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Dietary supplement

Kid-e-Col Ingredients & Drug Interactions

by Dr. Christopher's Original Formulas

Kid-e-Col label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Kid-e-Col against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Kid-e-Col is a dietary supplement by Dr. Christopher's Original Formulas with 2 active ingredients. Its ingredients are commonly taken for digestive upset and bloating, infant colic, menstrual cramps.Based on those ingredients, 894 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Fennel, Catnip. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Kid-e-Col by Dr. Christopher's Original Formulas

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HelloPharmacist Scorecard of Kid-e-Col by Dr. Christopher's Original Formulas

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

Kid-e-Col contains 2 active ingredients: fennel and catnip. Fennel is a seed traditionally used for digestive comfort and other purposes, while catnip is an herb known for its calming properties.

The product also includes a natural flavoring base to make it palatable for children.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: gentle herbal formula for colic and teething.
  • We looked for evidence on: Colic, teething discomfort, infant digestive upset.
  • The closest evidence on file: Fennel is rated "Insufficient Reliable Evidence To Rate" for Colic (Natural Medicines).
  • Also on file: Catnip is rated "Insufficient Reliable Evidence To Rate" for Colic.

The evidence for what Kid-e-Col's ingredients do is mixed. Fennel has been rated possibly effective for period pain (dysmenorrhea), but the data we hold don't establish its effectiveness for the other uses it's associated with—bronchitis, anxiety, bed-wetting, and cholera—so we list those as having insufficient reliable evidence.

Catnip's effectiveness for any condition, including anxiety, tension headache, upper respiratory infection, indigestion, and gas, also lacks established evidence in the data we hold.

The evidence, ingredient by ingredient Fennel Catnip

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 1 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Fennel and catnip are generally well tolerated in food amounts, but Kid-e-Col is a concentrated supplement, which changes the safety picture. The most common side effects from fennel are stomach upset, sensitivity to sun, and allergic reactions in sensitive people; rarely, seizures have been reported.

Catnip may cause headache, malaise (feeling unwell), vomiting, or stomach upset, especially in larger amounts. Fennel is rated possibly unsafe during pregnancy because of limited safety data and its estrogen-like compounds; it's also rated possibly unsafe while breastfeeding in medicinal doses, though food amounts are likely fine.

Catnip should be avoided during pregnancy because it may stimulate the uterus and safety isn't established, and there isn't enough safety information for use while breastfeeding, so it's best avoided then too.

Side effects, ingredient by ingredient Fennel Catnip

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Fennel, Catnip.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; lithium.
  • For scale: 895 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before using Kid-e-Col with any medications, double-check for interactions with blood thinners and antiplatelet drugs (Moderate risk of increased bleeding), birth control pills or hormone replacement therapy (Moderate risk of reduced effectiveness), drugs metabolized by CYP3A4 like certain statins, antibiotics, and heart medications (Moderate risk of raised levels), sedating drugs such as sleep aids and anxiety medications (Moderate risk of increased drowsiness), tamoxifen (Moderate risk of reduced cancer-fighting effect), ciprofloxacin antibiotic (Moderate risk of reduced effectiveness), and lithium for mood disorders (Moderate risk of raised levels). A pharmacist can run your child's specific medications through the interaction checker on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Kid-e-Col is a two-ingredient herbal liquid aimed at children, but it carries several documented interactions with common medications—most seriously with blood thinners, birth control, cancer drugs, and lithium. Before giving it to your child, check with your child's doctor or pharmacist about any current medications or health conditions.

Fennel carries the strongest cautions for pregnancy and breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Kid-e-Col, straight from the product label.

Brand Dr. Christopher's Original Formulas
Barcode (UPC) 084783447030
Net contents 2 fl. Oz.
Market status On market
Date entered into DSLD Apr 25, 2019
DSLD ID 200388
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Infants/Baby (0 - 1 Year)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Kid-e-Col by Dr. Christopher's Original Formulas, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Infants
Minimum serving Sizes:
10 Drop(s)
Maximum serving Sizes:
15 Drop(s)
Servings per container
114
UPC/BARCODE
084783447030
IngredientAmount% DV
Fennel0 NP--
Catnip0 NP--
Proprietary Blend0 NP--

Other ingredients: A base of, Natural flavoring

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Kid-e-Col: Great tasting Colic & Teething formula.

Suggested/Recommended/Usage/Directions

Recommendations: Shake well. For colic take 10 to 15 drops three times a day or every hour a needed. For teething rub 3 to 4 drops on the gums.

General Statements

Kid-e-Col is a gentle herbal formula for Colic & Teething.

Colic & Teething

Extract

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. It is not intended to diagnose or treat disease.

Precautions

Seek the advice of a health professional for serious illness.

Formulation

Contains no alcohol.

Brand IP Statement(s)

2006 Wholistic Botanicals All Rights Reserved

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Kid-e-Col by Dr. Christopher's Original Formulas label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Kid-e-Col label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Kid-e-Col by Dr. Christopher's Original Formulas

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size10 Drop(s) Dosage formLiquid Servings per container114 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

0 NP per serving

Other (inactive) ingredients: A base of, Natural flavoring. These complete the product’s ingredient list but are not active constituents.

Interaction report

Kid-e-Col by Dr. Christopher's Original Formulas Drug Interactions

Want to check YOUR meds against Kid-e-Col?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
894Drugs
894 Moderate

Ingredients driving the most interactions

Fennel 740
Catnip 248

Individual Drug Interactions

The ingredients in Kid-e-Col interact with 894 drugs. Click any drug to see the details.

2 of the 2 ingredients in Kid-e-Col interact with drugs. Each result below shows which ingredient is responsible. Fennel Catnip

Each ingredient & the kinds of drugs it affects

For each ingredient in Kid-e-Col with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Fennel6 drug types · 740 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, fennel might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.

Animal research suggests that fennel oil has antithrombotic and antiplatelet effects.

Likelihood Possible Evidence D
Ciprofloxacin (Cipro)

Theoretically, fennel might decrease the levels and clinical effects of ciprofloxacin.

Animal research shows that fennel reduces ciprofloxacin bioavailability by nearly 50%, possibly due to the metal cations such as calcium, iron, and magnesium contained in fennel. This study also found that fennel increased tissue distribution and slowed elimination of ciprofloxacin.

Likelihood Probable Evidence D
Contraceptive Drugs

Theoretically, taking large amounts of fennel might decrease the effects of contraceptive drugs due to competition for estrogen receptors.

Some constituents of fennel have estrogenic activity.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.

In vitro research suggests that fennel inhibits CYP3A4 enzyme activity. This effect has not been reported in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, taking large amounts of fennel might interfere with hormone replacement therapy due to competition for estrogen receptors.

Some constituents of fennel have estrogenic activity.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, taking large amounts of fennel might decrease the antiestrogenic effect of tamoxifen.

Some constituents of fennel have estrogenic activity, which may interfere with the antiestrogenic activity of tamoxifen.

Likelihood Possible Evidence D
Fennel full monograph & interactions

Catnip2 drug types · 248 drugs

Cns Depressants

Theoretically, concomitant use with drugs with sedative properties may cause additive effects and side effects.
Clinical and animal research shows that catnip has sedative properties.

Likelihood Possible Evidence D
Lithium

Theoretically, catnip might reduce excretion and increase levels of lithium.
Catnip is thought to have diuretic properties which might reduce lithium excretion. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Catnip full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Kid-e-Col, from the product label.

Dr. Christopher's Original Formulas

See all Dr. Christopher's Original Formulas products
Name
Wholistic Botanicals
City
Spanish Fork
State
UT
ZipCode
84660
Web Address
www.drchristopher.com
Pharmacist Counseling Corner

Kid-e-Col by Dr. Christopher's Original Formulas: Common Questions

Does Kid-e-Col by Dr. Christopher's Original Formulas interact with any medications?
Yes. Based on its ingredients, Kid-e-Col has a known interaction with 894 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Kid-e-Col contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is Kid-e-Col safe for my child if they're on medication?
Kid-e-Col contains fennel and catnip, both of which interact with numerous medications—including blood thinners, birth control, anxiety meds, and others. Before giving it to your child, check with your child's doctor or pharmacist about any prescriptions or over-the-counter drugs they're taking.
What is fennel supposed to do in this product?
Fennel is included for its traditional uses in supporting digestion and comfort. The strongest evidence supports its use for period pain (dysmenorrhea), though for other uses the evidence is insufficient to establish whether it works.
What are the side effects of catnip?
Catnip is generally well tolerated, but it can cause headache, malaise, vomiting, and stomach upset—especially in larger amounts. In one case, a toddler became sleepy and drowsy after ingesting catnip-soaked raisins.
Can I use Kid-e-Col if I'm pregnant or breastfeeding?
Fennel is rated possibly unsafe during pregnancy due to its estrogen-like compounds and limited safety data, and medicinal amounts aren't well studied while breastfeeding. Catnip should be avoided during pregnancy because it may stimulate the uterus, and there isn't enough safety data for breastfeeding. Talk with your doctor or pharmacist about what's right for you.
Does this product have any fillers?
Kid-e-Col contains a natural flavoring base and inactive ingredients to deliver the active herbs. The active ingredients are fennel and catnip only.
What's the difference between using fennel as a food versus this supplement?
Fennel in foods (like fennel seed in cooking) is generally safe, but Kid-e-Col is a concentrated supplement, which means higher doses and a different safety profile. Concentrated fennel and its essential oil need more caution, especially during pregnancy and breastfeeding, and it's more likely to cause side effects like stomach upset.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Kid-e-Col label
Go deeper

The Full Monographs Behind Kid-e-Col’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Fennel

Interacts with 740 drugs

Fennel is a Mediterranean herb widely used as a food and spice, and traditionally taken for digestive complaints, colic, and menstrual cramps. Some small studies suggest possible benefit for...

Read the full Fennel monograph → Herb & supplement monograph

Catnip

Interacts with 248 drugs

Catnip is a mint-family herb most often used as a calming tea for sleep, anxiety, and minor digestive upset, but solid human research supporting these uses is lacking. It is generally consid...

Read the full Catnip monograph →
Sources

Sources & How We Checked

Kid-e-Col's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 24 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Fennel 17 references
  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. Zhu M, Wong PY, Li RC. Effect of oral administration of fennel (Foeniculum vulgare) on ciprofloxacin absorption and disposition in the rat. J Pharm Pharmacol 1999;51:1391-6.
  4. Gral N, Beani JC, Bonnot D, et al. [Plasma levels of psoralens after celery ingestion]. Ann Dermatol Venereol 1993;120:599-603.
  5. Burkhard PR, Burkhardt K, Haenggeli CA, Landis T. Plant-induced seizures: reappearance of an old problem. J Neurol 1999;246:667-70. PubMed
  6. Rosti L, Nardini A, Bettinelli ME, Rosti D. Toxic effects of a herbal tea mixture in two newborns. Acta Paediatrica 1994;83:683. PubMed
  7. Cuzzolin L, Zaffani S, and Benoni G. Safety implications regarding use of phytomedicines. Eur.J Clin Pharmacol. 2006;62:37-42. PubMed
  8. Tognolini, M., Ballabeni, V., Bertoni, S., Bruni, R., Impicciatore, M., and Barocelli, E. Protective effect of Foeniculum vulgare essential oil and anethole in an experimental model of thrombosis. Pharmacol.Res 2007;56(3):254-260. PubMed
  9. Subehan, Usia, T., Iwata, H., Kadota, S., and Tezuka, Y. Mechanism-based inhibition of CYP3A4 and CYP2D6 by Indonesian medicinal plants. J Ethnopharmacol. 5-24-2006;105(3):449-455. PubMed
  10. Tognolini, M., Barocelli, E., Ballabeni, V., Bruni, R., Bianchi, A., Chiavarini, M., and Impicciatore, M. Comparative screening of plant essential oils: phenylpropanoid moiety as basic core for antiplatelet activity. Life Sci. 2-23-2006;78(13):1419-1432. PubMed
  11. Subehan, Zaidi, S. F., Kadota, S., and Tezuka, Y. Inhibition on human liver cytochrome P450 3A4 by constituents of fennel (Foeniculum vulgare): identification and characterization of a mechanism-based inactivator. J Agric.Food Chem. 12-12-2007;55(25):101 PubMed
  12. LEVY, S. B. Bronchial asthma due to ingestion of fennel and fennel seed. Ann.Allergy 1948;6(4):415.
  13. Ottolenghi, A., De Chiara, A., Arrigoni, S., Terracciano, L., and De Amici, M. [Diagnosis of food allergy caused by fruit and vegetables in children with atopic dermatitis]. Pediatr Med Chir 1995;17(6):525-530.
  14. Trabace L, Tucci P, Ciuffreda L, et al. "Natural" relief of pregnancy-related symptoms and neonatal outcomes: above all do no harm. J Ethnopharmacol. 2015;174:396-402. PubMed
  15. Denaxa D, Arkwright PD. Fennel as a cause of immediate hypersensitivity to toothpaste. Ann Allergy Asthma Immunol. 2020;125(1):99-100. PubMed
  16. Lee HW, Ang L, Lee MS, Alimoradi Z, Kim E. Fennel for reducing pain in primary dysmenorrhea: a systematic review and meta-analysis of randomized controlled trials. Nutrients 2020;12(11):3438. PubMed
  17. Mathew T, John SK, Javali M, Vasireddy M, Nadig R, Sarma GRK. Substance use related cluster headache: A case series. Headache 2022;62(7):908-910. PubMed

See these in context on the Fennel monograph →

Catnip 7 references
  1. Foster S, Tyler VE. Tyler's Honest Herbal: A Sensible Guide to the Use of Herbs and Related Remedies. 3rd ed., Binghamton, NY: Haworth Herbal Press, 1993.
  2. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Osterhoudt KC, Lee SK, Callahan JM, Henretig FM. Catnip and the alteration of human consciousness. Vet Hum Toxicol 1997;39:373-5.
  5. Sherry, C. J. and Hunter, P. S. The effect of an ethanol extract of catnip (Nepeta cataria) on the behavior of the young chick. Experientia 2-15-1979;35(2):237-238. PubMed
  6. Harney, J. W., Barofsky, I. M., and Leary, J. D. Behavioral and toxicological studies of cyclopentanoid monoterpenes from Nepeta cataria. Lloydia. 1978;41(4):367-374.
  7. Massoco, C. O., Silva, M. R., Gorniak, S. L., Spinosa, M. S., and Bernardi, M. M. Behavioral effects of acute and long-term administration of catnip (Nepeta cataria) in mice. Vet.Hum.Toxicol 1995;37(6):530-533.

See these in context on the Catnip monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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