by LifeLink Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Idebenone 45. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Idebenone 45, from the product label.
LifeLink
See all LifeLink products- Name
- LifeLink
- City
- Grover Beach
- State
- CA
- ZipCode
- 93433
- Web Address
- http://www.lifelinknet.com
Idebenone 45 by LifeLink: Common Questions
Does Idebenone 45 by LifeLink interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What is idebenone and what does it do?
Are there any common side effects I should know about?
Can I take this if I'm pregnant or breastfeeding?
Does idebenone interact with my medications?
How much idebenone is in this product?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Idebenone 45 is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Idebenone 45’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Idebenone 45's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 25 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Idebenone 25 references
- Mariotti C, Solari A, Torta D, et al. Idebenone treatment in Friedreich patients: one-year-long randomized placebo-controlled trial. Neurology 2003;60:1676-9. PubMed
- Filla A, Moss AJ. Idebenone for treatment of Friedreich's ataxia? Neurology 2003;60:1569-70. PubMed
- Hausse AO, Aggoun Y, Bonnet D, et al. Idebenone and reduced cardiac hypertrophy in Friedreich's ataxia. Heart 2002;87:346-9. PubMed
- Schols L, Vorgerd M, Schillings M, et al. Idebenone in patients with Friedreich ataxia. Neurosci Lett 2001;306:169-72. PubMed
- Lerman-Sagie T, Rustin P, Lev D, et al. Dramatic improvement in mitochondrial cardiomyopathy following treatment with idebenone. J Inherit Metab Dis 2001;24:28-34. PubMed
- Rustin P, von Kleist-Retzow JC, Chantrel-Groussard K, et al. Effect of idebenone on cardiomyopathy in Friedreich's ataxia: a preliminary study. Lancet 1999;354:477-9. PubMed
- Weyer G, Babej-Dolle RM, Hadler D, et al. A controlled study of 2 doses of idebenone in the treatment of Alzheimer's disease. Neuropsychobiology 1997;36:73-82. . PubMed
- Ikejiri Y, Mori E, Ishii K, et al. Idebenone improves cerebral mitochondrial oxidative metabolism in a patient with MELAS. Neurology 1996;47:583-5. PubMed
- Pisano P, Durand A, Autret E, et al. Plasma concentrations and pharmacokinetics of idebenone and its metabolites following single and repeated doses in young patients with mitochondrial encephalomyopathy. Eur J Clin Pharmacol 1996;51:167-9. PubMed
- Ihara Y, Namba R, Kuroda S, et al. Mitochondrial encephalomyopathy (MELAS): pathological study and successful therapy with coenzyme Q10 and idebenone. J Neurol Sci 1989;90:263-71. PubMed
- Gutzmann H, Hadler D. Sustained efficacy and safety of idebenone in the treatment of Alzheimer's disease: update on a 2-year double-blind multicentre study. J Neural Transm 1998;54:301-10. PubMed
- Di Prospero NA, Sumner CJ, Penzak SR, et al. Safety, tolerability, and pharmacokinetics of high-dose idebenone in patients with Friedreich ataxia. Arch Neurol 2007;64:803-8. PubMed
- Buyse GM, Voit T, Schara U, DELOS Study Group. Efficacy of idebenone on respiratory function in patients with Duchenne muscular dystrophy not using glucocorticoids (DELOS): a double-blind randomised placebo-controlled phase 3 trial. Lancet. 2015;385(9979) PubMed
- Corben LA, Lynch D, Pandolfo M, Schulz JB, Delatycki MB; Clinical Management Guidelines Writing Group. Consensus clinical management guidelines for Friedreich ataxia. Orphanet J Rare Dis. 2014;9:184. DOI
- Di Prospero NA, Baker A, Jeffries N, Fischbeck KH. Neurological effects of high-dose idebenone in patients with Friedreich's ataxia: a randomised, placebo-controlled trial. Lancet Neurol. 2007;6(10):878-86. PubMed
- Lagedrost SJ, Sutton MS, Cohen MS, et al. Idebenone in Friedreich ataxia cardiomyopathy-results from a 6-month phase III study (IONIA). Am Heart J. 2011;161(3):639-645.e1. PubMed
- Lynch DR, Perlman SL, Meier T. A phase 3, double-blind, placebo-controlled trial of idebenone in friedreich ataxia. Arch Neurol. 2010;67(8):941-7. PubMed
- Mc Aleer MA, Collins P. Allergic contact dermatitis to hydroxydecyl ubiquinone (idebenone) following application of anti-ageing cosmetic cream. Contact Dermatitis. 2008;59(3):178-9. PubMed
- McDaniel DH, Neudecker BA, DiNardo JC, Lewis JA 2nd, Maibach HI. Clinical efficacy assessment in photodamaged skin of 0.5% and 1.0% idebenone. J Cosmet Dermatol. 2005;4(3):167-73. PubMed
- Meier T, Perlman SL, Rummey C, Coppard NJ, Lynch DR. Assessment of neurological efficacy of idebenone in pediatric patients with Friedreich's ataxia: data from a 6-month controlled study followed by a 12-month open-label extension study. J Neurol. 2012;25 PubMed
- Pineda M, Arpa J, Montero R, et al. Idebenone treatment in paediatric and adult patients with Friedreich ataxia: long-term follow-up. Eur J Paediatr Neurol. 2008;12(6):470-5. PubMed
- Catarino CB, von Livonius B, Priglinger C, et al. Real-world clinical experience with idebenone in the treatment of leber hereditary optic neuropathy. J Neuroophthalmol. 2020 Dec;40(4):558-565.
- Kosa P, Wu T, Phillips J, et al. Idebenone does not inhibit disability progression in primary progressive MS. Mult Scler Relat Disord. 2020 Oct;45:102434. PubMed
- Zhao X, Zhang Y, Lu L, Yang H. Therapeutic effects of idebenone on leber hereditary optic neuropathy. Curr Eye Res. 2020 Oct;45(10):1315-1323. PubMed
- Yuan LL, Chen TY, Huang ZQ. Effects of paroxetine hydrochloride combined with idebenone on inflammatory factors and antioxidant molecules in treatment of depression after ischemic stroke. Pak J Med Sci 2023;39(1):17-22. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC