Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

KBomb Multi-Strain White Kratom Blend Ingredients & Drug Interactions

by KBomb

KBomb Multi-Strain White Kratom Blend label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking KBomb Multi-Strain White Kratom Blend against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

KBomb Multi-Strain White Kratom Blend is a dietary supplement by KBomb with 1 active ingredient. Its ingredients are commonly taken for pain relief, opioid withdrawal symptoms, anxiety and stress.Based on those ingredients, 995 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Mitragyna speciosa. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against KBomb Multi-Strain White Kratom Blend by KBomb

Ask about any prescription or over-the-counter medication and we check it for interactions with KBomb Multi-Strain White Kratom Blend by KBomb — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of KBomb Multi-Strain White Kratom Blend by KBomb

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.
  • “Premium Multi-Strain White Kratom Blend” is a proprietary blend — the label gives one combined amount (500 mg) without saying how much of each component you get.

This product contains one active ingredient: mitragyna speciosa, commonly called kratom, a plant from Southeast Asia. The capsules also contain a vegetable capsule as an inactive ingredient.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Kratom product and its label doesn't state a use — see Kratom's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for kratom's effectiveness for its marketed uses — sexual dysfunction, anxiety, athletic performance, cough, depression, and diabetes — is not established. We hold insufficient reliable evidence to rate it for any of these purposes.

The evidence, ingredient by ingredient Kratom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Kratom is rated as possibly unsafe for oral use and carries real risks you should know about. Dependence can develop with chronic use.

The most common side effects include constipation, dry mouth, nausea, vomiting, tongue numbness, and frequent urination. Rare but serious adverse effects have been reported, including respiratory depression (especially when kratom is mixed with opioids or other depressants), seizures, hallucinations, liver damage, and heart problems.

One poison control report analyzed over 3,400 kratom exposures; 75% involved neurologic effects like confusion, drowsiness, agitation, and seizures. Kratom is considered unsafe in pregnancy because it has been linked to newborn withdrawal symptoms.

It should not be used while breastfeeding, as kratom compounds may pass into breast milk. Additionally, kratom products are not regulated by the FDA as safe supplements, and contaminated products have been a documented concern.

Side effects, ingredient by ingredient Kratom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Kratom.
  • The most serious interaction on file is rated Moderate.
  • For scale: 996 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your pharmacist if you use central nervous system depressants (sedatives, sleep aids, opioids), drugs metabolized by liver enzymes CYP2D6, CYP1A2, or CYP3A4 (a large group), or these specific medications: quetiapine, modafinil, naltrexone, or venlafaxine. All carry documented Moderate-severity interaction risks with kratom.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Kratom is not established to work for the conditions it's marketed for, and the safety data raises significant concerns — especially dependence, respiratory depression, and seizure risk. If you take any medications, particularly those for mood, seizures, alertness, or pain, you need to check them against this product before starting.

Talk to your pharmacist or doctor about whether kratom is right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 24, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about KBomb Multi-Strain White Kratom Blend, straight from the product label.

Brand KBomb
Barcode (UPC) 850017128927
Net contents 60 Botanical Specimen Capsule(s)
Market status On market
Date entered into DSLD Apr 24, 2025
DSLD ID 329514
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for KBomb Multi-Strain White Kratom Blend by KBomb, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4 Capsule(s)
Maximum serving Sizes:
10 Capsule(s)
UPC/BARCODE
850017128927
IngredientAmount% DV
Mitragyna speciosa0 NP--
Premium Multi-Strain White Kratom Blend500 mg--

Other ingredients: Vegetable capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: 5-10 capsules (2.5 to 5 grams) up to 2x per day on an empty stomach. Start with 4 capsules 1x per day to assess tolerance.

Formulation

Tested for adulterants and heavy metals

100% natural Highest purity Fast acting Freshly ground from mature kratom trees Responsibly harvested and dried

FDA Disclaimer Statement

This product has not been evaluated by the FDA and is not intended to treat, prevent, cure or diagnose any disease.

