Lysine Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Lysine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Lysine is a dietary supplement by BRI Nutrition with 1 active ingredient. Its ingredients are commonly taken for cold sores (herpes labialis), genital herpes outbreaks, supporting protein and collagen formation.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated minor. The ingredients most likely to interact are L-Lysine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Lysine by BRI Nutrition
Ask about any prescription or over-the-counter medication and we check it for interactions with Lysine by BRI Nutrition — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Lysine by BRI Nutrition
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This supplement contains one active ingredient: L-lysine, an amino acid your body uses to build proteins and support immune function. The capsule also includes vegetable cellulose, microcrystalline cellulose, magnesium stearate, and silica as inactive ingredients.
Does it work?
Moderate evidence
L-lysine is possibly effective for cold sores (herpes labialis) — the evidence suggests it may help, though more research would strengthen confidence. For child growth, pressure ulcers, and diabetic foot ulcers, we don't have enough reliable evidence yet to know whether it works.
How safe is it?
Well-documented data
Lysine from food is safe. As a supplement, it's generally well tolerated at typical doses, but high amounts may cause stomach upset—particularly abdominal pain, diarrhea, and indigestion.
Long-term safety at higher doses isn't well studied. One rare case report linked oral lysine to kidney inflammation that progressed to chronic kidney damage, though this is uncommon.
Safety during pregnancy and breastfeeding hasn't been well studied in supplement form. Talk with your doctor or pharmacist before taking it if you're pregnant or breastfeeding.
Meds to double-check
Minor interactions only
If you take a 5-HT4 agonist (a medication for certain digestive motility problems), let your doctor or pharmacist know before starting this supplement — lysine may reduce its effectiveness.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.
If you get frequent cold sores, this supplement has some evidence behind it and is generally well tolerated at normal doses. If you take a 5-HT4 agonist, check with your doctor or pharmacist first — the supplement may affect how well the drug works.
Pregnant or breastfeeding? Same conversation with your healthcare provider before you start.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 26, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Lysine, straight from the product label.
| Brand | BRI Nutrition |
|---|---|
| Barcode (UPC) | X000PWSD5X |
| Net contents | 180 Vegetable Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Dec 26, 2020 |
| DSLD ID | 242274 |
| Product type | Amino Acid/protein |
| Supplement form | Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Lysine by BRI Nutrition, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| L-Lysine | 500 mg | -- |
Other ingredients: Vegetable Cellulose, Microcrystalline Cellulose, Magnesium Stearate, Silica
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested Use: 1 vegetable capsule taken 1 to 3 times daily between meals or as directed by a healthcare professional.
Formula
What it is: As one of the nine essential amino acids, L-Lysine is an indispensable amino acid that cannot be made by the body. Amino acids perform a variety of function and form the basis for protein. L-Lysine is commonly found in peas and other vegetables. It is used for the health and integrity of the skin & lips while also supporting a healthy immune system.
Formulation
Supports the health of you skin and lips Supports a healthy immune system Powerful & potent HCl
Quality Value Service Purity
FDA Statement of Identity
Dietary Supplement
Precautions
Keep out of the reach of children.
Do not use if safety seal is damaged or missing.
Caution: Do not exceed recommended dose.
Pregnant or nursing mothers, children under 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.
Pregnant or nursing mothers, children under 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.
This product is manufactured and packaged in a facility which may also process milk, soy, wheat, egg, peanuts, tree nuts, fish and crustacean shellfish.
Storage
Store in a cool, dry place.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Seals/Symbols
Good Manufacturing Practice Sourced from a GMP Certified Facility Quality Assured
Made in USA
General Statements
100% satisfaction guaranteed
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Lysine by BRI Nutrition label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Lysine by BRI Nutrition
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Vegetable Capsule(s) Dosage formCapsule Servings per container180 Amounts shown are per serving.
L-Lysine
Interacts with1 drug
Lysine is an essential amino acid your body cannot make on its own, so it must come from food or supplements. People most often take extra lysine to t...
L-Lysine monograph & interactionsOther (inactive) ingredients: Vegetable Cellulose, Microcrystalline Cellulose, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.
Lysine by BRI Nutrition Drug Interactions
HelloPharmacist Interaction Report
BRI Nutrition Lysine contains L-lysine, which has one documented interaction: it may reduce the effects of 5-HT4 agonists (a class of drugs used for certain GI motility issues).
The interaction is Minor in severity, based on animal research suggesting lysine acts as a partial antagonist to the serotonin receptor 4.
Read the full breakdown — every affected drug type, severity by severity
If you take a 5-HT4 agonist, your doctor or pharmacist should know you're considering this supplement so they can monitor whether the drug remains effective at your current dose. Altogether, these interactions span 1 individual medication.
Use the medication checker below to search your exact drugs before starting.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Lysine?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Lysine interact with 1 drug. Click any drug to see the details.
1 of the 1 ingredient in Lysine interact with drugs. Each result below shows which ingredient is responsible. L-Lysine
TegaserodZelnorm
How Tegaserod interacts with Lysine — through 1 ingredient. Tap an ingredient for the detail:
L-lysine5-ht4 Agonists Minor
Interaction Summary
Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Read the full L-lysine + Tegaserod interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Lysine with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
L-Lysine
5-Ht4 Agonists
Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Animal research suggests that L-lysine is a partial serotonin receptor 4 (5-HT4) antagonist and inhibits diarrhea induced by the 5-HT4 agonist, 5-hydroxytryptophane.
Brand information
Manufacturer and brand details for Lysine, from the product label.
BRI Nutrition
See all BRI Nutrition products- Name
- BRI Nutrition LLC
- Street Address
- 1460 Broadway
- City
- New York
- State
- NY
- ZipCode
- 10036
- Web Address
- www.brinutrition.com
Lysine by BRI Nutrition: Common Questions
Does Lysine by BRI Nutrition interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will lysine help me prevent or shorten cold sores?
What are the side effects of taking lysine supplements?
Is it safe to take lysine if I'm pregnant?
Can I take lysine while breastfeeding?
How much lysine should I take?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Lysine is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Lysine’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Lysine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 7 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Lysine 7 references
- Thein DJ, Hurt WC. Lysine as a prophylactic agent in the treatment of recurrent herpes simplex labialis. Oral Surg Oral Med Oral Pathol 1984;58:659-66. PubMed
- McCune MA, Perry HO, Muller SA, O'Fallon WM. Treatment of recurrent herpes simplex infections with L-lysine monohydrochloride. Cutis 1984;34:366-73.
- DiGiovanna JJ, Blank H. Failure of lysine in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Arch Dermatol 1984;120:48-51. DOI
- Milman N, Scheibel J, Jessen O. Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlled crossover study. Acta Derm Venereol 1980;60:85-7.
- Griffith RS, Walsh DE, Myrmel KH, et al. Success of L-lysine therapy in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Dermatologica 1987;175:183-90. DOI
- Lo JC, Chertow GM, Rennke H, Seifter JL. Fanconi's syndrome and tubulointerstitial nephritis in association with L-lysine ingestion. Am J Kidney Dis 1996;28:614-7. PubMed
- Smriga M, Torii K. L-Lysine acts like a partial serotonin receptor 4 antagonist and inhibits serotonin-mediated intestinal pathologies and anxiety in rats. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15370-5.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC