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Dietary supplement

PS Phosphatidylserine 100 mg Ingredients & Drug Interactions

by LifeLink

PS Phosphatidylserine 100 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking PS Phosphatidylserine 100 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

PS Phosphatidylserine 100 mg is a dietary supplement by LifeLink with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, age-related cognitive decline, attention and focus (adhd).Based on those ingredients, 219 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Phosphatidylserine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against PS Phosphatidylserine 100 mg by LifeLink

Ask about any prescription or over-the-counter medication and we check it for interactions with PS Phosphatidylserine 100 mg by LifeLink — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of PS Phosphatidylserine 100 mg by LifeLink

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: phosphatidylserine 100 mg per capsule. Phosphatidylserine is a naturally occurring fat compound found in cell membranes; it's often extracted from soy or cabbage for use in supplements.

The capsule itself is made from gelatin, and the product also contains ascorbyl palmitate (a form of vitamin C) as an inactive ingredient.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: cognitive abilities, memory, learning and depression.
  • We looked for evidence on: Age-related cognitive decline, Alzheimer disease, Attention deficit-hyperactivity disorder (ADHD), Cognitive function, Dementia, Depression — and 2 related terms.
  • The strongest evidence on file: Phosphatidylserine is rated "Possibly Effective" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Phosphatidylserine is rated "Possibly Effective" for Alzheimer disease.
  • Also on file: Phosphatidylserine is rated "Insufficient Reliable Evidence To Rate" for Attention deficit-hyperactivity disorder (ADHD), Cognitive function, Dementia, Depression.

Phosphatidylserine is rated possibly effective for age-related cognitive decline and Alzheimer disease based on available evidence. For other uses — including athletic performance, ADHD, general cognitive function, and dementia — the evidence is insufficient to rate its effectiveness reliably.

If you're considering it for a specific concern, talk it through with your doctor to see whether the evidence supports its use in your situation.

The evidence, ingredient by ingredient Phosphatidylserine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Phosphatidylserine is generally well tolerated in studies, though long-term safety hasn't been fully established. The most common side effects are flatulence, gastrointestinal upset, headache, insomnia, and nausea.

Insomnia is more likely at higher doses (around 600 mg); headache and stomach upset can occur at doses of 200–300 mg per day. There is not enough safety information to recommend use during pregnancy, so avoidance is advised.

Safety while breastfeeding is also unknown, so breastfeeding is not recommended while taking this product. If you're pregnant, planning pregnancy, or breastfeeding, talk with your doctor or pharmacist before use.

Side effects, ingredient by ingredient Phosphatidylserine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Phosphatidylserine.
  • The most serious interaction on file is rated Moderate.
  • For scale: 219 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take anticholinergic drugs (used for overactive bladder, tremor, or certain digestive issues) or cholinergic drugs (medications that increase acetylcholine activity). Both carry Moderate-severity interaction risks with phosphatidylserine.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

PS Phosphatidylserine may be worth considering if you have age-related cognitive decline or Alzheimer disease and your doctor thinks it's appropriate. If you take anticholinergic or cholinergic medications, you'll need to check your specific drugs and discuss this supplement with your own doctor or pharmacist before starting.

Stomach upset and insomnia are the main side effects to watch for, especially at higher doses.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 24, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about PS Phosphatidylserine 100 mg, straight from the product label.

Brand LifeLink
Barcode (UPC) 639793403073
Net contents 30 Capsule(s); 100 mg
Market status On market
Date entered into DSLD Aug 24, 2012
DSLD ID 11842
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for PS Phosphatidylserine 100 mg by LifeLink, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
4 Capsule(s)
UPC/BARCODE
639793403073
IngredientAmount% DV
Phosphatidylserine100 mg--

Other ingredients: Ascorbyl Palmitate, Gelatin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Phosphatidylserine is an essential component of nerve cell membranes. It plays a role in cell communication and metabolism. PS is used clinically for improving cognitive abilities (including memory and learning), for alleviating depression, and for reducing stress-induced cortisol excesses that cause visceral fatness.

Suggested/Recommended/Usage/Directions

Suggested Use: 2 to 4 capsules twice daily for the first week, then 1 to 2 capsules twice daily, or as directed by a health care professional.

Formula

PS Phosphatidylserine 100 mg

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See for yourself

PS Phosphatidylserine 100 mg by LifeLink label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

PS Phosphatidylserine 100 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in PS Phosphatidylserine 100 mg by LifeLink

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Phosphatidylserine

Interacts with
219 drugs
100 mg per serving

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinki...

Phosphatidylserine monograph & interactions

Other (inactive) ingredients: Ascorbyl Palmitate, Gelatin. These complete the product’s ingredient list but are not active constituents.

Interaction report

PS Phosphatidylserine 100 mg by LifeLink Drug Interactions

Want to check YOUR meds against PS Phosphatidylserine 100 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
219Drugs
219 Moderate

Ingredients driving the most interactions

Phosphatidylserine 219

Individual Drug Interactions

The ingredients in PS Phosphatidylserine 100 mg interact with 219 drugs. Click any drug to see the details.

1 of the 1 ingredient in PS Phosphatidylserine 100 mg interact with drugs. Each result below shows which ingredient is responsible. Phosphatidylserine

Each ingredient & the kinds of drugs it affects

For each ingredient in PS Phosphatidylserine 100 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Phosphatidylserine2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically interfere with the activity of anticholinergic agents.

Likelihood Possible Evidence B
Cholinergic Drugs

Theoretically, phosphatidylserine might have additive effects with cholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically lead to additive cholinergic effects when used with cholinergic drugs.

Likelihood Possible Evidence B
Phosphatidylserine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for PS Phosphatidylserine 100 mg, from the product label.

LifeLink

See all LifeLink products
Name
LifeLink
City
Grover Beach
State
CA
ZipCode
93433
Web Address
http://www.lifelinknet.com
Pharmacist Counseling Corner

PS Phosphatidylserine 100 mg by LifeLink: Common Questions

Does PS Phosphatidylserine 100 mg by LifeLink interact with any medications?
Yes. Based on its ingredients, PS Phosphatidylserine 100 mg has a known interaction with 219 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
PS Phosphatidylserine 100 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
There isn't enough safety information, so avoidance is advised during pregnancy and breastfeeding. Talk with your doctor or pharmacist about what's safest for your situation.
What are the most common side effects?
Flatulence, stomach upset, headache, insomnia, and nausea are the most commonly reported side effects. Insomnia is more likely with higher doses around 600 mg, and stomach problems can show up at doses of 200–300 mg per day.
Does phosphatidylserine actually work for memory and thinking?
It's rated possibly effective for age-related cognitive decline and Alzheimer disease. For other uses like ADHD or general brain function, the evidence isn't strong enough to rate. Your doctor can help you decide if it's worth trying for your specific situation.
What is phosphatidylserine?
It's a fat compound naturally found in cell membranes throughout your body. For supplements, it's usually extracted from soy or cabbage.
Is this supplement safe long-term?
It's generally well tolerated in studies, but long-term safety hasn't been fully established, so we don't have complete data on very long-term use.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if PS Phosphatidylserine 100 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

PS Phosphatidylserine 100 mg label
Go deeper

The Full Monographs Behind PS Phosphatidylserine 100 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Phosphatidylserine

Interacts with 219 drugs

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinking. Some research suggests possible bene...

Read the full Phosphatidylserine monograph →
Sources

Sources & How We Checked

PS Phosphatidylserine 100 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Phosphatidylserine 9 references
  1. Crook T, Petrie W, Wells C, Massari DC. Effects of phosphatidylserine in Alzheimer's disease. Psychopharmacol Bull 1992;28:61-6.
  2. Pepping J. Phosphatidylserine. Am J Health-Syst Pharm 1999;56:2038,2043-4.
  3. Kidd PM. Phosphatidylserine; Membrane nutrient for memory. A clinical and mechanistic assessment. Altern Med Rev 1996;1:70-84.
  4. Kim HY, Akbar M, Lau A, et al. Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3). Role of phosphatidylserine in antiapoptotic effect. J Biol Chem 2000;275:35215-23.. PubMed
  5. Zanotti A, Valzelli L, Toffano G. Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats. Psychopharmacology (Berl) 1989;99:316-21.. PubMed
  6. Schreiber S, Kampf-Sherf O, Gorfine M, et al. An open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive decline. Isr J Psychiatry Relat Sci 2000;37:302-7.
  7. Pepping, J. Phosphatidylserine. Am J Health Syst.Pharm. 10-15-1999;56(20):2038, 2043-2038, 2044.
  8. Monteverde, A., Gnemmi, P., Rossi, F., Monteverde, A., and Finali, G. C. Selegiline in the treatment of mild to moderate Alzheimer-type dementia. Clin.Ther 1990;12(4):315-322.
  9. Vakhapova V, Cohen T, Richter Y, Herzog Y, Kam Y, Korczyn AD. Phosphatidylserine containing omega-3 Fatty acids may improve memory abilities in nondemented elderly individuals with memory complaints: results from an open-label extension study. Dement Geri PubMed

See these in context on the Phosphatidylserine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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