Warning: This botanical specimen is not intended to treat, cure, or mitigate any disease or condition. The contents of this bottle are only to be used as a botanical specimen.

Formula

This product contains ground Mtragyna Speciosa Leaf in a capsule Each capsule contains 500 mg of premium multi-strain green kratom blend Capsules are used as a carrier for the Mitragyna Speciosa powder. They help facilitate the handling of raw powder (75gr per container.)

Precautions

21+

Seals/Symbols

Made in USA GMP GMP Facility Certified

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

KBomb Multi-Strain White Kratom Blend by KBomb label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

KBomb Multi-Strain White Kratom Blend label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in KBomb Multi-Strain White Kratom Blend by KBomb

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size4 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Premium Multi-Strain White Kratom Blend

500 mg per serving

Other (inactive) ingredients: Vegetable capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

KBomb Multi-Strain White Kratom Blend by KBomb Drug Interactions

Want to check YOUR meds against KBomb Multi-Strain White Kratom Blend?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
995Drugs
983 Moderate 12 Minor

Ingredients driving the most interactions

Mitragyna speciosa 995

Individual Drug Interactions

The ingredients in KBomb Multi-Strain White Kratom Blend interact with 995 drugs. Click any drug to see the details.

1 of the 1 ingredient in KBomb Multi-Strain White Kratom Blend interact with drugs. Each result below shows which ingredient is responsible. Mitragyna speciosa

Each ingredient & the kinds of drugs it affects

For each ingredient in KBomb Multi-Strain White Kratom Blend with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Mitragyna speciosa11 drug types · 995 drugs

Cns Depressants

Theoretically, concomitant use might increase the risk for adverse CNS depressant effects.
Kratom contains mitragynine, a mu-receptor agonist that may cause respiratory depression. Although results from animal research suggest that mitragynine causes less respiratory depression than the CNS depressant codeine, fatalities have been reported for patients who ingested a combination of kratom and O-desmethyltramadol, another mu-receptor agonist. Additionally, observational research suggests that adverse effects such as drowsiness and coma are more likely to occur in individuals taking kratom in combination with agents such as opioids and sedatives. Theoretically, ingesting kratom along with other CNS depressants can increase the risk of adverse effects, including drowsiness, coma, and/or severe or fatal respiratory depression.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, kratom might increase the levels and clinical effects of drugs metabolized by CYP1A2.
In vitro research suggests that kratom extract inhibits the activity of CYP1A2. In one case report, a 63-year-old male presented with possible serotonin syndrome after taking an unknown dose of kratom for up to 3 months along with serotonergic prescription medications bupropion, buspirone, desvenlafaxine, trazodone, and ziprasidone. It was hypothesized that kratom inhibited CYP1A2-mediaed metabolism of ziprasidone which consequently increased systemic exposure to serotonin.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, kratom might increase the levels and clinical effects of drugs metabolized by CYP2D6.
In vitro research suggests that kratom extract inhibits CYP2D6 enzyme activity. However, human research shows that a single low dose of kratom tea 2 grams does not inhibit CYP2D6 activity. However, this kratom dose is lower than what is normally taken for psychoactive effects. In one case report, a 63-year-old male presented with possible serotonin syndrome after taking an unknown dose of kratom for up to 3 months along with serotonergic prescription medications bupropion, buspirone, desvenlafaxine, trazodone, and ziprasidone. It was hypothesized that kratom inhibited CYP2D6-mediated metabolism of buspirone and consequently increased systemic exposure to serotonin. In another case, a 37-year-old male stable for 15 years on amitriptyline presented with anticholinergic symptoms including xerostomia, dry eyes, and constipation, along with mildly elevated bilirubin and liver enzymes after taking progressively higher doses of up to 14 grams of kratom daily for 12 weeks. It was hypothesized that the adverse effects of amitriptyline were precipitated by CYP2D6 inhibition by kratom.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Inhibitors

