L-Lysine Complete Ingredients & Drug Interactions
by PureFormulas
What is this page for?
First and foremost: checking L-Lysine Complete against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
L-Lysine Complete is a dietary supplement by PureFormulas with 1 active ingredient. Its ingredients are commonly taken for cold sores (herpes labialis), genital herpes outbreaks, supporting protein and collagen formation.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated minor. The ingredients most likely to interact are L-Lysine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against L-Lysine Complete by PureFormulas
Ask about any prescription or over-the-counter medication and we check it for interactions with L-Lysine Complete by PureFormulas — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of L-Lysine Complete by PureFormulas
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
L-Lysine Complete contains one active ingredient: L-lysine, an amino acid your body uses to build protein and support immune function. The capsule also holds inactive ingredients—vegetable cellulose, microcrystalline cellulose, and leucine—which help form and stabilize the capsule.
Does it work?
Couldn't assess
L-lysine is possibly effective for herpes labialis (cold sores). For other uses listed in the data—child growth, pressure ulcers, and diabetic foot ulcers—there isn't enough reliable evidence yet to know whether it works.
How safe is it?
Well-documented data
L-lysine from food is fine. As a supplement, it's generally well tolerated at typical doses, but high amounts may cause stomach upset, and long-term safety isn't well studied.
The most common side effects when taken orally are abdominal pain, diarrhea, and indigestion. There is one case report of high-dose lysine linked to kidney inflammation that progressed to chronic kidney failure, though this is rare.
For pregnancy and breastfeeding, there isn't enough data to know whether supplement doses are safe. Talk with your doctor or pharmacist before taking this if you're pregnant or nursing.
Meds to double-check
Minor interactions only
If you take a 5-HT4 agonist (a medication for certain digestive conditions), double-check the timing and dose with your doctor or pharmacist before using L-lysine—the supplement may reduce how well the drug works.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Only minor medication interactions are documented, and safety information is well characterized.
L-lysine may help with cold sores and is generally well tolerated at typical doses. If you take a 5-HT4 agonist or have a history of kidney problems, check with your doctor or pharmacist before starting.
Pregnant or breastfeeding? Confirm with your healthcare provider first, since long-term safety data is limited.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2019.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about L-Lysine Complete, straight from the product label.
| Brand | PureFormulas |
|---|---|
| Barcode (UPC) | PUF1134 |
| Net contents | 90 Vegetarian Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Aug 23, 2019 |
| DSLD ID | 205685 |
| Product type | Amino Acid/protein |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for L-Lysine Complete by PureFormulas, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| L-Lysine | 500 mg | -- |
Other ingredients: Vegetable Cellulose, Microcrystalline Cellulose, Leucine
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested use: As a dietary supplement take 1 capsule, 1 to 3 times daily between meals, or as directed by your healthcare practitioner.
Precautions
Keep out of reach of children.
Warning: If pregnant or nursing, consult your healthcare practitioner before taking this product.
Storage
Store in a cool, dry place.
General Statements
Color and flavor of this product may vary due to natural variations of the natural ingredients.
Live life pure.
Immune, hormone & enzyme support
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Seals/Symbols
Non-GMO
Formulation
Non-GMO
FDA Statement of Identity
A Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
L-Lysine Complete by PureFormulas label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in L-Lysine Complete by PureFormulas
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Vegetarian Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.
L-Lysine
Interacts with1 drug
Lysine is an essential amino acid your body cannot make on its own, so it must come from food or supplements. People most often take extra lysine to t...
L-Lysine monograph & interactionsOther (inactive) ingredients: Vegetable Cellulose, Microcrystalline Cellulose, Leucine. These complete the product’s ingredient list but are not active constituents.
L-Lysine Complete by PureFormulas Drug Interactions
HelloPharmacist Interaction Report
L-Lysine Complete from PureFormulas has one documented interaction.
Through its L-lysine content, it may reduce the effects of 5-HT4 agonists (medications that work on a specific serotonin receptor to treat certain digestive issues). Animal research suggests lysine acts as a partial blocker of this receptor, which could theoretically lower how well these drugs work.
Read the full breakdown — every affected drug type, severity by severity
Altogether, these interactions span 1 individual medication.
If you take a 5-HT4 agonist, run it through the medication checker on this page before you start L-lysine, and confirm the timing and dose with your doctor or pharmacist.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against L-Lysine Complete?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in L-Lysine Complete interact with 1 drug. Click any drug to see the details.
1 of the 1 ingredient in L-Lysine Complete interact with drugs. Each result below shows which ingredient is responsible. L-Lysine
TegaserodZelnorm
How Tegaserod interacts with L-Lysine Complete — through 1 ingredient. Tap an ingredient for the detail:
L-lysine5-ht4 Agonists Minor
Interaction Summary
Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Read the full L-lysine + Tegaserod interactionEach ingredient & the kinds of drugs it affects
For each ingredient in L-Lysine Complete with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
L-Lysine
5-Ht4 Agonists
Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Animal research suggests that L-lysine is a partial serotonin receptor 4 (5-HT4) antagonist and inhibits diarrhea induced by the 5-HT4 agonist, 5-hydroxytryptophane.
Brand information
Manufacturer and brand details for L-Lysine Complete, from the product label.
PureFormulas
See all PureFormulas products- Name
- PureFormulas
- Street Address
- 11800 NW 102nd Road, Suite 2
- City
- Miami
- State
- FL
- ZipCode
- 33178
- Web Address
- www.pureformulas.com
L-Lysine Complete by PureFormulas: Common Questions
Does L-Lysine Complete by PureFormulas interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does L-lysine actually work for cold sores?
What are the most common side effects?
Can I take this while pregnant?
Is it safe while breastfeeding?
What is L-lysine and why do I need it?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if L-Lysine Complete is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind L-Lysine Complete’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
L-Lysine Complete's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 7 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Lysine 7 references
- Thein DJ, Hurt WC. Lysine as a prophylactic agent in the treatment of recurrent herpes simplex labialis. Oral Surg Oral Med Oral Pathol 1984;58:659-66. PubMed
- McCune MA, Perry HO, Muller SA, O'Fallon WM. Treatment of recurrent herpes simplex infections with L-lysine monohydrochloride. Cutis 1984;34:366-73.
- DiGiovanna JJ, Blank H. Failure of lysine in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Arch Dermatol 1984;120:48-51. DOI
- Milman N, Scheibel J, Jessen O. Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlled crossover study. Acta Derm Venereol 1980;60:85-7.
- Griffith RS, Walsh DE, Myrmel KH, et al. Success of L-lysine therapy in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Dermatologica 1987;175:183-90. DOI
- Lo JC, Chertow GM, Rennke H, Seifter JL. Fanconi's syndrome and tubulointerstitial nephritis in association with L-lysine ingestion. Am J Kidney Dis 1996;28:614-7. PubMed
- Smriga M, Torii K. L-Lysine acts like a partial serotonin receptor 4 antagonist and inhibits serotonin-mediated intestinal pathologies and anxiety in rats. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15370-5.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC