L-Lysine 1000 mg Ingredients & Drug Interactions
by Nature Made
What is this page for?
First and foremost: checking L-Lysine 1000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
L-Lysine 1000 mg is a dietary supplement by Nature Made with 1 active ingredient. Its ingredients are commonly taken for cold sores (herpes labialis), genital herpes outbreaks, supporting protein and collagen formation.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated minor. The ingredients most likely to interact are L-Lysine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against L-Lysine 1000 mg by Nature Made
Ask about any prescription or over-the-counter medication and we check it for interactions with L-Lysine 1000 mg by Nature Made — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of L-Lysine 1000 mg by Nature Made
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: L-lysine, an amino acid (a building block of protein) that your body uses for various functions. L-lysine is available in foods like meat, cheese, and legumes, and this supplement provides it in concentrated form at 1,000 mg per tablet.
The inactive ingredients are cellulose gel, methylcellulose, stearic acid, croscarmellose sodium, hypromellose, polyethylene glycol, magnesium stearate, and silicon dioxide — these are fillers, binders, and other materials that help form and preserve the tablet.
Does it work?
Couldn't assess
L-lysine is possibly effective for herpes labialis, also called cold sores. The evidence suggests it may help, though more research would strengthen confidence.
For other uses listed — child growth, pressure ulcers, and diabetic foot ulcers — the evidence we hold is insufficient to rate whether it works. If you're considering lysine for one of these purposes, talk it over with your doctor or pharmacist about what the current science supports.
How safe is it?
Well-documented data
L-lysine is generally well tolerated at typical doses. At higher amounts, stomach upset is possible — mainly abdominal pain, diarrhea, and indigestion.
Long-term safety at high doses hasn't been well studied. For pregnancy: supplement safety hasn't been well studied, so check with your doctor first.
For breastfeeding: there isn't enough reliable information, so caution is advised and you should talk with your healthcare provider. Lysine from food sources is fine, but if you're pregnant or breastfeeding and considering the supplement, get personalized advice from your doctor or pharmacist.
Meds to double-check
Minor interactions only
If you take a 5-HT4 agonist, double-check with your doctor or pharmacist before adding this supplement — lysine may reduce how well the drug works. No other medication interactions are documented for the ingredients we could check.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Only minor medication interactions are documented, and safety information is well characterized.
L-Lysine 1000 mg is generally well tolerated and possibly effective for cold sores. If you take a 5-HT4 agonist, check with your doctor or pharmacist before starting it.
Pregnant or breastfeeding? Talk with your healthcare provider first, since safety data is limited in those settings.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 31, 2018.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about L-Lysine 1000 mg, straight from the product label.
| Brand | Nature Made |
|---|---|
| Barcode (UPC) | 031604013479 |
| Net contents | 60 Tablet(s) |
| Market status | On market |
| Date entered into DSLD | Aug 31, 2018 |
| DSLD ID | 179444 |
| Product type | Amino Acid/protein |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for L-Lysine 1000 mg by Nature Made, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| L-Lysine | 1 Gram(s) | -- |
Other ingredients: Cellulose Gel, Methylcellulose, Stearic Acid, Croscarmellose Sodium, Hypromellose, Polyethylene Glycol, Magnesium Stearate, Silicon Dioxide
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General
List No. 1347 L200 Cat. A805 5A006
FDA Statement of Identity
Dietary Supplement
General Statements
Actual size
Supports synthesis of proteins - L-Lysine, an essential amino acid, plays a key role in the makeup of body proteins.
L-Lysine Tablets are made to Nature Made’s guaranteed purity and potency standards.
Formulation
No color added No artificial flavors No preservatives No yeast Gluten free
Suggested/Recommended/Usage/Directions
Suggested use: Take one tablet daily with a meal. For easier swallowing, take with water before and during ingestion.
Storage
Keep bottle tightly closed. Store in a cool, dry place, out of reach of children.
Precautions
Store in a cool, dry place, out of reach of children.
Do not use if imprinted seal under cap is broken or missing.
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
L-Lysine 1000 mg by Nature Made label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in L-Lysine 1000 mg by Nature Made
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.
L-Lysine
Interacts with1 drug
Lysine is an essential amino acid your body cannot make on its own, so it must come from food or supplements. People most often take extra lysine to t...
L-Lysine monograph & interactionsOther (inactive) ingredients: Cellulose Gel, Methylcellulose, Stearic Acid, Croscarmellose Sodium, Hypromellose, Polyethylene Glycol, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.
L-Lysine 1000 mg by Nature Made Drug Interactions
HelloPharmacist Interaction Report
L-Lysine 1000 mg by Nature Made has one documented interaction.
Through its L-lysine content, it may reduce the effects of 5-HT4 agonists (drugs that work on a specific serotonin receptor). Animal research suggests lysine acts as a partial blocker of this receptor and can inhibit diarrhea caused by 5-HT4 agonists — meaning it could theoretically make these medications less effective.
Read the full breakdown — every affected drug type, severity by severity
Although the interaction is rated Minor, if you take a 5-HT4 agonist, it's worth discussing with your doctor or pharmacist before starting this supplement. Altogether, these interactions span 1 individual medication.
Check your exact medications with the search tool on this page to see if any apply to you.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against L-Lysine 1000 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in L-Lysine 1000 mg interact with 1 drug. Click any drug to see the details.
1 of the 1 ingredient in L-Lysine 1000 mg interact with drugs. Each result below shows which ingredient is responsible. L-Lysine
TegaserodZelnorm
How Tegaserod interacts with L-Lysine 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
L-lysine5-ht4 Agonists Minor
Interaction Summary
Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Read the full L-lysine + Tegaserod interactionEach ingredient & the kinds of drugs it affects
For each ingredient in L-Lysine 1000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
L-Lysine
5-Ht4 Agonists
Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Animal research suggests that L-lysine is a partial serotonin receptor 4 (5-HT4) antagonist and inhibits diarrhea induced by the 5-HT4 agonist, 5-hydroxytryptophane.
Brand information
Manufacturer and brand details for L-Lysine 1000 mg, from the product label.
Nature Made
See all Nature Made products- Name
- Nature Made Nutritional Products
- City
- Mission Hills
- State
- CA
- ZipCode
- 91346-9606
- Phone Number
- 1-800-276-2878
- Web Address
- www.NatureMade.com
L-Lysine 1000 mg by Nature Made: Common Questions
Does L-Lysine 1000 mg by Nature Made interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does L-lysine really work for cold sores?
What side effects might I get?
Is it safe to take while pregnant?
Can I take this while breastfeeding?
What is L-lysine and why would I need it?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if L-Lysine 1000 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind L-Lysine 1000 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
L-Lysine 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 7 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Lysine 7 references
- Thein DJ, Hurt WC. Lysine as a prophylactic agent in the treatment of recurrent herpes simplex labialis. Oral Surg Oral Med Oral Pathol 1984;58:659-66. PubMed
- McCune MA, Perry HO, Muller SA, O'Fallon WM. Treatment of recurrent herpes simplex infections with L-lysine monohydrochloride. Cutis 1984;34:366-73.
- DiGiovanna JJ, Blank H. Failure of lysine in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Arch Dermatol 1984;120:48-51. DOI
- Milman N, Scheibel J, Jessen O. Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlled crossover study. Acta Derm Venereol 1980;60:85-7.
- Griffith RS, Walsh DE, Myrmel KH, et al. Success of L-lysine therapy in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Dermatologica 1987;175:183-90. DOI
- Lo JC, Chertow GM, Rennke H, Seifter JL. Fanconi's syndrome and tubulointerstitial nephritis in association with L-lysine ingestion. Am J Kidney Dis 1996;28:614-7. PubMed
- Smriga M, Torii K. L-Lysine acts like a partial serotonin receptor 4 antagonist and inhibits serotonin-mediated intestinal pathologies and anxiety in rats. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15370-5.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC