Interactions on record — worth a quick check against your medications. Based on 2 of 5 ingredients. Check your meds →
Dietary supplement

Krill Oil 500 mg Ingredients & Drug Interactions

by Nutrients for Health

Krill Oil 500 mg label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Krill Oil 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Krill Oil 500 mg is a dietary supplement by Nutrients for Health with 5 active ingredients. Its ingredients are commonly taken for antioxidant support, skin health and aging, eye health.Based on those ingredients, 681 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Astaxanthin, Choline. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Krill Oil 500 mg by Nutrients for Health

Ask about any prescription or over-the-counter medication and we check it for interactions with Krill Oil 500 mg by Nutrients for Health — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Krill Oil 500 mg by Nutrients for Health

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • “Total Omega-3 Fatty Acids” is listed as a grouped ingredient — the label gives one combined amount (110 mg) without saying how much of each component you get.

This product contains 5 active ingredients. The two main ones are eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) — both are omega-3 fatty acids from Antarctic krill that support heart and brain health.

You'll also find choline, which your body uses to build cell membranes and support brain function; astaxanthin, a carotenoid antioxidant from algae; and a blend labeled Total Omega-3 Fatty Acids that draws from the EPA and DHA already listed. The softgel also contains inactive ingredients like krill oil, gelatin, glycerol, sorbitol, water, and ethyl vanillin as the capsule and base.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

The label doesn't state a purpose we can grade — see each ingredient's own graded uses on its monograph instead.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The facts we hold don't establish clear effectiveness for any condition in this product. Choline has been rated Possibly Ineffective for athletic performance and carries Insufficient Evidence for cognitive decline, Alzheimer's disease, and several other uses.

Astaxanthin likewise shows Insufficient Evidence across age-related cognitive decline, macular degeneration, aging skin, Alzheimer's disease, athletic performance, and carpal tunnel syndrome. If you're considering krill oil for a specific health goal, talk with your pharmacist or doctor — they can help you weigh what research exists outside our data.

The evidence, ingredient by ingredient Astaxanthin Choline

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Choline is generally well tolerated in the amounts found in food, but high-dose supplements can cause side effects. The upper safe daily limit is 3.5 grams; at 9 grams daily or higher, it may cause fishy body odor, diarrhea, nausea, sweating, and vomiting.

Astaxanthin appears well tolerated in studies, though long-term safety data are limited. In trials, doses of 6 mg daily caused increased bowel movements and red-colored stools in a small number of participants, and 40 mg daily caused severe abdominal pain in two cases.

For pregnancy, choline is rated Likely Safe — it's actually important during pregnancy — but use only the dose your doctor recommends. Astaxanthin has insufficient safety data, so it's best to avoid it during pregnancy and while breastfeeding.

If you're pregnant or nursing, talk with your doctor about whether this product is right for you.

Side effects, ingredient by ingredient Astaxanthin Choline

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Choline, Astaxanthin.
  • The most serious interaction on file is rated Moderate.
  • For scale: 682 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check these medication types before taking this product: drugs broken down by your liver via the CYP3A4 pathway (Moderate concern) and the CYP2B6 pathway (Moderate concern) — these include many cholesterol, heart, and psychiatric medications. Also ask about atropine or similar anticholinergic drugs if you use them.

Our interaction checker can tell you if your specific medications are affected.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Krill Oil 500 mg is worth considering if you're looking for omega-3 support, but run your medications through our interaction checker first — astaxanthin may affect how your liver processes a large group of common drugs. Avoid this product if you're pregnant or breastfeeding until you've talked with your doctor.

If you take atropine or any regular prescription, check with your pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Krill Oil 500 mg, straight from the product label.

Brand Nutrients for Health
Barcode (UPC) 850015036347
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Aug 22, 2024
DSLD ID 316936
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Krill Oil 500 mg by Nutrients for Health, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
60
UPC/BARCODE
850015036347
IngredientAmount% DV
Calories5 Calorie(s)--
Eicosapentaenoic Acid60 mg--
Docosahexaenoic Acid28 mg--
Total Omega-3 Fatty Acids110 mg--
Cholesterol5 mg2%
Total Fat0.5 Gram(s)1%
Choline25 mg5%
Astaxanthin50 mcg--
Phospholipids200 mg--

Other ingredients: Antarctic Krill Oil, Bovine Gelatin, Glycerol, Sorbitol, Water, Ethyl Vanillin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Take one softgel twice daily preferably with meals or as directed by a healthcare professional.

Formulation

Made in Romania.

Brand IP Statement(s)

Rawleigh A Friend of the Family since 1889

Nutrients for Health By W.T. Rawleigh

Precautions

Keep out of the reach of children

Do not use if seal is broken

Contains: Crustacean shellfish (Krill).

Storage

Store in a cool, dry place

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Formula

Phospholipid complex

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Krill Oil 500 mg by Nutrients for Health label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Krill Oil 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Krill Oil 500 mg by Nutrients for Health

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Total Omega-3 Fatty Acids

110 mg per serving
  • › Eicosapentaenoic Acid
  • › Docosahexaenoic Acid
  • › Astaxanthin
  • › Phospholipids

Choline

Interacts with
16 drugs
25 mg per serving

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like egg...

Choline monograph & interactions

Other (inactive) ingredients: Antarctic Krill Oil, Bovine Gelatin, Glycerol, Sorbitol, Water, Ethyl Vanillin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Krill Oil 500 mg by Nutrients for Health Drug Interactions

Want to check YOUR meds against Krill Oil 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
681Drugs
671 Moderate 10 Minor

Ingredients driving the most interactions

Astaxanthin 671
Choline 16

Individual Drug Interactions

The ingredients in Krill Oil 500 mg interact with 681 drugs. Click any drug to see the details.

2 of the 5 ingredients in Krill Oil 500 mg interact with drugs. Each result below shows which ingredient is responsible. Astaxanthin Choline

Each ingredient & the kinds of drugs it affects

For each ingredient in Krill Oil 500 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Astaxanthin2 drug types · 671 drugs

Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP2B6.
In vitro research shows that astaxanthin induces cytochrome CYP2B6 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
In vitro research shows that astaxanthin induces CYP3A4 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Astaxanthin full monograph & interactions

Choline1 drug type · 16 drugs

Atropine

Theoretically, choline might decrease the effects of atropine in the brain.
Animal research shows that administering choline one hour before administering atropine can attenuate atropine-induced decreases in brain levels of acetylcholine. Theoretically, concomitant use of choline and atropine may decrease the effects of atropine.

Likelihood Possible Evidence D
Choline full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Krill Oil 500 mg, from the product label.

Nutrients for Health

Name
Vitamins Direct (USA), Inc.
City
West Palm Beach
State
FL
ZipCode
33407
Phone Number
866-354-8384
Web Address
www.wtrawleigh.com
Pharmacist Counseling Corner

Krill Oil 500 mg by Nutrients for Health: Common Questions

Does Krill Oil 500 mg by Nutrients for Health interact with any medications?
Yes. Based on its ingredients, Krill Oil 500 mg has a known interaction with 681 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Krill Oil 500 mg contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is krill oil safe to take while pregnant?
Choline in the product is rated Likely Safe in pregnancy, but astaxanthin doesn't have enough safety data — we advise against it during pregnancy. Because this product contains both, talk with your doctor first to see if it's appropriate for you.
Will this give me side effects?
At the dose in this product, side effects are unlikely. However, choline can cause a fishy body odor, and astaxanthin may cause increased bowel movements or red-colored stools in some people. High doses of choline (9 grams daily or more) cause nausea, vomiting, and diarrhea.
What is astaxanthin, and why is it in krill oil?
Astaxanthin is a natural red pigment from algae that acts as an antioxidant. It's included to support overall health, though we hold insufficient evidence for specific conditions.
Does this product actually help with brain health or athletic performance?
For athletic performance, choline is rated Possibly Ineffective. For brain health and cognitive decline, both choline and astaxanthin show Insufficient Evidence in our data — meaning studies haven't established whether they work for these uses yet.
Can I take this if I'm breastfeeding?
Choline needs are higher while breastfeeding, but supplements should be used only under professional guidance. Astaxanthin lacks safety data during breastfeeding, so avoid it. Talk with your doctor or pharmacist about whether this product is safe for you.
What are the inactive ingredients?
The inactive ingredients are Antarctic krill oil, bovine gelatin (the capsule), glycerol, sorbitol, water, and ethyl vanillin. These are fillers, binders, and flavor — they're not active ingredients.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Krill Oil 500 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Krill Oil 500 mg label
Go deeper

The Full Monographs Behind Krill Oil 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Astaxanthin

Interacts with 671 drugs

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise benefits. Early human studies are promis...

Read the full Astaxanthin monograph → Herb & supplement monograph

Choline

Interacts with 16 drugs

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like eggs, meat, and fish. Supplements may help...

Read the full Choline monograph →
Sources

Sources & How We Checked

Krill Oil 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 17 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Choline 14 references
  1. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  2. Cho E, Willett WC, Colditz GA, et al. Dietary choline and betaine and the risk of distal colorectal adenoma in women. J Natl Cancer Inst 2007;99:1224-31. PubMed
  3. Schmidt, C., Abicht, A., Krampfl, K., Voss, W., Stucka, R., Mildner, G., Petrova, S., Schara, U., Mortier, W., Bufler, J., Huebner, A., and Lochmuller, H. Congenital myasthenic syndrome due to a novel missense mutation in the gene encoding choline acetyl
  4. Tamminga, C., Smith, R. C., Chang, S., Haraszti, J. S., and Davis, J. M. Depression associated with oral choline. Lancet 10-23-1976;2(7991):905. PubMed
  5. Wood, J. L. and Allison, R. G. Effects of consumption of choline and lecithin on neurological and cardiovascular systems. Fed.Proc. 1982;41(14):3015-3021.
  6. Growdon, J. H. and Gelenberg, A. J. Choline and lecithin administration to patients with tardive dyskinesia. Trans.Am.Neurol.Assoc. 1978;103:95-99.
  7. Smith, C. M., Swash, M., Exton-Smith, A. N., Phillips, M. J., Overstall, P. W., Piper, M. E., and Bailey, M. R. Choline therapy in Alzheimer's disease. Lancet 8-5-1978;2(8084):318. PubMed
  8. Morrison, L. M. and W. F. Gonzales. Choline in coronary atherosclerosis. Amer.Heart J. 1950;39:729.
  9. Christie, J. G. Blackburn 1. M. Glen A. I. M. Zeisel S. Shering A. & Yates C. M. Effects of choline and lecithin on CSF choline levels and on cognitive functioning in patients with presenile dementia of the Alzheimer type. Nutrition and the brain 1979;5
  10. Sidhu N, Davies S, Nadarajah A, et al. Oral choline supplementation for postoperative pain. Br J Anaesth 2013;111(2):249-55. PubMed
  11. Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol spectrum disorders has high feasibility and tolerability. Nutr Res. 2013;33(11):897-904. PubMed
  12. Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol disorders: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2015;102(5): 1113-25.
  13. Ross RG, Hunter SK, McCarthy L, et al. Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk. Am J Psychiatry. 2013;170(3):290-8. PubMed
  14. Food and Nutrition Board, Institute of Medicine. Choline. Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B-6, Vitamin B-12, Pantothenic Acid, Biotin, and Choline. Washington D.C.: National Academy Press; 1998:390-422.

See these in context on the Choline monograph →

Astaxanthin 3 references
  1. Kupcinskas L, Lafolie P, Lignell A, et al. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled
  2. Kistler, A., Liechti, H., Pichard, L., Wolz, E., Oesterhelt, G., Hayes, A., and Maurel, P. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. Arch.Toxicol. 2002;75(11-12):665-675. PubMed
  3. Choi HD, Youn YK, Shin WG. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods Hum Nutr. 2011;66:363-369. PubMed

See these in context on the Astaxanthin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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