Interactions on record — worth a quick check against your medications. Based on 2 of 4 ingredients. Check your meds →
Dietary supplement

Triple Strength Krill Oil Ingredients & Drug Interactions

by GNC

Triple Strength Krill Oil label
See full label image
Softgel Capsule Category: Fat/fatty Acid
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Triple Strength Krill Oil against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Triple Strength Krill Oil is a dietary supplement by GNC with 4 active ingredients. Its ingredients are commonly taken for liver health and fatty liver, brain and memory support, prenatal nutrition and fetal development.Based on those ingredients, 16 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Choline. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Triple Strength Krill Oil by GNC

Ask about any prescription or over-the-counter medication and we check it for interactions with Triple Strength Krill Oil by GNC — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Triple Strength Krill Oil by GNC

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • “Total Omega-3 Fatty Acids” is listed as a grouped ingredient — the label gives one combined amount (270 mg) without saying how much of each component you get.
  • “Total Phospholipids” is listed as a grouped ingredient — the label gives one combined amount (560 mg) without saying how much of each component you get.

This product contains 4 active ingredients. The main omega-3 components are eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)—two fatty acids from krill that are thought to support heart and brain health.

It also includes choline and phosphatidylcholine, both related compounds involved in cell function and liver health. The rest is a gelatin capsule with inactive ingredients like krill oil, medium chain triglyceride, and sorbitol to hold it together.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Supports heart, brain and joint health.
  • We looked for evidence on: Cardiovascular disease (CVD), Atherosclerosis, Angina, Hypertension, Hyperlipidemia, Hyperlipoproteinemia — and 4 related terms.
  • The closest evidence on file: Choline is rated "Insufficient Reliable Evidence To Rate" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Choline is rated "Insufficient Reliable Evidence To Rate" for Cardiovascular disease (CVD), Cognitive function, Dementia, Hypertension.
  • Also on file: Phosphatidylcholine is rated "Insufficient Reliable Evidence To Rate" for Angina, Atherosclerosis.

The evidence for this product's ingredients is mixed. Phosphatidylcholine is possibly effective for ulcerative colitis, but the evidence for other uses—including nonalcoholic fatty liver disease, alcohol-related liver disease, Alzheimer disease, and anxiety—is insufficient to rate.

For choline, the data shows it's possibly ineffective for athletic performance, and evidence is insufficient for bronchitis, age-related cognitive decline, and several other conditions. The omega-3 fatty acids (EPA and DHA) are the intended active components, but their effectiveness ratings aren't on file here.

The evidence, ingredient by ingredient Choline Phosphatidylcholine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Phosphatidylcholine is generally well tolerated when taken by mouth, though high doses (around 30 grams daily) can cause bloating, diarrhea, nausea, and altered taste. Choline is also generally safe in food amounts, but high-dose supplements can trigger side effects—most notably a fishy body odor at normal doses, and at very high doses (9 grams or more daily), diarrhea, nausea, sweating, and vomiting.

Choline has a daily upper limit of 3.5 grams. For pregnancy and breastfeeding, choline is rated Likely Safe, though the product labeling advises using only prenatal or supplement doses as advised by your doctor.

Phosphatidylcholine safety in pregnancy and breastfeeding is not well studied; check with your healthcare provider before use.

Side effects, ingredient by ingredient Choline Phosphatidylcholine

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Choline.
  • The most serious interaction on file is rated Minor.
  • For scale: 16 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take atropine, let your pharmacist know—choline in this product may reduce its effects (Minor severity). No other interactions are documented for the ingredients we could check, but we hold no data for the omega-3 acids EPA and DHA, so check your exact medications with the tool on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.

This is a krill oil supplement that also delivers choline and phosphatidylcholine. It's worth considering if you're looking for omega-3 support, but if you take atropine or any other prescription medication, run it through our checker first.

People with digestive sensitivity should know that these ingredients can cause bloating or diarrhea at higher doses. Talk to your pharmacist before you start, especially if you're pregnant, breastfeeding, or on any regular medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 21, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Triple Strength Krill Oil, straight from the product label.

Brand GNC
Barcode (UPC) 048107170523
Net contents 30 Softgel(s)
Market status On market
Date entered into DSLD May 21, 2025
DSLD ID 328792
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Triple Strength Krill Oil by GNC, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
30
UPC/BARCODE
048107170523
IngredientAmount% DV
Calories10 Calorie(s)--
Eicosapentaenoic Acid150 mg--
Docosahexaenoic Acid70 mg--
Total Omega-3 Fatty Acids270 mg--
Cholesterol30 mg10%
Total Fat1 Gram(s)1%
Choline70 mg13%
Phosphatidylcholine480 mg--
Total Phospholipids560 mg--

Other ingredients: Krill Oil, Gelatin, Water, Purified, Medium Chain Triglyceride, Sorbitol, Glycerin, Ethylcellulose, Sodium Alginate, Ammonium Hydroxide, Oleic Acid, Stearic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Keep out of reach of children.

Contains: Crustacean (Krill).

Storage

Store in a cool, dry place.

