Interactions on record — worth a quick check against your medications. Based on 4 of 5 ingredients. Check your meds →
Dietary supplement

Kyolic GABA, Vitamin B1, B6, & B12 Ingredients & Drug Interactions

by Kyolic

Kyolic GABA, Vitamin B1, B6, & B12 label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Kyolic GABA, Vitamin B1, B6, & B12 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Kyolic GABA, Vitamin B1, B6, & B12 is a dietary supplement by Kyolic with 5 active ingredients. Its ingredients are commonly taken for morning sickness in pregnancy, premenstrual syndrome (pms), preventing or treating b6 deficiency.Based on those ingredients, 1,131 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Aged Garlic extract powder, GABA, Vitamin B6. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Kyolic GABA, Vitamin B1, B6, & B12 by Kyolic

Ask about any prescription or over-the-counter medication and we check it for interactions with Kyolic GABA, Vitamin B1, B6, & B12 by Kyolic — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Kyolic GABA, Vitamin B1, B6, & B12 by Kyolic

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 5 active ingredients: vitamin B6, vitamin B12, vitamin B1, aged garlic extract powder, and GABA. Vitamin B6 supports nervous system function and is used for certain types of anemia and seizure disorders.

Vitamin B12 is essential for red blood cells and nerve health. Vitamin B1 (thiamine) helps your body convert food into energy.

Aged garlic extract is a traditional ingredient with possible benefits for blood pressure and blood sugar. GABA is a brain chemical thought to promote relaxation.

The tablet also contains inactive ingredients: cellulose, silica, and magnesium stearate, which are common binders and flow agents.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: stress and fatigue relief with relaxation.
  • We looked for evidence on: Anxiety, Fatigue, Depression, stress management, emotional balance, nervous system support.
  • The closest evidence on file: Garlic is rated "Insufficient Reliable Evidence To Rate" for Chronic fatigue syndrome (CFS) (Natural Medicines).
  • Also on file: Garlic is rated "Insufficient Reliable Evidence To Rate" for Stress.
  • Also on file: Gamma-aminobutyric Acid (gaba) is rated "Insufficient Reliable Evidence To Rate" for Anxiety, Depression.

The evidence varies widely across this product's ingredients. Vitamin B6 is effective for sideroblastic anemia and B6 deficiency, and possibly effective for pregnancy-related nausea.

Vitamin B12 is effective for B12 deficiency. For garlic extract, there is possibly effective evidence for high blood pressure, diabetes support, and liver health.

GABA, however, has insufficient reliable evidence to rate—we don't have enough data to say whether it works for anxiety, ADHD, or the other conditions studied. Vitamin B1's effectiveness data is not on file.

If you're considering this product for a specific condition, talk with your doctor or pharmacist about whether the evidence supports it for your needs.

The evidence, ingredient by ingredient Vitamin B6 Vitamin B12 Garlic Gamma-aminobutyric Acid (gaba)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin B6 is generally well tolerated at normal doses, but high doses over time can harm nerves (sensory neuropathy). It's often used for morning sickness under medical guidance.

Vitamin B12 is very safe—your body removes excess in urine—and is needed during pregnancy and breastfeeding. Aged garlic extract is generally safe as food but may cause stomach upset, body odor, or increase bleeding risk at supplement doses; avoid concentrated doses unless your doctor approves.

GABA is often well tolerated short-term, but long-term safety is not well studied, and it's best avoided during breastfeeding due to insufficient safety information. Common side effects across ingredients include nausea, headache, and drowsiness.

Side effects, ingredient by ingredient Vitamin B6 Vitamin B12 Garlic Gamma-aminobutyric Acid (gaba)

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Garlic, Gamma-aminobutyric Acid (gaba), Vitamin B12, Vitamin B6.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; Parkinson's medications.
  • For scale: 1,132 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take antihypertensive drugs (for blood pressure), blood thinners or antiplatelet drugs like warfarin, diabetes medications, seizure medications (phenobarbital or phenytoin), amiodarone, metformin, HIV protease inhibitors, tacrolimus, or any sedating medications (CNS depressants). The aged garlic extract may also affect how your body processes certain medications through liver enzymes.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product combines B vitamins and herbal ingredients with varying evidence for effectiveness and a notable interaction profile, especially with blood pressure and diabetes medications, blood thinners, and seizure drugs. If you take any prescription medication—particularly for blood pressure, diabetes, bleeding prevention, or seizures—check your specific drugs before starting.

Talk with your doctor or pharmacist about whether this product is right for you and whether any adjustments to your current medications are needed.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Kyolic GABA, Vitamin B1, B6, & B12, straight from the product label.

Brand Kyolic
Barcode (UPC) 023542101325
Net contents 200 Tablet(s)
Market status On market
Date entered into DSLD Feb 25, 2015
DSLD ID 42375
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Organic, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Kyolic GABA, Vitamin B1, B6, & B12 by Kyolic, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Tablet(s)
Maximum serving Sizes:
2 Tablet(s)
UPC/BARCODE
023542101325
IngredientAmount% DV
Vitamin B625 mg1250%
Vitamin B1250 mcg833%
Vitamin B125 mg1667%
Aged Garlic extract powder600 mg--
GABA15 mg--

Other ingredients: Cellulose, Silica, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Kyolic(R) Anti-Stress & Fatigue Formula 101 is a unique blend of Aged Garlic Extract(TM), gamma-aminobutyric acid (GABA), and vitamins B1, B6 and B12 designed to naturally promote mental, emotional, and physical balance in an increasingly hectic world.

General Statements

Aged Garlic Extract has been shown to reduce fatigue and assist in fighting stress. GABA, and Vitamins B1, B6 and B12 combine to support healthy relaxation and increased alertness. Taken together, these nutrients help to strengthen the immune system and create a sense of well-being.

STRESS & FATIGUE RELIEF

FORMULA 101

Suggested/Recommended/Usage/Directions

Take Kyolic 101 daily to help promote tranquility and soothe everyday stress and fatigue.

SUGGESTED USE: Take two tablets with a meal twice daily.

Precautions

Do not use if cap drop ring or inner seal is broken or missing.

Keep out of reach of children.

Seals/Symbols

GMP Certified

FDA Statement of Identity

Odorless Organic Garlic Supplement

Formulation

Odorless Organic Garlic Supplement

FREE OF: dairy, preservatives, gluten, artificial colors and flavors.

Storage

Store in a cool, dry place with cap tight.

General

L101A32M

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

Aged Garlic Extract(TM)

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Kyolic GABA, Vitamin B1, B6, & B12 by Kyolic label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Kyolic GABA, Vitamin B1, B6, & B12 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Kyolic GABA, Vitamin B1, B6, & B12 by Kyolic

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin B6

Interacts with
210 drugs
25 mg per serving

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B6 monograph & interactions

Vitamin B12

Interacts with
20 drugs
50 mcg per serving

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Vitamin B12 monograph & interactions

Vitamin B1

25 mg per serving

Aged Garlic extract powder

Interacts with
989 drugs
600 mg per serving

Garlic is a common food and supplement that may modestly help with blood pressure and cholesterol, though the evidence is mixed and effects are usuall...

Aged Garlic extract powder monograph & interactions

GABA

Interacts with
419 drugs
15 mg per serving

GABA is a calming chemical messenger (neurotransmitter) that your body makes on its own, and it is sold as a supplement for stress, anxiety, and sleep...

GABA monograph & interactions

Other (inactive) ingredients: Cellulose, Silica, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Kyolic GABA, Vitamin B1, B6, & B12 by Kyolic Drug Interactions

Want to check YOUR meds against Kyolic GABA, Vitamin B1, B6, & B12?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,131Drugs
1,016 Moderate 115 Minor

Ingredients driving the most interactions

Aged Garlic extract powder 989
GABA 419
Vitamin B6 210
Vitamin B12 20

Individual Drug Interactions

The ingredients in Kyolic GABA, Vitamin B1, B6, & B12 interact with 1,131 drugs. Click any drug to see the details.

4 of the 5 ingredients in Kyolic GABA, Vitamin B1, B6, & B12 interact with drugs. Each result below shows which ingredient is responsible. Aged Garlic extract powder GABA Vitamin B6 Vitamin B12

Each ingredient & the kinds of drugs it affects

For each ingredient in Kyolic GABA, Vitamin B1, B6, & B12 with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Aged Garlic extract powder12 drug types · 989 drugs

Anticoagulant/Antiplatelet Drugs

Garlic may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Raw garlic and a variety of garlic extracts have antiplatelet activity and can increase prothrombin time.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking garlic with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research suggests that garlic and garlic extract lower blood glucose levels in healthy and diabetic individuals.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking garlic with antihypertensive drugs might increase the risk of hypotension.
In human research, both garlic and garlic extracts have blood pressure-lowering effects.

Likelihood Possible Evidence D
Atazanavir (Reyataz)

Theoretically, garlic might decrease levels and effects of atazanavir.
In a case report, a patient consuming six stir-fried garlic cloves three times weekly developed suboptimal atazanavir levels and increases in HIV viral load. While the exact cause of this interaction is unclear, there is speculation that garlic might decrease the intestinal absorption of atazanavir or increase its metabolism by inducing cytochrome P450 3A4 (CYP3A4). Until more is known, advise patients not to consume large amounts of garlic while taking atazanavir.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Garlic might increase levels of drugs metabolized by CYP2E1.
Clinical research suggests garlic oil can inhibit the activity of CYP2E1 by 39%. Use garlic oil cautiously in patients taking drugs metabolized by these enzymes.

Likelihood Probable Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4. This may increase or decrease levels of drugs metabolized by CYP3A4.
Some human research suggests that garlic may induce INTESTINAL CYP3A4, reducing levels of drugs metabolized by this enzyme. This is primarily based on a study showing that taking a specific allicin-containing garlic product (GarliPure Maximum Allicin Formula, Natrol Inc.) twice daily for 3 days reduces saquinavir levels by approximately 50%. It is speculated that the allicin constituent induced CYP3A4 in the gut mucosa. Another study shows that giving docetaxel intravenously, bypassing the CYP3A4 enzymes in the gut mucosa, along with the same specific garlic product for 12 consecutive days, does not affect docetaxel levels. Conversely, there is concern that garlic may inhibit HEPATIC CYP3A4. In a single case report, increased tacrolimus levels and liver injury occurred in a liver transplant patient after taking a specific garlic supplement (Garlicin Cardio, Nature's Way) at up to three times the manufacturer recommended dose for 7 days. Several other studies have evaluated the impact of other garlic formulations on CYP3A4 substrates and have found no effect. Most of the products in these studies provided little or no allicin.

Likelihood Possible Evidence B
Isoniazid

Theoretically, garlic might decrease levels of isoniazid.
Animal research suggests that an aqueous extract of garlic reduces isoniazid levels by about 65%. Garlic reduced the maximum concentration (Cmax) and area under the curve (AUC), but not the half-life, of isoniazid. This suggests that garlic extract might inhibit isoniazid absorption across the intestinal mucosa; however, the exact mechanism of this potential interaction is not known.

Likelihood Possible Evidence D
Protease Inhibitors (Pis)

Theoretically, garlic products containing allicin might decrease levels of PIs.
Protease inhibitors are metabolized by cytochrome P450 3A4 (CYP3A4) isoenzymes. There is concern that garlic products containing allicin might induce intestinal CYP3A4, reducing plasma levels of protease inhibitors. This is primarily based on a study showing that taking a specific garlic product (GarliPure Maximum Allicin Formula, Natrol Inc.) twice daily for 3 days reduces levels of saquinavir, a PI, by approximately 50%. It is speculated that the allicin constituent induce CYP3A4 in the gut mucosa. Several studies have evaluated the impact of other garlic formulations on CYP3A4 substrates and have found no effect. Most of the products in these studies provided little or no allicin.

Likelihood Possible Evidence B
Saquinavir (Fortovase, Invirase)

Theoretically, garlic containing allicin might decrease levels of saquinavir.
Saquinavir is a substrate of cytochrome P450 3A4 (CYP3A4) isoenzymes. There is concern that garlic products containing allicin might induce intestinal CYP3A4 and cause subtherapeutic levels of saquinavir. This is primarily based on a pharmacokinetic study showing that taking a specific garlic product (GarliPure Maximum Allicin Formula, Natrol Inc.) twice daily for 3 days reduces saquinavir levels by approximately 50%. It is speculated that the allicin constituent induces CYP3A4 in the gut mucosa. Several pharmacokinetic studies have evaluated the impact of other garlic formulations on CYP3A4 substrates and have found no effect. Most of the products in these studies provided little or no allicin. Until more is known about this potential interaction, use garlic containing allicin cautiously in patients taking saquinavir.

Likelihood Possible Evidence B
Sofosbuvir (Sovaldi)

Theoretically, taking garlic with sofosbuvir might decrease its effectiveness.
Animal research in rats shows that giving aged garlic extract 120 mg/kg orally daily for 14 days decreases the area under the concentration time curve (AUC) after a single sofosbuvir dose of 40 mg/kg by 36%, increases the clearance by 63%, and decreases the plasma concentrations at 1 and 8 hours by 35% and 58%, respectively. This interaction is hypothesized to be due to induction of intestinal P-glycoprotein expression by garlic.

Likelihood Possible Evidence D
Tacrolimus (Prograf)

Theoretically, garlic might increase levels of tacrolimus.
In one case report, a liver transplant patient taking tacrolimus experienced increased tacrolimus levels and liver injury after taking a specific garlic supplement (Garlicin Cardio, Nature's Way) at up to three times the manufacturer recommended dose for 7 days. It is speculated that garlic inhibited hepatic cytochrome P450 3A4 (CYP3A4), which increased plasma levels of tacrolimus.

Likelihood Possible Evidence B
Warfarin (Coumadin)

Theoretically, garlic might increase the risk of bleeding with warfarin.
Raw garlic and a variety of garlic extracts have antiplatelet activity and can increase prothrombin time. In addition, there is a report of two patients who experienced an increase in a previously stabilized international normalized ratio (INR) with concomitant garlic and warfarin use. However, this report has been subsequently debated due to limited clinical information. Other clinical studies have not identified an effect of garlic on INR, warfarin pharmacokinetics, or bleeding risk. More evidence is needed to determine the safety of using garlic with warfarin.

Likelihood Possible Evidence D
Aged Garlic extract powder full monograph & interactions

GABA2 drug types · 419 drugs

Antihypertensive Drugs

Theoretically, taking GABA with antihypertensive drugs might increase the risk of hypotension.
Some clinical research shows that GABA can decrease blood pressure in patients with hypertension.

Likelihood Possible Evidence B
Cns Depressants

Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Endogenous GABA has well-established relaxant effects and GABA(A) receptors have an established physiological role in sleep. However, the effects of GABA supplements are unclear, as it is unknown whether exogenous GABA crosses the blood-brain barrier. Although there have been limited reports of drowsiness or tiredness with GABA supplements, these effects have not been widely reported in clinical studies. Additionally, intravenous GABA 0.1-1 mg/kg has been shown to induce anxiety in a dose-dependent manner.

Likelihood Unlikely Evidence D
GABA full monograph & interactions

Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Vitamin B6 full monograph & interactions

Vitamin B121 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Vitamin B12 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Kyolic GABA, Vitamin B1, B6, & B12, from the product label.

