Interactions on record — worth a quick check against your medications. Based on 6 of 7 ingredients. Check your meds →
Dietary supplement

ImmunEnz Ingredients & Drug Interactions

by ProEnzol

ImmunEnz label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking ImmunEnz against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

ImmunEnz is a dietary supplement by ProEnzol with 7 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.Based on those ingredients, 1,163 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Echinacea angustifolia (root) extract, Reishi (mushroom) extract, Bupleurum (root) extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against ImmunEnz by ProEnzol

Ask about any prescription or over-the-counter medication and we check it for interactions with ImmunEnz by ProEnzol — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of ImmunEnz by ProEnzol

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 7 active ingredients.
  • “Synergistic Herbal Blend” is a proprietary blend — the label gives one combined amount (375 mg) without saying how much of each component you get.

ImmunEnz contains 7 active ingredients: pHysioProtease (a proteolytic enzyme), astragalus root extract, echinacea angustifolia root extract, bupleurum root extract, echinacea purpurea root extract, reishi mushroom extract, and shiitake mushroom extract. The product also contains plant fiber and water as inactive ingredients.

These are enzyme and herbal extracts meant to support immune function. The two echinacea types and the mushroom extracts are included for their potential immune-stimulating properties, while astragalus and bupleurum are traditional botanicals added to the blend.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: support normal immune function.
  • We looked for evidence on: Common cold, Bronchitis, Coronavirus disease 2019 (COVID-19), Upper respiratory infection, Immune support, Flu.
  • The closest evidence on file: Shiitake Mushroom is rated "Insufficient Reliable Evidence To Rate" for Common cold (Natural Medicines).
  • Also on file: Shiitake Mushroom is rated "Insufficient Reliable Evidence To Rate" for Coronavirus disease 2019 (COVID-19).
  • Also on file: Reishi Mushroom is rated "Insufficient Reliable Evidence To Rate" for Bronchitis, Coronavirus disease 2019 (COVID-19).

The evidence we hold doesn't establish effectiveness for this product. Most of the individual ingredients—astragalus, both echinacea species, bupleurum, reishi, and shiitake—are rated as having insufficient reliable evidence for the conditions they're traditionally used for.

Reishi mushroom is rated possibly ineffective for high cholesterol. No effectiveness ratings support the use of pHysioProtease for any condition in our data.

The evidence, ingredient by ingredient Proteolytic Enzymes (proteases) Astragalus Echinacea Bupleurum Reishi Mushroom Shiitake Mushroom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

ProEnzol ImmunEnz is generally well tolerated short-term for most adults, but side effects are possible. pHysioProtease may cause digestive upset or allergic reactions; rarely, protease exposure (including airborne) has triggered allergic rhinitis, conjunctivitis, or asthma in sensitive individuals. Both echinacea extracts commonly cause stomach upset, nausea, diarrhea, constipation, rash, and heartburn; rarely, severe allergic reactions and hepatitis have been reported, particularly in people sensitive to ragweed or related plants.

Astragalus, bupleurum, reishi, and shiitake may each cause nausea, rash, or digestive symptoms. Bupleurum formulas have been linked to rare lung and liver problems.

Reishi can cause dizziness or dry mouth. Shiitake, especially raw, may trigger skin reactions resembling whiplash marks and, with inhalation or extensive handling, respiratory symptoms.

During pregnancy, astragalus and bupleurum should be avoided due to insufficient safety data. Echinacea is rated possibly safe in pregnancy, but evidence is limited.

Reishi and shiitake lack adequate pregnancy data. None of these ingredients have sufficient lactation safety data, so breastfeeding use is not recommended without guidance from your doctor or pharmacist.

Side effects, ingredient by ingredient Proteolytic Enzymes (proteases) Astragalus Echinacea Bupleurum Reishi Mushroom Shiitake Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 6 matched ingredients can interact with medications — Bupleurum, Shiitake Mushroom, Reishi Mushroom, Astragalus, Echinacea.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; lithium.
  • For scale: 1,164 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take ProEnzol ImmunEnz, double-check with your pharmacist or doctor if you're on any immunosuppressants (transplant rejection medications), diabetes medications, blood thinners or antiplatelet drugs (including aspirin), blood-pressure medications, drugs metabolized by your liver's CYP1A2 or CYP3A4 pathways, warfarin, HIV protease inhibitors like lopinavir/ritonavir, or sedatives like midazolam. These interactions range from Moderate to Minor in severity, but some may affect how well your medications work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

ImmunEnz is a multiherb immune blend that's generally well tolerated short-term but carries notable interactions with immunosuppressants, diabetes medications, blood thinners, blood-pressure drugs, and certain enzyme-metabolized medications. If you take any prescription drugs—especially transplant medications, diabetes treatments, anticoagulants, or antihypertensives—talk with your doctor or pharmacist before starting this product.

