Interactions on record — worth a quick check against your medications. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

CholestOff Complete Ingredients & Drug Interactions

by Nature Made

CholestOff Complete label
See full label image
Softgel Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking CholestOff Complete against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

CholestOff Complete is a dietary supplement by Nature Made with 3 active ingredients. Its ingredients are commonly taken for high cholesterol, high triglycerides, heart health support.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pantethine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against CholestOff Complete by Nature Made

Ask about any prescription or over-the-counter medication and we check it for interactions with CholestOff Complete by Nature Made — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of CholestOff Complete by Nature Made

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 3 active ingredients.
  • “Plant Sterols and Plant Stanols” is listed as a grouped ingredient — the label gives one combined amount (900 mg) without saying how much of each component you get.

CholestOff Complete has 3 active ingredients. Pantethine is a form of pantothenic acid (vitamin B5) that the body converts to coenzyme A, a compound involved in fat metabolism and cholesterol processing.

Plant sterols and plant stanols are natural compounds from plants that block some dietary cholesterol absorption in your gut — they're the same cholesterol-lowering compounds added to foods like margarines and yogurts. The softgel also contains inactive ingredients such as gelatin, sunflower oil, glycerin, and lecithin as carriers and binders.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Lowers dietary cholesterol and reduces cholesterol production.
  • We looked for evidence on: Hypercholesterolemia, Hyperlipidemia, Hyperlipoproteinemia, Familial hypercholesterolemia, Coronary heart disease (CHD), Myocardial infarction (MI) — and 3 related terms.
  • The strongest evidence on file: Plant Sterols is rated "Likely Effective" for Familial hypercholesterolemia (Natural Medicines).
  • Also on file: Plant Sterols is rated "Likely Effective" for Hypercholesterolemia.
  • Also on file: Pantethine is rated "Possibly Effective" for Hyperlipoproteinemia.

Plant sterols are likely effective for lowering total cholesterol (hypercholesterolemia) and possibly effective for reducing coronary heart disease risk. Pantethine is possibly effective for a condition called hyperlipoproteinemia (a blood fat disorder), but evidence for its use in ordinary high cholesterol isn't solid enough to rate reliably.

We don't have enough data to say whether pantethine helps athletic performance.

The evidence, ingredient by ingredient Pantethine Plant Sterols

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 1 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Plant sterols are generally well tolerated at the amounts in supplements for most adults. Pantethine is also generally well tolerated in studies, though long-term safety data are limited — the most common side effects are mild stomach issues like nausea, bloating, diarrhea, and gas.

Both ingredients warrant caution in pregnancy and breastfeeding: safety data are not well studied at concentrated supplement doses. Rare cases of skin rash and gastrointestinal upset have been reported with plant sterols, and one case of early puberty was reported in a young child given very high daily amounts.

Side effects, ingredient by ingredient Pantethine Plant Sterols

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Pantethine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking CholestOff Complete if you use anticoagulants or antiplatelet drugs (blood thinners like warfarin, clopidogrel, or aspirin for heart protection) — pantethine may increase the risk of bleeding at a moderate level.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

CholestOff Complete may help lower cholesterol, especially if you're looking to add plant sterols to your routine — they have solid evidence behind them. If you take any blood thinner (prescription or over-the-counter), check with your doctor or pharmacist before starting, because pantethine may increase bleeding risk.

Pregnant or breastfeeding? Talk it over with your doctor first — safety data at concentrated doses aren't well established.

For any questions about how it fits your personal health picture, ask your own healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about CholestOff Complete, straight from the product label.

Brand Nature Made
Net contents 120 Softgel(s)
Market status On market
Date entered into DSLD Jan 23, 2023
DSLD ID 285745
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Approved Health, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for CholestOff Complete by Nature Made, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Softgel(s)
Maximum serving Sizes:
3 Softgel(s)
Servings per container
40
IngredientAmount% DV
Calories20 Calorie(s)--
Total Carbohydrates2 Gram(s)1%
Total Fat2 Gram(s)3%
Protein1 Gram(s)--
Pantethine300 mg--
Plant Sterols and Plant Stanols900 mg--
Plant Sterols0 NP--
Plant Stanols0 NP--

Other ingredients: Plant Sterols, Plant Stanols, Gelatin, Sunflower Oil Esters, Pantethine, Glycerin, Medium Chain Triglycerides, Rapeseed Lecithin, Water, Colors added

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

#1 Pharmacist recommended vitamin & supplement brand

Based on a survey of pharmacists who recommend branded vitamins and supplements. Daily Sterol & Stanol Amounts Amount of Phytosterols The National Institutes of Health (NIH) Therapeutic Lifestyle Change Guidelines Recommends: 2000 mg Many Americans Consume as little as: -200 mg CholestOff Complete provides additional: 1800 mg

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Seals/Symbols

USP Verified Dietary Supplement

Formulation

Lowers dietary cholesterol

Reduces cholesterol production in the liver

No synthetic dyes - colors derived from natural sources No artificial flavors No preservatives Gluten free

USP has tested and verified ingredients, potency and manufacturing process. USP sets official standards for dietary supplements. www.uspverified.org

Before taking CholestOff Complete dietary cholesterol is absorbed into the bloodstream After taking CholestOff Complete less dietary cholesterol is absorbed into the bloodstream

Formula

With 900 mg plant sterols & stanols per serving

Products containing at least 400 mg per serving of plant sterols and stanols, eaten twice a day with meals for a daily intake of at least 800 mg as part of a diet low in saturated fat and cholesterol, may reduce the risk of heart disease. One serving of Nature Made CholestOff Complete supplies 900 mg of plant sterols and stanols for a daily intake of 1800 mg.

Nature Made CholestOff Complete combines esterified Reducol, a proprietary blend of plant-based sterols and stanols (also called phytosterols) and Pantesin. CholestOff Complete reduces dietary cholesterol and reduces cholesterol production in the liver. Reducol lowers cholesterol by reducing the absorption of dietary cholesterol into the bloodstream. Pantesin reduces the production of LDL ("bad") cholesterol in the liver. CholestOff Complete is an esty-to-swallow softgel.

Sterols/Stanols are esterified with sunflower oil fatty acids.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: Adults, take 3 softgels twice daily with water at your two largest meals.

Precautions

Store tightly closed, in a cool, dry place, out of reach of children.

Do not use if imprinted seal under cap is broken or missing.

Caution: If you are pregnant, nursing, or taking any medications, consult your physician before use.

Brand IP Statement(s)

Reducol is a trademark of Pharmachem Laboratories Inc. Pantesin is a trademark of Daiichi F.C.Co, Ltd of Tokyo, Japan

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

Store tightly closed, in a cool, dry place, out of reach of children.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

CholestOff Complete by Nature Made label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

CholestOff Complete label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in CholestOff Complete by Nature Made

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Softgel(s) Dosage formSoftgel Capsule Servings per container40 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Protein

1 Gram(s) per serving

Pantethine

Interacts with
122 drugs
300 mg per serving

Pantethine is a derivative of vitamin B5 (pantothenic acid) that some studies suggest may modestly lower cholesterol and triglycerides. The evidence i...

Pantethine monograph & interactions

Plant Sterols and Plant Stanols

No known
interactions
900 mg per serving Form: Esters

Plant sterols (and their close relatives, plant stanols) are natural compounds found in plants that can modestly lower LDL ('bad') cholesterol when ta...

Plant Sterols and Plant Stanols monograph & interactions

Other (inactive) ingredients: Plant Sterols, Plant Stanols, Gelatin, Sunflower Oil Esters, Pantethine, Glycerin, Medium Chain Triglycerides, Rapeseed Lecithin, Water, Colors added. These complete the product’s ingredient list but are not active constituents.

Interaction report

CholestOff Complete by Nature Made Drug Interactions

Want to check YOUR meds against CholestOff Complete?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

Pantethine 122

Individual Drug Interactions

The ingredients in CholestOff Complete interact with 122 drugs. Click any drug to see the details.

1 of the 3 ingredients in CholestOff Complete interact with drugs. Each result below shows which ingredient is responsible. Pantethine

Each ingredient & the kinds of drugs it affects

For each ingredient in CholestOff Complete with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pantethine1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, pantethine might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Some evidence suggests that pantethine reduces platelet aggregation.

Likelihood Possible Evidence B
Pantethine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for CholestOff Complete, from the product label.

Nature Made

See all Nature Made products
Name
Nature Made Nutritional Products
City
West Hills
State
CA
ZipCode
91309-9903
Phone Number
1-800-276-2878
Web Address
www.NatureMade.com
Pharmacist Counseling Corner