Kyolic

See all Kyolic products
Name
Wakunaga of America Co., Ltd.
Street Address
23501 Madero
City
Mission Viejo
State
CA
ZipCode
92691
Web Address
www.kyolic.com
Pharmacist Counseling Corner

Kyolic GABA, Vitamin B1, B6, & B12 by Kyolic: Common Questions

Does Kyolic GABA, Vitamin B1, B6, & B12 by Kyolic interact with any medications?
Yes. Based on its ingredients, Kyolic GABA, Vitamin B1, B6, & B12 has a known interaction with 1,131 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Kyolic GABA, Vitamin B1, B6, & B12 contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant?
Vitamin B6 is likely safe at normal amounts and is often used for pregnancy-related nausea under a doctor's guidance, though some data suggests possibly unsafe concerns. Vitamin B12 is considered safe and is actually needed during pregnancy. Aged garlic extract is likely safe in food amounts but possibly unsafe at supplement doses. GABA has insufficient safety data in pregnancy. Talk with your doctor before starting any supplement while pregnant—pregnancy is an individual situation and your provider can give personalized advice.
Is this safe for breastfeeding?
Vitamin B6 and B12 are considered safe at recommended amounts while breastfeeding. Aged garlic extract is likely safe at food amounts. GABA is best avoided while breastfeeding due to insufficient safety information. As always, discuss any supplement with your doctor or pharmacist before taking it while nursing.
What does the aged garlic extract do?
Aged garlic extract has possibly effective evidence for high blood pressure, diabetes support, liver health, and heart health. However, the evidence is not strong or conclusive, and it can interact with blood thinners and blood pressure medications, so check with your pharmacist first.
Does GABA in this product actually work?
We don't have enough reliable evidence to say whether GABA supplements work for anxiety, ADHD, or other uses people try it for. The evidence is insufficient to rate, so we can't confirm it's effective for any of those conditions.
What are the common side effects?
The most common side effects are nausea, headache, stomach upset, drowsiness, and loss of appetite. High-dose vitamin B6 can also cause nerve damage (numbness or tingling) over time. Aged garlic may cause body odor and bad breath. These side effects are usually mild, but if you experience nerve symptoms or severe reactions, stop and contact your doctor.
Is there an upper limit on how much B12 I can take?
No established upper limit—your body removes excess B12 in urine, so it's very safe even at high doses. That's one reason B12 is often used in supplements.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Kyolic GABA, Vitamin B1, B6, & B12 label
Go deeper

The Full Monographs Behind Kyolic GABA, Vitamin B1, B6, & B12’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph → Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph → Herb & supplement monograph

Garlic

Interacts with 989 drugs

Garlic is a common food and supplement that may modestly help with blood pressure and cholesterol, though the evidence is mixed and effects are usually small. It is generally safe in food am...

Read the full Garlic monograph → Herb & supplement monograph

Gamma-aminobutyric Acid (gaba)

Interacts with 419 drugs

GABA is a calming chemical messenger (neurotransmitter) that your body makes on its own, and it is sold as a supplement for stress, anxiety, and sleep. The science behind oral GABA supplemen...

Read the full Gamma-aminobutyric Acid (gaba) monograph →
Sources

Sources & How We Checked

Kyolic GABA, Vitamin B1, B6, & B12's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 228 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B6 32 references
  1. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
  4. South M. Neonatal seizures after pyridoxine use -- reply. Lancet 1999;354:2083. PubMed
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  6. Baxter P, Aicardi J. Neonatal seizures after pyridoxine use. Lancet 1999;354:2082-3. PubMed
  7. Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
  8. Schaumburg H, Kaplan J, Windebank A. Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med 1983;309:445-8. PubMed
  9. Gordon N. Pyridoxine dependency: an update. Dev Med Child Neurol 1997;39:63-5. PubMed
  10. Lewis PJ. Pain in the hand and wrist. Pyridoxine supplements may help patients with carpal tunnel syndrome. BMJ 1995;310:1534. PubMed
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