Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Immune Mushroom Blend Ingredients & Drug Interactions

by Gaia Herbs

Immune Mushroom Blend label
See full label image
Capsule Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Immune Mushroom Blend against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Immune Mushroom Blend is a dietary supplement by Gaia Herbs with 5 active ingredients. Its ingredients are commonly taken for immune support, general wellness and nutrition, cholesterol and heart health.Based on those ingredients, 704 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Reishi Fruiting Body Extract, Chaga (Inonotus obliquus) sclerotium extract, Shiitake (Lentinula edodes) fruiting body extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Immune Mushroom Blend by Gaia Herbs

Ask about any prescription or over-the-counter medication and we check it for interactions with Immune Mushroom Blend by Gaia Herbs — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Immune Mushroom Blend by Gaia Herbs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 5 active ingredients.
  • “Proprietary Mushroom Extract Blend” is a proprietary blend — the label gives one combined amount (425 mg) without saying how much of each component you get.
  • “Chaga (Inonotus obliquus) sclerotium extract” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Gaia Herbs Immune Mushroom Blend contains five active mushroom ingredients: shiitake fruiting body extract, reishi fruiting body extract, beta-glucan, cordyceps fruiting body extract, and turkey tail fruiting body extract. These are combined in a proprietary blend to support immune function.

The capsule also contains pullulan, an inactive ingredient used as a capsule material and binder.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: immune support.
  • We looked for evidence on: Allergic rhinitis (hay fever), Asthma, Bronchitis, Common cold, Coronavirus disease 2019 (COVID-19), Cough — and 4 related terms.
  • The closest evidence on file: Cordyceps is rated "Insufficient Reliable Evidence To Rate" for Asthma (Natural Medicines).
  • Also on file: Cordyceps is rated "Insufficient Reliable Evidence To Rate" for Cough.
  • Also on file: Shiitake Mushroom is rated "Insufficient Reliable Evidence To Rate" for Common cold, HIV/AIDS, Coronavirus disease 2019 (COVID-19).

The evidence for this blend is mixed. Beta-glucan is likely effective for high cholesterol and heart disease risk.

Turkey tail mushroom is possibly effective for cancer support. The other ingredients—shiitake, reishi, and cordyceps—lack reliable evidence for the conditions they're marketed for, though shiitake has been rated possibly ineffective for dental plaque.

Most other uses listed (athletic performance, sexual function, respiratory conditions) fall into the insufficient-evidence category, meaning we simply don't have enough data to say whether they work.

The evidence, ingredient by ingredient Shiitake Mushroom Reishi Mushroom Cordyceps Turkey Tail Mushroom Chaga

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

The mushroom extracts in this blend are generally well tolerated overall. You may experience mild gastrointestinal side effects like nausea, diarrhea, bloating, or stomach discomfort.

Shiitake carries a caution: concentrated supplements lack robust safety data, and raw shiitake can cause a skin rash (shiitake dermatitis) with systemic symptoms. Reishi safety data beyond short-term use is limited.

For pregnancy and breastfeeding, the safety data advises against reishi, cordyceps, and turkey tail; shiitake and beta-glucan data on these situations is not on file, so talk with your doctor or pharmacist for personalized guidance.

Side effects, ingredient by ingredient Shiitake Mushroom Reishi Mushroom Cordyceps Turkey Tail Mushroom Chaga

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Cordyceps, Turkey Tail Mushroom, Shiitake Mushroom, Reishi Mushroom, Beta-glucans.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 704 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this blend, check with your doctor or pharmacist if you take blood pressure medications, blood thinners (anticoagulants or antiplatelet drugs), diabetes medications, or immune-suppressing drugs. Also double-check if you're on cyclophosphamide (chemotherapy), tamoxifen (breast cancer treatment), testosterone supplements, or any drugs metabolized by your liver's CYP2D6 or CYP2C9 enzymes.

These are the medication types with documented interactions in this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This blend may help support immune function, and beta-glucan has solid evidence for cholesterol and heart health. However, it interacts with many common medications—especially blood pressure drugs, blood thinners, diabetes treatments, and chemotherapy—so it's essential to check your specific medications before taking it.

If you're pregnant, breastfeeding, or on any prescription medication, discuss this product with your doctor or pharmacist to make sure it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Immune Mushroom Blend, straight from the product label.

Brand Gaia Herbs
Net contents 40 Vegan Capsule(s)
Market status On market
Date entered into DSLD Sep 22, 2022
DSLD ID 272352
Product type Botanical With Nutrients
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Organic, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Immune Mushroom Blend by Gaia Herbs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
40
IngredientAmount% DV
Shiitake (Lentinula edodes) fruiting body extract0 NP--
Reishi Fruiting Body Extract0 NP--
Beta-Glucan99 mg--
organic Cordyceps (Cordyceps militaris) fruiting body extract0 NP--
Proprietary Mushroom Extract Blend425 mg--
Turkey Tail Mushroom fruiting body extract0 NP--
Chaga (Inonotus obliquus) sclerotium extract0 NP--

Other ingredients: Pullulan

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Gaia Herbs EST 1987

Formula

With fruiting body extracts Made with organic mushrooms

Each 425 mg capsule is equivalent to 2.5 g of dry mushrooms

Why fruiting bodies We use the fruiting bodies of mushrooms, as the concentration of active beneficial compounds like beta glucans is greatest in this part vs. the mycelium.

Formulation

Made with organic mushrooms

5X strength

Non GMO Project Verified nongmoproject.org

Certified organic by Oregon tilth.

Natural separation may occur. This does not affect product quality.

The Gaia Difference Organic mushrooms

Sustainably sourced Guaranteed beta glucan levels

No grain & rice fillers Gluten free

Seals/Symbols

Non GMO Project Verified nongmoproject.org

Certified B Corporation

Suggested/Recommended/Usage/Directions

1 One a day

Suggested Use Adults take 1 capsule once daily. Benefits build overtime.

FDA Statement of Identity

Herbal Supplement

Precautions

Warning: Reproductive Harm-www.P65Warnings.ca.gov/food

Not for use during pregnancy or lactation. If you have a medical condition or take medications, please consult with your doctor before use.

Store away from children.

Use only as directed on label. Safety-sealed for your protection.

Storage

Keep bottle capped at all times and store in a cool, dry place.

General Statements

meetyourherbs.com Gaia Herbs delivers unprecedented traceability by screening every product and sharing the results online. See for yourself, and learn more about your herbs, by entering the unique ID # below at meetyourherbs.com

Discover our guiding truths at: Facebook Instagram @gaiaherbs

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Immune Mushroom Blend by Gaia Herbs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Immune Mushroom Blend label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Immune Mushroom Blend by Gaia Herbs

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container40 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Other (inactive) ingredients: Pullulan. These complete the product’s ingredient list but are not active constituents.

Interaction report

Immune Mushroom Blend by Gaia Herbs Drug Interactions

Want to check YOUR meds against Immune Mushroom Blend?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
704Drugs
654 Moderate 50 Minor

Ingredients driving the most interactions

Reishi Fruiting Body Extract 375
Chaga (Inonotus obliquus) sclerotium extract 327
Shiitake (Lentinula edodes) fruiting body extract 312
organic Cordyceps (Cordyceps militaris) fruiting body extract 249
Turkey Tail Mushroom fruiting body extract 187

Individual Drug Interactions

The ingredients in Immune Mushroom Blend interact with 704 drugs. Click any drug to see the details.

5 of the 5 ingredients in Immune Mushroom Blend interact with drugs. Each result below shows which ingredient is responsible. Reishi Fruiting Body Extract Chaga (Inonotus obliquus) sclerotium extract Shiitake (Lentinula edodes) fruiting body extract organic Cordyceps (Cordyceps militaris) fruiting body extract Turkey Tail Mushroom fruiting body extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Immune Mushroom Blend with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Reishi Fruiting Body Extract3 drug types · 375 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
A dose of 1.5 grams daily of reishi mushroom does not seem to decrease platelet aggregation, but a higher dose of 3 grams daily does.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Animal research suggests that reishi mushroom decreases blood sugar. However, in patients with type 2 diabetes, taking reishi mushroom does not reduce fasting glucose levels, and its effects on glycated hemoglobin are inconsistent.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Reishi mushroom has shown hypotensive activity in animal research. Clinical evidence suggests that reishi mushroom reduces blood pressure in some, but not all, patients with hypertension.

Likelihood Possible Evidence D
Reishi Fruiting Body Extract full monograph & interactions

Chaga (Inonotus obliquus) sclerotium extract3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, chaga may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that chaga extract can inhibit platelet aggregation. This effect has not been reported in humans.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking chaga with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that chaga might decrease blood glucose levels and increase insulin levels. This has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, chaga might interfere with immunosuppressive therapy.
In vitro research suggests that certain constituents of chaga stimulate immune function. This has not been reported in humans.