CholestOff Complete by Nature Made: Common Questions

Does CholestOff Complete by Nature Made interact with any medications?
Yes. Based on its ingredients, CholestOff Complete has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
CholestOff Complete contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does pantethine do?
Pantethine is a form of pantothenic acid (vitamin B5) that your body converts into a compound called coenzyme A, which helps regulate how your body handles fats and cholesterol. It's possibly effective for a blood fat disorder called hyperlipoproteinemia, but the evidence for typical high cholesterol isn't strong enough to rate reliably.
Are plant sterols the same thing as plant stanols?
They're similar — both are plant compounds that block cholesterol absorption in your gut — but they're different molecules. Plant sterols have solid evidence for lowering cholesterol; we don't have interaction data on the plant stanols in this product.
What are the most common side effects?
Pantethine can cause mild stomach upset — nausea, bloating, diarrhea, and gas are the most reported. Plant sterols are generally well tolerated, though abdominal discomfort is possible. Skin rash has been reported rarely.
Is it safe to take during pregnancy or breastfeeding?
Safety data at concentrated supplement doses aren't well studied for either ingredient during pregnancy or breastfeeding. Talk with your doctor before using CholestOff Complete if you're pregnant or nursing — they can help you decide whether it's right for you.
Will this lower my cholesterol?
Plant sterols are likely effective for lowering cholesterol. Pantethine is possibly effective for certain blood fat disorders, but evidence for typical high cholesterol is mixed. Results can vary, and lifestyle changes like diet and exercise matter too.
Does this product have any fillers?
The softgel contains gelatin, sunflower oil, glycerin, lecithin, and other inactive ingredients that hold the capsule together and help your body absorb the active ingredients — these are standard carriers, not harmful fillers.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

CholestOff Complete label
Go deeper

The Full Monographs Behind CholestOff Complete’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pantethine

Interacts with 122 drugs

Pantethine is a derivative of vitamin B5 (pantothenic acid) that some studies suggest may modestly lower cholesterol and triglycerides. The evidence is limited and not strong enough to repla...

Read the full Pantethine monograph → Herb & supplement monograph

Plant Sterols

Plant sterols (and their close relatives, plant stanols) are natural compounds found in plants that can modestly lower LDL ('bad') cholesterol when taken regularly in adequate amounts, usual...

Read the full Plant Sterols monograph →
Sources

Sources & How We Checked

CholestOff Complete's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pantethine 9 references
  1. Da Col PG, Cattin L, Fonda M, et al. Pantethine in the treatment of hypercholesterolemia: a randomized double-blind trial versus tiadenol. Curr Ther Res 1984;36:314-22.
  2. Rubba P, Postaiglione B, De Simone F, et al. Comparative evaluation of the lipid-lowering effects of fenofibrate and pantethine in type II hyperlipoproteinemia. Curr Ther Res 1985;38:719-27.
  3. Coronel F, Tornero F, Torrente J, et al. Treatment of hyperlipemia in diabetic patients on dialysis with a physiological substance. Am J Nephrol 1991;11:32-6.. PubMed
  4. Agrati AM, Ambrosi G, Ferraro G, Palmieri. Gemfibrozil efficacy vs pantethine in dyslipoproteinemic patients: a controlled study. Curr Ther Res 1989;45:650-63.
  5. Rumberger, J. A., Napolitano, J., Azumano, I., Kamiya, T., and Evans, M. Pantethine, a derivative of vitamin B(5) used as a nutritional supplement, favorably alters low-density lipoprotein cholesterol metabolism in low- to moderate-cardiovascular risk No
  6. Hiramatsu, K., Nozaki, H., and Arimori, S. Influence of pantethine on platelet volume, microviscosity, lipid composition and functions in diabetes mellitus with hyperlipidemia. Tokai J.Exp.Clin.Med. 1981;6(1):49-57.
  7. McRae MP. Treatment of hyperlipoproteinemia with pantethine: A review and analysis of efficacy and tolerability. Nutrition Res 2005;25:319-333. DOI
  8. Cattin, L., Da Col, P. G., Fonda, M., Mameli, M. G., and Fergulio, G. A. Treatment of hypercholesterolemia with pantethine and fenofibrate; open randomized study on 43 subjects. Current Therapeutic Research 1985;38(Sep):386-395.
  9. Evans M, Rumberger JA, Azumano I, Napolitano JJ, Citrolo D, Kamiya T. Pantethine, a derivative of vitamin B5, favorably alters total, LDL and non-HDL cholesterol in low to moderate cardiovascular risk subjects eligible for statin therapy: a triple-blinded

See these in context on the Pantethine monograph →

Plant Sterols 3 references
  1. Guardamagna, O., Abello, F., Baracco, V., Federici, G., Bertucci, P., Mozzi, A., Mannucci, L., Gnasso, A., and Cortese, C. Primary hyperlipidemias in children: effect of plant sterol supplementation on plasma lipids and markers of cholesterol synthesis a
  2. Haque Hussain SS, Weir J, Roberts N. Severe dermatitis secondary to plant sterol supplements. Clin Exp Dermatol. 2009 Oct;34(7):e276-7. PubMed
  3. Xue P, Wang Y, Chen Y, et al. A Case of Peripheral Precocious Puberty May Be Caused by a Diet Containing Phytosterols in a 20-Month-Old Boy. Horm Res Paediatr 2022;95(5):484-491. PubMed

See these in context on the Plant Sterols monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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