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Dietary supplement

L-Tyrosine 500 mg Ingredients & Drug Interactions

by GNC

L-Tyrosine 500 mg label
See full label image
Other (e.g. Tea Bag) Category: Amino Acid/protein
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking L-Tyrosine 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

L-Tyrosine 500 mg is a dietary supplement by GNC with 1 active ingredient. Its ingredients are commonly taken for mental focus and alertness, coping with stress, fatigue and sleep loss.Based on those ingredients, 21 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Tyrosine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against L-Tyrosine 500 mg by GNC

Ask about any prescription or over-the-counter medication and we check it for interactions with L-Tyrosine 500 mg by GNC — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of L-Tyrosine 500 mg by GNC

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This supplement contains one active ingredient: L-tyrosine, an amino acid your body uses to make certain neurotransmitters and thyroid hormones. The product also includes cellulose and acacia as inactive ingredients (fillers and binders).

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: support for normal healthy nervous system function.
  • We looked for evidence on: Cognitive function, Stress, Fatigue, Sleep deprivation, Athletic performance, Attention deficit-hyperactivity disorder (ADHD) — and 4 related terms.
  • The strongest evidence on file: Tyrosine is rated "Possibly Effective" for Cognitive function (Natural Medicines).
  • Also on file: Tyrosine is rated "Possibly Effective" for Memory.
  • Also on file: Tyrosine is rated "Possibly Ineffective" for Athletic performance.

L-tyrosine is effective for phenylketonuria (PKU), a rare genetic condition where the body can't process phenylalanine properly. For cognitive function and memory, the evidence is possibly effective — some research suggests it may help, but we don't have strong proof.

For athletic performance, current evidence suggests it's probably not effective. For alcohol use disorder and dementia, we don't have enough reliable data to say whether it works.

The evidence, ingredient by ingredient Tyrosine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-tyrosine is generally well tolerated in healthy adults, but there's not enough long-term safety data to recommend regular use without talking to your doctor first. The most common side effects from oral use are fatigue, headache, heartburn, and nausea.

Higher doses can increase these effects, though lowering your dose may reduce them. Safety data for pregnancy and breastfeeding is limited — there isn't enough information to know whether it's safe, so talk with your doctor or pharmacist if you're pregnant or nursing.

Side effects, ingredient by ingredient Tyrosine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Tyrosine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: Parkinson's medications.
  • For scale: 21 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take levodopa (a Parkinson's medication) — tyrosine can reduce its effectiveness and you'd need to space them apart. Also flag it if you're on any thyroid hormone medication, since tyrosine may have additive effects.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

L-tyrosine may be worth considering if you're looking to support cognitive function or memory, though the evidence is modest. If you take levodopa for Parkinson's or any thyroid medication, you'll need to check with your doctor or pharmacist first — this supplement could interfere with how well those drugs work.

Start a conversation with your own healthcare provider before making it part of your routine.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 23, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about L-Tyrosine 500 mg, straight from the product label.

Brand GNC
Barcode (UPC) 048107122454
Net contents 60 Vegetarian Caplet(s)
Market status On market
Date entered into DSLD Jun 23, 2017
DSLD ID 74439
Product type Amino Acid/protein
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for L-Tyrosine 500 mg by GNC, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Caplet(s)
Maximum serving Sizes:
4 Caplet(s)
UPC/BARCODE
048107122454
IngredientAmount% DV
L-Tyrosine500 mg--

Other ingredients: Cellulose, Acacia

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Support for normal, healthy nervous system function

Potency verified by GNC procedure #5061. Conforms to USP <2091> for weight. Meets USP <2040> disintegration.

FDA Statement of Identity

Dietary Supplement

General

CODE 031713 CRG

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take one to four caplets daily on an empty stomach. For maximum support, take as directed every day.

Precautions

Keep out of reach of children.

Storage

Store in a cool, dry place.

Seals/Symbols

Ko

Formula

Ko

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

L-Tyrosine 500 mg by GNC label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

L-Tyrosine 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in L-Tyrosine 500 mg by GNC

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Caplet(s) Dosage formOther (e.g. Tea Bag) Amounts shown are per serving.

L-Tyrosine

Interacts with
21 drugs
500 mg per serving

L-tyrosine is an amino acid your body uses to make brain chemicals like dopamine and norepinephrine. Some studies suggest it may help mental performan...