Likelihood Possible Evidence D
Chaga (Inonotus obliquus) sclerotium extract full monograph & interactions

Shiitake (Lentinula edodes) fruiting body extract2 drug types · 312 drugs

Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
In vitro studies suggest that the shiitake mushroom extract AHCC might induce the CYP2D6 enzyme. This effect has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, taking shiitake mushroom might decrease the effects of immunosuppressive therapy.
In vitro evidence suggests that shiitake mushroom extracts stimulate immune function.

Likelihood Possible Evidence D
Shiitake (Lentinula edodes) fruiting body extract full monograph & interactions

organic Cordyceps (Cordyceps militaris) fruiting body extract3 drug types · 249 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
In vitro and animal research suggests that cordyceps extract inhibits platelet aggregation and function. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Animal and in vitro research suggests that cordyceps stimulates the immune system. However, limited clinical research suggests that taking cordyceps may lower the necessary therapeutic dose of the immunosuppressant cyclosporine, which suggests that cordyceps may have an immunosuppressive effect.

Likelihood Possible Evidence B
Testosterone

Theoretically, concurrent use of cordyceps and testosterone might have additive effects.
Animal research suggests that cordyceps can increase testosterone levels. The clinical significance of this finding is unclear.

Likelihood Possible Evidence D
organic Cordyceps (Cordyceps militaris) fruiting body extract full monograph & interactions

Turkey Tail Mushroom fruiting body extract4 drug types · 187 drugs

Antidiabetes Drugs

Theoretically, taking turkey tail mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that turkey tail mushroom and a polysaccharide component can have hypoglycemic effects.

Likelihood Possible Evidence D
Cyclophosphamide

Theoretically, the polysaccharide peptide (PSP) component of turkey tail mushroom might increase exposure to cyclophosphamide.
Some animal research shows that the PSP component of turkey tail mushroom can increase the area under the concentration-time curve (AUC) of cyclophosphamide by 44% to 50% and the half-life by 34% to 43%. This interaction could potentially increase the effects and adverse effects of cyclophosphamide. However, it is not known whether PSP affects the levels of the active metabolites of cyclophosphamide that are responsible for its clinical activity.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, the polysaccharide peptide (PSP) component of turkey tail mushroom might interfere with the absorption of tamoxifen.
Animal research suggests that PSP increases the time to reach maximum concentration of a single dose of tamoxifen by about 9.5 hours, or 228%. When repeated doses of tamoxifen were given, the time to reach maximum concentration was increased by about 5.6 hours, or 93%. However, PSP did not affect the maximum concentration or the area under the curve of tamoxifen.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, the polysaccharide peptide (PSP) component of turkey tail mushroom might inhibit CYP2C9.
Laboratory research suggests that the PSP component of turkey tail mushroom dose-dependently inhibits CYP2C9. Theoretically, taking PSP with drugs metabolized by CYP2C9 might increase drug levels and the risk of adverse effects. However, this has not been reported in humans.

Likelihood Possible Evidence D
Turkey Tail Mushroom fruiting body extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Immune Mushroom Blend, from the product label.

Gaia Herbs

See all Gaia Herbs products
Name
Gaia Herbs, Inc.
Street Address
101 Gaia Herbs Drive
City
Brevard
State
NC
ZipCode
28712
Web Address
www.gaiaherbs.com
Pharmacist Counseling Corner

Immune Mushroom Blend by Gaia Herbs: Common Questions

Does Immune Mushroom Blend by Gaia Herbs interact with any medications?
Yes. Based on its ingredients, Immune Mushroom Blend has a known interaction with 704 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Immune Mushroom Blend contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this blend safe to take if I'm on blood pressure medication?
No—reishi and beta-glucan both lower blood pressure, so taking them alongside blood pressure drugs could push your pressure too low. Your doctor or pharmacist needs to review this with you and potentially adjust your medication dose.
Can I take this if I'm on a blood thinner like warfarin?
Not without checking with your doctor or pharmacist first. Reishi and cordyceps both have compounds that affect how your blood clots, so combining them with blood thinners could increase your bleeding risk.
What are the most common side effects?
Mild gastrointestinal upset—nausea, diarrhea, bloating, or stomach discomfort—is most common. Taking cordyceps with food can help reduce these symptoms.
Is this safe during pregnancy?
The safety data advises against reishi, cordyceps, and turkey tail during pregnancy due to insufficient data. For shiitake and beta-glucan, we don't have pregnancy safety information on file, so talk with your doctor or pharmacist for personalized advice.
Can I take this if I'm undergoing chemotherapy?
This is a significant concern—turkey tail mushroom may increase exposure to cyclophosphamide (a common chemotherapy drug), which could raise your risk of side effects. Do not take this without explicit clearance from your oncologist.
Does this actually boost immunity?
The ingredients are traditional immune-support mushrooms, but for most conditions (athletic performance, chronic fatigue, infections), reliable evidence is lacking. Turkey tail is possibly effective for cancer support, and beta-glucan has solid evidence for heart and cholesterol benefits, but we simply don't have strong data for immune-boosting claims overall.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Immune Mushroom Blend is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Immune Mushroom Blend label
Go deeper

The Full Monographs Behind Immune Mushroom Blend’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Shiitake Mushroom

Interacts with 312 drugs

Shiitake is a popular edible mushroom that is nutritious and safe to eat as food for most people. Some of its extracts (like lentinan and AHCC) have been studied as immune support, mainly al...

Read the full Shiitake Mushroom monograph → Herb & supplement monograph

Reishi Mushroom

Interacts with 375 drugs

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits is limited or low-quality, so it should...

Read the full Reishi Mushroom monograph → Herb & supplement monograph

Cordyceps

Interacts with 249 drugs

Cordyceps is a fungus used in traditional Chinese medicine for energy, exercise performance, and lung and immune support. Human research is limited and mostly low quality, so its benefits ar...

Read the full Cordyceps monograph → Herb & supplement monograph

Turkey Tail Mushroom

Interacts with 187 drugs

Turkey tail is a woodland mushroom rich in polysaccharides like beta-glucans, and it is mainly used to support the immune system. Some of its purified extracts (PSK and PSP) have been studie...

Read the full Turkey Tail Mushroom monograph → Herb & supplement monograph

Chaga

Interacts with 327 drugs

Chaga is a fungus that grows mostly on birch trees and is used as a tea or supplement, mainly for immune and antioxidant support. Human evidence for its benefits is very limited, and it may...

Read the full Chaga monograph →
Sources

Sources & How We Checked

Immune Mushroom Blend's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 133 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Shiitake Mushroom 67 references
  1. Hitosugi M, Kitamura O, Takatsu A, Yoshino Y. Autopsy case of duodenal obstruction from impacted mushroom. J Gastroenterol 1998;33:562-5. PubMed
  2. Hanada K, Hashimoto I. Flagellate mushroom (Shiitake) dermatitis and photosensitivity. Dermatol 1998;197:255-7. PubMed
  3. Levy AM, Kita H, Phillips SF, et al. Eosinophilia and gastrointestinal symptoms after ingestion of shiitake mushrooms. J Allergy Clin Immunol 1998;101:613-20. PubMed
  4. Murakami M, Kawabe K, Hosoi Y, et al. Decreased pulmonary perfusion in hypersensitivity pneumonitis caused by Shiitake mushroom spores. J Intern Med 1997;241:85-8. PubMed
  5. Matsui S, Nakazawa T, Umegae Y, Mori M. Hypersensitivity pneumonitis induced by Shiitake mushroom spores. Intern Med 1992;31:1204-6.
  6. Nakamura T. Shiitake (Lentinus edodes) dermatitis. Contact Dermatitis 1992;27:65-70.
  7. Ueda A, Obama K, Aoyama K, et al. Allergic contact dermatitis in shiitake (Lentinus edodes (Berk) Sing) growers. Contact Dermatitis 1992;26:228-33.
  8. Burikhanov, R. B., Wakame, K., Igarashi, Y., Wang, S., and Matsuzaki, S. Suppressive effect of active hexose correlated compound (AHCC) on thymic apoptosis induced by dexamethasone in the rat. Endocr.Regul. 2000;34(4):181-188.
  9. Gao, Y., Zhang, D., Sun, B., Fujii, H., Kosuna, K., and Yin, Z. Active hexose correlated compound enhances tumor surveillance through regulating both innate and adaptive immune responses. Cancer Immunol.Immunother. 2006;55(10):1258-1266. PubMed
  10. Ritz, B. W., Nogusa, S., Ackerman, E. A., and Gardner, E. M. Supplementation with active hexose correlated compound increases the innate immune response of young mice to primary influenza infection. J Nutr. 2006;136(11):2868-2873. PubMed
  11. Aviles, H., O'Donnell, P., Sun, B., and Sonnenfeld, G. Active hexose correlated compound (AHCC) enhances resistance to infection in a mouse model of surgical wound infection. Surg.Infect.(Larchmt.) 2006;7(6):527-535. PubMed
  12. Spierings, E. L., Fujii, H., Sun, B., and Walshe, T. A Phase I study of the safety of the nutritional supplement, active hexose correlated compound, AHCC, in healthy volunteers. J Nutr Sci Vitaminol.(Tokyo) 2007;53(6):536-539. PubMed
  13. Aviles, H., O'Donnell, P., Orshal, J., Fujii, H., Sun, B., and Sonnenfeld, G. Active hexose correlated compound activates immune function to decrease bacterial load in a murine model of intramuscular infection. Am J Surg. 2008;195(4):537-545. PubMed
  14. Ritz, B. W. Supplementation with active hexose correlated compound increases survival following infectious challenge in mice. Nutr.Rev. 2008;66(9):526-531. PubMed
  15. Terakawa, N., Matsui, Y., Satoi, S., Yanagimoto, H., Takahashi, K., Yamamoto, T., Yamao, J., Takai, S., Kwon, A. H., and Kamiyama, Y. Immunological effect of active hexose correlated compound (AHCC) in healthy volunteers: a double-blind, placebo-controll
  16. Mach, C. M., Fugii, H., Wakame, K., and Smith, J. Evaluation of active hexose correlated compound hepatic metabolism and potential for drug interactions with chemotherapy agents. J Soc Integr.Oncol. 2008;6(3):105-109.
  17. Wang, S., Welte, T., Fang, H., Chang, G. J., Born, W. K., O'Brien, R. L., Sun, B., Fujii, H., Kosuna, K., and Wang, T. Oral administration of active hexose correlated compound enhances host resistance to West Nile encephalitis in mice. J Nutr. 2009;139(3 PubMed
  18. Sumiyoshi, Y., Hashine, K., Kakehi, Y., Yoshimura, K., Satou, T., Kuruma, H., Namiki, S., and Shinohara, N. Dietary administration of mushroom mycelium extracts in patients with early stage prostate cancers managed expectantly: a phase II study. Jpn.J Cl PubMed
  19. Yin, Z., Fujii, H., and Walshe, T. Effects of active hexose correlated compound on frequency of CD4+ and CD8+ T cells producing interferon-gamma and/or tumor necrosis factor-alpha in healthy adults. Hum.Immunol. 2010;71(12):1187-1190.
  20. Lee, W. W., Lee, N., Fujii, H., and Kang, I. Active Hexose Correlated Compound promotes T helper (Th) 17 and 1 cell responses via inducing IL-1beta production from monocytes in humans. Cell Immunol. 2012;275(1-2):19-23.
  21. Daddaoua, A., Martinez-Plata, E., Ortega-Gonzalez, M., Ocon, B., Aranda, C. J., Zarzuelo, A., Suarez, M. D., de Medina, F. S., and Martinez-Augustin, O. The nutritional supplement Active Hexose Correlated Compound (AHCC) has direct immunomodulatory actio
  22. Roman, B. E., Beli, E., Duriancik, D. M., and Gardner, E. M. Short-term supplementation with active hexose correlated compound improves the antibody response to influenza B vaccine. Nutr Res. 2013;33(1):12-17. PubMed
  23. Uno, K., Kosuna, K., Sun, B., Fujii, H., Wakame, K., Chikumaru, S., Hosokawa, G., and Ueda, Y. Active Hexose Correlated Compound (AHCC) Improves Immunological Parameters and Performance Status of Patients with Solid Tumors. Biotherapy 2000;14(3):303-309.
  24. Ghoneum, M., Wimbley, M., Salem, F., McKlain, A., Attallah, N., and Gill, G. Immunomodulatory and anticancer effects of active hexose correlated compound (AHCC). Int J Immunother 1995;11:23-28.
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Reishi Mushroom 17 references
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Beta-glucans 11 references
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Cordyceps 14 references
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Turkey Tail Mushroom 15 references
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Chaga 9 references
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