CYP3A4 inhibitors might increase the concentrations and clinical effects of kratom's primary active alkaloid mitragynine.
A pharmacokinetic study in healthy adults suggests that CYP3A4 inhibition with itraconazole increases the peak plasma concentration (Cmax) of mitragynine by about 1.5-fold. However, CYP3A4 inhibition reduces the Cmax and area under the plasma concentration time curve (AUC) over 72 hours of 7-hydroxymitragynine, one of kratom's active constituents, by about 3-fold, possibly by decreasing the metabolism of mitragynine to 7-hydroxymitragynin.
Animal research suggests that CYP3A4 inhibition with ketoconazole reduces the metabolism and clearance of kratom, increasing the Cmax of the active metabolite mitragynine by 130%, time to reach maximum plasma concentration (Tmax) from 1 to 2.6 hours, and AUC by 120%. Additionally, CYP3A4-mediated conversion of mitragynine into 7-hydroxymitragynine increases systematic exposure by 130%. However, other CYP isoforms are likely involved in this conversion. CYP3A4 inhibition could lead to increased adverse effects and mu-opioid-receptor-mediated behavioral effects associated with kratom and its metabolites.

Likelihood Possible Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Kratom might increase the levels and clinical effects of drugs metabolized by CYP3A4.
In vitro research shows that kratom extract inhibits CYP3A4 enzyme activity. A pharmacokinetic study in adults shows that taking kratom tea 2 grams modestly increases the plasma concentration time-curve (AUC) and maximum concentration (Cmax) of CYP3A4 probe midazolam by 40-50% and its CYP3A4-mediated metabolites 18-27%. However, a lack of change in the half-life of midazolam and a simulation of the kratom-midazolam interaction suggest that kratom inhibits CYP3A4 enzymes in the small intestine but not the liver. Additionally, there is one case report of a 27-year-old male who died from neuroleptic malignant-like symptoms after concomitant use of kratom and quetiapine, a CYP3A4 substrate. Although it did not appear that the patient had consumed large quantities of quetiapine, postmortem plasma levels were in the lethal range, indicating possible inhibition of CYP3A4 by kratom. In another case report, a 63-year-old male presented with possible serotonin syndrome after taking an unknown dose of kratom for up to 3 months along with serotonergic prescription medications bupropion, buspirone, desvenlafaxine, trazodone, and ziprasidone. It is hypothesized that CYP3A4 inhibition by kratom reduced metabolism of desvenlafaxine, trazodone, and ziprasidone and consequently increased systemic exposure to serotonin.

Likelihood Possible Evidence D
Modafinil (Provigil)

Theoretically, taking kratom in combination with modafinil may increase the risk of seizures.
A 43-year-old male patient experienced generalized tonic-clonic seizures after adding modafinil 100 mg to his chronic ingestion of kratom tea four times daily to further improve alertness and as a self-treatment for opioid withdrawal. The exact mechanism by which this interaction may occur is unknown.

Likelihood Possible Evidence D
Naltrexone (Vivitrol)

Taking kratom in combination with naltrexone might precipitate withdrawal.
Animal research shows that, while naltrexone does not antagonize the primary kratom alkaloid mitragynine, it does inhibit the behavioral effects of the metabolite 7-hyroxymitragynine by antagonizing its binding at the mu-opioid receptor. In humans, taking naltrexone has precipitated withdrawal from kratom. In one case, a patient chronically consuming kratom developed agitation, hallucinations, and delirium within about 2 hours of beginning oral naltrexone therapy. In another case, a 38-year-old male who was admitted to a residential rehabilitation treatment program for polysubstance abuse experienced opioid withdrawal after administration of intramuscular naltrexone. Although the patient reported discontinuing kratom, continued use was confirmed through positive urine mitragynine tests. Manufacturer guidance states that patients should be opioid-free for a minimum of 7-10 days prior to initiating treatment with naltrexone; this case report suggests that kratom use should be given similar consideration.

Likelihood Possible Evidence D
Quetiapine (Seroquel)

Theoretically, taking kratom in combination with quetiapine may increase levels and adverse effects of quetiapine.
A 27-year-old male was found deceased due to neuroleptic malignant-like symptoms after concomitant consumption of quetiapine and kratom. Although it did not appear that he had consumed large quantities of the medication, he was found to have a lethal plasma level of quetiapine. It is hypothesized that kratom inhibited cytochrome P450 (CYP) 3A4, the primary metabolic pathway for quetiapine. Also, a 36-year-old male presented to the emergency department with serotonin syndrome and QT interval prolongation after concomitant use of quetiapine, venlafaxine, and kratom. It is hypothesized that kratom may have inhibited the metabolism of both venlafaxine and quetiapine.

Likelihood Possible Evidence D
Serotonergic Drugs

Theoretically, taking kratom in combination with serotonergic drugs may increase levels of serotonin, increasing the risk of serotonin syndrome.
A 63-year-old male presented with possible serotonin syndrome after taking an unknown dose of kratom for up to 3 months along with serotonergic prescription medications bupropion, buspirone, desvenlafaxine, trazodone, and ziprasidone. It was hypothesized that kratom inhibited the cytochrome P450 3A4-, 2C9-, 2D6-, and 1A2-mediated metabolism of several of these serotonergic medications, consequently increasing systemic exposure to serotonin.

Likelihood Possible Evidence D
Venlafaxine (Effexor)

Theoretically, taking kratom in combination with venlafaxine may increase levels and clinical effects of venlafaxine.
A 36-year-old male presented to the emergency department with serotonin syndrome and QT interval prolongation after concomitant use of venlafaxine, quetiapine, and kratom. It is hypothesized that kratom may have inhibited the cytochrome P450 (CYP) metabolism of both venlafaxine and quetiapine.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, kratom might increase the levels of drugs metabolized by CYP2C19.
In vitro research shows that kratom extract weakly inhibits CYP2C19 enzyme activity.

Likelihood Possible Evidence D
Mitragyna speciosa full monograph & interactions
The maker

Brand information

Manufacturer and brand details for KBomb Multi-Strain White Kratom Blend, from the product label.

KBomb

See all KBomb products
Name
KBomb Kratom
Web Address
www.kbombkratom.com
Pharmacist Counseling Corner

KBomb Multi-Strain White Kratom Blend by KBomb: Common Questions

Does KBomb Multi-Strain White Kratom Blend by KBomb interact with any medications?
Yes. Based on its ingredients, KBomb Multi-Strain White Kratom Blend has a known interaction with 995 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
KBomb Multi-Strain White Kratom Blend contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is kratom safe to take while pregnant or nursing?
No. Kratom is considered unsafe in pregnancy — it's been linked to withdrawal symptoms in newborns. It should also be avoided while breastfeeding because kratom compounds pass into breast milk. If you're pregnant, planning pregnancy, or nursing, do not use this product.
What are the most common side effects of kratom?
The most common ones are constipation, dry mouth, nausea, vomiting, tongue numbness, and frequent urination. With chronic use, dependence can develop. Rare but serious effects like seizures, liver damage, and breathing problems have also been reported.
Can I become dependent on kratom?
Yes. Dependence can develop with chronic (long-term) use. Kratom carries a real risk of physical and psychological dependence.
Does kratom actually work for anxiety, depression, or pain?
The evidence isn't established in our data. Kratom is marketed for anxiety, depression, pain, sexual dysfunction, athletic performance, and cough, but we hold insufficient reliable evidence to say it works for any of these.
Why is kratom not regulated by the FDA?
Kratom is not approved or regulated as a safe supplement by the FDA. This means quality, purity, and safety claims aren't verified, and contaminated products have been a documented problem.
What should I do if I'm thinking about taking kratom?
Check any medications you take using the tool on this page — kratom interacts with hundreds of drugs. Then talk to your pharmacist or doctor about your specific situation. If you're pregnant, nursing, or have heart, breathing, liver, or seizure concerns, kratom is not a good choice.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

KBomb Multi-Strain White Kratom Blend label
Go deeper

The Full Monographs Behind KBomb Multi-Strain White Kratom Blend’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Kratom

Interacts with 995 drugs

Kratom is a Southeast Asian plant whose leaves act on the brain's opioid receptors and can produce both stimulant-like and opioid-like effects. It is not approved or proven safe by health re...

Read the full Kratom monograph →
Sources

Sources & How We Checked

KBomb Multi-Strain White Kratom Blend's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 77 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Kratom 77 references
  1. Singh D, Müller CP, Vicknasingam BK. Kratom (Mitragyna speciosa) dependence, withdrawal symptoms and craving in regular users. Drug Alcohol Depend 2014 Jun 1;139:132-7. PubMed
  2. Backstrom BG, Classon G, Lowenhielm P, Thelander G. [Krypton--new, deadly Internet drug. Since October 2009 have nine young persons died in Sweden]. Lakartidningen 2010;107(50):3196-3197.
  3. Kronstrand R, Roman M, Thelander G, Eriksson A. Unintentional fatal intoxications with mitragynine and O-desmethyltramadol from the herbal blend Krypton. J Anal Toxicol 2011;35(4):242-247. PubMed
  4. Boyer EW, Babu KM, Adkins JE, McCurdy CR, Halpern JH. Self-treatment of opioid withdrawal using kratom (Mitragynia speciosa korth). Addiction 2008;103(6):1048-1050.
  5. Jansen KL, Prast CJ. Ethnopharmacology of kratom and the Mitragyna alkaloids. J Ethnopharmacol 1988;23(1):115-119. PubMed
  6. Nelsen JL, Lapoint J, Hodgman MJ, Aldous KM. Seizure and coma following Kratom (Mitragynina speciosa Korth) exposure. J Med Toxicol 2010;6(4):424-426. PubMed
  7. Sheleg SV, Collins GB. A coincidence of addiction to "Kratom" and severe primary hypothyroidism. J Addict Med 2011;5(4):300-301. PubMed
  8. Kapp FG, Maurer HH, Auwarter V, Winkelmann M, Hermanns-Clausen M. Intrahepatic cholestasis following abuse of powdered kratom (Mitragyna speciosa). J Med Toxicol 2011;7(3):227-231. PubMed
  9. Kong WM, Chik Z, Ramachandra M, et al. Evaluation of the effects of Mitragyna speciosa alkaloid extract on cytochrome P450 enzymes using a high throughput assay. Molecules. 2011;16(9):7344-7356. PubMed
  10. US Food and Drug Administration (2014). SNI National is Voluntarily recalling Kratom XL 4 Pack, Maeng Da Kratom 10 Pack, Max Kratom 20 Pack, and Bali Kratom 40 pack Due to Undeclared Drug Ingredients [Press Release].
  11. Castillo A, Payne JD, Nugent K. Posterior reversible leukoencephalopathy syndrome after kratom ingestion. Proc (Bayl Univ Med Cent). 2017;30(3):355-357. PubMed
  12. Cumpston KL, Carter M, Wills BK. Clinical outcomes after Kratom exposures: A poison center case series. Am J Emerg Med. 2018;36(1):166-168. PubMed
  13. FDA Adverse Event Reporting System: Kratom Deaths. February 6, 2018. https://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/CDERFOIAElectronicReadingRoom/UCM595575.pdf. Accessed March 6, 2018.
  14. Trakulsrichai S, Sathirakul K, Auparakkitanon S, et al. Pharmacokinetics of mitragynine in man. Drug Des Devel Ther. 2015;9:2421-9. PubMed
  15. Kruegel AC, Grundmann O. The medicinal chemistry and neuropharmacology of kratom: A preliminary discussion of a promising medicinal plant and analysis of its potential for abuse.Neuropharmacology. 2017. pii: S0028-3908(17)30393-3. PubMed
  16. Singh D, Murugaiyah V, Hamid SBS, et al. Assessment of gonadotropins and testosterone hormone levels in regular Mitragyna speciosa (Korth.) users. J Ethnopharmacol 2018;221:30-6. doi: 10.1016/j.jep.2018.04.005. PubMed
  17. Singh D, Müller CP, Murugaiyah V, et al. Evaluating the hematological and clinical-chemistry parameters of kratom (Mitragyna speciosa) users in Malaysia. J Ethnopharmacol 2018;214:197-206. doi: 10.1016/j.jep.2017.12.017. PubMed
  18. Olsen EO, O'Donnell J, Mattson CL, Schier JG, Wilson N. Notes from the field: Unintentional drug overdose deaths with kratom detected - 27 States, July 2016-December 2017. MMWR Morb Mortal Wkly Rep. 2019;68(14):326-327.
  19. Hughes RL. Fatal combination of mitragynine and quetiapine - a case report with discussion of a potential herb-drug interaction. Forensic Sci Med Pathol. 2019 Mar;15(1):110-113. PubMed
  20. Gershman K, Timm K, Frank M, et al. Deaths in Colorado Attributed to Kratom. N Engl J Med. 2019 Jan 3;380(1):97-98. PubMed
  21. Mackay L, Abrahams R. Novel case of maternal and neonatal kratom dependence and withdrawal. Can Fam Physician. 2018 Feb;64(2):121-122.
  22. Davidson L, Rawat M, Stojanovski S, Chandrasekharan P. Natural drugs, not so natural effects: Neonatal abstinence syndrome secondary to 'kratom'. J Neonatal Perinatal Med. 2019;12(1):109-112. PubMed
  23. Smid MC, Charles JE, Gordon AJ, Wright TE. Use of Kratom, an Opioid-like Traditional Herb, in Pregnancy. Obstet Gynecol. 2018 Oct;132(4):926-928. PubMed
  24. Muhammad BY, Abdullahi AD, Kadir, SS, Abdul Razak TB, Ahmed QU. In-utero effects of the crude ethanolic extract of the leaves of Mitragyna speciose on neural tube formation in rats. Asian J Exp Biol Sci. 2010;1(2):404-408.
  25. Aldyab M, Ells PF, Bui R, Chapman TD, Lee H. Kratom-Induced Cholestatic Liver Injury Mimicking Anti-Mitochondrial Antibody-Negative Primary Biliary Cholangitis: A Case Report and Review of Literature. Gastroenterology Res. 2019 Aug;12(4):211-215. PubMed
  26. Nacca N, Schult RF, Li L, Spink DC, Ginsberg G, Navarette K, Marraffa J. Kratom Adulterated with Phenylethylamine and Associated Intracerebral Hemorrhage: Linking Toxicologists and Public Health Officials to Identify Dangerous Adulterants. J Med Toxicol. PubMed
  27. Abdullah HMA, Haq I, Lamfers R. Cardiac arrest in a young healthy male patient secondary to kratom ingestion: is this 'legal high' substance more dangerous than initially thought ? BMJ Case Rep. 2019 Jul 19;12(7). pii: e229778. PubMed
  28. Eggleston W, Stoppacher R, Suen K, Marraffa JM, Nelson LS. Kratom Use and Toxicities in the United States. Pharmacotherapy. 2019 Jul;39(7):775-777. doi: 10.1002/phar.2280. Epub 2019 Jun 13. PubMed
  29. Afzal H, Esang M, Rahman S. A case of kratom-induced seizures. Cureus. 2020;12(1):e6588. PubMed
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Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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