L-Tyrosine monograph & interactions

Other (inactive) ingredients: Cellulose, Acacia. These complete the product’s ingredient list but are not active constituents.

Interaction report

L-Tyrosine 500 mg by GNC Drug Interactions

Want to check YOUR meds against L-Tyrosine 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
21Drugs
21 Moderate

Ingredients driving the most interactions

L-Tyrosine 21

Individual Drug Interactions

The ingredients in L-Tyrosine 500 mg interact with 21 drugs. Click any drug to see the details.

1 of the 1 ingredient in L-Tyrosine 500 mg interact with drugs. Each result below shows which ingredient is responsible. L-Tyrosine

Each ingredient & the kinds of drugs it affects

For each ingredient in L-Tyrosine 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Tyrosine2 drug types · 21 drugs

Levodopa

Theoretically, tyrosine might decrease the effectiveness of levodopa.
Tyrosine and levodopa compete for absorption in the proximal duodenum by the large neutral amino acid (LNAA) transport system. Advise patients to separate doses of tyrosine and levodopa by at least 2 hours.

Likelihood Probable Evidence D
Thyroid Hormone

Theoretically, tyrosine might have additive effects with thyroid hormone medications.
Tyrosine is a precursor to thyroxine and might increase levels of thyroid hormones.

Likelihood Probable Evidence D
L-Tyrosine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for L-Tyrosine 500 mg, from the product label.

GNC

See all GNC products
Name
General Nutrition Corporation
City
Pittsburgh
State
PA
ZipCode
15222
Phone Number
1-888-462-2548
Web Address
www.gnc.com
Pharmacist Counseling Corner

L-Tyrosine 500 mg by GNC: Common Questions

Does L-Tyrosine 500 mg by GNC interact with any medications?
Yes. Based on its ingredients, L-Tyrosine 500 mg has a known interaction with 21 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
L-Tyrosine 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does L-tyrosine actually do in my body?
L-tyrosine is an amino acid your body uses to build neurotransmitters (brain chemicals) and thyroid hormones. It's especially important if you have phenylketonuria (PKU), a rare genetic condition. For otherwise healthy people, research suggests it might support cognitive function and memory, though the evidence isn't rock-solid.
What are the most common side effects?
Most people tolerate it well, but some experience fatigue, headache, heartburn, or nausea. Higher doses are more likely to cause these effects, and they usually improve if you lower your dose.
Is L-tyrosine safe to take while pregnant or breastfeeding?
There isn't enough safety data on supplemental tyrosine during pregnancy or breastfeeding to say either way. Talk with your doctor or pharmacist before taking it if you're pregnant or nursing.
Will this help with athletic performance?
Current evidence suggests L-tyrosine is probably not effective for boosting athletic performance, so if that's your main goal, this supplement likely won't help.
Can I take this with my other supplements?
The product facts don't include interaction data with other supplements. The main concerns we track are with medications — specifically levodopa and thyroid medications. For combinations with other supplements, check with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if L-Tyrosine 500 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

L-Tyrosine 500 mg label
Go deeper

The Full Monographs Behind L-Tyrosine 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tyrosine

Interacts with 21 drugs

L-tyrosine is an amino acid your body uses to make brain chemicals like dopamine and norepinephrine. Some studies suggest it may help mental performance during short-term stress, sleep loss,...

Read the full Tyrosine monograph →
Sources

Sources & How We Checked

L-Tyrosine 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tyrosine 4 references
  1. Meyer JS, Welch KM, Deshmukh VD, et al. Neurotransmitter precursor amino acids in the treatment of multi-infarct dementia and Alzheimer's disease. J Amer Geriat Soc 1977;25:289-98.
  2. DiPiro JT, Talbert RL, Yee GC, et al; eds. Pharmacotherapy: A pathophysiologic approach. 4th ed. Stamford, CT: Appleton & Lange, 1999.
  3. Wood DR, Reimherr FW, Wender PH. Amino acid precursors for the treatment of attention deficit disorder, residual type. Psychopharmacol Bull 1985;21:146-9.
  4. van Spronsen FJ, van Rijn M, Bekhof J. Phenylketonuria: tyrosine supplementation in phenylalanine-restricted diets. Am J Clin Nutr 2001;73:153-7. PubMed

See these in context on the Tyrosine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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