It's not recommended during pregnancy or breastfeeding without medical approval.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about ImmunEnz, straight from the product label.

Brand ProEnzol
Barcode (UPC) 707636123812
Net contents 90 Vegan Capsule(s)
Market status On market
Date entered into DSLD May 22, 2020
DSLD ID 221373
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for ImmunEnz by ProEnzol, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
Servings per container
90
UPC/BARCODE
707636123812
IngredientAmount% DV
pHysioProtease1500 mg--
Astragalus (root) extract0 NP--
Echinacea angustifolia (root) extract0 NP--
Bupleurum (root) extract0 NP--
Synergistic Herbal Blend375 mg--
Echinacea purpurea (root) extract0 NP--
Reishi (mushroom) extract0 NP--
Shiitake (mushroom) extract0 NP--

Other ingredients: Plant Fiber, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

ProEnzol ImmunEnz provides a powerful blend of modulating herbal and mushroom extracts including Astragalus, Echinacea and Reishi, plus pHysioProtease to support normal immune function by helping to maintain healthy white blood cell activity.

Suggested/Recommended/Usage/Directions

Directions: Take one (1) capsule three times daily between meals or on an empty stomach, or as directed by your healthcare professional.

Precautions

Caution: If you are pregnant, nursing, have a serious medical condition, or take any medications, consult your healthcare professional before use.

Use only if tamper-evident seal is unbroken.

Keep out of reach of children.

Storage

Store tightly closed in a cool, dry place.

Brand IP Statement(s)

pHysioProtease is a registered trademark of Enzymes Inc.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, mitigate, cure, or prevent any disease.

Formulation

Sustains healthy cellular defense and adaptive immune responses

Contains No: Sugar, soy, wheat, yeast, gluten, peanuts, tree nuts, eggs, dairy, animal products, artificial colors, flavors and sweeteners or genetically modified organisms (GMOs).

FDA Statement of Identity

Dietary Supplement

General Statements

Exclusively for professionals

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

ImmunEnz by ProEnzol label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

ImmunEnz label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in ImmunEnz by ProEnzol

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

PHysioProtease

No known
interactions
1500 mg per serving Form: Endoprotease, Exoprotease

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

PHysioProtease monograph & interactions

Other (inactive) ingredients: Plant Fiber, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

ImmunEnz by ProEnzol Drug Interactions

Want to check YOUR meds against ImmunEnz?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,163Drugs
1,162 Moderate 1 Minor

Ingredients driving the most interactions

Echinacea angustifolia (root) extract 816
Reishi (mushroom) extract 375
Bupleurum (root) extract 327
Shiitake (mushroom) extract 312
Astragalus (root) extract 208

Individual Drug Interactions

The ingredients in ImmunEnz interact with 1,163 drugs. Click any drug to see the details.

5 of the 7 ingredients in ImmunEnz interact with drugs. Each result below shows which ingredient is responsible. Echinacea angustifolia (root) extract Reishi (mushroom) extract Bupleurum (root) extract Shiitake (mushroom) extract Astragalus (root) extract

Each ingredient & the kinds of drugs it affects

For each ingredient in ImmunEnz with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Echinacea angustifolia (root) extract12 drug types · 816 drugs

Caffeine

Echinacea can increase plasma levels of caffeine by inhibiting its metabolism.
Echinacea seems to increase plasma concentrations of caffeine by around 30%. This is likely due to inhibition of cytochrome P450 1A2 (CYP1A2) by echinacea.

Likelihood Probable Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Echinacea might inhibit the metabolism of CYP1A2 and increase plasma levels of some drugs.
Echinacea appears to inhibit CYP1A2 enzymes in humans. Additionally, echinacea seems to increase plasma concentrations of caffeine, a CYP1A2 substrate, by around 30%. Theoretically, echinacea might increase levels of other drugs metabolized by CYP1A2.

Likelihood Possible Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4. This may increase or decrease levels of drugs metabolized by CYP3A4.
Several clinical trials have shown that taking echinacea for up to one month does not significantly affect the metabolism of various CYP3A4 substrates, including midazolam, docetaxel, etravirine, lopinavir-ritonavir, and darunavir-ritonavir. However, other clinical research shows that echinacea may increase the clearance of midazolam, suggesting that echinacea might induce CYP3A4. The discrepancy is thought to be due to differing effects of echinacea on intestinal versus hepatic CYP3A4 enzymes. Echinacea appears to induce hepatic CYP3A4 but inhibit intestinal CYP3A4. In some cases, these effects might cancel each other out, but in others, drug levels may be increased or decreased depending on the level of effect at hepatic and intestinal sites. The effect of echinacea on CYP3A4 activity may differ depending on the CYP3A4 substrate.

Likelihood Possible Evidence B
Etoposide (Vepesid)

Echinacea may increase levels of etoposide.
In one report, concomitant use of etoposide and echinacea was associated with more severe thrombocytopenia than the use of etoposide alone, suggesting inhibition of etoposide metabolism. Etoposide is a cytochrome P450 3A4 (CYP3A4) substrate. Echinacea has variable effects on CYP3A4, but some studies have reported inhibition of the enzyme.

Likelihood Possible Evidence D
Immunosuppressants

Echinacea has immunostimulant activity which may interfere with immunosuppressant therapy.
Theoretically, echinacea may interfere with immunosuppressant therapy because of its immunostimulant activity.

Likelihood Possible Evidence B
Darunavir (Prezista)

Theoretically, echinacea may interfere with the metabolism of darunavir; however, a small clinical study found no effect.
Darunavir is metabolized by cytochrome P450 3A4 (CYP3A4) and is administered with the CYP3A4 inhibitor ritonavir to increase its plasma concentrations. Echinacea has variable effects on CYP3A4, but administration of an E. purpurea root extract (Arkocapsulas Echinacea, Arkopharma) 500 mg four times daily for 14 days did not affect darunavir/ritonavir pharmacokinetics in 15 HIV-infected patients.

Likelihood Unlikely Evidence B
Dayquil Severe

Echinacea is reported to have varying effects on a number of Cytochrome P450 metabolizing enzymes in the liver, including CYP1A2 and CYP3A4, which play a role in acetaminophen and dextromethorphan metabolism (both contained in DayQuil Severe), respectively. Studies have reported both enzyme inhibition and induction, making it difficult to predict clinically significant drug interactions with reliability. Specific drug interaction studies reporting definitive results are rare, and potential drug interactions involving echinacea should likely be taken on a case-by-case basis. Based on what we know about how acetaminophen and dextromethorphan are metabolized, the risk of a clinically significant interaction between echinacea and DayQuil Severe is low.

Likelihood Unlikely Evidence A
Docetaxel (Taxotere)

Theoretically, echinacea may interfere with the metabolism of docetaxel; however, a small clinical study found no effect.
Docetaxel is metabolized by cytochrome P450 3A4 (CYP3A4). Echinacea has variable effects on CYP3A4, but taking E. purpurea whole plant extract (Echinaforce, A. Vogel Biopharma AG) 20 drops three times daily for 2 weeks did not alter the pharmacokinetics of docetaxel in one clinical study.

Likelihood Unlikely Evidence B
Etravirine (Intelence)

Theoretically, echinacea may interfere with the metabolism of etravirine; however, a small clinical study found no effect.
Etravirine is metabolized by cytochrome P450 3A4 (CYP3A4). Echinacea has variable effects on CYP3A4, but taking E. purpurea root extract (Arkocapsulas Echinacea, Arkopharma) 500 mg three times daily for 14 days did not alter the pharmacokinetics of etravirine in HIV-infected patients.

Likelihood Unlikely Evidence B
Lopinavir/Ritonavir (Kaletra)

Theoretically, echinacea may interfere with the metabolism of lopinavir; however, a small clinical study found no effect.
Lopinavir is metabolized by cytochrome P450 3A4 (CYP3A4) and is administered with the CYP3A4 inhibitor ritonavir to increase its plasma concentrations. Echinacea has variable effects on CYP3A4, but taking E. purpurea (Echinamide, Natural Factors Nutritional Products, Inc.) 500 mg three times daily for 14 days did not alter the pharmacokinetics of lopinavir/ritonavir in healthy volunteers.

