L-Lysine 1000 mg Ingredients & Drug Interactions
by GNC
What is this page for?
First and foremost: checking L-Lysine 1000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
L-Lysine 1000 mg is a dietary supplement by GNC with 1 active ingredient. Its ingredients are commonly taken for cold sores (herpes labialis), genital herpes outbreaks, supporting protein and collagen formation.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated minor. The ingredients most likely to interact are L-Lysine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against L-Lysine 1000 mg by GNC
Ask about any prescription or over-the-counter medication and we check it for interactions with L-Lysine 1000 mg by GNC — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of L-Lysine 1000 mg by GNC
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: L-lysine, an amino acid at 1000 mg per dose. The inactive ingredients are povidone, stearic acid, silicon dioxide, and magnesium stearate—all fillers and binders that help hold the tablet together.
Does it work?
Moderate evidence
L-lysine is possibly effective for herpes labialis, commonly known as cold sores. The evidence for child growth, pressure ulcers, and diabetic foot ulcers is insufficient—we don't have enough reliable data to rate how well it works for those uses.
How safe is it?
Well-documented data
L-lysine is generally well tolerated at typical doses. The most common side effects are abdominal pain, diarrhea, and indigestion.
High amounts may cause stomach upset, and long-term safety of supplements hasn't been thoroughly studied. There's also one case report of kidney inflammation linked to oral lysine, though this is rare.
Pregnancy and breastfeeding safety data for supplements is limited. Lysine from food is fine, but if you're pregnant or breastfeeding and want to take a supplement, talk with your doctor first—there isn't enough reliable information to know either way.
Meds to double-check
Minor interactions only
If you take a 5-HT4 agonist—a drug used for certain digestive issues—check with your doctor or pharmacist before starting L-lysine. Animal research suggests lysine may reduce how well these medications work, though the interaction is rated minor.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.
L-lysine may help with cold sores if you're looking for a possibly effective option. It's generally well tolerated, but high doses can upset your stomach and long-term safety isn't fully established.
If you take a 5-HT4 agonist or have any kidney concerns, check with your doctor or pharmacist before starting. Either way, it's worth running your full medication list past them to be sure.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 22, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about L-Lysine 1000 mg, straight from the product label.
| Brand | GNC |
|---|---|
| Barcode (UPC) | 048107211318 |
| Net contents | 90 Vegetarian Caplet(s) |
| Market status | On market |
| Date entered into DSLD | Jan 22, 2021 |
| DSLD ID | 242992 |
| Product type | Amino Acid/protein |
| Supplement form | Other (e.g. Tea Bag) |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for L-Lysine 1000 mg by GNC, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| L-Lysine | 1000 mg | -- |
Other ingredients: Povidone, Stearic Acid, Silicon Dioxide, Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions
Keep out of reach of children.
Storage
Store in a cool, dry place.
Formulation
Supports repair & maintenance of tissue Involved in collagen formation
Potency verified by GNC procedure #5054. Conforms to USP <2091> for weight. Meets USP <2040> disintegration.
No sugar, no artificial colors, no artificial flavors, no preservatives, sodium free, no wheat, gluten free, no corn, no soy, no dairy.
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Directions: As a dietary supplement, take one caplet up to three times per day, an hour before meals or on an empty stomach.
Seals/Symbols
Ko Kosher Service
Formula
Ko Kosher Service
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
L-Lysine 1000 mg by GNC label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in L-Lysine 1000 mg by GNC
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Caplet(s) Dosage formOther (e.g. Tea Bag) Servings per container90 Amounts shown are per serving.
L-Lysine
Interacts with1 drug
Lysine is an essential amino acid your body cannot make on its own, so it must come from food or supplements. People most often take extra lysine to t...
L-Lysine monograph & interactionsOther (inactive) ingredients: Povidone, Stearic Acid, Silicon Dioxide, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
L-Lysine 1000 mg by GNC Drug Interactions
HelloPharmacist Interaction Report
GNC L-Lysine 1000 mg contains one ingredient—L-lysine—that has documented interactions with medications.
The most serious finding is a minor interaction with 5-HT4 agonists (a class of drugs used for certain gastrointestinal conditions). Animal research suggests lysine may reduce how well these drugs work by partially blocking their target receptor.
Read the full breakdown — every affected drug type, severity by severity
Although this interaction is rated minor, it's worth knowing about if you take a 5-HT4 agonist. Check your exact medications with the search tool on this page, and if you're on one of these drugs, run it by your doctor or pharmacist before starting lysine.
Algether, these interactions span 1 individual medication.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against L-Lysine 1000 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in L-Lysine 1000 mg interact with 1 drug. Click any drug to see the details.
1 of the 1 ingredient in L-Lysine 1000 mg interact with drugs. Each result below shows which ingredient is responsible. L-Lysine
TegaserodZelnorm
How Tegaserod interacts with L-Lysine 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
L-lysine5-ht4 Agonists Minor
Interaction Summary
Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Read the full L-lysine + Tegaserod interactionEach ingredient & the kinds of drugs it affects
For each ingredient in L-Lysine 1000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
L-Lysine
5-Ht4 Agonists
Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Animal research suggests that L-lysine is a partial serotonin receptor 4 (5-HT4) antagonist and inhibits diarrhea induced by the 5-HT4 agonist, 5-hydroxytryptophane.
Brand information
Manufacturer and brand details for L-Lysine 1000 mg, from the product label.
GNC
See all GNC products- Name
- General Nutrition Corporation
- City
- Pittsburgh
- State
- PA
- ZipCode
- 15222
- Phone Number
- 1-888-462-2548
- Web Address
- gnc.com
L-Lysine 1000 mg by GNC: Common Questions
Does L-Lysine 1000 mg by GNC interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will L-lysine actually help my cold sores?
What side effects should I watch for?
Can I take this if I'm pregnant or breastfeeding?
Does L-lysine work for other conditions, like pressure ulcers or wound healing?
What's actually in this product besides the lysine?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if L-Lysine 1000 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind L-Lysine 1000 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
L-Lysine 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 7 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Lysine 7 references
- Thein DJ, Hurt WC. Lysine as a prophylactic agent in the treatment of recurrent herpes simplex labialis. Oral Surg Oral Med Oral Pathol 1984;58:659-66. PubMed
- McCune MA, Perry HO, Muller SA, O'Fallon WM. Treatment of recurrent herpes simplex infections with L-lysine monohydrochloride. Cutis 1984;34:366-73.
- DiGiovanna JJ, Blank H. Failure of lysine in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Arch Dermatol 1984;120:48-51. DOI
- Milman N, Scheibel J, Jessen O. Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlled crossover study. Acta Derm Venereol 1980;60:85-7.
- Griffith RS, Walsh DE, Myrmel KH, et al. Success of L-lysine therapy in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Dermatologica 1987;175:183-90. DOI
- Lo JC, Chertow GM, Rennke H, Seifter JL. Fanconi's syndrome and tubulointerstitial nephritis in association with L-lysine ingestion. Am J Kidney Dis 1996;28:614-7. PubMed
- Smriga M, Torii K. L-Lysine acts like a partial serotonin receptor 4 antagonist and inhibits serotonin-mediated intestinal pathologies and anxiety in rats. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15370-5.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC