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Dietary supplement

CardiPeptase Serrapeptase 5 Ingredients & Drug Interactions

by LifeLink

CardiPeptase Serrapeptase 5 label
See full label image
Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking CardiPeptase Serrapeptase 5 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

CardiPeptase Serrapeptase 5 is a dietary supplement by LifeLink with 1 active ingredient. Its ingredients are commonly taken for inflammation and swelling, sinus and respiratory congestion, pain after surgery or injury.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Serrapeptase. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against CardiPeptase Serrapeptase 5 by LifeLink

Ask about any prescription or over-the-counter medication and we check it for interactions with CardiPeptase Serrapeptase 5 by LifeLink — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of CardiPeptase Serrapeptase 5 by LifeLink

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

CardiPeptase Serrapeptase 5 contains one active ingredient: serrapeptase, an enzyme with fibrinolytic activity (meaning it breaks down blood clots). The tablet also includes several inactive ingredients — dicalcium phosphate, microcrystalline cellulose, stearic acid, magnesium stearate, silicon dioxide, and methyl cellulose — which serve as binders and fillers to hold the tablet together.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Serrapeptase's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: arterial plaque digestion and inflammation support.
  • We looked for evidence on: Atherosclerosis, Cardiovascular disease (CVD), Postoperative swelling, arterial calcification, vascular inflammation.
  • The closest evidence on file: Serrapeptase is rated "Insufficient Reliable Evidence To Rate" for Atherosclerosis (Natural Medicines).
  • Also on file: Serrapeptase is rated "Insufficient Reliable Evidence To Rate" for Cardiovascular disease (CVD), Postoperative swelling.

The evidence for serrapeptase is not yet established in our data. The facts we hold show insufficient reliable evidence to rate it for chronic bronchitis, asthma, atherosclerosis, back pain, and osteoporosis — the conditions most often promoted for it.

That doesn't mean it doesn't work; it means large, well-designed studies haven't yet proven whether it does.

The evidence, ingredient by ingredient Serrapeptase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Serrapeptase is generally well tolerated in the short term, though long-term safety hasn't been thoroughly studied. The most common side effects are epigastric pain (discomfort in the upper abdomen), gastrointestinal upset, and nausea — and these appear to occur at roughly the same rate as placebo in trials.

A rare serious side effect called bullous pemphigoid (a blistering skin condition) has been reported. There isn't enough safety data to recommend serrapeptase during pregnancy or breastfeeding, so it's best avoided if you are pregnant or nursing.

Talk with your doctor or pharmacist about whether it's right for your situation.

Side effects, ingredient by ingredient Serrapeptase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Serrapeptase.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take anticoagulants or antiplatelet drugs — blood thinners like warfarin, apixaban, or rivaroxaban, or antiplatelet drugs like aspirin or clopidogrel — double-check with your doctor or pharmacist before adding this product. Serrapeptase may increase your risk of bruising and bleeding when combined with these medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

CardiPeptase Serrapeptase 5 might appeal to someone looking for a natural enzyme supplement, but the evidence that it works for common claims — asthma, chronic bronchitis, back pain, or osteoporosis — is not yet established. The main caution is if you take blood thinners or antiplatelet medications; the moderate risk of bleeding means you'll want to check with your doctor or pharmacist before combining them.

If you're pregnant or breastfeeding, skip it until you've talked it over with your healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 1, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about CardiPeptase Serrapeptase 5, straight from the product label.

Brand LifeLink
Barcode (UPC) 639793701018
Net contents 100 Enteric Coated Tablet(s); 5 mg
Market status On market
Date entered into DSLD Oct 1, 2012
DSLD ID 11850
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for CardiPeptase Serrapeptase 5 by LifeLink, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
UPC/BARCODE
639793701018
IngredientAmount% DV
Serrapeptase5 mg--

Other ingredients: Dicalcium Phosphate, Microcrystalline Cellulose, Stearic Acid, Magnesium Stearate, Silicon Dioxide, Methyl Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

CardioPeptase: A naturally occurring proteolytic enzyme that digests "non-living" matter, i.e. arterial plaque. CardioPeptase is also used as an alternative to salicylates and NSAIDs.

Suggested/Recommended/Usage/Directions

Suggested Use: 1 tablet 3 times a day on an empty stomach.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

CardiPeptase Serrapeptase 5 by LifeLink label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

CardiPeptase Serrapeptase 5 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in CardiPeptase Serrapeptase 5 by LifeLink

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Serrapeptase

Interacts with
122 drugs
5 mg per serving

Serrapeptase is an enzyme marketed to reduce inflammation, swelling, pain, and mucus, but the human evidence is limited and mostly low quality. If you...

Serrapeptase monograph & interactions

Other (inactive) ingredients: Dicalcium Phosphate, Microcrystalline Cellulose, Stearic Acid, Magnesium Stearate, Silicon Dioxide, Methyl Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

CardiPeptase Serrapeptase 5 by LifeLink Drug Interactions

Want to check YOUR meds against CardiPeptase Serrapeptase 5?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

Serrapeptase 122

Individual Drug Interactions

The ingredients in CardiPeptase Serrapeptase 5 interact with 122 drugs. Click any drug to see the details.

1 of the 1 ingredient in CardiPeptase Serrapeptase 5 interact with drugs. Each result below shows which ingredient is responsible. Serrapeptase

Each ingredient & the kinds of drugs it affects

For each ingredient in CardiPeptase Serrapeptase 5 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Serrapeptase1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking serrapeptase with drugs that have antiplatelet or anticoagulant effects might increase the risk of bruising and bleeding.
In vitro research shows that serrapeptase has fibrinolytic activity.

Likelihood Possible Evidence D
Serrapeptase full monograph & interactions
The maker

Brand information

Manufacturer and brand details for CardiPeptase Serrapeptase 5, from the product label.

LifeLink

See all LifeLink products
Name
Life Link
City
Grover Beach
State
CA
ZipCode
93433
Web Address
http://www.lifelinknet.com
Pharmacist Counseling Corner

CardiPeptase Serrapeptase 5 by LifeLink: Common Questions

Does CardiPeptase Serrapeptase 5 by LifeLink interact with any medications?
Yes. Based on its ingredients, CardiPeptase Serrapeptase 5 has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
CardiPeptase Serrapeptase 5 contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does serrapeptase actually work for bronchitis, asthma, or back pain?
The evidence we hold shows insufficient reliable data to say whether it works for those conditions. That means large, rigorous trials haven't yet proven benefit — not that it's useless, just that we can't make a strong claim either way.
What are the side effects?
Most people tolerate it well. The most common side effects are epigastric pain (upper abdominal discomfort), gastrointestinal upset, and nausea — though these appear to happen at about the same rate as placebo in trials. A rare serious side effect, bullous pemphigoid (a blistering skin condition), has been reported.
Is it safe to take while pregnant or breastfeeding?
No. There isn't enough safety data, so serrapeptase is best avoided during pregnancy and while breastfeeding. Talk with your doctor or pharmacist about safe alternatives if you need support during this time.
Can I take this with my blood thinner?
Not without checking first. Serrapeptase breaks down clots, so mixing it with anticoagulants or antiplatelet drugs increases your risk of bruising and bleeding. Confirm with your doctor or pharmacist that it's safe for your specific medications.
How long has serrapeptase been studied?
It's generally well tolerated in the short term, but long-term safety hasn't been thoroughly studied. If you're thinking of taking it for weeks or months, that's worth discussing with your healthcare provider.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if CardiPeptase Serrapeptase 5 is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

CardiPeptase Serrapeptase 5 label
Go deeper

The Full Monographs Behind CardiPeptase Serrapeptase 5’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Serrapeptase

Interacts with 122 drugs

Serrapeptase is an enzyme marketed to reduce inflammation, swelling, pain, and mucus, but the human evidence is limited and mostly low quality. If you want to try it, choose an enteric-coate...

Read the full Serrapeptase monograph →
Sources

Sources & How We Checked

CardiPeptase Serrapeptase 5's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Serrapeptase 2 references
  1. Tachibana M, Mizukoshi O, Harada Y, et al. A multi-centre, double-blind study of serrapeptase versus placebo in post-antrotomy buccal swelling. Pharmatherapeutica 1984;3:526-30..
  2. Mazzone A, Catalani M, Costanzo M, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res 1990;18:379-88.. PubMed

See these in context on the Serrapeptase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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