Likelihood Unlikely Evidence B
Midazolam (Versed)

Theoretically, echinacea may increase the metabolism of intravenous midazolam.
Echinacea induces hepatic CYP3A4 and might decrease plasma levels of midazolam by about 20%, reducing the effectiveness of intravenous midazolam. Echinacea also appears to inhibit intestinal CYP3A4, which could theoretically increase the bioavailability of oral midazolam. This may cancel out the decrease in availability caused by induction of hepatic CYP3A4, such that overall plasma levels after oral administration of midazolam are not affected by echinacea.

Likelihood Possible Evidence B
Warfarin (Coumadin)

Echinacea seems to increase the clearance of warfarin, although the effect may not be clinically significant.
Preliminary clinical research in healthy male volunteers suggests that taking echinacea increases the clearance of the active S-isomer of warfarin after a single dose of warfarin, but there was not a clinically significant effect on the INR.

Likelihood Possible Evidence B
Echinacea angustifolia (root) extract full monograph & interactions

Reishi (mushroom) extract3 drug types · 375 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
A dose of 1.5 grams daily of reishi mushroom does not seem to decrease platelet aggregation, but a higher dose of 3 grams daily does.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Animal research suggests that reishi mushroom decreases blood sugar. However, in patients with type 2 diabetes, taking reishi mushroom does not reduce fasting glucose levels, and its effects on glycated hemoglobin are inconsistent.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Reishi mushroom has shown hypotensive activity in animal research. Clinical evidence suggests that reishi mushroom reduces blood pressure in some, but not all, patients with hypertension.

Likelihood Possible Evidence D
Reishi (mushroom) extract full monograph & interactions

Bupleurum (root) extract3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, bupleurum might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research suggests that saikosaponins, constituents of bupleurum, can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, bupleurum might decrease the effects of antidiabetes drugs.
Animal research suggests that saikosaponins, constituents of bupleurum, can increase blood glucose.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, bupleurum might decrease the effects of immunosuppressants.
In vitro and animal research suggests that bupleurum might stimulate immune function.

Likelihood Possible Evidence D
Bupleurum (root) extract full monograph & interactions

Shiitake (mushroom) extract2 drug types · 312 drugs

Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
In vitro studies suggest that the shiitake mushroom extract AHCC might induce the CYP2D6 enzyme. This effect has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, taking shiitake mushroom might decrease the effects of immunosuppressive therapy.
In vitro evidence suggests that shiitake mushroom extracts stimulate immune function.

Likelihood Possible Evidence D
Shiitake (mushroom) extract full monograph & interactions

Astragalus (root) extract4 drug types · 208 drugs

Antidiabetes Drugs

Theoretically, taking astragalus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research in humans shows that astragalus might have hypoglycemic effects. Theoretically, taking astragalus, especially in combination with other hypoglycemic agents, might increase the risk of hypoglycemia.

Likelihood Probable Evidence A
Cyclophosphamide

Theoretically, astragalus might interfere with cyclophosphamide therapy.
Evidence regarding the effect of astragalus on immunosuppression caused by cyclophosphamide is conflicting. Some animal research suggests that astragalus reverses cyclophosphamide-induced immunosuppression. However, other animal research shows no effect.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, astragalus might interfere with immunosuppressive therapy.
Astragalus seems to stimulate immune function. Theoretically, taking astragalus might decrease the effects of immunosuppressive therapy.

Likelihood Possible Evidence D
Lithium

Theoretically, astragalus might increase levels and adverse effects of lithium.
Animal research suggests that astragalus has diuretic properties. Theoretically, due to this diuretic effect, astragalus might reduce excretion and increase levels of lithium.

Likelihood Probable Evidence D
Astragalus (root) extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for ImmunEnz, from the product label.