General Statements

For more information: GNC.com

30-day supply

Formula

Krill Oil as Superba Boost. 220 mg of highly absorbable EPA/DHA Omega-3s

Brand IP Statement(s)

Superba Boost is a trademark of the Aker Group.

Formulation

Supports heart, brain & joint health

No sugar, no starch, no artificial colors, not artificial flavors, no preservatives, sodium free, gluten free, no soy, no dairy.

Enteric coated to help control fishy burps - guaranteed Purified to reduce contaminants such as heavy metals, dioxins and PCBs

GF (Gluten Free)

FDA Statement of Identity

Omega-3 Supplement

Seals/Symbols

High Quality Purified

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take one softgel capsule daily.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Triple Strength Krill Oil by GNC label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Triple Strength Krill Oil label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Triple Strength Krill Oil by GNC

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Total Omega-3 Fatty Acids

270 mg per serving
  • › Eicosapentaenoic Acid
  • › Docosahexaenoic Acid

Choline

Interacts with
16 drugs
70 mg per serving

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like egg...

Choline monograph & interactions

Total Phospholipids

560 mg per serving

Other (inactive) ingredients: Krill Oil, Gelatin, Water, Purified, Medium Chain Triglyceride, Sorbitol, Glycerin, Ethylcellulose, Sodium Alginate, Ammonium Hydroxide, Oleic Acid, Stearic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Triple Strength Krill Oil by GNC Drug Interactions

Want to check YOUR meds against Triple Strength Krill Oil?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
16Drugs
16 Minor

Ingredients driving the most interactions

Choline 16

Individual Drug Interactions

The ingredients in Triple Strength Krill Oil interact with 16 drugs. Click any drug to see the details.

1 of the 4 ingredients in Triple Strength Krill Oil interact with drugs. Each result below shows which ingredient is responsible. Choline

Each ingredient & the kinds of drugs it affects

For each ingredient in Triple Strength Krill Oil with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Choline1 drug type · 16 drugs

Atropine

Theoretically, choline might decrease the effects of atropine in the brain.
Animal research shows that administering choline one hour before administering atropine can attenuate atropine-induced decreases in brain levels of acetylcholine. Theoretically, concomitant use of choline and atropine may decrease the effects of atropine.

Likelihood Possible Evidence D
Choline full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Triple Strength Krill Oil, from the product label.

GNC

See all GNC products
Name
GNC Holdings, LLC
City
Pittsburgh
State
PA
ZipCode
15222
Web Address
GNC.com
Pharmacist Counseling Corner

Triple Strength Krill Oil by GNC: Common Questions

Does Triple Strength Krill Oil by GNC interact with any medications?
Yes. Based on its ingredients, Triple Strength Krill Oil has a known interaction with 16 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Triple Strength Krill Oil contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
Choline is rated Likely Safe in pregnancy and breastfeeding, but the product label advises using only prenatal or supplement doses as your doctor recommends. Phosphatidylcholine safety in pregnancy and breastfeeding isn't well studied. Talk with your doctor or pharmacist before starting.
What's the difference between choline and phosphatidylcholine in here?
Both are choline-related compounds involved in cell health and liver function. Phosphatidylcholine is a specific form found naturally in cell membranes, while choline is a nutrient your body uses for brain and nerve signaling. This product includes both.
Will this cause side effects?
At the doses in a typical krill oil supplement, side effects are uncommon. At very high doses, choline can cause a fishy body odor, bloating, nausea, or diarrhea. Phosphatidylcholine can also cause bloating or digestive upset if you take a lot. Most people tolerate it well.
Does this actually work for heart or brain health?
The omega-3 fatty acids (EPA and DHA) are the main active ingredients, but their effectiveness ratings aren't on file here. Phosphatidylcholine is possibly effective for ulcerative colitis, but evidence for other uses is insufficient to rate.
Is there a daily limit for choline in this product?
Yes—choline has a tolerable upper intake level of 3.5 grams daily. High-dose supplements can push past this, so check the label for how much choline per serving and don't exceed the recommended dose.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Triple Strength Krill Oil is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Triple Strength Krill Oil label
Go deeper

The Full Monographs Behind Triple Strength Krill Oil’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Choline

Interacts with 16 drugs

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like eggs, meat, and fish. Supplements may help...

Read the full Choline monograph → Herb & supplement monograph

Phosphatidylcholine

Phosphatidylcholine is a phospholipid that is part of every cell membrane and a source of choline. People take it for liver, brain, and gut health, but solid human evidence is limited for mo...

Read the full Phosphatidylcholine monograph →
Sources

Sources & How We Checked

Triple Strength Krill Oil's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 29 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Choline 14 references
  1. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  2. Cho E, Willett WC, Colditz GA, et al. Dietary choline and betaine and the risk of distal colorectal adenoma in women. J Natl Cancer Inst 2007;99:1224-31. PubMed
  3. Schmidt, C., Abicht, A., Krampfl, K., Voss, W., Stucka, R., Mildner, G., Petrova, S., Schara, U., Mortier, W., Bufler, J., Huebner, A., and Lochmuller, H. Congenital myasthenic syndrome due to a novel missense mutation in the gene encoding choline acetyl
  4. Tamminga, C., Smith, R. C., Chang, S., Haraszti, J. S., and Davis, J. M. Depression associated with oral choline. Lancet 10-23-1976;2(7991):905. PubMed
  5. Wood, J. L. and Allison, R. G. Effects of consumption of choline and lecithin on neurological and cardiovascular systems. Fed.Proc. 1982;41(14):3015-3021.
  6. Growdon, J. H. and Gelenberg, A. J. Choline and lecithin administration to patients with tardive dyskinesia. Trans.Am.Neurol.Assoc. 1978;103:95-99.
  7. Smith, C. M., Swash, M., Exton-Smith, A. N., Phillips, M. J., Overstall, P. W., Piper, M. E., and Bailey, M. R. Choline therapy in Alzheimer's disease. Lancet 8-5-1978;2(8084):318. PubMed
  8. Morrison, L. M. and W. F. Gonzales. Choline in coronary atherosclerosis. Amer.Heart J. 1950;39:729.
  9. Christie, J. G. Blackburn 1. M. Glen A. I. M. Zeisel S. Shering A. & Yates C. M. Effects of choline and lecithin on CSF choline levels and on cognitive functioning in patients with presenile dementia of the Alzheimer type. Nutrition and the brain 1979;5
  10. Sidhu N, Davies S, Nadarajah A, et al. Oral choline supplementation for postoperative pain. Br J Anaesth 2013;111(2):249-55. PubMed
  11. Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol spectrum disorders has high feasibility and tolerability. Nutr Res. 2013;33(11):897-904. PubMed
  12. Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol disorders: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2015;102(5): 1113-25.
  13. Ross RG, Hunter SK, McCarthy L, et al. Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk. Am J Psychiatry. 2013;170(3):290-8. PubMed
  14. Food and Nutrition Board, Institute of Medicine. Choline. Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B-6, Vitamin B-12, Pantothenic Acid, Biotin, and Choline. Washington D.C.: National Academy Press; 1998:390-422.

See these in context on the Choline monograph →

Phosphatidylcholine 15 references
  1. Domino EF, May WW, Demetriou S, et al. Lack of clinically significant improvement of patients with tardive dyskinesia following phosphatidylcholine therapy. Biol Psychiatry 1985;20:1189-96. PubMed
  2. Aronson PJ, Lorincz AL. Promotion of palmar sweating with oral phosphatidylcholine. Acta Derm Venereol 1985;65:19-24. DOI
  3. Hexsel DM, Serra M, de Oliveira Dal'Forno T, et al. Cosmetic uses of injectable phosphatidylcholine on the face. Otolaryngol Clin North Am 2005;38:1119-29. PubMed
  4. Kopera D, Binder B, Toplak H, et al. Histopathologic changes after intralesional application of phosphatidylcholine for lipoma reduction: report of a case. Am J Dermatopathol 2006;28:331-3. PubMed
  5. Rittes PG. The use of phosphatidylcholine for correction of lower lid bulging due to prominent fat pads. Dermatol Surg 2001;27:391-2. PubMed
  6. Rotunda AM, Kolodney MS. Mesotherapy and phosphatidylcholine injections: historical clarification and review. Dermatol Surg 2006;32:465-80. PubMed
  7. Hexsel D, Serra M, Mazzuco R, et al. Phosphatidylcholine in the treatment of localized fat. J Drugs Dermatol 2003;2:511-8.
  8. Hasengschwandtner F. Phosphatidylcholine treatment to induce lipolysis. Cosmet Dermatol 2005;4:308-13. PubMed
  9. Rittes PG. The use of phosphatidylcholine for correction of localized fat deposits. Aesthetic Plast Surg 2003;27:315-8. PubMed
  10. Ablon G, Rotunda AM. Treatment of lower eyelid fat pads using phosphatidylcholine: clinical trial and review. Dermatol Surg 2004;30:422-7. PubMed
  11. Loguercio C, Andreone P, Brisc C, et al. Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: a randomized controlled trial. Free Radic Biol Med 2012;52(9):1658-65. PubMed
  12. Panos, J. M., Palson, R., Johnson, R., Portmann, B., and Williams, R. Polyunsaturated phosphatidylcholine for acute alcoholic hepatitis: a double blind randomized placebo controlled trial. Eur.J.Gastroenterol 1990;2:351-355.
  13. Stremmel W, Braun A, Hanemann A, Ehehalt R, Autschbach F, Karner M. Delayed release phosphatidylcholine in chronic-active ulcerative colitis: a randomized, double-blinded, dose finding study. J Clin Gastroenterol 2010;44(5):e101-7. PubMed
  14. Stremmel W, Ehehalt R, Autschbach F, Karner M. Phosphatidylcholine for steroid-refractory chronic ulcerative colitis: a randomized trial. Ann Intern Med. 2007;147(9):603-10. PubMed
  15. Stremmel W, Vural H, Evliyaoglu O, Weiskirchen R. Delayed Release Phosphatidylcholine is Effective for Treatment of Ulcerative Colitis: A Meta-Analysis. Dig Dis 2021;39(5):508-515. PubMed

See these in context on the Phosphatidylcholine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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