ProEnzol

See all ProEnzol products
Name
Enzymes Inc.
City
Kansas City
State
MO
ZipCode
64153
Phone Number
1-800-637-7893
Web Address
www.proenzol.com
Pharmacist Counseling Corner

ImmunEnz by ProEnzol: Common Questions

Does ImmunEnz by ProEnzol interact with any medications?
Yes. Based on its ingredients, ImmunEnz has a known interaction with 1,163 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
ImmunEnz contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take ImmunEnz if I'm on a blood thinner like warfarin?
Not without checking first. Echinacea may speed up warfarin clearance (a minor interaction), and bupleurum theoretically raises bleeding risk. Your doctor or pharmacist needs to know before you start.
Will ImmunEnz help my immune system?
The evidence we hold doesn't establish that it works for any specific condition. The ingredients are traditionally used for immune support, but reliable studies backing their effectiveness are lacking.
Is ImmunEnz safe during pregnancy?
Most ingredients lack adequate pregnancy safety data and should be avoided. Echinacea is rated possibly safe, but evidence is limited. Talk with your doctor or pharmacist before taking it while pregnant.
What are the most common side effects?
Echinacea, astragalus, and the mushroom extracts may cause nausea, diarrhea, rash, or stomach upset. Reishi can cause dizziness and dry mouth. Protease may trigger digestive symptoms or, rarely, allergic reactions.
Will this interact with my diabetes medication?
Possibly. Astragalus, bupleurum, and reishi all theoretically increase the risk of low blood sugar (hypoglycemia) if combined with diabetes drugs. Check with your pharmacist before starting.
Can I take ImmunEnz if I've had a transplant?
Not without approval from your doctor. Four of the ingredients—astragalus, echinacea, bupleurum, and shiitake—may interfere with immunosuppressants used to prevent transplant rejection.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

ImmunEnz label
Go deeper

The Full Monographs Behind ImmunEnz’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Astragalus

Interacts with 208 drugs

Astragalus is a root used for centuries in traditional Chinese medicine, mainly to support the immune system and help the body cope with stress. While early studies are interesting, strong h...

Read the full Astragalus monograph → Herb & supplement monograph

Echinacea

Interacts with 816 drugs

Echinacea is a popular herb taken to help prevent or shorten the common cold, but study results are mixed and the overall benefit appears small at best. It is generally well tolerated for sh...

Read the full Echinacea monograph → Herb & supplement monograph

Bupleurum

Interacts with 327 drugs

Bupleurum (Chai Hu) is a root used in traditional Chinese medicine, usually as part of multi-herb formulas, for liver, digestive, and fever-related complaints. High-quality human evidence fo...

Read the full Bupleurum monograph → Herb & supplement monograph

Reishi Mushroom

Interacts with 375 drugs

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits is limited or low-quality, so it should...

Read the full Reishi Mushroom monograph → Herb & supplement monograph

Shiitake Mushroom

Interacts with 312 drugs

Shiitake is a popular edible mushroom that is nutritious and safe to eat as food for most people. Some of its extracts (like lentinan and AHCC) have been studied as immune support, mainly al...

Read the full Shiitake Mushroom monograph →
Sources

Sources & How We Checked

ImmunEnz's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 168 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Astragalus 13 references
  1. Upton R, ed. Astragalus Root: Analytical, quality control, and therapeutic monograph. Santa Cruz, CA: American Herbal Pharmacopoeia. 1999:1-25.
  2. Khoo KS, Ang PT. Extract of astragalus membranaceus and ligustrum lucidum does not prevent cyclophosphamide-induced myelosuppression. Singapore Med J 1995;36:387-90.
  3. Chu DT, Wong WL, Mavligit GM. Immunotherapy with Chinese medicinal herbs. II. Reversal of cyclophosphamide-induced immune suppression by administration of fractionated Astragalus membranaceus in vivo. J Clin Lab Immunol 1988;25:125-9.
  4. Sun Y, Hersh EM, Lee SL, et al. Preliminary observations on the effects of the Chinese medicinal herbs Astragalus membranaceus and Ligustrum lucidum on lymphocyte blastogenic responses. J Biol Response Mod 1983;2:227-37..
  5. Ma J, Peng A, Lin S. Mechanisms of the therapeutic effect of astragalus membranaceus on sodium and water retention in experimental heart failure. Chin Med J (Engl) 1998;111:17-23.
  6. Matkovic Z, Zivkovic V, Korica M, et al. Efficacy and safety of Astragalus membranaceus in the treatment of patients with seasonal allergic rhinitis. Phytother Res 2010;24:175-81.
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